Dermatitis due to ingested food

L12_FOODDERMAT

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L27.2
  • Hospital discharge: ICD-8 6925
  • Cause of death: ICD-10 L27.2
  • Cause of death: ICD-8 6925

2 out of 7 registries used, show all original rules.

1397

4. Check minimum number of events

None

1397

5. Include endpoints

None

1397

6. Filter based on genotype QC (FinnGen only)

1328

Control definitions (FinnGen only)

Control exclude
L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L27
Name in latin
Dermatitis ex cibo devorato

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 54667 23247 31410
Only index persons 37769 16243 21526
Unadjusted period prevalence (%)
Whole population 0.79 0.67 0.88
Only index persons 0.73 0.60 0.82
Median age at first event (years)
Whole population 1.20 1.28 1.14
Only index persons 1.19 1.31 1.10

-FinnGen-

Key figures

All Female Male
Number of individuals 1328 845 483
Unadjusted period prevalence (%) 0.30 0.33 0.24
Median age at first event (years) 3.52 4.43 1.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1367
Matched controls
13257
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
501
Kela drug reimbursment
Cow's milk and / or soy protein allergy in young children
42.7
323.0
422
137
C01CA24
ATC
epinephrine; parenteral
19.8
323.0
534
416
L20.0
ICD-10 Finland
Besnier prurigo
+∞
323.0
786
*
L27.2
ICD-10 Finland
Dermatitis due to ingested food
4503599627370496.0
323.0
1340
11
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
15.8
261.3
462
414
D07AA02
ATC
hydrocortisone; topical
9.1
249.3
637
1162
E0000UV
ATC
NA
6.9
234.6
940
3207
XQ800
NOMESCO Finland
Prick test
11.6
222.1
458
550
J45.0
ICD-10 Finland
Predominantly allergic asthma
10.4
221.7
492
679
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
8.3
192.5
494
843
D07BA04
ATC
hydrocortisone and antiseptics; topical
8.1
191.2
504
895
E000002
ATC
NA
7.8
188.7
514
956
K52.2
ICD-10 Finland
Allergic and dietetic gastroenteritis and colitis
26.8
186.4
265
118
E000001
ATC
NA
6.3
185.4
630
1582
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
178.2
169
*
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
+∞
177.2
168
*
L20
ICD-10 Finland
Atopic dermatitis
+∞
163.1
155
*
R06AE07
ATC
cetirizine; oral
4.5
145.0
870
3741
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
5.6
133.8
466
1117
D07AB08
ATC
desonide; topical
8.6
119.1
282
390
R03AC02
ATC
salbutamol; inhalant
3.7
111.4
928
4809
S01GX01
ATC
cromoglicic acid; ophthalmic
4.3
108.1
506
1594
R03BA05
ATC
fluticasone; inhalant
4.2
102.7
498
1606
T78.4
ICD-10 Finland
Allergy, unspecified
8.1
99.0
241
342
D11AH01
ATC
tacrolimus; topical
206.8
95.6
99
5
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
5.9
94.6
298
602
R06AX27
ATC
desloratadine; oral
3.4
93.6
662
2866
E000003
ATC
NA
11.6
93.6
183
175
N05BB01
ATC
hydroxyzine; systemic
9.2
92.8
207
253
D07AB02
ATC
hydrocortisone butyrate; topical
4.2
88.4
410
1240
R06AE09
ATC
levocetirizine; oral
4.2
86.1
386
1127
E000006
ATC
NA
8.1
82.9
200
276
R03BA02
ATC
budesonide; inhalant
4.1
82.7
379
1124
XQ802
NOMESCO Finland
Epicutan test
56.7
82.2
98
18
J45.9
ICD-10 Finland
Asthma, unspecified
4.0
76.2
358
1075
R03DC03
ATC
montelukast; oral
4.0
75.8
364
1114
H02AB06
ATC
prednisolone; systemic
3.2
75.0
545
2304
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
+∞
73.8
71
*
D07AC13
ATC
mometasone; topical
4.0
70.6
331
984
R06AX13
ATC
loratadine; oral
3.9
68.2
329
1000
D02AX
ATC
Other emollients and protectives
6.7
67.4
183
297
XQ830
NOMESCO Finland
Exposure to foodstuff
66.7
67.2
78
12
D11AX14
ATC
[U] tacrolimus; topical
+∞
64.4
62
*
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
30.4
59.1
80
27
R03AC03
ATC
terbutaline; inhalant
4.1
56.7
250
691
D07AC01
ATC
betamethasone; topical
3.3
55.1
328
1157
E000007
ATC
NA
5.5
54.6
174
343
505
Kela drug reimbursment
Allergy to cow's milk in infants
21.6
53.7
80
38
Z51.6
ICD-10 Finland
Desensitization to allergens
9.7
53.1
112
121
D11AH02
ATC
pimecrolimus; topical
+∞
52.9
51
*
J30.3
ICD-10 Finland
Other allergic rhinitis
6.5
52.2
144
236
D07CA01
ATC
hydrocortisone and antibiotics; topical
3.5
51.3
272
873
L20.8
ICD-10 Finland
Other atopic dermatitis
+∞
50.8
49
*
D11AX15
ATC
[U] pimecrolimus; topical
+∞
48.7
47
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.9
48.2
217
605
D09AB01
ATC
zinc bandage without supplements; topical
41.8
46.3
58
14
R01AD09
ATC
mometasone; nasal
2.3
45.9
615
3440
D02AE01
ATC
carbamide; topical
6.2
45.7
130
221
T78.0
ICD-10 Finland
Anaphylactic shock due to adverse food reaction
71.7
43.7
50
7
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
7.5
43.1
106
147
A92
ICPC
Allergy/allergic reaction NOS
4.4
42.7
169
416
J45
ICD-10 Finland
Asthma
4.0
42.3
187
510
J45.8
ICD-10 Finland
Mixed asthma
8.3
40.5
93
116
J45.1
ICD-10 Finland
Nonallergic asthma
3.6
40.0
196
583
R01AD08
ATC
fluticasone; nasal
2.6
39.3
344
1515
XG410
NOMESCO Finland
Flow-volume spirometry
5.4
36.2
114
219
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
+∞
34.1
33
*
L50.0
ICD-10 Finland
Allergic urticaria
6.3
34.1
94
153
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.7
32.2
151
430
S87
ICPC
Dermatitis/atopic eczema
5.8
31.9
94
167
D07CC01
ATC
betamethasone and antibiotics; topical
3.4
31.7
166
516
R06AX22
ATC
ebastine; oral
3.1
31.7
192
663
XG474
NOMESCO Finland
Exhalation nntrogen oxide
5.0
30.8
104
216
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.1
30.7
186
641
R01AD12
ATC
fluticasone furoate; nasal
2.1
30.4
470
2665
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
29.2
30.4
41
14
R96
ICPC
Asthma
3.5
30.3
150
446
E000004
ATC
NA
8.0
29.7
69
88
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.2
28.5
115
286
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
18.2
27.1
42
23
69250
ICD-8 Finland
Other eczema and dermatitis, Due to food
+∞
26.9
26
*
D07BC01
ATC
betamethasone and antiseptics; topical
4.8
26.6
92
196
WQ000
NOMESCO Finland
Hyposensibilisation
8.8
26.3
57
65
R01AC01
ATC
cromoglicic acid; nasal
4.5
26.1
96
218
R03AK07
ATC
formoterol and budesonide; inhalant
2.5
24.8
210
885
6931A
ICD-9 Finland
Dermatitis due to substances taken internally, Due to food
+∞
23.7
23
*
D07AC14
ATC
methylprednisolone aceponate; topical
5.8
23.3
67
116
R06.2
ICD-10 Finland
Wheezing
3.4
22.7
118
363
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
2.1
22.1
311
1659
D07AB01
ATC
clobetasone; topical
7.2
21.6
53
74
J46
ICD-10 Finland
Status asthmaticus
7.3
20.6
50
69
S01GX02
ATC
levocabastine; ophthalmic
3.6
20.6
98
282
Z3231
NOMESCO Finland
Registered nurse
1.8
20.5
424
2602
H02AB07
ATC
prednisone; oral
3.1
19.2
108
352
D07AD01
ATC
clobetasol; topical
3.2
18.9
102
323
TQW80
NOMESCO Finland
Local dermatologic skincare
8.5
18.8
41
48
J01DA01
ATC
[U] cefalexin; systemic
1.7
18.4
580
4026
R06AX26
ATC
fexofenadine; oral
3.5
17.8
85
246
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
17.6
108
374
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.3
17.6
169
757
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
+∞
17.5
17
*
J30.19
ICD-10 Finland
Pollen allergy UNS
3.2
17.5
94
297
H02AB04
ATC
methylprednisolone; systemic
2.8
17.2
113
409
R01AD05
ATC
budesonide; nasal
3.6
16.6
77
218
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
62.2
16.5
19
*
D11AH05
ATC
dupilumab; topical
+∞
16.5
16
*
395
Kela drug reimbursment
Dupilumab
+∞
16.5
16
*
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
4.2
16.0
61
145
R03BC01
ATC
cromoglicic acid; inhalant
7.7
16.0
37
48
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.7
15.9
116
448
S01AD03
ATC
aciclovir; ophthalmic
6.5
15.5
40
61
L50.9
ICD-10 Finland
Urticaria, unspecified
3.0
15.4
89
296
S01GX09
ATC
olopatadine; ophthalmic
4.1
15.2
59
143
506
Kela drug reimbursment
Allergy to cow's milk and hypersensibility to conventional formula in infants
23.0
14.9
21
9
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
3.2
14.6
78
247
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
35.3
14.2
18
5
R03BA01
ATC
beclometasone; inhalant
2.6
13.8
104
408
S01GX08
ATC
ketotifen; ophthalmic
3.2
13.7
73
230
L30.3
ICD-10 Finland
Infective dermatitis
7.2
13.4
32
44
R06.0
ICD-10 Finland
Dyspnoea
1.9
13.2
200
1082
R05
ICD-10 Finland
Cough
1.8
12.9
253
1491
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
12.9
203
1114
R02
ICPC
Shortness of breath/dyspnoea
2.1
12.5
142
683
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.2
12.5
128
587
J01FA01
ATC
erythromycin; systemic
2.0
12.5
166
854
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
15.1
12.4
20
13
J01DB01
ATC
cefalexin; oral
1.5
12.1
964
8051
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
5.6
11.9
34
60
L01.1
ICD-10 Finland
Impetiginization of other dermatoses
7.3
11.9
28
38
D07XB05
ATC
dexamethasone, combinations; topical
6.3
11.9
31
49
L50.3
ICD-10 Finland
Dermatographic urticaria
5.7
11.8
33
57
R03AC12
ATC
salmeterol; inhalant
5.2
11.8
36
69
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
11.7
233
1379
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
6.7
11.6
29
43
L23.6
ICD-10 Finland
Allergic contact dermatitis due to food in contact with skin
63.5
11.5
13
*
J01FA10
ATC
azithromycin; systemic
1.5
11.4
945
7901
R06AX12
ATC
terfenadine; oral
4.4
11.1
39
87
R03BA08
ATC
ciclesonide; inhalant
2.6
11.0
81
316
R06AX11
ATC
astemizole; oral
3.7
10.9
47
127
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
3.1
10.9
59
190
L50.8
ICD-10 Finland
Other urticaria
4.7
10.9
36
76
X57
ICD-10 Finland
Unspecified privation
4.5
10.8
37
81
J01FF01
ATC
clindamycin; systemic
1.8
10.8
194
1110
R01AD11
ATC
triamcinolone; nasal
2.7
10.8
75
283
J01FA09
ATC
clarithromycin; systemic
1.6
10.7
380
2629
W84
ICD-10 Finland
Unspecified threat to breathing
11.7
10.6
19
16
R06AX18
ATC
acrivastine; oral
8.1
10.6
23
28
R03CC02
ATC
salbutamol; systemic
1.6
10.5
351
2391
T78.1
ICD-10 Finland
Other adverse food reactions, not elsewhere classified
21.0
10.5
15
7
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
10.3
207
1227
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
107.5
10.3
11
*
134
Kela drug reimbursment
General erythroderma
107.5
10.3
11
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
10.2
145
760
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.9
10.2
162
887
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.2
9.9
51
159
B00.10
ICD-10 Finland
Herpes simplex facialis
8.9
9.8
20
22
R03DA04
ATC
theophylline; systemic, rectal
4.3
9.7
35
81
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.7
9.6
222
1370
A03FA02
ATC
cisapride; oral, rectal
2.6
9.6
68
260
XQ820
NOMESCO Finland
Exposure to medicinal substance
13.1
9.5
16
12
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
9.4
810
6678
R03AC13
ATC
formoterol; inhalant
4.5
9.4
32
70
UJF32
NOMESCO Finland
Coloscopy
1.9
9.4
131
684
WZC30
NOMESCO Finland
Teaching
2.1
9.3
108
525
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.4
9.3
43
124
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.6
9.2
310
2107
R06AE08
ATC
NA
11.2
8.9
16
14
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.6
8.8
61
231
XQ899
NOMESCO Finland
Other assessment of skin
18.2
8.8
13
7
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
4.3
8.8
31
71
D07CB01
ATC
triamcinolone and antibiotics; topical
6.4
8.7
22
34
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
8.7
268
1780
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.4
8.7
73
308
J05AB01
ATC
aciclovir; systemic
1.8
8.6
165
963
A07EB01
ATC
cromoglicic acid; oral
48.8
8.6
10
*
L27.1
ICD-10 Finland
Localized skin eruption due to drugs and medicaments
48.8
8.6
10
*
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
2.8
8.5
54
194
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
4.6
8.5
28
60
W79
ICD-10 Finland
Inhalation and ingestion of food causing obstruction of respiratory tract
26.9
8.4
11
*
H03.1*B00.5
ICD-10 Finland
Herpesviral dermatitis of eyelid
26.9
8.4
11
*
T78.3
ICD-10 Finland
Angioneurotic oedema
6.8
8.3
20
29
R01AD01
ATC
beclometasone; nasal
2.1
8.3
95
461
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
8.3
169
1004
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
8.3
231
1494
D07XC01
ATC
betamethasone, combinations; topical
2.5
8.3
63
251
L26
ICD-10 Finland
Exfoliative dermatitis
+∞
8.2
8
*
S01GX04
ATC
nedocromil; ophthalmic
5.2
8.2
24
45
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
8.0
769
6378
49300
ICD-8 Finland
Asthma, bronchiale
11.4
7.9
14
12
A02BC01
ATC
omeprazole; systemic
1.7
7.9
176
1073
R01AC02
ATC
levocabastine; nasal
3.6
7.8
33
90
R03BB04
ATC
tiotropium bromide; inhalant
3.2
7.7
38
117
SPAT1312
SPAT
General health counselling
1.4
7.6
606
4846
R03BC03
ATC
nedocromil; inhalant
3.1
7.5
39
124
SPAT1059
SPAT
Spirometry at the office
3.1
7.5
39
125
R03AK08
ATC
formoterol and beclometasone; inhalant
3.3
7.2
34
101
SPAT1058
SPAT
PEF monitoring instruction
2.0
7.2
84
411
ZXE00
NOMESCO Finland
One hour or less
1.4
7.2
437
3331
XQ801
NOMESCO Finland
Intracutantest
19.5
7.0
10
5
A02BA02
ATC
ranitidine; systemic
2.2
6.9
69
318
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
16.3
6.6
10
6
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
7.0
6.5
15
21
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.9
6.5
38
131
V700A
ICD-9 Finland
General medical examination, Routine general medical examination at a health care facility
4.8
6.5
20
41
XQ848
NOMESCO Finland
Dermatological photography
4.8
6.5
20
41
R04
ICPC
Breathing problem other
2.8
6.4
39
139
J04.0
ICD-10 Finland
Acute laryngitis
1.8
6.4
109
613
EMB30
NOMESCO Finland
Adenotomy
1.5
6.3
210
1413
E0001A1
ATC
NA
2.5
6.3
48
194
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
6.3
59
264
L27.8
ICD-10 Finland
Dermatitis due to other substances taken internally
+∞
6.2
6
*
H13.1*B00.5
ICD-10 Finland
Herpesviral conjunctivitis
+∞
6.2
6
*
L27.9
ICD-10 Finland
Dermatitis due to unspecified substance taken internally
+∞
6.2
6
*
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
10.7
6.2
11
10
7080A
ICD-9 Finland
Urticaria, Allergic urticaria
17.6
6.2
9
5
Z27.4
ICD-10 Finland
Need for immunization against measles-mumps-rubella [MMR]
17.6
6.2
9
5
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
6.1
468
3685
J35.2
ICD-10 Finland
Hypertrophy of adenoids
1.6
6.1
145
899
J01FA06
ATC
roxithromycin; oral
1.5
6.1
214
1459
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
6.0
292
2122
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.1
6.0
62
290

Mortality – FinRegistry

Association

Association between endpoint L12_FOODDERMAT and mortality.

Females

Parameter HR [95% CI] p-value
L12_FOODDERMAT 1.166 [0.82, 1.66] 0.397
Birth year 0.994 [0.99, 1.0] 0.143

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 20631 females with L12_FOODDERMAT died.

Males

Parameter HR [95% CI] p-value
L12_FOODDERMAT 1.004 [0.79, 1.28] 0.975
Birth year 0.99 [0.98, 1.0] 0.035

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 27933 males with L12_FOODDERMAT died.

Mortality risk

Mortality risk for people of age

years, who have L12_FOODDERMAT.

N-year risk Females Males
1 0.097% 0.229%
5 0.584% 1.365%
10 1.745% 3.324%
15 3.17% 6.496%
20 5.573% 10.774%

Relationships between endpoints

Index endpoint: L12_FOODDERMAT – Dermatitis due to ingested food

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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