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Benign neoplasm: Pituitary gland, craniopharyngeal duct

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_PITUITARY_CRANIPHAR

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D35.2&, D35.3
  • Hospital discharge: ICD-9 — 2273
  • Hospital discharge: ICD-8 — 2262
  • Cause of death: ICD-10 — D35.2&, D35.3
  • Cause of death: ICD-9 — 2273
  • Cause of death: ICD-8 — 2262

2 out of 7 registries used, show all original rules.

1958

4. Check minimum number of events

None

1958

5. Include endpoints

None

1958

6. Filter based on genotype QC (FinnGen only)

1958

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10221 5749 4361
Only index persons 9206 5345 3861
Unadjusted period prevalence (%)
Whole population 0.15 0.16 0.12
Only index persons 0.18 0.20 0.15
Median age at first event (years)
Whole population 50.74 47.54 55.24
Only index persons 49.72 46.32 54.42

-FinnGen-

Key figures

All Female Male
Number of individuals 1958 1142 816
Unadjusted period prevalence (%) 0.38 0.39 0.36
Median age at first event (years) 50.74 46.87 56.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1736
Matched controls
17358
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
343.2
323.0
699
34
H02AB09
ATC
hydrocortisone; systemic
68.7
323.0
605
134
N04BC06
ATC
cabergoline; oral (dopamine agonists)
253.3
323.0
329
16
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
+∞
323.0
1510
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
+∞
323.0
554
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
166.2
323.0
388
30
E23.00
ICD-10 Finland
Panhypopituitarism
448.2
323.0
331
9
101
Kela drug reimbursment
Anterior pituitary hypofunction
203.3
323.0
330
20
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
512.8
230.8
225
5
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
+∞
213.0
200
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
461.2
170.8
168
*
ZXC86
NOMESCO Finland
Use of endoscopic device
79.8
153.9
173
24
H03AA01
ATC
levothyroxine sodium; systemic
4.4
153.6
728
2450
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
10.4
145.4
303
346
G02CB01
ATC
bromocriptine; systemic
27.4
144.8
202
83
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
376.7
141.0
140
*
XCK00
NOMESCO Finland
Perimetry
8.0
133.6
328
491
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
356.0
133.6
133
*
102
Kela drug reimbursment
Diabetes insipidus
220.4
120.3
123
6
H53.4
ICD-10 Finland
Visual field defects
17.9
113.2
181
112
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
17.5
105.5
170
107
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
96.8
92
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.8
95.7
478
1560
E23.05
ICD-10 Finland
Lack of TSH
165.5
90.1
94
6
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
9.1
88.6
195
237
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
310.8
87.6
88
*
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
44.2
84.0
104
25
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.9
80.8
294
699
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
9.6
79.6
170
195
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
76.6
73
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.6
75.4
171
217
ZXC95
NOMESCO Finland
Use of surgical navigator
23.3
68.3
99
45
E23.2
ICD-10 Finland
Diabetes insipidus
121.5
65.3
70
6
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
24.7
61.2
87
37
2542
FHL
Transasal hypophysectomy
+∞
58.7
56
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
53.9
383
1541
H01AC01
ATC
somatropin; parenteral
96.4
51.1
56
6
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
257.3
49.3
50
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
11.9
49.2
92
81
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.6
46.8
229
697
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
30.6
46.4
62
21
CS494
NOMESCO Finland
Other visual field testing
8.2
44.4
102
131
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
43.9
42
*
301
Kela drug reimbursment
Growth hormone
215.0
41.0
42
*
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
38.7
37
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
38.0
457
2389
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
102.3
36.9
40
*
9350/1-C75.2
ICD-O-3
Craniopharyngioma, NOS, of craniopharyngeal duct
+∞
36.6
35
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
10.1
36.2
73
75
E23.03
ICD-10 Finland
Lack of ACTH
45.0
36.1
44
10
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
34.1
523
3014
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.9
33.6
226
857
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
12.6
33.4
60
49
H01CB03
ATC
lanreotide; parenteral
56.9
33.3
39
7
H01CB02
ATC
octreotide; parenteral
34.9
31.9
41
12
E23.6
ICD-10 Finland
Other disorders of pituitary gland
71.2
31.0
35
5
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
12.9
30.9
55
44
R51.80
ICD-10 Finland
Headache
2.3
30.6
316
1517
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.7
30.4
141
407
G02CB04
ATC
quinagolide; oral
108.6
29.7
32
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
11.3
29.6
56
51
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
285.9
27.8
28
*
2370A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Pituitary gland and craniopharyngeal duct
285.9
27.8
28
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
27.8
228
966
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
8.8
27.3
59
69
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.8
26.6
188
732
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
26.1
25
*
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
61.0
26.0
30
5
H47.2
ICD-10 Finland
Optic atrophy
17.8
25.8
40
23
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.2
25.3
98
241
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.9
24.6
70
123
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
23.7
227
1042
WX882
NOMESCO Finland
High dependency care
4.7
23.3
81
179
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
6.7
23.1
59
90
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
121.6
22.6
24
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
10.7
21.9
42
40
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
20.9
20
*
E23.08
ICD-10 Finland
Hypopituitarism
212.4
20.6
21
*
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
111.4
20.6
22
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
5.2
20.4
64
127
Y28
ICPC
Limited function/disability (Y)
20.3
20.4
30
15
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
15.5
19.8
32
21
UDM02
NOMESCO Finland
Sinoscopy
4.6
19.0
67
151
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
18.8
357
2154
E23.0
ICD-10 Finland
Hypopituitarism
+∞
18.8
18
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
5.4
18.7
56
106
E23.7
ICD-10 Finland
Disorder of pituitary gland, unspecified
191.9
18.6
19
*
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
30.4
18.3
24
8
R42
ICD-10 Finland
Dizziness and giddiness
1.8
18.0
355
2166
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
17.8
674
4949
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
17.7
17
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
15.0
17.1
28
19
G47.3
ICD-10 Finland
Sleep apnoea
1.8
17.0
354
2191
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
64.0
16.8
19
*
T99
ICPC
Endocr/metab/nutrit disease other
5.3
16.7
51
99
WX402
NOMESCO Finland
General anaesthesia
1.9
16.4
279
1612
105
Kela drug reimbursment
Adrenal cortical hypofunction
18.7
16.0
24
13
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.6
15.8
114
449
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
15.7
153
705
TAB00
NOMESCO Finland
Lumbar puncture
2.9
15.6
96
342
AA4DM
NOMESCO Finland
Very extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
15.6
15
*
N04BC01
ATC
bromocriptine; oral
85.9
15.6
17
*
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
19.4
15.6
23
12
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
10.2
15.4
30
30
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
10.5
15.2
29
28
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.6
14.8
51
114
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
14.7
655
4934
H47.4
ICD-10 Finland
Disorders of optic chiasm
+∞
14.6
14
*
D352, E221
ICD-10 Finland
NA
+∞
14.6
14
*
D35.9
ICD-10 Finland
Benign neoplasm: Endocrine gland, unspecified
80.8
14.6
16
*
WX110
NOMESCO Finland
Local anesthesy
1.5
14.6
1144
9741
ZXA10
NOMESCO Finland
Bilateral
1.8
14.5
293
1792
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
22.5
14.2
20
9
G44.2
ICD-10 Finland
Tension-type headache
1.9
13.8
232
1333
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.0
13.8
54
137
121
Kela drug reimbursment
Severe hypofunction of sexual glands
4.2
13.6
51
124
D35.3
ICD-10 Finland
Benign neoplasm: Craniopharyngeal duct
+∞
13.6
13
*
A02BC02
ATC
pantoprazole; systemic
1.5
13.3
1014
8494
2532A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Panhypopituitarism[PANHYPOPITUITARISMUS]
130.9
12.4
13
*
V04CD01
ATC
metyrapone; oral
130.9
12.4
13
*
J01DB01
ATC
cefalexin; oral
1.5
12.0
1347
12076
N75
ICPC
Benign neoplasm nervous system
47.0
11.9
14
*
2159
FHL
Other measure in this category
47.0
11.9
14
*
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
16.5
11.7
18
11
H02AA02
ATC
fludrocortisone; oral
7.7
11.6
26
34
UJF32
NOMESCO Finland
Coloscopy
1.6
11.6
383
2662
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
11.5
427
3053
E89.39
ICD-10 Finland
Postprocedural hypopituitarism, other or several procedures
+∞
11.5
11
*
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
6.4
11.4
29
46
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
35.3
11.3
14
*
T73
ICPC
Neoplasm endocrine other/unspecified
35.3
11.3
14
*
-50
ICPC
Medication/prescr/renewal
2.6
11.3
79
308
N02BE01
ATC
paracetamol; systemic, rectal
1.5
11.1
1408
12805
E27.2
ICD-10 Finland
Addisonian crisis
25.2
11.1
15
6
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
12.8
11.1
19
15
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
11.0
648
5094
G03DB01
ATC
dydrogesterone; oral
1.8
10.8
210
1262
D35.50
ICD-10 Finland
Carotid body
110.6
10.4
11
*
AA4BM
NOMESCO Finland
MRI examination of sella turcica with 3 Tesla magnet
+∞
10.4
10
*
AA4AD
NOMESCO Finland
CT of sella turcica
+∞
10.4
10
*
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
16.1
10.3
16
10
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
4.1
10.1
38
94
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
6.5
10.0
25
39
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
10.0
260
1700
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
55.3
9.6
11
*
R51
ICD-10 Finland
Headache
2.2
9.5
94
437
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
6.6
9.4
23
35
2397A
ICD-9 Finland
Neoplasm of unspecified nature, Endocrine glands and other parts of nervous system
100.5
9.4
10
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
6.5
9.3
23
36
H53.1
ICD-10 Finland
Subjective visual disturbances
2.1
9.2
99
480
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
9.2
89
411
E66.8
ICD-10 Finland
Other obesity
2.2
9.1
91
425
H53.2
ICD-10 Finland
Diplopia
2.7
9.1
59
221
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
9.0
172
1028
D33.2
ICD-10 Finland
Benign neoplasm: Brain, unspecified
24.1
8.9
12
5
E24.8
ICD-10 Finland
Other Cushing syndrome
24.1
8.9
12
5
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
8.8
230
1504
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.9
8.7
119
637
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
7.0
8.5
20
29
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
8.4
200
1276
D352, E220
ICD-10 Finland
NA
+∞
8.3
8
*
M14.5*E22.0
ICD-10 Finland
Arthropathy associated with acromegaly
+∞
8.3
8
*
2549
FHL
NA
+∞
8.3
8
*
2550C
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERSECRETIO HYPOFYSEOS]
+∞
8.3
8
*
E2300, D352
ICD-10 Finland
NA
+∞
8.3
8
*
D35.6
ICD-10 Finland
Benign neoplasm: Aortic body and other paraganglia
+∞
8.3
8
*
AA4BD
NOMESCO Finland
Extensive CT of sella turcica
+∞
8.3
8
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
8.3
140
803
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
8.3
786
6604
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
14.5
8.2
13
9
A55
ICPC
General and Unspecified, Local injection/infiltration
4.6
8.2
27
60
R55
ICD-10 Finland
Syncope and collapse
1.7
8.1
152
903
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
8.1
106
559
R53
ICD-10 Finland
Malaise and fatigue
1.5
8.0
297
2105
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
7.9
321
2316
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
7.9
257
1767
E21.0
ICD-10 Finland
Primary hyperparathyroidism
4.2
7.8
28
68
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.5
7.8
57
230
UKC02
NOMESCO Finland
Cystoscopy
1.6
7.7
207
1360
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
45.2
7.7
9
*
R93.0
ICD-10 Finland
Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
15.1
7.7
12
8
YX8AD
NOMESCO Finland
Stereotactic CT examination for dose design of radiotherapy
25.1
7.6
10
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
7.5
424
3259
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.7
7.5
166
1035
S10
ICPC
Boil/carbuncle
2.1
7.5
82
403
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
7.5
405
3089
D32.03
ICD-10 Finland
Benign meningioma in ventricles
80.4
7.4
8
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.0
7.4
91
469
XCK10
NOMESCO Finland
Photography of fundus of eye
1.7
7.4
139
827
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
3.3
7.4
35
108
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
7.3
150
916
G93.0
ICD-10 Finland
Cerebral cysts
8.4
7.3
15
18
9350/1-C75.1
ICD-O-3
Craniopharyngioma, NOS, of pituitary gland
+∞
7.3
7
*
H01AX01
ATC
pegvisomant; parenteral
+∞
7.3
7
*
25300
ICD-8 Finland
Diseases of pituitary gland, Aeromegalia
+∞
7.3
7
*
E24.1
ICD-10 Finland
Nelson syndrome
+∞
7.3
7
*
SPAT1254
SPAT
Administration of medicine
1.6
7.3
202
1337
XLA10
NOMESCO Finland
NA
2.2
7.2
73
344
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
15.8
7.2
11
7
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.3
7.2
63
280
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.5
7.1
254
1783
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
6.0
7.1
18
30
BC1AD
NOMESCO Finland
CT of adrenal glands
6.0
7.1
18
30
A02BC01
ATC
omeprazole; systemic
1.4
7.0
392
2999
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
10.1
7.0
13
13
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
7.0
7.0
16
23
104
Kela drug reimbursment
Thyroid insufficiency
1.9
6.9
100
546
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
40.2
6.8
8
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
7.2
6.7
15
21
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.2
6.7
33
106
XA800
NOMESCO Finland
Neuropsychological investigation
2.1
6.7
69
331
ZX120
NOMESCO Finland
Intravenous
1.7
6.6
127
760
SPAT1240
SPAT
Therapeutic discussion
1.6
6.6
162
1038
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
3.0
6.6
35
118
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.6
6.5
187
1247
E29.1
ICD-10 Finland
Testicular hypofunction
4.4
6.5
22
51
J01MA02
ATC
ciprofloxacin; systemic
1.3
6.5
540
4399
E22
ICD-10 Finland
Hyperfunction of pituitary gland
70.1
6.4
7
*
2535A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Diabetes insipidus
70.1
6.4
7
*
2250A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Brain
70.1
6.4
7
*
C08CA01
ATC
amlodipine; oral
1.3
6.4
455
3617
C08CA13
ATC
lercanidipine; oral
1.6
6.4
157
1006
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.6
6.4
42
161
BCA30
NOMESCO Finland
Unilateral adrenalectomy
14.4
6.4
10
7
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
6.4
210
1448
SPAT1263
SPAT
Sampling
1.3
6.4
638
5339
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
2.5
6.4
46
187
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
8.2
6.3
13
16
XX1ZW
NOMESCO Finland
Very extensive written report from radiologist
8.2
6.3
13
16
TPH07
NOMESCO Finland
Cathetrisation of artery
1.7
6.3
129
787
SPAT1153
SPAT
Removal of sutures
1.3
6.3
443
3515
WF099
NOMESCO Finland
Other radiotherapy
5.5
6.3
17
31
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.7
6.3
122
737
E24
ICD-10 Finland
Cushing syndrome
+∞
6.3
6
*
E220, D352
ICD-10 Finland
NA
+∞
6.3
6
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.9
6.2
36
127
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
2.7
6.2
38
141
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
6.2
198
1358
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
3.3
6.2
29
90
XX3DW
NOMESCO Finland
Time consuming IT work
1.6
6.2
139
874
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
6.1
172
1142
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
6.1
122
741
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
6.1
329
2499
ZZC00
NOMESCO Finland
Graft of fascia
12.6
6.1
10
8
N06AX21
ATC
duloxetine; oral
1.6
6.0
149
961
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.0
318
2405
R20.2
ICD-10 Finland
Paraesthesia of skin
1.8
6.0
97
552

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_PITUITARY_CRANIPHAR and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_PITUITARY_CRANIPHAR 1.615 [1.4, 1.86] < 0.001
Birth year 0.995 [0.99, 1.0] 0.242

During the follow-up period (1.1.1998 — 31.12.2019), 512 out of 4286 females with CD2_BENIGN_PITUITARY_CRANIPHAR died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_PITUITARY_CRANIPHAR 1.312 [1.15, 1.5] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 610 out of 3161 males with CD2_BENIGN_PITUITARY_CRANIPHAR died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PITUITARY_CRANIPHAR.

N-year risk Females Males
1 0.146% 0.276%
5 0.905% 1.452%
10 2.203% 3.392%
15 4.48% 6.597%
20 7.905% 11.263%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_PITUITARY_CRANIPHAR – Benign neoplasm: Pituitary gland, craniopharyngeal duct

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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