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Pseudomembranous colitis

COLITENTER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K52.80#
  • Cause of death: ICD-10 K52.80#

2 out of 7 registries used, show all original rules.

317

4. Check minimum number of events

None

317

5. Include endpoints

None

317

6. Filter based on genotype QC (FinnGen only)

317

Control definitions (FinnGen only)

Control exclude
K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K52
Name in latin
Colitis [haemorrhagica] ex usu antibioticorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 317 204 113
Unadjusted period prevalence (%) 0.06 0.07 0.05
Median age at first event (years) 48.78 45.15 55.33

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
289
Matched controls
2890
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K52.80
ICD-10 Finland
(Hemorrhagic) colitis caused by antibiotics
+∞
323.0
289
*
A07EC02
ATC
mesalazine; oral, rectal
161.9
71.7
73
6
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
294.9
69.6
68
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
569.2
50.0
48
*
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
49.0
49.2
59
15
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
47.2
44
*
A07EA06
ATC
budesonide; oral, local oral
69.7
41.7
47
8
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
24.9
38.8
55
27
P01AB01
ATC
metronidazole; oral, rectal
5.3
38.4
190
771
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
6.2
34.6
110
261
UJF32
NOMESCO Finland
Coloscopy
5.1
32.9
132
407
K51.5
ICD-10 Finland
Left sided colitis
+∞
31.9
30
*
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
27.5
26
*
A07AA09
ATC
vancomycin; oral
29.6
20.4
27
10
L04AX01
ATC
azathioprine; systemic
11.9
17.5
32
30
H02AB06
ATC
prednisolone; systemic
2.9
17.0
165
904
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
16.8
16
*
J01MA02
ATC
ciprofloxacin; systemic
2.9
16.3
144
734
A07EA02
ATC
hydrocortisone; rectal
63.7
15.9
18
*
C10AC01
ATC
colestyramine; oral
9.6
13.8
28
32
K50.8
ICD-10 Finland
Other Crohn disease
+∞
13.6
13
*
UJF30
NOMESCO Finland
Ileoscopy through colon
4.7
13.0
45
108
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
12.6
12
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
11.8
101
483
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
+∞
11.5
11
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
+∞
11.5
11
*
K59.1
ICD-10 Finland
Functional diarrhoea
6.0
11.3
31
57
A07EC01
ATC
sulfasalazine; oral, rectal
4.6
11.2
39
94
A02BC03
ATC
lansoprazole; oral
2.5
10.9
104
526
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
7.5
10.8
25
36
N02AX02
ATC
tramadol; systemic, rectal
2.4
10.8
140
824
A02BC01
ATC
omeprazole; systemic
2.5
10.7
101
506
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
10.5
10
*
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
10.5
10
*
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
10.5
10
*
J01FF01
ATC
clindamycin; systemic
2.5
10.3
102
522
H02AB07
ATC
prednisone; oral
3.1
10.2
60
224
J01FA06
ATC
roxithromycin; oral
2.3
10.1
139
833
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
4.0
9.7
39
108
A06AC01
ATC
ispaghula (psylla seeds); oral
2.5
9.6
91
454
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
9.4
9
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
9.4
9
*
J01MA12
ATC
levofloxacin; systemic
2.6
8.9
69
306
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.3
8.5
44
151
K51
ICD-10 Finland
Ulcerative colitis
92.7
8.5
9
*
A07DA03
ATC
loperamide; oral
5.5
8.4
24
47
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
8.4
8
*
A02BA02
ATC
ranitidine; systemic
2.5
8.1
70
328
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.5
8.1
38
121
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
5.0
8.0
25
54
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
8.0
116
692
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.5
7.7
69
327
N06AA09
ATC
amitriptyline; systemic
3.0
7.6
44
163
N03AX12
ATC
gabapentin; oral
2.6
7.4
58
256
A01AB09
ATC
miconazole; local oral
3.2
7.4
39
135
UJF92
NOMESCO Finland
Capsular endoscopy
12.5
7.1
12
10
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
7.1
61
283
N03AE01
ATC
clonazepam; systemic
4.2
6.9
25
64
A04.9
ICD-10 Finland
Bacterial intestinal infection, unspecified
11.3
6.9
12
11
A46
ICD-10 Finland
Erysipelas
2.6
6.8
50
215
N06AB04
ATC
citalopram; systemic
2.2
6.7
75
396
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.2
6.6
34
116
K92.1
ICD-10 Finland
Melaena
4.7
6.6
21
47
A07AA02
ATC
nystatin; oral
3.5
6.5
29
89
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
8.4
6.4
13
16
L04AB04
ATC
adalimumab; parenteral
11.4
6.3
11
10
D94
ICPC
Chronic enteritis/ulcerative colitis
+∞
6.3
6
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
6.3
6
*
N05CD07
ATC
temazepam; oral
2.5
6.3
49
217
J45.1
ICD-10 Finland
Nonallergic asthma
3.6
6.3
27
81
SPAT1263
SPAT
Sampling
1.9
6.2
123
811
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
6.2
45
189
X58
ICD-10 Finland
Exposure to other specified factors
2.6
6.2
43
179
212
Kela drug reimbursment
Gout
8.9
6.1
12
14
M13.9
ICD-10 Finland
Arthritis, unspecified
3.5
6.1
27
83

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: COLITENTER – Pseudomembranous colitis

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).