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Malignant neoplasms of independent (primary) multiple sites

CD2_INDEPENDENT_MULTIPLE_SITES_NAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C97
  • Cause of death: ICD-10 C97

2 out of 7 registries used, show all original rules.

20

4. Check minimum number of events

None

20

5. Include endpoints

None

20

6. Filter based on genotype QC (FinnGen only)

20

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
C97-C97
Name in latin
Neoplasmata maligna locis multis non dependentibus (primariis)

Similar endpoints

List of similar endpoints to Malignant neoplasms of independent (primary) multiple sites based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 20 8 12
Unadjusted period prevalence (%) 0.00 0.00 0.01
Median age at first event (years) 59.50 45.23 69.01

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3023368) Bacteria identified in Blood by Culture
10
34
4.88
2.90
5.9
3.9
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
10
38
4.26
2.45
2.2
1.9
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
6
18
4.29
1.91
5.2
1.4
—
—
—
0
0
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
6
18
4.29
1.91
3.3
1.7
%
16.2
29.6
—
6
18
(3022948) Iron [Moles/volume] in Serum or Plasma
6
19
4.04
1.82
3.5
1.6
umol/l
7.7
15.6
—
6
19
(3004789) Transferrin [Mass/volume] in Serum or Plasma
6
20
3.82
1.73
3.5
1.6
g/l
1.7
2.3
—
6
20
(3042936) Bacteria identified in Isolate by Culture
6
20
3.82
1.73
3.8
1.6
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
8
132
0.35
1.55
6.4
4.6
mu/l
2.0
2.0
—
8
126
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
6
23
3.27
1.50
2.0
1.6
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
5
18
3.34
1.37
1.8
1.1
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
5
19
3.15
1.30
2.0
1.3
—
—
—
0
0
(3003458) Phosphate [Moles/volume] in Serum or Plasma
5
19
3.15
1.30
3.0
4.1
mmol/l
1.2
1.0
—
5
19
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
6
108
0.37
1.23
5.5
4.0
pmol/l
13.6
15.0
—
6
103
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
8
48
2.10
0.76
1.6
2.6
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
10
65
2.08
0.73
5.3
5.6
mmol/l
1.2
1.2
—
10
57
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
9
66
1.66
0.49
4.3
3.3
—
—
—
0
0
(3013512) EKG study
5
34
1.62
0.44
4.0
3.7
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
15
0.00
0.43
0.0
2.0
—
—
—
0
0
(40758558) Short blood count panel - Blood
6
43
1.56
0.40
21.8
6.0
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
7
50
1.61
0.38
2.6
2.0
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
10
78
1.56
0.33
7.3
5.3
mmol/l
8.0
6.7
—
10
72
(3009542) Hematocrit [Volume Fraction] of Blood
14
120
1.55
0.32
23.8
14.5
%
30.0
40.2
—
8
93
(3037467) Urinalysis macro (dipstick) panel - Urine
11
91
1.46
0.31
9.5
3.5
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
5
37
1.47
0.26
1.2
2.7
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
6
46
1.43
0.24
9.0
4.5
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
6
48
1.36
0.23
3.0
1.9
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
6
48
1.36
0.23
6.8
3.1
—
—
—
0
0
(3015736) pH of Urine
6
50
1.28
0.22
7.2
2.7
—
—
—
0
0
(3000492) Spirometry study
0
11
0.00
0.22
0.0
1.5
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
11
0.00
0.22
0.0
1.7
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
0
11
0.00
0.22
0.0
1.1
—
—
—
0
0
(3044889) 12 lead EKG panel
9
101
0.80
0.09
3.2
3.7
—
—
—
0
0
(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
4.3
—
4.1
—
0
7
(3003338) MCHC [Mass/volume]
12
120
1.00
0.00
32.1
17.2
g/l
330.9
333.1
0.29
12
120
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3003181) Sodium [Moles/volume] in Urine
0
5
0.00
0.00
0.0
1.4
—
69.2
—
0
5
(3001019) Free T4 and TSH panel - Serum or Plasma
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
0
6
0.00
0.00
0.0
8.7
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
0
5
0.00
0.00
0.0
3.4
—
4.4
—
0
5
(40768443) Skin Pathology biopsy report
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
9
89
1.02
0.00
4.0
3.4
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
13
130
1.00
0.00
4.2
4.3
mmol/l
6.1
5.9
0.19
13
125
(3027315) Oxygen [Partial pressure] in Blood
0
5
0.00
0.00
0.0
3.4
—
8.4
—
0
5
(3009214) Lutropin [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.1
—
7.1
—
0
7
(3003327) Ova and parasites identified in Stool by Light microscopy
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
6
64
0.91
0.00
14.8
7.3
e9/l
0.0
0.0
—
6
52
(40768800) Prostate Pathology biopsy report
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INDEPENDENT_MULTIPLE_SITES_NAS – Malignant neoplasms of independent (primary) multiple sites

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).