Cirrhosis of liver, NAS

CHIRHEP_NAS

non-alcoholic fatty liver disease: A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K74.6
  • Cause of death: ICD-10 K74.6

2 out of 7 registries used, show all original rules.

1520

4. Check minimum number of events

None

1520

5. Include endpoints

None

1520

6. Filter based on genotype QC (FinnGen only)

1470

Control definitions (FinnGen only)

Control exclude
CIRRHOSIS_BROAD

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K74
Name in latin
Cirrhosis hepatis alia sive non specificata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 15092 5951 8918
Only index persons 11422 4569 6853
Unadjusted period prevalence (%)
Whole population 0.22 0.17 0.25
Only index persons 0.22 0.17 0.26
Median age at first event (years)
Whole population 66.47 68.55 65.01
Only index persons 66.10 67.59 65.10

-FinnGen-

Key figures

All Female Male
Number of individuals 1470 589 881
Unadjusted period prevalence (%) 0.36 0.23 0.44
Median age at first event (years) 65.84 65.22 66.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1518
Matched controls
15189
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
+∞
323.0
1518
*
C03DA01
ATC
spironolactone; oral
17.8
323.0
821
942
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
10.5
323.0
1095
2992
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
5484.4
323.0
417
*
R18
ICD-10 Finland
Ascites
78.5
323.0
430
76
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
5743.1
323.0
431
*
C03CA01
ATC
furosemide; systemic
6.9
261.1
990
3245
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
11.3
244.1
508
644
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
28.4
210.5
292
126
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
45.4
200.8
248
65
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.8
182.4
540
1135
A06AD11
ATC
lactulose; oral
6.4
178.6
564
1286
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
935.2
173.6
167
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
72.0
161.5
184
29
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
+∞
160.3
151
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.6
157.0
740
2576
103
Kela drug reimbursment
Diabetes, insulin-treated
4.4
153.0
798
3043
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
19.6
129.5
201
117
A10AE04
ATC
insulin glargine; parenteral
6.2
129.2
392
802
A10BA02
ATC
metformin; oral
3.6
111.8
737
3172
D64.9
ICD-10 Finland
Anaemia, unspecified
5.3
108.7
382
912
Z94.4
ICD-10 Finland
Liver transplant status
172.5
107.8
112
7
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.6
105.8
663
2708
K92.0
ICD-10 Finland
Haematemesis
14.5
104.4
182
141
JJC00
NOMESCO Finland
Allogenic transplantation of liver
220.7
100.8
103
5
C07AA05
ATC
propranolol; systemic
4.1
99.4
474
1521
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
5.9
98.2
303
613
T90
ICPC
Diabetes non-insulin dependent
3.4
95.1
623
2580
A07AA11
ATC
rifaximin; oral
920.5
89.7
87
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.7
89.1
346
899
K76.9
ICD-10 Finland
Liver disease, unspecified
22.4
86.9
128
62
K92.1
ICD-10 Finland
Melaena
6.7
83.1
228
391
K72.9
ICD-10 Finland
Hepatic failure, unspecified
71.4
82.4
94
14
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
57.4
82.3
97
18
B18.2
ICD-10 Finland
Chronic viral hepatitis C
34.1
80.2
105
33
A05AA02
ATC
ursodeoxycholic acid; oral
21.8
80.1
119
59
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
29.2
80.1
109
40
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.6
79.4
254
528
K70.4
ICD-10 Finland
Alcoholic hepatic failure
+∞
75.6
72
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
14.5
73.4
127
95
K72.1
ICD-10 Finland
Chronic hepatic failure
259.0
73.0
74
*
K76.7
ICD-10 Finland
Hepatorenal syndrome
374.5
72.3
72
*
A10BH01
ATC
sitagliptin; oral
4.1
72.1
325
956
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
4.9
72.0
259
610
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.3
70.3
234
505
UJF32
NOMESCO Finland
Coloscopy
2.9
68.8
576
2678
127
Kela drug reimbursment
Transplant complication
14.7
67.6
116
85
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
10.0
66.1
137
149
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
8.3
65.5
152
201
D97
ICPC
Liver disease NOS
54.0
64.7
77
15
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
36.1
61.4
79
23
N02AX02
ATC
tramadol; systemic, rectal
2.5
61.0
812
4821
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
5.1
60.1
203
442
K70.1
ICD-10 Finland
Alcoholic hepatitis
600.5
59.1
58
*
A02BC02
ATC
pantoprazole; systemic
2.5
58.7
1113
7884
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
58.3
846
5207
C07AG02
ATC
carvedilol; oral
4.6
58.1
221
545
A10BB12
ATC
glimepiride; oral
4.2
57.8
240
644
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
6.8
57.7
153
246
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
124.8
56.2
60
5
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
13.9
56.0
98
75
L04AA06
ATC
mycophenolic acid; systemic
12.5
55.5
102
87
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
55.2
391
1590
TK800
NOMESCO Finland
Hemodialysis
8.9
54.9
121
146
K74.0
ICD-10 Finland
Hepatic fibrosis
+∞
54.5
52
*
K74.3
ICD-10 Finland
Primary biliary cirrhosis
33.3
53.4
70
22
K70.0
ICD-10 Finland
Alcoholic fatty liver
+∞
52.4
50
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
53.8
52.2
62
12
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
11.0
52.1
102
99
WW500
NOMESCO Finland
Blood transfusion
5.8
51.7
155
292
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
75.1
51.4
58
8
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
51.1
447
2059
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.4
50.1
195
489
I50.9
ICD-10 Finland
Heart failure, unspecified
3.0
49.6
343
1362
A10AE05
ATC
insulin detemir; parenteral
4.6
49.3
183
437
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
252.9
48.3
49
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.4
48.0
265
896
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.7
47.3
377
1630
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.2
46.3
153
322
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
45.9
358
1523
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
11.6
45.5
86
78
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
9.1
44.4
96
112
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
16.5
43.8
71
45
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
43.6
275
1017
A46
ICD-10 Finland
Erysipelas
2.7
42.9
334
1415
E66.00
ICD-10 Finland
Metabolic syndrome
4.4
42.7
167
418
JN3AD
NOMESCO Finland
Abdominal CT examination
3.6
41.6
204
624
Z51.5
ICD-10 Finland
Palliative care
4.0
41.4
178
487
160
Kela drug reimbursment
exenatide
7.9
41.0
96
128
JJ5AT
NOMESCO Finland
NA
147.4
40.9
43
*
L04AD01
ATC
ciclosporin; systemic
9.3
40.1
85
96
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
10.6
39.5
78
77
A41.9
ICD-10 Finland
Sepsis, unspecified
5.3
39.4
127
259
R50.9
ICD-10 Finland
Fever, unspecified
2.8
39.3
290
1182
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.4
38.8
150
371
SPAT1262
SPAT
Handing over of treatment supplies
2.4
38.1
396
1953
K29.6
ICD-10 Finland
Other gastritis
13.2
37.8
67
53
K76.6
ICD-10 Finland
Portal hypertension
+∞
37.7
36
*
I81
ICD-10 Finland
Portal vein thrombosis
40.4
37.6
47
12
WX892
NOMESCO Finland
Monitored bed care
3.5
37.5
191
601
K83.0
ICD-10 Finland
Cholangitis
11.6
37.2
70
63
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.3
36.6
116
232
N02AA05
ATC
oxycodone; systemic
2.6
36.3
312
1383
K29.7
ICD-10 Finland
Gastritis, unspecified
5.1
36.2
119
248
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
36.0
243
933
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.6
35.0
172
525
R4110
NOMESCO Finland
Physiotherapy
2.2
34.9
476
2649
205
Kela drug reimbursment
Chronic hypertension
2.1
34.8
558
3326
8000/3-C22.0
ICD-O-3
Neoplasm, malignant of liver
126.3
34.8
37
*
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
26.9
34.2
47
18
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.7
33.4
119
270
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.2
33.1
132
335
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
33.1
210
770
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
11.9
33.0
61
53
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
32.9
334
1608
198
Kela drug reimbursment
Sorafenib
45.5
32.9
40
9
JN4CD
NOMESCO Finland
Very extensive body CT
4.2
32.6
129
325
J01MA02
ATC
ciprofloxacin; systemic
1.9
32.1
685
4522
UJF30
NOMESCO Finland
Ileoscopy through colon
3.0
31.8
205
760
E87.5
ICD-10 Finland
Hyperkalaemia
6.9
31.4
80
121
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
32.4
31.4
41
13
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
5.5
31.2
95
181
A10BH05
ATC
linagliptin; oral
3.8
30.6
139
396
M04AA01
ATC
allopurinol; systemic
2.4
30.6
307
1467
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.4
30.4
160
513
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
30.4
541
3316
I50.0
ICD-10 Finland
Congestive heart failure
3.0
30.4
190
688
A10BD07
ATC
metformin and sitagliptin; systemic
4.0
29.9
126
336
177
Kela drug reimbursment
Insulin glargine 300 U / ml
7.1
29.9
75
111
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
4.6
29.8
107
245
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
4.5
29.7
109
255
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
35.4
29.7
38
11
TJA10
NOMESCO Finland
Laparocentesis
51.1
29.4
35
7
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
6.7
29.0
75
116
A28
ICPC
Limited function/disability NOS
2.3
28.9
296
1425
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
20.5
28.3
42
21
XW000
NOMESCO Finland
Bone marrow biopsy
4.0
28.3
119
317
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
79.2
27.8
31
*
G93.4
ICD-10 Finland
Encephalopathy, unspecified
30.7
27.3
36
12
A10BJ02
ATC
liraglutide; parenteral
5.7
27.0
79
144
L04AX01
ATC
azathioprine; systemic
4.4
26.9
101
242
UJD02
NOMESCO Finland
Gastroscopy
3.7
26.9
124
358
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
26.5
541
3448
E66.01
ICD-10 Finland
Obesity due to excess calories
3.3
26.4
144
474
Z2446
NOMESCO Finland
Social worker
3.3
26.2
137
437
PC2DT
NOMESCO Finland
Embolisation of lesion of liver
74.0
25.8
29
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
137.3
25.7
27
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
25.6
340
1830
WX002
NOMESCO Finland
Sedation and analgesia
2.1
25.6
351
1917
ZX120
NOMESCO Finland
Intravenous
2.6
25.5
205
864
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.0
25.4
106
281
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.5
25.3
220
968
C07AB07
ATC
bisoprolol; oral
1.8
25.1
802
5886
A10BX07
ATC
[U] liraglutide; parenteral
8.0
24.9
57
74
JN4BD
NOMESCO Finland
Extensive body CT
2.4
24.7
232
1062
R06.0
ICD-10 Finland
Dyspnoea
1.9
24.7
423
2514
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
43.6
24.6
30
7
WX872
NOMESCO Finland
Intensive care
3.3
24.6
132
429
A10BG03
ATC
pioglitazone; oral
4.7
24.5
85
188
P15
ICPC
Chronic alcohol abuse
5.1
24.4
78
158
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.8
24.2
108
303
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
24.1
958
7484
I86.4
ICD-10 Finland
Gastric varices
88.2
23.7
26
*
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
4.4
23.7
88
209
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.6
23.5
70
131
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
6.0
23.4
66
115
L01XE05
ATC
[U] sorafenib; oral
47.5
23.4
28
6
162
Kela drug reimbursment
liraglutide
8.2
23.3
52
65
N19
ICD-10 Finland
Unspecified kidney failure
4.1
23.3
93
237
ZXD05
NOMESCO Finland
Urgent procedure
1.8
23.1
489
3120
K70.2
ICD-10 Finland
Alcoholic fibrosis and sclerosis of liver
+∞
23.0
22
*
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
7.8
22.9
53
70
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
4.6
22.2
79
180
R60.0
ICD-10 Finland
Localized oedema
2.4
22.2
212
977
Z3231
NOMESCO Finland
Registered nurse
1.9
22.2
442
2756
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.7
22.1
76
167
F10.25
ICD-10 Finland
Alcohol dependence continuous use
7.1
22.0
54
78
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
22.0
442
2764
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.4
22.0
205
932
JCA20
NOMESCO Finland
Ligature of oesophageal varices
+∞
21.9
21
*
F10.20
ICD-10 Finland
Alcohol dependence currently independent
5.7
21.9
64
117
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
6.8
21.8
55
83
A10BX04
ATC
[U] exenatide; parenteral
8.6
21.7
47
56
K76.89
ICD-10 Finland
Other specified diseases of liver
223.0
21.6
22
*
J01FF01
ATC
clindamycin; systemic
1.8
21.5
445
2803
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
21.5
386
2318
R41.0
ICD-10 Finland
Disorientation, unspecified
4.2
21.4
83
206
JJA20
NOMESCO Finland
Open biopsy of liver
23.5
21.3
30
13
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.8
21.2
93
258
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
21.1
405
2486
N05CD07
ATC
temazepam; oral
2.2
20.9
239
1193
E66.9
ICD-10 Finland
Obesity, unspecified
4.5
20.9
76
177
B18.1
ICD-10 Finland
Chronic viral hepatitis B without delta-agent
77.9
20.7
23
*
J01MA12
ATC
levofloxacin; systemic
1.9
20.5
333
1918
Z2221
NOMESCO Finland
Medical doctor
1.8
20.5
419
2622
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.9
20.4
87
235
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
4.2
20.4
78
191
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
20.2
259
1360
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.3
20.2
76
183
Z3226
NOMESCO Finland
Physiotherapist
2.0
20.1
304
1704
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.0
20.0
119
414
L28
ICPC
Limited function/disability (L)
2.0
19.8
269
1447
H02AB06
ATC
prednisolone; systemic
1.7
19.7
714
5292
N05BA04
ATC
oxazepam; oral
1.9
19.7
364
2196
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
19.6
475
3128
K75.4
ICD-10 Finland
Autoimmune hepatitis
24.9
19.6
27
11
E66.8
ICD-10 Finland
Other obesity
3.5
19.4
95
288
JAH01
NOMESCO Finland
Laparoscopy
3.8
19.3
83
226
R53
ICD-10 Finland
Malaise and fatigue
1.9
19.3
310
1777
TKC20
NOMESCO Finland
Catheterisation of bladder
2.6
19.3
146
591
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
19.0
218
1091
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.5
18.9
90
267
R04.0
ICD-10 Finland
Epistaxis
2.5
18.9
151
632
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.0
18.8
114
403
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
18.8
275
1520
I85
ICD-10 Finland
Oesophageal varices
+∞
18.8
18
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
18.7
167
740
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
10.5
18.7
36
35
JJ6LT
NOMESCO Finland
Coagulation of focal hepatic lesion under ultrasound guidance
38.9
18.6
23
6
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
38.9
18.6
23
6
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
4.5
18.5
66
151
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.3
18.4
95
300
H02AB04
ATC
methylprednisolone; systemic
2.0
18.4
251
1349
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.1
18.2
102
340
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
2.9
17.9
112
404
A10BK03
ATC
empagliflozin; oral
2.5
17.8
149
636
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.7
17.7
79
223
A08
ICPC
Swelling
3.4
17.7
88
271
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.8
17.7
77
213
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
17.6
250
1364
AA1AD
NOMESCO Finland
CT of head and brain
1.7
17.5
403
2598
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
9.7
17.4
35
37
JN4AD
NOMESCO Finland
Body CT examination
2.4
17.3
158
708
A10BB01
ATC
glibenclamide; oral
3.0
17.3
100
343
N05CF01
ATC
zopiclone; oral
1.7
17.1
498
3433
I50
ICD-10 Finland
Heart failure
3.7
17.1
76
214
PC2ET
NOMESCO Finland
Extensive embolisation of lesion of liver
64.0
16.8
19
*
UJK02
NOMESCO Finland
ERCP
4.3
16.7
63
153
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
8.9
16.7
35
40
K74.2
ICD-10 Finland
Hepatic fibrosis with hepatic sclerosis
+∞
16.7
16
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.1
16.7
66
168
F10.24
ICD-10 Finland
Alcohol depence active use
6.3
16.6
44
72
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
2.8
16.6
110
413
R02
ICPC
Shortness of breath/dyspnoea
2.1
16.5
198
1004
N18.8
ICD-10 Finland
Other chronic renal failure
3.7
16.3
73
207
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
5.1
16.2
51
103
J01DB01
ATC
cefalexin; oral
1.7
16.1
1184
10299
N06AX11
ATC
mirtazapine; oral
1.7
16.1
450
3059
WX882
NOMESCO Finland
High dependency care
3.9
15.8
65
171
R60.9
ICD-10 Finland
Oedema, unspecified
3.0
15.8
95
333
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.0
15.8
91
312
S97
ICPC
Chronic ulcer skin
2.7
15.8
112
437
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.8
15.7
106
402
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
6.1
15.5
42
71
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
3.8
15.3
64
172
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.1
15.2
59
148
V03AE01
ATC
polystyrene sulfonate; oral
6.1
15.2
41
69
D05AX52
ATC
calcipotriol, combinations; topical
2.7
15.2
109
429
UJF92
NOMESCO Finland
Capsular endoscopy
4.3
15.1
56
134
K65.0
ICD-10 Finland
Acute peritonitis
6.7
15.1
38
58
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.9
15.0
92
329
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.6
14.9
112
453
D64.8
ICD-10 Finland
Other specified anaemias
4.9
14.9
48
100
D25
ICPC
Abdominal distension
5.6
14.9
43
79
M10.9
ICD-10 Finland
Gout, unspecified
2.3
14.9
142
651
SPAT1254
SPAT
Administration of medicine
1.9
14.7
238
1353
XCK10
NOMESCO Finland
Photography of fundus of eye
2.1
14.7
183
941
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
14.6
187
977
A10AB06
ATC
insulin glulisine; parenteral
6.8
14.5
36
54
A41.8
ICD-10 Finland
Other specified sepsis
4.6
14.5
50
112
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
10.2
14.5
28
28
N17.8
ICD-10 Finland
Other acute renal failure
5.5
14.4
42
78
RS220
NOMESCO Finland
NA
5.9
14.3
39
67
N05AH04
ATC
quetiapine; oral
1.9
14.2
215
1196
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
14.2
444
3089
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.6
14.2
64
183
E000001
ATC
NA
1.8
14.2
296
1834
F11.25
ICD-10 Finland
Relationship caused by opiates continuously used
42.9
14.1
17
*
B01AB05
ATC
enoxaparin; parenteral
1.6
14.0
456
3204
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.4
13.9
122
533
C01AA05
ATC
digoxin; systemic
2.2
13.9
154
753
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
6.3
13.8
36
58
E88.0
ICD-10 Finland
Disorders of plasma-protein metabolism, not elsewhere classified
24.0
13.8
19
8
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.0
13.8
55
142
A12BA01
ATC
potassium chloride; oral
2.7
13.8
93
353
C10AC01
ATC
colestyramine; oral
3.9
13.8
57
152
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.1
13.7
172
886
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
13.6
236
1378
ZXE00
NOMESCO Finland
One hour or less
1.5
13.4
563
4199
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
13.4
229
1329
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
13.4
466
3322
C09AA05
ATC
ramipril; oral
1.6
13.3
411
2838
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
8.6
13.3
28
33
A10BJ06
ATC
semaglutide; parenteral
3.2
13.2
68
216
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
9.1
13.2
27
30
E66.0
ICD-10 Finland
Obesity due to excess calories
6.2
13.2
35
58
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
13.2
112
483
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
4.7
13.1
44
96
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
4.4
13.1
47
110
K25.7
ICD-10 Finland
Gastric ulcer, Chronic without haemorrhage or perforation
6.0
13.0
35
59
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
16.9
13.0
20
12
D73.1
ICD-10 Finland
Hypersplenism
28.6
13.0
17
6
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
12.9
199
1114
B82
ICPC
Anaemia other/unspecified
3.7
12.9
56
156
C09AA02
ATC
enalapril; systemic
1.7
12.9
326
2136
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.3
12.8
126
586
K86.1
ICD-10 Finland
Other chronic pancreatitis
7.3
12.8
30
42
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
6.3
12.8
33
53
K42.0
ICD-10 Finland
Umbilical hernia with obstruction, without gangrene
5.3
12.7
38
73
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
12.7
550
4120
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.7
12.6
89
346
K74
ICD-10 Finland
Fibrosis and cirrhosis of liver
+∞
12.5
12
*
J94.8
ICD-10 Finland
Other specified pleural conditions
4.4
12.4
44
102
K83.1
ICD-10 Finland
Obstruction of bile duct
5.7
12.4
35
63
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
12.4
200
1135
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
8.1
12.3
27
34
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
11.7
12.3
22
19
E87.6
ICD-10 Finland
Hypokalaemia
3.2
12.3
63
200
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.4
12.3
44
103
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
14.5
12.3
20
14
D50.8
ICD-10 Finland
Other iron deficiency anaemias
5.8
12.3
34
60
A98
ICPC
Health maint/preventive medicine
0.6
12.2
1201
13091
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.6
12.1
54
154
Z02.7
ICD-10 Finland
Issue of medical certificate
2.5
12.1
97
407
D07AC01
ATC
betamethasone; topical
1.5
12.1
483
3541
SPAT1255
SPAT
Intravenous administration of medicine
2.2
12.1
119
554
K29.0
ICD-10 Finland
Acute haemorrhagic gastritis
8.2
12.1
26
32
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
21.5
12.0
17
8
3A422
NOMESCO Finland
NA
21.5
12.0
17
8
F10.09
ICD-10 Finland
Alcohol intoxication UNS
4.6
12.0
41
92
A10BH02
ATC
vildagliptin; oral
3.6
11.9
54
156
TJA40
NOMESCO Finland
Percutaneous local drainage of peritoneal cavity
47.0
11.9
14
*
A10BK01
ATC
dapagliflozin; oral
2.6
11.8
88
354
E83.1
ICD-10 Finland
Disorders of iron metabolism
10.6
11.8
22
21
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
4.7
11.7
39
85
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
4.3
11.7
42
99
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
5.4
11.7
34
64
JAH00
NOMESCO Finland
Laparotomy
3.3
11.6
58
181
PC2DE
NOMESCO Finland
Ultrasound examination of liver vasculature with Doppler method
65.4
11.6
13
*
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.1
11.6
62
204
Z72.2
ICD-10 Finland
Drug use
23.1
11.6
16
7
WVA20
NOMESCO Finland
Medicine administration
3.8
11.5
48
130
B17.1
ICD-10 Finland
Acute hepatitis C
+∞
11.5
11
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.1
11.4
124
603
F11.29
ICD-10 Finland
Addiction caused by opiates UNS
120.9
11.4
12
*
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.7
11.4
79
305
201
Kela drug reimbursment
Chronic cardiac insufficiency
2.4
11.4
96
414
XF600
NOMESCO Finland
Bloodpressure measurement
2.2
11.3
111
516
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
11.2
550
4201
B01AA03
ATC
warfarin; systemic
1.6
11.2
346
2376
N07BB01
ATC
disulfiram; oral
2.6
11.2
79
310
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.3
11.1
105
481
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.7
11.1
229
1409
R60.1
ICD-10 Finland
Generalized oedema
8.6
11.0
23
27
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.4
11.0
90
382
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
4.4
11.0
39
91
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
11.0
165
913
JDA05
NOMESCO Finland
Endoscopic polypectomy in stomach or pylorus
14.0
11.0
18
13
K65.9
ICD-10 Finland
Peritonitis, unspecified
14.0
11.0
18
13
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
10.9
307
2056
A07EA06
ATC
budesonide; oral, local oral
3.0
10.9
62
210
JJ7LT
NOMESCO Finland
Coagulation of focal hepatic lesion under CT guidance
43.6
10.9
13
*
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.4
10.9
90
385
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
3.5
10.9
50
147
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
4.4
10.8
38
88
323
Kela drug reimbursment
Sorafenib
28.2
10.7
14
5
E86
ICD-10 Finland
Volume depletion
3.4
10.7
50
149
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
21.6
10.7
15
7
JDA22
NOMESCO Finland
Endoscopic ligature of varices of stomach
60.4
10.6
12
*
B80
ICPC
Iron deficiency anaemia
3.9
10.6
42
109
3AC01
NOMESCO Finland
NA
5.3
10.6
31
59
UJF02
NOMESCO Finland
Peroral enteroscopy
8.0
10.6
23
29
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
4.8
10.6
34
72
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
14.3
10.5
17
12
K76.4
ICD-10 Finland
Peliosis hepatis
110.7
10.4
11
*
N05BA01
ATC
diazepam; systemic, rectal
1.8
10.4
194
1155
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.2
10.4
52
164
K02.2
ICD-10 Finland
Caries of cementum
2.6
10.4
74
293
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
10.4
244
1556
RS120
NOMESCO Finland
NA
16.2
10.4
16
10
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
3.0
10.3
59
202
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
3.4
10.3
48
143
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
10.3
158
881
D69.5
ICD-10 Finland
Secondary thrombocytopenia
10.7
10.3
19
18
A10BD03
ATC
metformin and rosiglitazone; systemic
4.1
10.2
39
98
K80.8
ICD-10 Finland
Other cholelithiasis
4.6
10.2
34
75
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.8
10.2
187
1108
TK810
NOMESCO Finland
Hemofiltration
7.5
10.2
23
31
C02EA02
ATC
NA
2.4
10.2
84
357
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
5.5
10.1
29
54
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.8
10.1
65
242
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
4.1
10.0
38
95
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
4.4
10.0
35
81
JDA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in stomach or pylorus
10.1
10.0
19
19
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.2
10.0
51
163
A40.8
ICD-10 Finland
Other streptococcal sepsis
5.8
10.0
27
47
K26.9
ICD-10 Finland
Duodenal ulcer, unspecified as acute or chronic, without haemorrhage or perforation
5.8
10.0
27
47
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
40.3
10.0
12
*
F15.1
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use
40.3
10.0
12
*
K55.2
ICD-10 Finland
Angiodysplasia of colon
6.8
9.9
24
36
K31.8
ICD-10 Finland
Other specified diseases of stomach and duodenum
6.8
9.9
24
36
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.5
9.9
373
2678
F05.9
ICD-10 Finland
Delirium, unspecified
3.5
9.9
44
127
A02BC01
ATC
omeprazole; systemic
1.5
9.9
396
2884
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
3.3
9.8
49
154
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
3.1
9.8
52
171
A10BJ05
ATC
dulaglutide; parenteral
5.7
9.8
27
48
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
9.8
248
1613
N06AB04
ATC
citalopram; systemic
1.6
9.8
284
1913
N05BA12
ATC
alprazolam; oral
1.9
9.8
144
789
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.2
9.8
49
155
JAF10
NOMESCO Finland
Repair of umbilical hernia
3.2
9.7
50
161
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
6.6
9.7
24
37
A10BG02
ATC
rosiglitazone; oral
4.2
9.7
35
84
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.3
9.7
92
421
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.5
9.7
78
328
K26.0
ICD-10 Finland
Duodenal ulcer, acute with haemorrhage
5.9
9.7
26
45
C08CA01
ATC
amlodipine; oral
1.4
9.7
545
4248
Z72.1
ICD-10 Finland
Alcohol use
4.9
9.6
30
62
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.8
9.6
159
909
DKW00
NOMESCO Finland
Cauterisation of mucosa of nose
5.1
9.6
29
58
JDA32
NOMESCO Finland
Endoscopic injection in stomach or pylorus
9.1
9.5
19
21
UJK12
NOMESCO Finland
Peroral cholangioscopy
15.1
9.5
15
10
H3600, E113
ICD-10 Finland
NA
4.1
9.5
35
86
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
3.2
9.5
47
148
130
Kela drug reimbursment
Malignant tumour
1.9
9.4
140
772
N03AX16
ATC
pregabalin; oral
1.5
9.4
327
2302
JJA44
NOMESCO Finland
Laparoscopic destruction of lesion of liver
100.6
9.4
10
*
SPAT1088
SPAT
Blood transfusion
7.6
9.4
21
28
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.1
9.4
111
558
M01AB01
ATC
indometacin; systemic, rectal
1.9
9.4
141
778
F11.24
ICD-10 Finland
Addiction-induced dependence caused by opiates active addiction
30.2
9.4
12
*
2BD01
NOMESCO Finland
NA
17.6
9.4
14
8
I98.2
ICD-10 Finland
Oesophageal varices without bleeding in diseases classified elsewhere
+∞
9.4
9
*
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.4
9.4
27
51
ZX108
NOMESCO Finland
Inhalation
5.9
9.4
25
43
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
21.8
9.4
13
6
3A064
NOMESCO Finland
NA
8.1
9.3
20
25
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.1
9.3
100
485
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
3.8
9.3
38
102
K08.3
ICD-10 Finland
Retained dental root
2.1
9.3
109
549
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
8.7
9.3
19
22
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.2
9.3
94
443
T74.1
ICD-10 Finland
Physical abuse
5.3
9.2
27
52
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
4.8
9.2
29
61
K07
ICPC
Swollen ankles/oedema
2.4
9.1
76
328
E0000UV
ATC
NA
1.4
9.1
511
3969
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.6
9.1
30
66
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.6
9.1
110
1870
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
5.2
9.1
27
53
SPAT1265
SPAT
Breathalyser
5.6
9.1
25
45
B03XA02
ATC
darbepoetin alfa; parenteral
3.4
9.0
42
126
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
15.7
9.0
14
9
F19.25
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances continuously used
15.7
9.0
14
9
J01CF05
ATC
flucloxacillin; systemic
2.6
9.0
64
251
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
3.4
8.9
42
127
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
7.5
8.9
20
27
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.8
8.9
162
953
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.4
8.9
71
299
A10BJ01
ATC
exenatide; parenteral
5.5
8.9
25
46
Z49.1
ICD-10 Finland
Extracorporeal dialysis
4.1
8.9
33
82
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
8.8
271
1851
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
3.5
8.8
40
118
D02AE01
ATC
carbamide; topical
2.1
8.8
100
497
JDA42
NOMESCO Finland
Other endoscopic haemostatic procedure in stomach or pylorus
9.5
8.8
17
18
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.7
8.8
59
225
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
3.9
8.7
34
88
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.4
8.7
443
3372
A04
ICPC
Weakness/tiredness general
1.8
8.7
167
1001
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.6
8.7
225
1468
K65.8
ICD-10 Finland
Other peritonitis
14.1
8.7
14
10
602
Kela drug reimbursment
Children's severe malnutrition
50.3
8.7
10
*
K76.1
ICD-10 Finland
Chronic passive congestion of liver
50.3
8.7
10
*
SPAT1216
SPAT
Assessment of functional ability
1.6
8.6
226
1483
N40
ICD-10 Finland
Hyperplasia of prostate
0.6
8.6
188
2779
K25.3
ICD-10 Finland
Gastric ulcer, Acute without haemorrhage or perforation
5.5
8.6
24
44
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
5.8
8.6
23
40
N06AB10
ATC
escitalopram; oral
1.6
8.6
218
1419
RS221
NOMESCO Finland
NA
4.1
8.6
32
80
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
8.6
346
2512
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
4.8
8.6
27
57
EBA10
NOMESCO Finland
Surgical removal of tooth
1.9
8.5
123
672
J01DA01
ATC
[U] cefalexin; systemic
1.4
8.5
855
7333
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
3.0
8.5
46
155
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
4.0
8.5
32
81
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
3.8
8.4
34
91
K55.8
ICD-10 Finland
Other vascular disorders of intestine
7.4
8.4
19
26
K74.4
ICD-10 Finland
Secondary biliary cirrhosis
90.5
8.4
9
*
K75.8
ICD-10 Finland
Other specified inflammatory liver diseases
90.5
8.4
9
*
R4190
NOMESCO Finland
Nutritional therapy
2.7
8.4
55
209
N06AX16
ATC
venlafaxine; oral
1.7
8.4
161
967
K22.6
ICD-10 Finland
Gastro-oesophageal laceration-haemorrhage syndrome
6.7
8.4
20
30
A10BX02
ATC
repaglinide; oral
4.0
8.4
32
82
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
8.3
125
690
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
2.8
8.3
51
186
R10.0
ICD-10 Finland
Acute abdomen
3.0
8.3
46
157
C22
ICD-10 Finland
Malignant neoplasm of liver and intrahepatic bile ducts
+∞
8.3
8
*
3019
Kela drug reimbursment
Lenvatinib
+∞
8.3
8
*
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.5
8.3
64
266
I50.1
ICD-10 Finland
Left ventricular failure
2.2
8.3
81
379
K31.7
ICD-10 Finland
Polyp of stomach and duodenum
9.5
8.3
16
17
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
8.3
501
3934
D50
ICD-10 Finland
Iron deficiency anaemia
3.9
8.3
32
83
N30.0
ICD-10 Finland
Acute cystitis
1.7
8.2
173
1068
K77
ICPC
Heart failure
3.1
8.2
42
136
F60.2
ICD-10 Finland
Dissocial personality disorder
14.5
8.2
13
9
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
2.4
8.2
69
299
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.8
8.2
144
842
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
6.5
8.2
20
31
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
3.2
8.2
41
131
E87.2
ICD-10 Finland
Acidosis
7.6
8.2
18
24
F60.9
ICD-10 Finland
Personality disorder, unspecified
5.4
8.1
23
43
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.1
8.1
42
137
JKA20
NOMESCO Finland
Cholecystectomy
2.7
8.1
55
211
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
8.1
293
2076
R03BB04
ATC
tiotropium bromide; inhalant
1.7
8.1
158
953
L04AA01
ATC
[U] ciclosporin; systemic
4.1
8.1
30
75
S42.2
ICD-10 Finland
Fracture of upper end of humerus
2.3
8.1
69
303
R52.0
ICD-10 Finland
Acute pain
3.1
8.1
42
138
UJD10
SPAT
NA
3.9
8.1
31
80
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
8.0
272
1897
G62.1
ICD-10 Finland
Alcoholic polyneuropathy
10.1
8.0
15
15
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.3
8.0
73
329
F41.09
ICD-10 Finland
UNS Panic Syndrome
4.0
8.0
30
76
319
Kela drug reimbursment
Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)
7.3
8.0
18
25
K02.9
ICD-10 Finland
Dental caries, unspecified
3.9
8.0
31
81
K51.5
ICD-10 Finland
Left sided colitis
3.1
7.9
42
140
TGC00
NOMESCO Finland
Bronchial lavation
2.8
7.9
50
184
H36.01
ICD-10 Finland
Diabetic maculopathy
4.5
7.9
26
58
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
13.1
7.9
13
10
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.6
7.9
194
1252
WX402
NOMESCO Finland
General anaesthesia
1.6
7.8
212
1401
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
6.1
7.8
20
33
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.0
7.8
102
537
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
5.4
7.8
22
41
Z94.0
ICD-10 Finland
Kidney transplant status
4.7
7.8
25
54
R94.5
ICD-10 Finland
Abnormal results of liver function studies
4.7
7.8
25
54
EBA00
NOMESCO Finland
Extraction of tooth
1.4
7.8
419
3208
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
0.3
7.8
22
620
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.8
7.8
144
855
30041
ICD-8 Finland
Neuroses, Depressiva
4.2
7.8
28
68
T89
ICPC
Diabetes insulin dependent
2.6
7.8
55
219
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
4.0
7.8
29
73
358
Kela drug reimbursment
liraglutide
7.0
7.8
18
26
K25.4
ICD-10 Finland
Gastric ulcer, Chronic or unspecified with haemorrhage
4.9
7.8
24
50
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.5
7.8
58
238
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
2.8
7.8
47
171
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
7.8
231
1560
K05.31
ICD-10 Finland
Periodontitis pronounced
1.7
7.7
147
881
Z71.8
ICD-10 Finland
Other specified counselling
1.5
7.7
282
1996
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
7.7
109
592
B01AB10
ATC
tinzaparin; parenteral
1.9
7.7
107
578
K25.0
ICD-10 Finland
Gastric ulcer, Acute with haemorrhage
4.1
7.7
28
69
A11CC03
ATC
alfacalcidol; systemic
2.8
7.7
46
166
R11
ICD-10 Finland
Nausea and vomiting
1.9
7.7
105
564
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
2.7
7.6
50
191
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.6
7.6
53
209
D07XC01
ATC
betamethasone, combinations; topical
1.7
7.6
168
1049
XF612
NOMESCO Finland
Measurement of central venous pressure
11.9
7.6
13
11
F15.2
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome
11.9
7.6
13
11
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
5.2
7.6
22
43
A41.1
ICD-10 Finland
Sepsis due to other specified staphylococcus
5.8
7.5
20
35
G03FA14
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, fixed comb.)
0.2
7.5
6
334
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.0
7.5
97
509
WVA40
NOMESCO Finland
Initiation and monitoring of intravenous hydration
4.4
7.5
25
57
S18
ICPC
Laceration/cut
1.4
7.5
595
4876
C07AB02
ATC
metoprolol; systemic
1.5
7.4
309
2249
N05AA02
ATC
levomepromazine; systemic
2.3
7.4
65
290
L01EX02
ATC
sorafenib; oral
80.5
7.4
8
*
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
4.2
7.4
26
62
H25.8
ICD-10 Finland
Other senile cataract
1.7
7.3
159
989
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
10.9
7.3
13
12
1508
Kela drug reimbursment
Lenvatinib
+∞
7.3
7
*
JJC60
NOMESCO Finland
Total excision of transplanted liver
+∞
7.3
7
*
F13.20
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent
9.4
7.3
14
15
Z71.4
ICD-10 Finland
Alcohol abuse counselling and surveillance
9.4
7.3
14
15
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.7
7.3
141
851
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
5.2
7.2
21
41
A10BX01
ATC
guar gum; systemic
2.3
7.2
66
300
XX4BW
NOMESCO Finland
NA
15.8
7.2
11
7
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
0.5
7.2
53
1041
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
7.2
116
660
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.8
7.2
119
681
M10.0
ICD-10 Finland
Idiopathic gout
2.4
7.2
57
242
S76
ICPC
Skin infection other
2.1
7.2
77
374
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
4.4
7.1
24
55
F11.20
ICD-10 Finland
Addiction-induced dependence caused by opiates currently independent
30.1
7.1
9
*
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
20.1
7.1
10
5
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
7.1
248
1737
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.1
7.1
79
389
9694A
ICD-9 Finland
Poisoning by psychotropic agents, Benzodiazepine-based tranquillisers
5.3
7.1
20
38
WZC30
NOMESCO Finland
Teaching
1.6
7.1
186
1219
P01AB01
ATC
metronidazole; oral, rectal
1.4
7.0
484
3859
A10BB07
ATC
glipizide; oral
3.4
7.0
32
96
JAF30
NOMESCO Finland
Repair of umbilical hernia using prosthetic material
2.7
7.0
45
168
K81.0
ICD-10 Finland
Acute cholecystitis
2.9
7.0
40
138
N06AB06
ATC
sertraline; oral
1.8
7.0
114
649
D07AA02
ATC
hydrocortisone; topical
1.6
7.0
159
1006
B99
ICD-10 Finland
Other and unspecified infectious diseases
2.9
6.9
40
140
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.2
6.9
64
293
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
4.3
6.9
24
57
K85
ICD-10 Finland
Acute pancreatitis
3.1
6.9
35
114
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.2
6.9
66
306
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
7.6
6.9
15
20
R77.0
ICD-10 Finland
Abnormality of albumin
13.8
6.9
11
8
R31
ICD-10 Finland
Unspecified haematuria
1.7
6.9
155
976
P16
ICPC
Acute alcohol abuse
3.9
6.9
26
67
C03AA03
ATC
hydrochlorothiazide; oral
1.7
6.9
150
935
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.7
6.8
148
921
A40.1
ICD-10 Finland
Sepsis due to streptococcus, group B
11.0
6.8
12
11
SPAT1251
SPAT
Organisation of medication
2.4
6.8
55
237
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
3.9
6.8
26
68
SPAT1263
SPAT
Sampling
1.3
6.8
559
4587
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.5
6.7
245
1733
RJ411
NOMESCO Finland
NA
7.2
6.7
15
21
M01AH05
ATC
etoricoxib; oral
0.8
6.7
562
6668
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
1.9
6.7
87
460
K81.9
ICD-10 Finland
Cholecystitis, unspecified
4.0
6.7
25
64
N05AB01
ATC
dixyrazine; systemic
3.7
6.7
27
74
RD210
NOMESCO Finland
NA
3.2
6.7
33
106
S29
ICPC
Skin symptom/complaint other
1.5
6.7
222
1541
TPH05
NOMESCO Finland
Open cannulation of peripheral vein
5.2
6.6
19
37
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
7.8
6.6
14
18
L29.9
ICD-10 Finland
Pruritus, unspecified
2.9
6.6
38
133
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.5
6.6
221
1532
WX730
NOMESCO Finland
Conventional respirator
3.1
6.6
33
107
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
4.6
6.6
21
46
A02BC05
ATC
esomeprazole; systemic
1.3
6.6
542
4442
WX722
NOMESCO Finland
PEEP
2.1
6.6
75
374
N06AX03
ATC
mianserin; oral
2.1
6.6
71
349
4019X
ICD-9 Finland
Essential hypertension, Unspecified
2.4
6.5
53
228
S91.3
ICD-10 Finland
Open wound of other parts of foot
2.7
6.5
40
148
N03AX14
ATC
levetiracetam; systemic
2.7
6.5
42
158
Z71.9
ICD-10 Finland
Counselling, unspecified
2.1
6.5
70
341
N03AX12
ATC
gabapentin; oral
1.5
6.5
199
1355
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.9
6.5
91
492
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
2.6
6.5
44
173
A10AE06
ATC
insulin degludec; parenteral
2.6
6.5
44
173
A03
ICPC
Fever
1.6
6.5
165
1074
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.4
6.5
321
2412
3044A
ICD-9 Finland
Drug dependence, Amphetamine and other psychostimulant dependence
70.1
6.4
7
*
5716A
ICD-9 Finland
Chronic liver disease and cirrhosis, Biliary cirrhosis[CIRRHOSIS BILIARIS PRIMARIA]
70.1
6.4
7
*
SPAT1229
SPAT
Assessment of need for aid
1.7
6.4
123
739
474
NOMESCO Finland
NA
14.4
6.4
10
7
C61
ICD-10 Finland
Malignant neoplasm of prostate
0.5
6.4
60
1093
C09BA02
ATC
enalapril and diuretics; systemic
1.7
6.4
129
787
C07AB03
ATC
atenolol; systemic
1.9
6.4
92
504
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
6.0
6.3
16
27
F13.25
ICD-10 Finland
Addiction caused by sedative and hypnotic continuous use
11.1
6.3
11
10
H36.00
ICD-10 Finland
Diabetic background retinopathy
3.6
6.3
26
73
ZZA00
NOMESCO Finland
Split skin graft
2.4
6.3
51
219
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
4.0
6.3
23
58
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
4.0
6.3
23
58
K29.2
ICD-10 Finland
Alcoholic gastritis
9.3
6.3
12
13
N06AB03
ATC
fluoxetine; oral
1.6
6.3
152
976
3049X
ICD-9 Finland
Drug dependence, Unspecified drug dependence
18.1
6.3
9
5
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
18.1
6.3
9
5
A07EC02
ATC
mesalazine; oral, rectal
2.0
6.3
77
396
N06AA12
ATC
doxepin; systemic
2.0
6.3
77
397
JCA35
NOMESCO Finland
Endoscopic contact coagulation in oesophagus
+∞
6.3
6
*
5710A
ICD-9 Finland
Chronic liver disease and cirrhosis, Alcoholic fatty liver
+∞
6.3
6
*
D23
ICPC
Hepatomegaly
26.8
6.2
8
*
TJA00
NOMESCO Finland
Puncture of peritoneum
26.8
6.2
8
*
E000006
ATC
NA
1.9
6.2
89
486
RJ421
NOMESCO Finland
NA
7.1
6.2
14
20
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
6.2
131
810
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.8
6.2
96
539
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
6.2
205
1418
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.9
6.2
92
509
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.0
6.1
72
366
JKE25
NOMESCO Finland
Endoscopic external drainage of bile duct
7.7
6.1
13
17
F13.22
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent but uses substitute intermittent medication
7.7
6.1
13
17
L84
ICD-10 Finland
Corns and callosities
2.4
6.1
48
205
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
4.0
6.1
22
55
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
3.6
6.1
25
70
JCA42
NOMESCO Finland
Other endoscopic procedure for hemostasis
12.6
6.1
10
8
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
8.6
6.1
12
14
H26.3
ICD-10 Finland
Drug-induced cataract
6.7
6.0
14
21
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.3
6.0
50
219
I95.2
ICD-10 Finland
Hypotension due to drugs
5.2
6.0
17
33
H3601, E113
ICD-10 Finland
NA
2.9
6.0
33
115
K50.8
ICD-10 Finland
Other Crohn disease
3.6
6.0
25
71

Mortality – FinRegistry

Association

Association between endpoint CHIRHEP_NAS and mortality.

Females

Parameter HR [95% CI] p-value
CHIRHEP_NAS 8.169 [6.82, 9.79] < 0.001
Birth year 1.0 [0.99, 1.01] 0.963

During the follow-up period (1.1.1998 — 31.12.2019), 2224 out of 3896 females with CHIRHEP_NAS died.

Males

Parameter HR [95% CI] p-value
CHIRHEP_NAS 9.397 [7.67, 11.51] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 3499 out of 5661 males with CHIRHEP_NAS died.

Mortality risk

Mortality risk for people of age

years, who have CHIRHEP_NAS.

N-year risk Females Males
1 1.008% 1.497%
5 5.56% 9.387%
10 12.789% 23.294%
15 24.546% 38.804%
20 39.066% 57.792%

Relationships between endpoints

Index endpoint: CHIRHEP_NAS – Cirrhosis of liver, NAS

GWS hits: 6

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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