info icon

This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Hypergammalglobulinemia, unspecified

D3_HYPERGAMMAGLONAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D89.2
  • Cause of death: ICD-10 D89.2

2 out of 7 registries used, show all original rules.

35

4. Check minimum number of events

None

35

5. Include endpoints

None

35

6. Filter based on genotype QC (FinnGen only)

35

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D89
Name in latin
Hypergammaglobulinaemia non specificata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 225 103 120
Only index persons 169 84 85
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 66.41 65.47 67.14
Only index persons 64.83 64.44 65.22

-FinnGen-

Key figures

All Female Male
Number of individuals 35 15 20
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 60.02 51.45 66.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3020630) Protein [Mass/volume] in Serum or Plasma
11
19
7.98
6.56
4.6
1.7
g/l
74.2
67.9
1.00
11
14
(40768446) Kidney Pathology biopsy report
6
0
+∞
6.43
1.8
0.0
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
10
16
8.35
6.34
4.6
1.6
—
—
—
0
0
(3012565) Volume of 24 hour Urine
5
0
+∞
5.33
2.6
0.0
ml
1890.0
—
—
5
0
(42870588) Differential panel, method unspecified - Blood
19
84
3.76
3.60
10.3
5.2
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
23
116
3.87
3.57
16.0
5.6
mmol/l
1.2
1.2
0.01
17
98
(3022096) Basophils/100 leukocytes in Blood
22
113
3.55
3.22
11.0
6.0
%
0.6
0.7
0.18
22
108
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
5
5
11.34
3.07
2.8
1.2
g/l
0.2
0.2
—
5
5
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
5
5
11.34
3.07
2.8
1.4
g/l
1.3
0.9
—
5
5
(3002030) Lymphocytes/100 leukocytes in Blood
22
116
3.41
3.03
11.2
6.4
%
28.5
26.6
0.34
22
111
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
6
9
7.76
2.99
1.5
1.4
—
—
—
0
0
(3018418) pH of Serum or Plasma
16
70
3.37
2.97
14.1
3.3
ph
7.4
7.4
—
6
15
(3015171) Extractable nuclear Ab [Units/volume] in Serum
5
6
9.44
2.84
1.2
1.3
—
—
—
0
0
(1616796) Gas panel - Central venous blood
5
7
8.08
2.63
5.8
1.7
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
5
7
8.08
2.63
5.8
2.0
kpa
4.6
5.3
—
5
7
(3027315) Oxygen [Partial pressure] in Blood
5
7
8.08
2.63
5.8
2.0
kpa
9.1
7.2
—
5
7
(40768443) Skin Pathology biopsy report
5
8
7.05
2.45
1.2
1.1
—
—
—
0
0
(3022313) Gas panel - Capillary blood
5
9
6.26
2.29
7.6
1.8
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
5
10
5.62
2.14
3.0
5.5
mmol/l
23.9
24.6
—
5
10
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
8
27
3.53
2.09
2.0
1.9
—
—
—
0
0
(4035726)
7
24
3.38
1.83
2.3
1.2
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
8
31
3.04
1.79
2.3
1.8
—
—
—
0
0
(3023024) Carbon dioxide [Partial pressure] in Capillary blood
5
13
4.29
1.78
8.6
2.2
kpa
4.8
4.7
—
5
13
(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation
5
13
4.29
1.78
8.2
2.0
mmol/l
-2.3
0.6
—
5
7
(3007853) Bacteria identified in Skin by Aerobe culture
7
25
3.24
1.75
2.4
1.3
—
—
—
0
0
(3019225) pH of Specimen
6
20
3.40
1.66
9.5
5.4
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
8
33
2.84
1.66
2.9
2.8
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
6
21
3.23
1.58
1.3
1.2
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
9
40
2.67
1.54
2.3
1.2
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
17
103
2.26
1.49
5.2
2.1
ug/l
155.6
84.1
1.03
17
95
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
5
16
3.46
1.49
1.8
1.8
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
5
16
3.46
1.49
1.4
1.3
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
11
55
2.46
1.46
10.3
4.9
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
6
23
2.93
1.43
2.2
1.3
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
5
17
3.25
1.41
1.8
1.7
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
26
197
2.24
1.32
7.5
3.9
mm/h
31.3
10.7
2.25
26
174
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
8
40
2.29
1.21
3.6
1.5
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
8
41
2.23
1.18
9.6
1.6
umol/l
13.5
14.5
—
8
36
(3037522) Nuclear Ab [Titer] in Serum
7
32
2.48
1.16
1.9
1.4
—
297.1
—
0
7
(3023368) Bacteria identified in Blood by Culture
12
69
2.12
1.14
8.8
3.7
—
—
—
0
0
(3012544) pH of Venous blood
5
21
2.60
1.13
5.8
3.0
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
9
49
2.12
1.09
3.7
2.1
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
7
35
2.24
1.07
4.6
1.3
—
—
—
0
0
(3015736) pH of Urine
16
105
1.96
1.07
5.6
3.0
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
16
106
1.94
1.03
12.8
7.7
inr
1.3
1.1
—
5
38
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
13
80
1.99
1.03
1.7
3.2
ng/l
1150.8
976.8
0.09
13
60
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
6
28
2.37
0.97
3.3
3.8
u/l
27.8
26.5
—
6
21
(3013512) EKG study
12
75
1.91
0.89
3.5
4.0
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
24
188
1.88
0.88
5.5
4.5
pmol/l
14.9
15.1
0.15
24
166
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
15
102
1.82
0.87
4.1
2.2
nmol/l
67.3
71.9
0.39
15
85
(36304419) Bacteria [Presence] in Urine
12
76
1.88
0.86
9.9
2.4
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
5
25
2.16
0.76
19.4
3.4
—
—
—
0
0
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
19
143
1.72
0.76
10.4
6.7
umol/l
9.1
11.4
1.50
19
137
(3019832) Treponema pallidum Ab [Presence] in Serum
5
26
2.07
0.74
3.0
1.9
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
12
83
1.68
0.62
4.7
2.5
u/l
112.6
51.4
0.49
12
78
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
23
0.00
0.60
0.0
1.0
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
9
129
0.59
0.57
4.2
3.5
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
11
76
1.65
0.57
4.2
3.9
u/l
27.0
37.7
0.68
11
70
(40768797) Stomach Pathology biopsy report
6
40
1.60
0.54
1.0
1.3
—
—
—
0
0
(40758558) Short blood count panel - Blood
10
68
1.66
0.54
7.1
4.8
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
27
239
1.57
0.47
6.1
4.9
mu/l
2.6
2.0
0.96
27
212
(3011397) Hemoglobin [Presence] in Urine by Test strip
8
58
1.49
0.46
8.8
2.9
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
10
71
1.57
0.45
2.3
1.4
nmol/l
19.5
18.6
—
10
58
(3004716) Salmonella sp identified in Stool by Organism specific culture
0
16
0.00
0.42
0.0
1.3
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
14
111
1.44
0.38
2.6
1.8
pmol/l
80.5
93.2
—
8
59
(1761868) Lipid panel - Serum or Plasma
8
105
0.69
0.36
3.4
3.0
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
13
103
1.42
0.35
11.8
2.7
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
8
65
1.30
0.30
1.6
1.7
mmol/l
1.3
1.4
—
8
53
(3026008) Bacteria identified in Urine by Culture
9
73
1.31
0.29
3.6
3.0
—
—
—
0
0
(3003338) MCHC [Mass/volume]
20
223
0.76
0.25
26.1
17.3
g/l
331.9
332.5
0.12
20
223
(3037467) Urinalysis macro (dipstick) panel - Urine
20
177
1.30
0.24
10.8
4.5
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
18
158
1.29
0.23
4.1
2.9
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
15
129
1.28
0.22
10.3
3.6
estimate
0.0
0.0
—
5
26
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
11
0.00
0.22
0.0
1.2
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
11
0.00
0.22
0.0
2.2
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
10
0.00
0.22
0.0
1.1
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
0
10
0.00
0.22
0.0
1.2
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
6
76
0.75
0.18
13.7
3.8
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
9
107
0.79
0.16
11.6
3.7
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
22
236
0.82
0.14
20.2
15.0
%
38.5
40.4
0.78
15
170
(3044889) 12 lead EKG panel
20
187
1.16
0.09
5.5
3.8
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
19
177
1.16
0.09
8.0
4.0
—
26.2
—
0
5
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
19
177
1.16
0.09
5.8
3.2
u/l
49.8
63.5
0.52
19
169
(3000963) Hemoglobin [Mass/volume] in Blood
29
294
0.92
0.09
41.6
19.9
g/l
127.7
135.8
2.19
29
289
(3035941) MCH [Entitic mass]
29
294
0.92
0.09
40.9
19.6
pg
31.0
30.4
0.77
29
289
(3024731) MCV [Entitic volume]
29
294
0.92
0.09
41.1
19.7
fl
93.2
91.1
1.12
29
289
(3010813) Leukocytes [#/volume] in Blood
29
294
0.92
0.09
41.4
19.7
e9/l
6.9
6.5
0.51
29
287
(3026361) Erythrocytes [#/volume] in Blood
29
294
0.92
0.09
41.2
19.7
e12/l
4.2
4.5
3.01
29
286
(3007461) Platelets [#/volume] in Blood
29
293
0.94
0.09
41.4
19.8
e9/l
250.2
247.1
0.07
29
287
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
29
280
1.21
0.08
21.4
10.8
u/l
21.8
26.3
1.70
29
273
(40761511) CBC panel - Blood by Automated count
27
277
0.89
0.08
27.3
12.7
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
7
82
0.82
0.08
3.6
2.1
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
23
219
1.15
0.07
31.7
16.2
%
13.6
13.6
0.05
23
214
(40768804) Tissue Pathology biopsy report
11
105
1.07
0.00
3.0
2.0
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
24
245
0.94
0.00
9.2
6.1
mmol/mol
41.5
40.0
0.30
24
226
(3009261) Glucose [Presence] in Urine by Test strip
13
132
0.98
0.00
11.8
3.6
estimate
0.0
0.0
—
5
25
(3021601) Nitrite [Presence] in Urine by Test strip
13
129
1.01
0.00
14.8
4.8
estimate
0.0
0.0
—
5
26
(3041354) Potassium [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
5.0
—
4.1
—
0
5
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.4
—
6.0
—
0
5
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
5.4
—
19.6
—
0
5
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4268621)
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
5.0
—
—
—
0
0
(4027681)
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3035285) Chloride [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
5.0
—
105.8
—
0
5
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.4
—
100.4
—
0
5
(3035637) Corticotropin [Mass/volume] in Plasma
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
28
272
1.15
0.00
32.1
14.7
mmol/l
4.0
4.0
0.28
28
267
(3003694) ABO and Rh group [Type] in Blood
6
65
0.91
0.00
2.2
1.5
—
—
—
0
0
(3024474) Albumin [Mass/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.0
—
228.0
—
0
6
(3008037) Lactate [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
5.5
—
1.4
—
0
6
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
6
59
1.02
0.00
3.8
2.1
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
6
62
0.96
0.00
4.3
3.0
—
1.0
—
0
11
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(4034850)
0
8
0.00
0.00
0.0
5.4
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
7
0.00
0.00
0.0
3.1
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
5.5
—
9.5
—
0
6
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
6
0.00
0.00
0.0
8.0
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
29
282
1.17
0.00
35.9
15.6
umol/l
113.8
78.5
1.48
29
282

Mortality – FinRegistry

Association

Association between endpoint D3_HYPERGAMMAGLONAS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
D3_HYPERGAMMAGLONAS 2.562 [1.51, 4.34] < 0.001
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 109 males with D3_HYPERGAMMAGLONAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_HYPERGAMMAGLONAS.

N-year risk Females Males
1 No data 0.467%
5 No data 2.937%
10 No data 7.793%
15 No data 14.578%
20 No data 23.334%

Relationships between endpoints

Index endpoint: D3_HYPERGAMMAGLONAS – Hypergammalglobulinemia, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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