Biliary cirrhosis, NAS

CHIRBIL_NAS

primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K74.5 Cause of death: ICD-10 — K74.5 2 out of 7 registries used, show all original rules.	97
4. Check minimum number of events None	97
5. Include endpoints None	97
6. Filter based on genotype QC (FinnGen only)	97

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: K74
Name in latin: Cirrhosis biliaris non specificata

NAME	CHIRBIL_NAS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K745
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K745
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Biliary cirrhosis, NAS based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	740	440	291
Only index persons	591	365	226
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	66.30	67.90	64.08
Only index persons	65.48	66.47	63.90

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	97	62	35
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	63.45	62.78	64.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
89: Matched controls
890

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K74.5

ICD-10 Finland

Biliary cirrhosis, unspecified

+∞

128.1

A05AA02

ATC

ursodeoxycholic acid; oral

256.0

61.2

K74.3

ICD-10 Finland

Primary biliary cirrhosis

460.4

50.6

JJ2AT

NOMESCO Finland

Biopsy of liver with ultrasound guidance

65.5

32.0

K74.6

ICD-10 Finland

Other and unspecified cirrhosis of liver

+∞

28.7

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

16.1

27.5

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

7.9

18.3

176

I85.9

ICD-10 Finland

Oesophageal varices without bleeding

222.0

18.2

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

11.2

17.9

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

10.3

15.6

C03CA01

ATC

furosemide; systemic

5.4

12.7

189

JA3AT

NOMESCO Finland

Cathetrisation of abdominal cavity with ultrasound guidance

68.3

10.9

JJ1LE

NOMESCO Finland

Ultrasound elastography of liver

68.3

10.9

I85.0

ICD-10 Finland

Oesophageal varices with bleeding

111.1

9.6

K92.1

ICD-10 Finland

Melaena

13.6

9.5

K76.9

ICD-10 Finland

Liver disease, unspecified

30.9

8.7

R18

ICD-10 Finland

Ascites

30.9

8.7

A07EA06

ATC

budesonide; oral, local oral

12.6

8.7

M34.1

ICD-10 Finland

CR(E)ST syndrome

+∞

8.5

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.6

7.8

232

JCA22

NOMESCO Finland

Endoscopic ligature of oesophageal varices

86.8

7.5

K73.9

ICD-10 Finland

Chronic hepatitis, unspecified

86.8

7.5

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

6.8

7.2

UJF32

NOMESCO Finland

Coloscopy

3.5

7.0

166

JN1CG

NOMESCO Finland

Extensive MRI examination of upper part of abdomen with high intensity magnet

12.4

7.0

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.3

6.9

280

K73.2

ICD-10 Finland

Chronic active hepatitis, not elsewhere classified

43.4

6.9

C10AC01

ATC

colestyramine; oral

13.7

6.8

C03DA01

ATC

spironolactone; oral

4.4

6.7

L04AA06

ATC

mycophenolic acid; systemic

74.8

6.5

TJJ00

NOMESCO Finland

Percutaneous needle biopsy of liver

74.8

6.5

K83.0

ICD-10 Finland

Cholangitis

19.7

6.4

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

+∞

6.3

5716A

ICD-9 Finland

Chronic liver disease and cirrhosis, Biliary cirrhosis[CIRRHOSIS BILIARIS PRIMARIA]

+∞

6.3

ZX120

NOMESCO Finland

Intravenous

4.9

6.2

Mortality – FinRegistry

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Association

Association between endpoint CHIRBIL_NAS and mortality.

Females

Parameter	HR [95% CI]	p-value
CHIRBIL_NAS	4.689 [3.16, 6.97]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.134

During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 349 females with CHIRBIL_NAS died.

Males

Parameter	HR [95% CI]	p-value
CHIRBIL_NAS	5.621 [3.23, 9.79]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.01

During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 207 males with CHIRBIL_NAS died.

Mortality risk

Mortality risk for people of age

years, who have CHIRBIL_NAS.

N-year risk	Females	Males
1	0.314%	1.206%
5	2.226%	6.182%
10	6.182%	15.232%
15	11.143%	27.835%
20	19.285%	44.691%

Relationships between endpoints

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Index endpoint: CHIRBIL_NAS – Biliary cirrhosis, NAS

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Biliary cirrhosis, NAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints