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Carcinoma in situ of lip

CD2_INSITU_LIP

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not C3_LIP
519930

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D00.00&
  • Cause of death: ICD-10 D00.00&
  • Cancer registry: Topography ICD-O-3 C00
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

3 out of 7 registries used, show all original rules.

33

4. Check minimum number of events

None

33

5. Include endpoints

None

33

6. Filter based on genotype QC (FinnGen only)

33

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D00
Name in latin
Carcinoma in situ glandulae thyreoideae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 33 10 23
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 67.61 58.16 71.73

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(40768804) Tissue Pathology biopsy report
16
72
3.37
2.85
2.8
2.3
—
—
—
0
0
(3002256) Pathology report gross observation
8
23
4.24
2.46
1.9
1.6
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
5
8
7.11
2.46
4.4
8.4
—
—
—
0
0
(3027946) Carbon dioxide [Partial pressure] in Arterial blood
8
25
3.88
2.27
3.8
4.0
kpa
4.8
4.7
—
8
25
(3027801) Oxygen [Partial pressure] in Arterial blood
8
25
3.88
2.27
3.8
4.0
kpa
11.6
10.7
—
8
25
(3016502) Oxygen saturation in Arterial blood
8
25
3.88
2.27
4.0
4.2
%
92.0
94.9
—
8
25
(3000494) Fungus identified in Specimen by Culture
7
21
3.94
2.10
1.4
1.3
—
—
—
0
0
(3002173) Hemoglobin [Mass/volume] in Arterial blood
7
24
3.42
1.84
4.0
4.3
g/l
114.3
124.9
—
7
24
(3014007) Fractional oxyhemoglobin in Arterial blood
5
15
3.73
1.58
2.8
5.9
%
94.3
93.8
—
5
15
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
7
28
2.89
1.55
3.6
2.0
—
—
—
0
0
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
5
16
3.49
1.49
2.8
5.3
%
0.8
0.7
—
5
16
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
5
16
3.49
1.49
2.6
3.6
%
0.9
1.2
—
5
16
(3000991) Gas panel - Venous blood
5
17
3.27
1.41
4.0
6.2
—
—
—
0
0
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
6
24
2.82
1.37
5.0
1.7
umol/l
45.7
4.2
—
6
19
(3023368) Bacteria identified in Blood by Culture
13
73
2.29
1.35
9.2
4.1
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
13
74
2.25
1.30
4.4
3.1
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
5
19
2.91
1.26
1.6
2.0
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
7
30
2.68
1.21
2.9
2.1
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
7
33
2.42
1.14
4.3
1.5
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
9
51
2.05
1.05
1.4
1.5
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
28
232
2.36
0.98
23.9
15.1
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
11
65
2.04
0.97
3.7
2.2
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
15
100
1.92
0.95
3.1
4.7
ng/l
39.0
42.2
—
10
81
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
15
100
1.92
0.95
6.6
3.4
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
23
181
1.89
0.84
35.8
18.2
%
34.6
39.0
0.57
11
111
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
5
23
2.38
0.80
1.4
1.7
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
5
25
2.17
0.76
7.8
9.8
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
7
42
1.84
0.74
3.6
2.0
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
5
28
1.92
0.69
1.8
2.3
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
8
50
1.79
0.68
3.0
1.9
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
8
50
1.79
0.68
5.1
4.3
—
1.0
—
0
6
(3020564) Creatinine [Moles/volume] in Serum or Plasma
27
233
1.87
0.65
35.0
19.7
umol/l
106.8
85.8
0.85
27
233
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
14
101
1.67
0.63
5.8
3.1
—
—
—
0
0
(3017181) Myelocytes/100 leukocytes in Blood
0
19
0.00
0.62
0.0
4.6
—
0.8
—
0
5
(3002385) Erythrocyte distribution width [Ratio]
22
180
1.67
0.60
37.8
20.5
%
14.0
13.9
0.07
22
173
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
13
94
1.63
0.57
2.0
2.4
nmol/l
77.7
74.4
0.18
13
85
(36304419) Bacteria [Presence] in Urine
11
81
1.54
0.43
4.7
2.9
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
15
0.00
0.42
0.0
1.3
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
16
0.00
0.42
0.0
1.6
—
—
—
0
0
(3013512) EKG study
5
77
0.59
0.42
3.4
5.6
—
—
—
0
0
(3025159) Blasts/100 leukocytes in Blood
0
17
0.00
0.42
0.0
4.6
—
1.6
—
0
5
(3002179) Metamyelocytes/100 leukocytes in Blood
0
18
0.00
0.41
0.0
4.5
—
0.8
—
0
5
(3021440) Promyelocytes/100 leukocytes in Blood
0
18
0.00
0.41
0.0
4.9
—
0.2
—
0
5
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
14
110
1.47
0.41
3.4
2.9
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
10
75
1.48
0.35
6.1
5.7
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
18
153
1.39
0.32
6.2
4.6
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
5
73
0.63
0.30
4.4
3.7
—
—
—
0
0
(3044889) 12 lead EKG panel
17
149
1.29
0.22
5.7
4.3
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
0
11
0.00
0.22
0.0
3.4
—
4.7
—
0
11
(3012501) Base excess in Blood by calculation
0
11
0.00
0.22
0.0
3.4
—
2.8
—
0
6
(3045414) Leukocytes [Presence] in Urine
0
11
0.00
0.22
0.0
1.3
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
0
11
0.00
0.22
0.0
3.4
—
8.6
—
0
11
(3010421) pH of Blood
0
11
0.00
0.22
0.0
3.7
—
7.4
—
0
11
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
11
0.00
0.22
0.0
1.1
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
10
0.00
0.22
0.0
1.5
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
10
0.00
0.22
0.0
1.0
—
—
—
0
0
(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma
0
10
0.00
0.22
0.0
1.0
—
26.2
—
0
5
(21494755) Public health laboratory ask at order entry panel
0
10
0.00
0.22
0.0
1.2
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
6
49
1.27
0.21
5.3
4.3
—
—
—
0
0
(3000492) Spirometry study
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
5
66
0.71
0.19
1.2
1.4
mmol/l
2.0
1.3
—
5
58
(3000850) Epithelial cells [#/volume] in Urine
8
69
1.21
0.18
5.6
2.4
e6/l
2.4
4.8
—
8
60
(3015736) pH of Urine
10
83
1.29
0.18
5.0
3.8
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
12
106
1.21
0.12
2.0
2.2
pmol/l
116.4
89.7
—
6
60
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
5
47
1.08
0.10
1.2
1.6
mg/l
1.4
0.8
—
5
35
(3026493) Urate [Moles/volume] in Serum or Plasma
7
64
1.12
0.09
3.4
3.0
umol/l
326.3
10976.7
—
7
58
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
12
131
0.87
0.07
4.1
3.1
u/l
100.1
46.3
0.75
12
122
(40768800) Prostate Pathology biopsy report
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
(3023323) Follitropin [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
22.4
—
0
6
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3045424) Erythrocytes [Presence] in Urine
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
9
96
0.91
0.00
5.6
4.3
—
—
—
0
0
(4094501)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3027456) Digoxin [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.8
—
0.6
—
0
5
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(40758558) Short blood count panel - Blood
5
57
0.86
0.00
6.2
6.6
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3024980) IgG subclass 4 [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
0.7
—
0
5
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
4.6
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3026782) Osmolality of Urine
6
63
0.94
0.00
6.0
3.3
mosm/kgh2o
501.7
561.4
—
6
51

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_LIP – Carcinoma in situ of lip

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).