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Allergic colitis

COLITALLERG

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K52.2
  • Cause of death: ICD-10 K52.2

2 out of 7 registries used, show all original rules.

940

4. Check minimum number of events

None

940

5. Include endpoints

None

940

6. Filter based on genotype QC (FinnGen only)

940

Control definitions (FinnGen only)

Control exclude
K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K52
Name in latin
Gastroenteritis allergica/diaetetica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 940 621 319
Unadjusted period prevalence (%) 0.19 0.21 0.14
Median age at first event (years) 4.54 5.66 2.37

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
834
Matched controls
8349
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K52.2
ICD-10 Finland
Allergic and dietetic gastroenteritis and colitis
+∞
323.0
835
12
L27.2
ICD-10 Finland
Dermatitis due to ingested food
17.2
160.2
270
226
501
Kela drug reimbursment
Cow's milk and / or soy protein allergy in young children
19.1
131.6
209
143
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
7.3
89.4
242
442
L20.0
ICD-10 Finland
Besnier prurigo
5.1
79.3
306
853
XQ800
NOMESCO Finland
Prick test
5.1
60.5
218
541
C01CA24
ATC
epinephrine; parenteral
5.4
51.1
169
374
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.4
48.3
201
564
505
Kela drug reimbursment
Allergy to cow's milk in infants
16.0
37.2
61
41
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
35.7
34
*
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
23.6
34.3
49
22
UJF32
NOMESCO Finland
Coloscopy
4.3
32.6
132
351
A07EC02
ATC
mesalazine; oral, rectal
55.2
31.5
37
7
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
31.5
370
2044
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.9
30.1
213
871
E0000UV
ATC
NA
2.3
29.4
429
2614
R06AE07
ATC
cetirizine; oral
2.3
28.4
414
2506
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.0
28.2
184
711
R03AC02
ATC
salbutamol; inhalant
2.2
27.7
499
3320
XQ830
NOMESCO Finland
Exposure to foodstuff
14.4
26.1
44
32
S01GX01
ATC
cromoglicic acid; ophthalmic
2.5
24.9
230
1088
A03FA02
ATC
cisapride; oral, rectal
5.0
24.5
81
174
D07AA02
ATC
hydrocortisone; topical
2.5
24.2
239
1167
E000002
ATC
NA
2.7
24.2
188
804
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
24.0
184
781
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
246.8
23.8
24
*
R03DC03
ATC
montelukast; oral
2.7
23.7
185
794
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.8
23.3
169
693
E000001
ATC
NA
2.3
23.1
258
1338
H02AB06
ATC
prednisolone; systemic
2.2
21.4
284
1589
R03BA05
ATC
fluticasone; inhalant
2.3
21.0
240
1251
A07EA06
ATC
budesonide; oral, local oral
22.2
20.9
30
14
T78.4
ICD-10 Finland
Allergy, unspecified
3.6
20.2
95
285
E000006
ATC
NA
3.8
19.7
88
253
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.5
18.7
171
792
A02BC01
ATC
omeprazole; systemic
2.6
18.0
147
638
R01AD08
ATC
fluticasone; nasal
2.3
17.7
193
973
R03BA02
ATC
budesonide; inhalant
2.4
17.4
172
823
R06AE09
ATC
levocetirizine; oral
2.3
17.2
172
830
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
10.7
16.8
32
31
R01AD09
ATC
mometasone; nasal
1.9
16.8
342
2223
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
16.7
16
*
J30.3
ICD-10 Finland
Other allergic rhinitis
3.9
16.1
68
186
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.4
16.0
80
252
R11
ICD-10 Finland
Nausea and vomiting
2.8
15.8
110
434
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
57.7
14.8
17
*
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.5
13.9
65
194
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
13.6
13
*
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.5
13.2
107
458
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.2
13.0
71
239
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
13.0
156
810
506
Kela drug reimbursment
Allergy to cow's milk and hypersensibility to conventional formula in infants
50.8
12.9
15
*
ZXE00
NOMESCO Finland
One hour or less
1.8
12.7
316
2143
K51.5
ICD-10 Finland
Left sided colitis
+∞
12.5
12
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
12.5
12
*
J45.1
ICD-10 Finland
Nonallergic asthma
2.4
12.5
109
487
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.4
11.8
102
452
R06AX13
ATC
loratadine; oral
2.2
11.7
131
656
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
11.5
11
*
R06AX27
ATC
desloratadine; oral
1.7
11.4
303
2078
R51.80
ICD-10 Finland
Headache
1.9
11.0
166
943
A07EA02
ATC
hydrocortisone; rectal
43.9
10.9
13
*
XG410
NOMESCO Finland
Flow-volume spirometry
3.3
10.9
54
170
Z51.6
ICD-10 Finland
Desensitization to allergens
4.4
10.7
38
90
UJF30
NOMESCO Finland
Ileoscopy through colon
3.5
10.5
48
142
J45.8
ICD-10 Finland
Mixed asthma
3.9
10.5
43
116
UJF92
NOMESCO Finland
Capsular endoscopy
6.9
10.4
25
37
Z3231
NOMESCO Finland
Registered nurse
1.7
10.3
266
1796
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.3
10.2
51
162
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.8
10.0
63
234
R01AD12
ATC
fluticasone furoate; nasal
1.7
10.0
257
1729
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
9.9
151
856
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
16.9
9.9
15
9
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
9.8
106
525
R68.1
ICD-10 Finland
Nonspecific symptoms peculiar to infancy
5.0
9.7
30
62
E000003
ATC
NA
2.9
9.7
57
204
R03AC03
ATC
terbutaline; inhalant
2.2
9.6
98
472
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
9.6
183
1121
L04AX01
ATC
azathioprine; systemic
4.5
9.6
33
76
R05
ICD-10 Finland
Cough
1.8
9.6
176
1064
D07AB08
ATC
desonide; topical
2.2
9.6
100
488
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
9.4
162
959
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
9.4
9
*
K50.8
ICD-10 Finland
Other Crohn disease
+∞
9.4
9
*
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
3.9
9.3
37
98
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
9.3
93
443
WQ000
NOMESCO Finland
Hyposensibilisation
5.3
9.0
26
50
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
8.9
324
2378
A02BA02
ATC
ranitidine; systemic
2.7
8.8
61
241
J01FA10
ATC
azithromycin; systemic
1.6
8.6
577
4890
R96
ICPC
Asthma
2.3
8.6
78
354
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.8
8.6
166
1019
N05BB01
ATC
hydroxyzine; systemic
2.7
8.5
55
209
S01GX02
ATC
levocabastine; ophthalmic
3.0
8.5
48
165
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
8.5
148
880
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
90.9
8.4
9
*
H02AB07
ATC
prednisone; oral
2.6
8.3
60
244
J01DA01
ATC
[U] cefalexin; systemic
1.5
8.2
345
2611
EMB30
NOMESCO Finland
Adenotomy
1.8
8.2
150
904
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
8.1
128
734
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
8.0
258
1829
D07AC13
ATC
mometasone; topical
1.8
8.0
142
849
K59.0
ICD-10 Finland
Constipation
2.7
7.9
52
200
M25.5
ICD-10 Finland
Pain in joint
1.7
7.9
176
1127
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
7.9
171
1086
N02AX02
ATC
tramadol; systemic, rectal
1.8
7.9
146
882
UJD02
NOMESCO Finland
Gastroscopy
4.2
7.8
28
68
Z3226
NOMESCO Finland
Physiotherapist
1.7
7.5
168
1074
R03AC12
ATC
salmeterol; inhalant
4.0
7.5
28
71
R01AC01
ATC
cromoglicic acid; nasal
2.9
7.5
44
158
K55.2
ICD-10 Finland
Angiodysplasia of colon
80.8
7.4
8
*
K51
ICD-10 Finland
Ulcerative colitis
80.8
7.4
8
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
7.4
219
1513
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.4
215
1479
J01FA01
ATC
erythromycin; systemic
2.0
7.4
93
490
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.0
7.4
42
147
R01AD01
ATC
beclometasone; nasal
2.3
7.3
66
301
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
7.2
67
307
L30.3
ICD-10 Finland
Infective dermatitis
4.0
7.1
27
70
J01FF01
ATC
clindamycin; systemic
1.8
7.1
128
766
M79.7
ICD-10 Finland
Fibromyalgia
4.4
7.1
24
56
ZX112
NOMESCO Finland
Subcutaneous
4.8
7.1
22
47
T78.0
ICD-10 Finland
Anaphylactic shock due to adverse food reaction
10.1
7.0
13
13
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
4.2
7.0
25
61
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
7.0
112
642
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.9
7.0
41
148
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.6
6.9
46
180
XG474
NOMESCO Finland
Exhalation nntrogen oxide
2.9
6.9
40
143
D11AX14
ATC
[U] tacrolimus; topical
11.0
6.8
12
11
J01DB01
ATC
cefalexin; oral
1.5
6.8
593
5170
D07AC01
ATC
betamethasone; topical
1.7
6.7
154
994
R03DC01
ATC
zafirlukast; oral
12.4
6.6
11
9
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
4.5
6.4
21
48
R01AD05
ATC
budesonide; nasal
2.6
6.3
42
164
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
6.3
108
634
R03AC13
ATC
formoterol; inhalant
3.8
6.3
25
68
R06AX26
ATC
fexofenadine; oral
2.7
6.3
41
158
A02BC02
ATC
pantoprazole; systemic
1.5
6.3
247
1814
D94
ICPC
Chronic enteritis/ulcerative colitis
+∞
6.3
6
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.4
6.2
50
216
E000004
ATC
NA
3.5
6.2
27
80
H02AB04
ATC
methylprednisolone; systemic
2.1
6.1
65
320
A92
ICPC
Allergy/allergic reaction NOS
2.2
6.1
60
284
J01FA06
ATC
roxithromycin; oral
1.7
6.1
146
949
J46
ICD-10 Finland
Status asthmaticus
3.9
6.1
23
60
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.8
6.0
111
669
A02BC05
ATC
esomeprazole; systemic
1.6
6.0
148
971

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: COLITALLERG – Allergic colitis

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).