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This is a non-core endpoint: only basic statistics are computed.

Benign neoplasm: Pituitary gland, craniopharyngeal duct

CD2_BENIGN_PITUITARY_CRANIPHAR_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D35.2&, D35.3
  • Hospital discharge: ICD-9 2273
  • Hospital discharge: ICD-8 2262
  • Cause of death: ICD-10 D35.2&, D35.3
  • Cause of death: ICD-9 2273
  • Cause of death: ICD-8 2262

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1958 1142 816
Unadjusted period prevalence (%) 0.38 0.39 0.36
Median age at first event (years) 50.74 46.87 56.15

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1736
Matched controls
17359
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.1
ICD-10 Finland
Hyperprolactinaemia
121.7
323.0
388
41
101
Kela drug reimbursment
Anterior pituitary hypofunction
254.2
323.0
330
16
N04BC06
ATC
cabergoline; oral (dopamine agonists)
192.9
323.0
329
21
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
4503599627370496.0
323.0
1510
*
E23.00
ICD-10 Finland
Panhypopituitarism
578.8
323.0
331
7
H02AB09
ATC
hydrocortisone; systemic
89.6
323.0
605
103
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
7811.1
323.0
554
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
388.9
323.0
699
30
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
858.3
234.1
225
*
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
+∞
213.0
200
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
461.1
170.8
168
*
H03AA01
ATC
levothyroxine sodium; systemic
4.7
166.5
728
2302
ZXC86
NOMESCO Finland
Use of endoscopic device
101.0
158.5
173
19
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
1535.0
145.9
140
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
1439.5
138.4
133
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
9.0
133.7
303
398
G02CB01
ATC
bromocriptine; systemic
20.3
131.7
202
112
XCK00
NOMESCO Finland
Perimetry
7.5
127.7
328
523
102
Kela drug reimbursment
Diabetes insipidus
165.2
117.9
123
8
H53.4
ICD-10 Finland
Visual field defects
16.4
109.5
181
122
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
16.7
103.6
170
112
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.2
99.7
294
555
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
96.8
92
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
10.4
95.4
195
208
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.8
94.3
478
1577
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
92.1
94.2
104
12
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
460.4
89.0
88
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.3
83.5
171
182
E23.05
ICD-10 Finland
Lack of TSH
66.1
81.5
94
15
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
9.0
77.1
170
206
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
76.6
73
*
H02AB02
ATC
dexamethasone; systemic
19.0
76.5
119
67
ZXC95
NOMESCO Finland
Use of surgical navigator
23.3
68.3
99
45
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
66.7
383
1349
C61
ICD-10 Finland
Malignant neoplasm of prostate
339.5
65.9
66
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
63.9
61
*
130
Kela drug reimbursment
Malignant tumour
+∞
62.9
60
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
22.3
59.3
87
41
2542
FHL
Transasal hypophysectomy
+∞
58.7
56
*
E23.2
ICD-10 Finland
Diabetes insipidus
52.0
58.5
70
14
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
57.1
523
2462
WF002
NOMESCO Finland
Radical radiotherapy
67.4
56.6
65
10
H01AC01
ATC
somatropin; parenteral
192.7
54.3
56
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
53.4
51
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
136.5
50.1
53
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
42.7
50.0
62
15
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.7
48.4
229
679
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
171.4
48.1
50
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
10.7
46.7
92
90
PJA12
NOMESCO Finland
Sentinel node biopsy
85.8
45.1
50
6
115
Kela drug reimbursment
Breast cancer
+∞
45.0
43
*
CS494
NOMESCO Finland
Other visual field testing
8.2
44.4
102
131
301
Kela drug reimbursment
Growth hormone
+∞
43.9
42
*
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
43.9
42
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
34.0
43.1
56
17
H01CB02
ATC
octreotide; parenteral
+∞
42.9
41
*
AA1AD
NOMESCO Finland
CT of head and brain
2.3
42.0
457
2293
ZXE20
NOMESCO Finland
More than three and less than five hours
3.1
41.6
258
933
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
40.8
39
*
H01CB03
ATC
lanreotide; parenteral
+∞
40.8
39
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
12.6
40.4
73
60
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
38.7
37
*
E23.03
ICD-10 Finland
Lack of ACTH
64.4
38.2
44
7
A04AA02
ATC
granisetron; systemic, transdermal
104.9
37.9
41
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
136.3
37.9
40
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
16.7
37.4
60
37
9350/1-C75.2
ICD-O-3
Craniopharyngioma, NOS, of craniopharyngeal duct
+∞
36.6
35
*
XX3DW
NOMESCO Finland
Time consuming IT work
4.4
36.2
139
339
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.0
35.9
226
820
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
53.7
35.5
42
8
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
35.0
607
3685
A03FA01
ATC
metoclopramide; systemic, rectal
2.6
32.1
263
1119
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
13.8
31.9
55
41
JN4BD
NOMESCO Finland
Extensive body CT
4.2
31.8
128
326
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
31.8
674
4367
R51.80
ICD-10 Finland
Headache
2.4
31.7
316
1492
WX402
NOMESCO Finland
General anaesthesia
2.5
31.7
279
1233
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
31.7
357
1789
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
31.3
30
*
116
Kela drug reimbursment
Prostate cancer
+∞
31.3
30
*
E23.6
ICD-10 Finland
Other disorders of pituitary gland
71.2
31.0
35
5
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
30.3
29
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.7
30.2
228
925
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
29.2
28
*
2370A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Pituitary gland and craniopharyngeal duct
+∞
29.2
28
*
WX882
NOMESCO Finland
High dependency care
6.1
29.2
81
137
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.9
29.0
188
691
Z3231
NOMESCO Finland
Registered nurse
2.0
29.0
464
2689
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
296.6
28.9
29
*
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
81.5
28.8
32
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.8
28.7
98
212
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
9.4
28.3
59
65
HAC20
NOMESCO Finland
Total mastectomy
101.7
27.7
30
*
G02CB04
ATC
quinagolide; oral
54.3
27.2
32
6
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
76.4
26.8
30
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.9
26.6
114
308
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.2
26.0
141
460
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
25.4
227
1005
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
58.9
25.0
29
5
H47.2
ICD-10 Finland
Optic atrophy
16.3
25.0
40
25
A04AA01
ATC
ondansetron; systemic, rectal
5.6
24.8
74
138
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
253.6
24.7
25
*
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
7.3
24.4
59
83
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
24.0
23
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.7
24.0
70
127
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.0
23.3
97
255
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
6.1
23.1
64
109
WX110
NOMESCO Finland
Local anesthesy
1.7
22.7
1144
9287
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
121.6
22.6
24
*
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
121.6
22.6
24
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
21.9
21
*
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
222.6
21.6
22
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
116.4
21.6
23
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
21.2
598
4105
L03AA13
ATC
pegfilgrastim; parenteral
+∞
20.9
20
*
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
20.9
20
*
UJF32
NOMESCO Finland
Coloscopy
1.9
20.8
383
2295
WF003
NOMESCO Finland
Adjuvant radiotherapy
77.7
20.7
23
*
E23.08
ICD-10 Finland
Hypopituitarism
212.3
20.6
21
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
25.8
20.4
28
11
Y28
ICPC
Limited function/disability (Y)
20.3
20.4
30
15
A02BC02
ATC
pantoprazole; systemic
1.6
20.1
1014
8094
N02BE01
ATC
paracetamol; systemic, rectal
1.8
20.0
1408
12300
ZX050
NOMESCO Finland
Stereotactic radiotherapy
58.2
19.9
23
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
12.7
19.9
35
28
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
+∞
19.8
19
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
202.1
19.6
20
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
8.2
19.0
42
52
L01BC06
ATC
capecitabine; oral
+∞
18.8
18
*
E23.0
ICD-10 Finland
Hypopituitarism
+∞
18.8
18
*
R42
ICD-10 Finland
Dizziness and giddiness
1.8
18.8
355
2138
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
70.6
18.7
21
*
T99
ICPC
Endocr/metab/nutrit disease other
6.1
18.7
51
86
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
191.9
18.6
19
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
191.9
18.6
19
*
ZXA10
NOMESCO Finland
Bilateral
1.9
18.3
293
1664
ZX120
NOMESCO Finland
Intravenous
2.7
18.3
127
487
AA1BD
NOMESCO Finland
Extensive CT of head and brain
5.5
18.2
54
101
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
18.1
447
2924
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
33.3
18.0
23
7
105
Kela drug reimbursment
Adrenal cortical hypofunction
27.0
17.8
24
9
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.4
17.8
89
274
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
17.7
17
*
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
17.7
17
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
17.7
17
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
17.7
17
*
E23.7
ICD-10 Finland
Disorder of pituitary gland, unspecified
96.0
17.6
19
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
96.0
17.6
19
*
UDM02
NOMESCO Finland
Sinoscopy
4.2
17.6
67
164
121
Kela drug reimbursment
Severe hypofunction of sexual glands
5.6
17.4
51
94
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
14.0
17.3
29
21
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
17.2
427
2790
NK6AN
NOMESCO Finland
Total body bone isotope imaging
31.8
17.0
22
7
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
16.9
424
2778
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
16.7
655
4829
G47.3
ICD-10 Finland
Sleep apnoea
1.8
16.6
354
2203
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
171.5
16.5
17
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
16.2
648
4784
N91.1
ICD-10 Finland
Secondary amenorrhoea
4.6
16.2
56
125
HAB40
NOMESCO Finland
Wedge excision of mammary gland
11.8
16.0
29
25
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
5.0
16.0
51
104
C50.99
ICD-10 Finland
Breast, unspecified
+∞
15.6
15
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
15.6
15
*
AA4DM
NOMESCO Finland
Very extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
15.6
15
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
15.6
15
*
TAB00
NOMESCO Finland
Lumbar puncture
2.9
15.5
96
344
D35.9
ICD-10 Finland
Benign neoplasm: Endocrine gland, unspecified
161.3
15.5
16
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
161.3
15.5
16
*
G44.2
ICD-10 Finland
Tension-type headache
1.9
15.1
232
1292
Z3229
NOMESCO Finland
Other healthcare associate professional
2.3
15.1
139
623
UKC02
NOMESCO Finland
Cystoscopy
2.0
15.1
207
1105
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
5.5
15.0
44
82
J01DB01
ATC
cefalexin; oral
1.6
14.9
1347
11893
N04BC01
ATC
bromocriptine; oral
57.2
14.8
17
*
WF099
NOMESCO Finland
Other radiotherapy
57.2
14.8
17
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
14.6
153
728
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
14.6
14
*
2159
FHL
Other measure in this category
+∞
14.6
14
*
D352, E221
ICD-10 Finland
NA
+∞
14.6
14
*
H47.4
ICD-10 Finland
Disorders of optic chiasm
+∞
14.6
14
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
36.3
14.4
18
5
-50
ICPC
Medication/prescr/renewal
3.1
14.2
79
264
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
14.2
140
646
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.4
13.8
49
113
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
20.2
13.8
20
10
L02AE02
ATC
leuprorelin; implant, parenteral
6.5
13.7
35
55
L02BA01
ATC
tamoxifen; oral
75.7
13.6
15
*
2532A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Panhypopituitarism[PANHYPOPITUITARISMUS]
+∞
13.6
13
*
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
+∞
13.6
13
*
V04CD01
ATC
metyrapone; oral
+∞
13.6
13
*
D35.3
ICD-10 Finland
Benign neoplasm: Craniopharyngeal duct
+∞
13.6
13
*
L02BB03
ATC
bicalutamide; oral
+∞
13.6
13
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
13.6
13
*
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
13.6
13
*
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
141.0
13.5
14
*
E27.2
ICD-10 Finland
Addisonian crisis
50.4
12.8
15
*
WZC30
NOMESCO Finland
Teaching
2.0
12.8
162
835
T73
ICPC
Neoplasm endocrine other/unspecified
70.4
12.6
14
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
12.6
260
1597
128
Kela drug reimbursment
Cancers of female genital organs
+∞
12.5
12
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
12.5
12
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
12.5
12
*
JN4AD
NOMESCO Finland
Body CT examination
3.4
12.5
60
181
H02AA02
ATC
fludrocortisone; oral
8.8
12.5
26
30
Y77
ICPC
Malignant neoplasm prostate
130.9
12.4
13
*
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
14.4
12.3
20
14
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
12.2
200
1137
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
26.9
12.0
16
6
L02BG04
ATC
letrozole; oral
4.1
11.9
45
111
N75
ICPC
Benign neoplasm nervous system
47.0
11.9
14
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
11.8
129
626
A55
ICPC
General and Unspecified, Local injection/infiltration
7.4
11.7
27
37
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
65.4
11.6
13
*
A04AD12
ATC
aprepitant; systemic
65.4
11.6
13
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.3
11.5
108
491
E89.39
ICD-10 Finland
Postprocedural hypopituitarism, other or several procedures
+∞
11.5
11
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
11.5
11
*
D35.50
ICD-10 Finland
Carotid body
+∞
11.5
11
*
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
11.5
11
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
120.7
11.4
12
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
4.7
11.4
38
83
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
11.4
321
2145
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
8.9
11.3
23
26
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
6.0
11.2
30
51
ZZR00
NOMESCO Finland
Flap of skin
8.1
11.1
24
30
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
14.0
11.0
18
13
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
43.6
10.9
13
*
R53
ICD-10 Finland
Malaise and fatigue
1.6
10.9
297
1963
HA1AA
NOMESCO Finland
X-ray mammography
3.2
10.8
55
175
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
7.2
10.8
25
35
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
10.5
786
6433
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
10.5
273
1780
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
10.5
122
608
G03DB01
ATC
dydrogesterone; oral
1.7
10.4
210
1275
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
110.6
10.4
11
*
AA4BM
NOMESCO Finland
MRI examination of sella turcica with 3 Tesla magnet
+∞
10.4
10
*
AA4AD
NOMESCO Finland
CT of sella turcica
+∞
10.4
10
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
10.4
10
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
10.4
10
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
10.4
10
*
C50
ICD-10 Finland
Malignant neoplasm of breast
+∞
10.4
10
*
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
5.7
10.4
29
52
SPAT1153
SPAT
Removal of sutures
1.5
10.3
443
3253
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
9.6
10.3
20
21
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.6
10.2
72
282
R06.0
ICD-10 Finland
Dyspnoea
1.5
10.2
336
2329
E24.8
ICD-10 Finland
Other Cushing syndrome
40.3
10.0
12
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
9.9
198
1198
ZXE00
NOMESCO Finland
One hour or less
1.4
9.9
578
4510
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
9.8
257
1680
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
26.2
9.8
13
5
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
9.7
230
1461
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.1
9.6
106
516
A02BC01
ATC
omeprazole; systemic
1.5
9.6
392
2847
J01MA02
ATC
ciprofloxacin; systemic
1.4
9.6
540
4177
B01AB10
ATC
tinzaparin; parenteral
2.6
9.6
69
275
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.3
9.5
47
147
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
9.5
150
842
R51
ICD-10 Finland
Headache
2.2
9.5
94
439
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.1
9.5
112
564
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.1
9.4
107
528
2397A
ICD-9 Finland
Neoplasm of unspecified nature, Endocrine glands and other parts of nervous system
100.5
9.4
10
*
D33.2
ICD-10 Finland
Benign neoplasm: Brain, unspecified
30.2
9.4
12
*
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
+∞
9.4
9
*
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
+∞
9.4
9
*
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
+∞
9.4
9
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
9.4
9
*
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
9.4
9
*
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
+∞
9.4
9
*
8500/3-C50.4
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast
+∞
9.4
9
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
9.4
9
*
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
10.7
9.3
17
16
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.5
9.3
42
123
ZX114
NOMESCO Finland
Intramuscular
5.1
9.3
28
56
H53.2
ICD-10 Finland
Diplopia
2.8
9.2
59
219
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.7
9.2
182
1098
JN4CD
NOMESCO Finland
Very extensive body CT
4.6
9.1
30
66
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
11.5
9.1
16
14
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.8
9.0
57
209
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
36.9
9.0
11
*
S18
ICPC
Laceration/cut
1.4
8.9
569
4493
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.2
8.8
44
139
N02AA05
ATC
oxycodone; systemic
1.8
8.8
139
781
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.5
8.8
64
257
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
2.8
8.8
53
191
TQW99
NOMESCO Finland
Other minor procedure on skin
2.8
8.7
55
201
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.7
8.7
28
60
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
50.2
8.7
10
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
8.7
405
3015
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
8.6
172
1039
ZYC01
NOMESCO Finland
Remote contact by phone
2.3
8.5
74
324
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.7
8.5
166
998
R11
ICD-10 Finland
Nausea and vomiting
2.0
8.5
113
596
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
27.6
8.5
11
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
90.4
8.4
9
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
90.4
8.4
9
*
E66.8
ICD-10 Finland
Other obesity
2.1
8.4
91
444
R50.9
ICD-10 Finland
Fever, unspecified
1.7
8.4
181
1123
M14.5*E22.0
ICD-10 Finland
Arthropathy associated with acromegaly
+∞
8.3
8
*
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
+∞
8.3
8
*
AA4BD
NOMESCO Finland
Extensive CT of sella turcica
+∞
8.3
8
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
8.3
8
*
C18.71
ICD-10 Finland
Malignant tumor of the sigmoid invasive carcinoma
+∞
8.3
8
*
2549
FHL
NA
+∞
8.3
8
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
8.3
8
*
2550C
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERSECRETIO HYPOFYSEOS]
+∞
8.3
8
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
8.3
8
*
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
+∞
8.3
8
*
L01AX03
ATC
temozolomide; systemic
+∞
8.3
8
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
8.3
8
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
8.3
8
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
+∞
8.3
8
*
D352, E220
ICD-10 Finland
NA
+∞
8.3
8
*
E2300, D352
ICD-10 Finland
NA
+∞
8.3
8
*
XKD00
NOMESCO Finland
Uroflowmetry
1.7
8.3
171
1046
D70.82
ICD-10 Finland
Drug-induced neutropenia
10.8
8.3
15
14
L57.0
ICD-10 Finland
Actinic keratosis
2.1
8.2
87
419
S10
ICPC
Boil/carbuncle
2.2
8.2
82
384
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
4.1
8.2
30
74
C08CA01
ATC
amlodipine; oral
1.4
8.2
455
3495
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.4
8.1
38
115
104
Kela drug reimbursment
Thyroid insufficiency
2.0
8.1
100
514
R55
ICD-10 Finland
Syncope and collapse
1.7
8.1
152
904
XJH00
NOMESCO Finland
Transanal ultrasonography
2.3
8.1
69
302
ZZC00
NOMESCO Finland
Graft of fascia
33.5
8.1
10
*
YX8AD
NOMESCO Finland
Stereotactic CT examination for dose design of radiotherapy
33.5
8.1
10
*
L03AA02
ATC
filgrastim; parenteral
17.2
8.1
12
7
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
11.7
8.1
14
12
H53.1
ICD-10 Finland
Subjective visual disturbances
2.0
8.0
99
510
N03AX14
ATC
levetiracetam; systemic
3.1
8.0
42
139
SPAT1263
SPAT
Sampling
1.4
8.0
638
5207
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.4
7.9
36
107
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
7.9
770
6479
A06AD11
ATC
lactulose; oral
1.7
7.8
168
1040
J01MA12
ATC
levofloxacin; systemic
1.6
7.8
230
1548
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
7.8
172
1072
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.6
7.8
33
93
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
7.7
210
1384
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
45.2
7.7
9
*
R93.0
ICD-10 Finland
Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
15.1
7.7
12
8
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
4.6
7.7
25
55
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
7.6
274
1927
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
11.9
7.6
13
11
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
2.8
7.6
46
168
WF004
NOMESCO Finland
Palliative radiotherapy
80.4
7.4
8
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
80.4
7.4
8
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
80.4
7.4
8
*
D35.6
ICD-10 Finland
Benign neoplasm: Aortic body and other paraganglia
80.4
7.4
8
*
ZXD05
NOMESCO Finland
Urgent procedure
1.4
7.4
455
3547
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
7.4
147
889
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.0
7.3
92
477
XW000
NOMESCO Finland
Bone marrow biopsy
3.0
7.3
40
137
9350/1-C75.1
ICD-O-3
Craniopharyngioma, NOS, of pituitary gland
+∞
7.3
7
*
H01AX01
ATC
pegvisomant; parenteral
+∞
7.3
7
*
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
+∞
7.3
7
*
E22
ICD-10 Finland
Hyperfunction of pituitary gland
+∞
7.3
7
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
7.3
7
*
8240/3-C25.9
ICD-O-3
Neuroendocrine tumor, NOS, of pancreas, NOS
+∞
7.3
7
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
+∞
7.3
7
*
E24.1
ICD-10 Finland
Nelson syndrome
+∞
7.3
7
*
L02AE04
ATC
triptorelin; parenteral
+∞
7.3
7
*
2535A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Diabetes insipidus
+∞
7.3
7
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
7.3
7
*
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
+∞
7.3
7
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
7.3
7
*
8140/3-C18.7
ICD-O-3
Adenocarcinoma, NOS, of sigmoid colon
+∞
7.3
7
*
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
+∞
7.3
7
*
XX1ZW
NOMESCO Finland
Very extensive written report from radiologist
10.9
7.3
13
12
E21.0
ICD-10 Finland
Primary hyperparathyroidism
3.9
7.3
28
73
ZZR10
NOMESCO Finland
Flap of skin and muscle
30.1
7.1
9
*
XCH00
NOMESCO Finland
Eye pressure measurement
2.4
7.1
56
234
SPAT1254
SPAT
Administration of medicine
1.6
7.1
202
1343
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
7.1
115
652
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
7.1
164
1037
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.8
7.1
119
686
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
6.0
7.1
18
30
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
3.2
7.1
35
112
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
7.0
512
4099
B01AB05
ATC
enoxaparin; parenteral
1.4
7.0
349
2620
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
3.6
7.0
29
81
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
6.9
415
3212
DFF00
NOMESCO Finland
Pure tone audiometry
1.8
6.9
119
691
A02BC05
ATC
esomeprazole; systemic
1.3
6.9
567
4623
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.2
6.9
63
286
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.5
6.8
254
1795
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
6.8
670
5603
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
2.6
6.8
45
173
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.6
6.8
187
1236
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
9.3
6.8
13
14
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
40.2
6.8
8
*
KCD05
NOMESCO Finland
Excision of bladder lesion during urinary tract endoscopy with photodynamic diagnosis (PDD)
40.2
6.8
8
*
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
40.2
6.8
8
*
JN3AD
NOMESCO Finland
Abdominal CT examination
1.9
6.7
95
516
SPAT1301
SPAT
No procedures
1.4
6.7
451
3560
XCK10
NOMESCO Finland
Photography of fundus of eye
1.7
6.7
139
852
R31
ICD-10 Finland
Unspecified haematuria
1.8
6.7
108
614
Y99
ICPC
Genital disease male other
22.6
6.7
9
*
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
22.6
6.7
9
*
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
5.9
6.6
17
29
106
Kela drug reimbursment
Hypoparathyroidism
12.3
6.6
11
9
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.7
6.6
140
867
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
3.9
6.6
25
65
XA800
NOMESCO Finland
Neuropsychological investigation
2.1
6.5
69
336
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
6.5
554
4535
Z51.5
ICD-10 Finland
Palliative care
3.3
6.5
30
92
G04CA02
ATC
tamsulosin; oral
1.5
6.5
244
1730
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.6
6.5
179
1186
XX9XW
NOMESCO Finland
NA
5.3
6.5
18
34
X76
ICPC
Malignant neoplasm breast female
70.1
6.4
7
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
70.1
6.4
7
*
25300
ICD-8 Finland
Diseases of pituitary gland, Aeromegalia
70.1
6.4
7
*
H35.20
ICD-10 Finland
Proliferative vitreoretinopathy
70.1
6.4
7
*
N76
ICPC
Neoplasm nervous system unspecified
70.1
6.4
7
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
70.1
6.4
7
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
70.1
6.4
7
*
BCA30
NOMESCO Finland
Unilateral adrenalectomy
14.4
6.4
10
7
T28
ICPC
Limited function/disability (T)
4.1
6.4
23
57
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.9
6.4
96
531
N02AX02
ATC
tramadol; systemic, rectal
1.3
6.3
561
4612
R20.2
ICD-10 Finland
Paraesthesia of skin
1.8
6.3
97
543
Z3226
NOMESCO Finland
Physiotherapist
1.5
6.3
236
1673
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
+∞
6.3
6
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
6.3
6
*
8720/3-C44.6
ICD-O-3
Malignant melanoma, NOS, of skin of upper limb and shoulder
+∞
6.3
6
*
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
+∞
6.3
6
*
E24
ICD-10 Finland
Cushing syndrome
+∞
6.3
6
*
E220, D352
ICD-10 Finland
NA
+∞
6.3
6
*
M35.2
ICD-10 Finland
Behçet disease
+∞
6.3
6
*
8720/3-C44.5
ICD-O-3
Malignant melanoma, NOS, of skin of trunk
+∞
6.3
6
*
E27.5
ICD-10 Finland
Adrenomedullary hyperfunction
+∞
6.3
6
*
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
+∞
6.3
6
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
6.3
6
*
25310
ICD-8 Finland
Diseases of pituitary gland, Panhypopituitarismus
+∞
6.3
6
*
C50.82
ICD-10 Finland
Overall malignant tumor of the mammary gland, lobular tumor
+∞
6.3
6
*
C34.19
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung other or unspecified histology
+∞
6.3
6
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.4
6.2
375
2905
K02.1
ICD-10 Finland
Caries of dentine
1.3
6.2
863
7541
G93.0
ICD-10 Finland
Cerebral cysts
6.3
6.2
15
24
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
1.7
6.1
110
647
R01AD08
ATC
fluticasone; nasal
1.3
6.1
415
3278
A28
ICPC
Limited function/disability NOS
1.6
6.0
161
1057
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
6.0
329
2504
ZX112
NOMESCO Finland
Subcutaneous
5.2
6.0
17
33

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_BENIGN_PITUITARY_CRANIPHAR_EXALLC – Benign neoplasm: Pituitary gland, craniopharyngeal duct

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).