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Carcinoma in situ of lip, excluding all cancers

CD2_INSITU_LIP_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

  • not C3_LIP
-

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D00.00&
  • Cause of death: ICD-10 D00.00&
  • Cancer registry: Topography ICD-O-3 C00
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

3 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D00
Name in latin
Carcinoma in situ glandulae thyreoideae

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population - - -
Only index persons - - -
Unadjusted period prevalence (%)
Whole population - - -
Only index persons - - -
Median age at first event (years)
Whole population - - -
Only index persons - - -

-FinnGen-

Key figures

All Female Male
Number of individuals 33 10 23
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 67.61 58.16 71.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(40768804) Tissue Pathology biopsy report
16
51
5.15
5.02
2.8
1.5
—
—
—
0
0
(3002256) Pathology report gross observation
8
15
6.66
3.43
1.9
1.1
—
—
—
0
0
(3027801) Oxygen [Partial pressure] in Arterial blood
8
22
4.45
2.56
3.8
3.8
kpa
11.6
9.8
—
8
22
(3027946) Carbon dioxide [Partial pressure] in Arterial blood
8
22
4.45
2.56
3.8
3.8
kpa
4.8
4.7
—
8
22
(3016502) Oxygen saturation in Arterial blood
8
23
4.24
2.46
4.0
3.7
%
92.0
92.1
—
8
23
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
5
8
7.11
2.46
4.4
4.9
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
7
20
4.15
2.19
1.4
1.4
—
—
—
0
0
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
5
10
5.66
2.15
2.2
2.1
ug/l
15.6
3.1
—
5
10
(3002173) Hemoglobin [Mass/volume] in Arterial blood
7
21
3.94
2.10
4.0
3.9
g/l
114.3
127.2
—
7
21
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
7
26
3.13
1.69
3.6
1.7
—
—
—
0
0
(3000991) Gas panel - Venous blood
5
15
3.73
1.58
4.0
4.5
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
7
28
2.89
1.55
2.9
1.8
—
—
—
0
0
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
5
17
3.27
1.41
2.8
4.4
%
0.8
0.8
—
5
17
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
5
17
3.27
1.41
2.6
4.5
%
0.9
1.4
—
5
17
(3014007) Fractional oxyhemoglobin in Arterial blood
5
17
3.27
1.41
2.8
4.8
%
94.3
93.1
—
5
17
(3026008) Bacteria identified in Urine by Culture
13
72
2.33
1.40
4.4
2.6
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
13
73
2.29
1.35
9.2
4.1
—
—
—
0
0
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
6
25
2.70
1.31
5.0
2.2
umol/l
45.7
5.4
—
6
19
(3044640) Blood type and Crossmatch panel - Blood
11
60
2.25
1.20
3.7
1.9
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
5
21
2.62
1.13
1.4
1.7
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
15
96
2.03
1.09
6.6
3.2
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
5
22
2.49
1.07
1.6
1.3
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
7
36
2.19
1.04
4.3
1.8
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
8
47
1.92
0.88
3.0
1.7
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
7
40
1.95
0.77
3.6
1.8
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
14
97
1.77
0.75
5.8
2.7
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
5
26
2.08
0.74
1.8
2.2
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
5
29
1.85
0.66
7.8
10.6
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
11
74
1.73
0.63
4.7
2.4
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
9
59
1.72
0.62
1.4
1.4
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
14
103
1.62
0.58
3.4
2.8
—
—
—
0
0
(3013512) EKG study
5
82
0.54
0.54
3.4
4.5
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
28
248
1.85
0.54
23.9
13.3
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
15
116
1.54
0.49
3.1
4.2
ng/l
39.0
51.9
—
10
91
(3002385) Erythrocyte distribution width [Ratio]
22
186
1.55
0.47
37.8
17.3
%
14.0
13.9
0.07
22
180
(3019150) Specific gravity of Urine by Refractometry
8
57
1.53
0.47
5.1
4.1
—
1.0
—
0
8
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
13
99
1.52
0.44
2.0
2.4
nmol/l
77.7
77.4
0.01
13
87
(3000850) Epithelial cells [#/volume] in Urine
8
60
1.44
0.44
5.6
1.9
e6/l
2.4
4.8
—
8
52
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
15
0.00
0.42
0.0
1.6
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
17
0.00
0.42
0.0
1.3
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
23
199
1.51
0.41
35.8
15.3
%
34.6
38.7
0.52
11
116
(42870588) Differential panel, method unspecified - Blood
10
73
1.53
0.40
6.1
4.7
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
27
245
1.56
0.39
35.0
16.9
umol/l
106.8
86.6
0.81
27
245
(3041096) Erythrocytes [Presence] in Urine by Automated
5
73
0.63
0.30
4.4
3.1
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
12
144
0.74
0.27
4.1
2.8
u/l
100.1
41.2
0.85
12
132
(21494755) Public health laboratory ask at order entry panel
0
11
0.00
0.22
0.0
1.3
—
—
—
0
0
(3045414) Leukocytes [Presence] in Urine
0
11
0.00
0.22
0.0
1.5
—
—
—
0
0
(3000492) Spirometry study
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
7
60
1.21
0.19
3.4
2.0
umol/l
326.3
12197.7
—
7
52
(3037467) Urinalysis macro (dipstick) panel - Urine
18
161
1.26
0.18
6.2
4.2
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
9
103
0.83
0.16
5.6
3.6
—
—
—
0
0
(3044889) 12 lead EKG panel
17
154
1.21
0.14
5.7
4.1
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
6
55
1.11
0.09
5.3
4.0
—
—
—
0
0
(3026782) Osmolality of Urine
6
57
1.06
0.09
6.0
2.1
mosm/kgh2o
501.7
558.8
—
6
44
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
5
59
0.82
0.09
1.2
1.4
mmol/l
2.0
1.3
—
5
50
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
12
116
1.05
0.00
2.0
2.2
pmol/l
116.3
89.5
—
6
65
(3015736) pH of Urine
10
96
1.06
0.00
5.0
3.6
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40758558) Short blood count panel - Blood
5
50
1.00
0.00
6.2
5.1
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(4094501)
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3010421) pH of Blood
0
8
0.00
0.00
0.0
3.9
—
7.5
—
0
8
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
(3023323) Follitropin [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
22.4
—
0
6
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
0
8
0.00
0.00
0.0
3.6
—
8.7
—
0
8
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
0
8
0.00
0.00
0.0
3.6
—
4.8
—
0
8
(3044290) Cell count panel - Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
5
57
0.86
0.00
1.2
1.4
mg/l
1.4
1.2
—
5
45
(3009466) Valproate [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
3.6
—
364.6
—
0
5
(3039162) Centromere protein B Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3045424) Erythrocytes [Presence] in Urine
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3024980) IgG subclass 4 [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
0.8
—
0
5
(3029080) Hemoglobin [Entitic mass] in Reticulocytes
0
5
0.00
0.00
0.0
1.4
—
32.0
—
0
5
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3030366) Cystatin C [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
2.6
—
2.1
—
0
7
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
(3016921) Smith extractable nuclear Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_INSITU_LIP_EXALLC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_LIP_EXALLC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: CD2_INSITU_LIP_EXALLC – Carcinoma in situ of lip, excluding all cancers

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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