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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Carcinoma in situ of anus and anal canal

Endpoint Browser

CD2_INSITU_ANUS_ANAL_EXALLC

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

  • not C3_ANUS_ANALCANAL
-

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D01.3&
  • Hospital discharge: ICD-9 — 230[5-6]
  • Cause of death: ICD-10 — D01.3&
  • Cause of death: ICD-9 — 230[5-6]
  • Cancer registry: Topography ICD-O-3 — C21
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 2

3 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D01
Name in latin
Carcinoma in situ laryngis

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population - - -
Only index persons - - -
Unadjusted period prevalence (%)
Whole population - - -
Only index persons - - -
Median age at first event (years)
Whole population - - -
Only index persons - - -

-FinnGen-

Key figures

All Female Male
Number of individuals 33 20 13
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 63.32 61.93 65.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3002256) Pathology report gross observation
18
18
20.80
17.44
1.7
1.0
—
—
—
0
0
(4035726)
12
5
36.13
9.74
1.3
1.0
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
22
74
6.92
6.91
5.1
1.7
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
16
40
6.82
6.84
2.6
2.7
e6/l
4.5
1.6
—
10
20
(40758558) Short blood count panel - Blood
19
57
6.50
6.70
17.1
4.9
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
23
85
6.63
6.39
3.8
3.0
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
9
9
13.16
5.41
3.1
1.4
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
21
80
5.47
5.40
4.0
2.6
e6/l
23.5
108.2
0.61
16
60
(3022145) Colonoscopy Study observation
12
29
5.93
5.13
3.4
1.3
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
22
92
5.17
4.93
4.5
3.0
e6/l
132.2
77.5
0.23
16
64
(36304419) Bacteria [Presence] in Urine
19
71
4.95
4.89
3.9
2.6
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
19
75
4.61
4.48
3.7
2.2
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
19
76
4.54
4.38
4.2
2.5
e6/l
1.1
0.4
0.52
14
55
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
14
48
4.33
3.87
2.8
2.4
e6/l
0.6
1.6
—
8
27
(3023368) Bacteria identified in Blood by Culture
16
61
4.15
3.83
7.9
4.1
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
10
27
4.88
3.67
1.9
1.6
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
20
99
3.59
3.13
17.1
7.5
e9/l
0.0
0.0
0.00
14
74
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
14
57
3.53
2.93
3.4
2.2
—
—
—
0
0
(3014576) Chloride [Moles/volume] in Serum or Plasma
9
25
4.54
2.83
8.0
8.0
mmol/l
103.4
104.6
—
9
25
(3007853) Bacteria identified in Skin by Aerobe culture
10
33
3.91
2.80
2.6
2.1
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
21
113
3.36
2.78
4.8
3.5
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
8
21
4.68
2.66
2.9
3.2
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
13
58
3.05
2.27
2.5
4.2
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
10
38
3.34
2.25
3.7
1.9
—
—
—
0
0
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
7
21
3.94
2.10
8.6
2.9
u/l
262.3
232.3
—
7
21
(42870588) Differential panel, method unspecified - Blood
17
92
2.75
2.06
12.7
4.9
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
8
29
3.31
1.94
3.1
1.8
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
28
207
3.32
1.92
6.4
4.1
mm/h
15.5
10.9
0.73
28
193
(3026008) Bacteria identified in Urine by Culture
15
79
2.65
1.88
4.0
3.1
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
26
187
2.83
1.81
6.4
4.0
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
14
74
2.55
1.72
5.8
1.8
mmol/l
2.3
2.4
0.16
14
59
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
19
117
2.47
1.69
1.9
2.0
pmol/l
98.4
97.0
—
10
53
(3000494) Fungus identified in Specimen by Culture
8
35
2.69
1.39
1.7
1.5
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
5
18
3.08
1.33
3.0
1.8
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
5
18
3.08
1.33
3.0
1.7
—
—
—
0
0
(3000991) Gas panel - Venous blood
5
20
2.76
1.19
9.6
10.5
—
—
—
0
0
(3044889) 12 lead EKG panel
24
183
2.14
1.18
4.5
3.7
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
21
151
2.07
1.12
2.3
2.7
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
17
117
1.93
0.99
4.3
2.6
ug/l
124.1
100.9
0.40
17
108
(3003694) ABO and Rh group [Type] in Blood
11
68
1.93
0.85
1.4
1.2
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
11
68
1.93
0.85
5.5
1.8
umol/l
390.3
351.3
0.48
11
61
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
15
195
0.58
0.73
3.4
2.8
u/l
81.8
42.3
0.75
15
183
(3017732) Neutrophils [#/volume] in Blood
0
22
0.00
0.62
0.0
3.0
—
4.2
—
0
16
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
6
37
1.76
0.59
1.7
1.5
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
24
267
0.63
0.59
5.1
4.8
mmol/l
4.6
4.5
0.09
24
242
(3003338) MCHC [Mass/volume]
27
238
1.74
0.52
46.4
16.6
g/l
331.1
332.2
0.29
27
238
(40760892) CBC W Ordered Manual Differential panel - Blood
7
48
1.58
0.51
3.0
8.0
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
5
31
1.72
0.45
1.0
1.1
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
15
0.00
0.42
0.0
1.7
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
18
210
0.69
0.40
7.0
3.9
pmol/l
14.3
14.8
0.53
18
189
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
6
41
1.56
0.39
1.3
1.3
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
8
100
0.74
0.26
2.3
2.0
u/l
155.0
216.2
—
8
95
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
0
11
0.00
0.22
0.0
1.4
—
1.1
—
0
11
(4094501)
0
11
0.00
0.22
0.0
1.1
—
—
—
0
0
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
0
11
0.00
0.22
0.0
1.4
—
0.2
—
0
11
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
12
101
1.30
0.20
3.3
4.1
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
6
74
0.77
0.18
3.7
3.1
—
—
—
0
0
(3013512) EKG study
7
85
0.78
0.17
5.7
3.7
—
—
—
0
0
(3015736) pH of Urine
12
103
1.26
0.17
3.5
3.7
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
10
88
1.20
0.09
4.6
3.0
ng/l
2557.6
2218.7
—
10
69
(3021960) Folate [Moles/volume] in Serum or Plasma
7
64
1.12
0.09
1.3
1.6
nmol/l
21.0
19.4
—
7
55
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
27
261
1.19
0.08
7.1
6.5
mmol/mol
43.7
40.6
0.68
27
242
(1761868) Lipid panel - Serum or Plasma
8
82
0.97
0.00
2.6
3.0
—
—
—
0
0
(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
(3044927) Protein electrophoresis panel - Urine
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019230) Fractional oxyhemoglobin in Venous blood
0
8
0.00
0.00
0.0
2.9
—
76.4
—
0
8
(3043409) Potassium [Moles/volume] in Arterial blood
0
6
0.00
0.00
0.0
5.3
—
3.5
—
0
6
(3039443) Prostate specific Ag panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3003181) Sodium [Moles/volume] in Urine
0
5
0.00
0.00
0.0
1.0
—
60.2
—
0
5
(3009214) Lutropin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
5.8
—
0
5
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
7
0.00
0.00
0.0
1.0
—
0.0
—
0
7
(3018405) Lactate [Moles/volume] in Arterial blood
0
7
0.00
0.00
0.0
5.0
—
1.2
—
0
7
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
9
92
0.97
0.00
5.6
2.9
mg/l
65.9
74.0
—
9
53
(3044290) Cell count panel - Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020891) Body temperature
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
19.6
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_INSITU_ANUS_ANAL_EXALLC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_ANUS_ANAL_EXALLC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_ANUS_ANAL_EXALLC – Carcinoma in situ of anus and anal canal

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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