Cardiomyopathy due to drugs and other external agents

CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I42.7# 1 out of 7 registries used, show all original rules.	70
4. Check minimum number of events None	70
5. Include endpoints None	70
6. Filter based on genotype QC (FinnGen only)	70

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I427
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cardiomyopathy due to drugs and other external agents based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	370	194	172
Only index persons	288	154	134
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	58.64	60.72	56.11
Only index persons	57.79	60.94	54.16

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	70	46	24
Unadjusted period prevalence (%)	0.01	0.02	0.01
Median age at first event (years)	60.89	57.22	67.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
63: Matched controls
629

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I42.7

ICD-10 Finland

Cardiomyopathy due to drugs and other external agents

+∞

90.4

201

Kela drug reimbursment

Chronic cardiac insufficiency

53.6

26.5

I42.0

ICD-10 Finland

Dilated cardiomyopathy

50.9

23.0

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

53.8

20.8

I50.1

ICD-10 Finland

Left ventricular failure

28.4

19.1

C09AA05

ATC

ramipril; oral

10.7

16.1

I42.9

ICD-10 Finland

Cardiomyopathy, unspecified

105.0

15.4

I50.9

ICD-10 Finland

Heart failure, unspecified

12.5

14.8

C03CA01

ATC

furosemide; systemic

9.2

14.6

C03DA01

ATC

spironolactone; oral

13.0

14.4

I50.0

ICD-10 Finland

Congestive heart failure

18.9

13.1

I47.2

ICD-10 Finland

Ventricular tachycardia

26.1

11.9

L03AA02

ATC

filgrastim; parenteral

29.3

10.8

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

7.7

10.7

C01AA05

ATC

digoxin; systemic

19.0

10.7

H02AB02

ATC

dexamethasone; systemic

8.6

10.3

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

6.3

10.1

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

10.8

9.8

115

Kela drug reimbursment

Breast cancer

9.9

9.7

A03FA01

ATC

metoclopramide; systemic, rectal

6.4

9.3

C07AB07

ATC

bisoprolol; oral

5.2

8.6

214

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

5.7

8.6

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

11.9

8.3

Z95.0

ICD-10 Finland

Presence of electronic cardiac devices

12.5

8.0

PJD52

NOMESCO Finland

Block dissection of axillary lymph nodes

9.5

7.4

A49.9

ICD-10 Finland

Bacterial infection, unspecified

7.9

7.0

C83.31

ICD-10 Finland

Diffuse lymphoma with large B cells

45.0

6.9

L02BA01

ATC

tamoxifen; oral

12.0

6.9

AN1

Coronary angiography

6.2

6.9

127

Kela drug reimbursment

Transplant complication

77.4

6.6

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

20.6

6.5

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

6.8

6.4

C50.99

ICD-10 Finland

Breast, unspecified

14.5

6.3

J01MA12

ATC

levofloxacin; systemic

4.6

6.3

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

10.8

6.1

N02AA05

ATC

oxycodone; systemic

5.0

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

6.68

10.02

3.9

2.5

ng/l

453.1

166.0

1.09

(3023368) Bacteria identified in Blood by Culture

149

3.92

7.37

5.4

4.2

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

3.97

6.57

7.8

3.0

mmol/l

0.8

0.34

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

131

3.45

5.91

2.3

2.0

mg/l

2.9

3.4

0.44

117

(3001604) Monocytes [#/volume] in Blood

286

3.62

5.78

10.2

5.5

e9/l

0.6

0.5

0.77

252

(3006315) Basophils [#/volume] in Blood

286

3.62

5.78

10.3

5.6

e9/l

0.0

0.47

252

(3013650) Neutrophils [#/volume] in Blood by Automated count

339

3.90

5.55

18.6

10.2

e9/l

4.4

4.0

0.56

300

(3013115) Eosinophils [#/volume] in Blood

293

3.47

5.42

10.4

5.7

e9/l

0.1

0.2

1.14

265

(3001122) Ferritin [Mass/volume] in Serum or Plasma

235

2.97

4.69

3.0

2.5

ug/l

174.7

90.2

1.04

213

(4035726)

3.62

4.49

1.5

1.3

—

(36304419) Bacteria [Presence] in Urine

146

2.85

4.25

3.6

2.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.99

3.99

2.7

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

200

2.65

3.87

4.6

2.9

—

(40768806) Pleura Pathology biopsy report

12.93

3.83

2.0

1.6

—

(3045788) Cell count panel - Pleural fluid

12.93

3.83

2.2

1.0

—

(3018095) Leukocytes [#/volume] in Urine

194

2.61

3.76

4.1

3.4

e6/l

161.7

72.1

0.28

137

(42870588) Differential panel, method unspecified - Blood

181

2.56

3.58

9.4

5.1

—

(3036782) Glucose [Moles/volume] in Pleural fluid

10.77

3.56

1.3

1.2

mmol/l

5.6

6.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.89

3.49

1.5

1.2

—

(3042936) Bacteria identified in Isolate by Culture

2.80

3.46

2.8

2.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.89

3.43

3.7

2.6

e6/l

1.9

1.2

0.19

(3021589) Normoblasts [#/volume] in Blood

264

2.48

3.34

11.7

9.6

e9/l

0.0

0.80

214

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.51

3.27

1.3

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

133

2.52

3.20

3.8

2.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

165

2.43

3.16

2.5

2.2

u/l

136.1

156.8

0.18

154

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.24

3.11

2.2

1.4

—

(3045142) Bone marrow Pathology biopsy report

10.62

3.02

2.0

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.44

2.95

5.3

8.7

0.5

0.7

1.45

(3000991) Gas panel - Venous blood

3.24

2.92

12.0

7.7

—

(3000850) Epithelial cells [#/volume] in Urine

123

2.45

2.91

2.8

2.6

e6/l

6.8

4.4

0.71

106

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

275

2.32

2.91

11.3

7.1

mmol/l

1.2

0.28

233

(3002256) Pathology report gross observation

2.75

2.80

1.5

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.75

2.80

1.9

2.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.75

2.80

1.8

1.9

—

(3002582) Erythrocytes [#/volume] in Urine

166

2.28

2.72

3.7

3.0

e6/l

23.4

31.2

0.26

129

(3016650) Hepatitis A virus Ab [Presence] in Serum

5.85

2.60

1.2

1.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

7.58

2.59

2.8

2.0

—

(3018418) pH of Serum or Plasma

179

2.18

2.51

7.3

4.8

7.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.97

2.45

3.9

2.1

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

4.45

2.43

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

270

2.12

2.42

5.3

4.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

228

2.07

2.29

5.7

4.1

ng/l

35.1

32.0

0.09

160

(40761535) Cells panel - Urine sediment

2.67

2.28

6.4

3.8

—

(3020891) Body temperature

3.62

2.26

6.6

4.8

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.99

2.21

4.3

8.6

1.6

1.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

4.58

2.20

2.5

4.3

u/ml

19.3

66.8

—

(3044640) Blood type and Crossmatch panel - Blood

187

2.06

2.19

4.4

2.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.77

2.11

2.9

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.34

2.08

3.4

7.1

mmol/l

24.7

25.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

140

2.09

2.07

6.4

5.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.52

2.06

2.6

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.00

1.98

1.8

1.4

—

(40768443) Skin Pathology biopsy report

3.42

1.93

1.0

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.98

1.85

2.1

1.8

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

4.40

1.85

1.2

2.6

g/l

3.1

3.9

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.54

1.79

1.0

1.2

—

(3012544) pH of Venous blood

2.38

1.73

8.4

2.6

—

(3044889) 12 lead EKG panel

404

1.97

1.70

7.0

3.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.35

1.70

2.7

2.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.35

1.70

2.3

2.1

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.76

1.64

1.2

2.6

96.6

93.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

3.76

1.64

2.6

2.1

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.29

1.60

9.8

2.6

kpa

6.0

5.7

0.50

(3022313) Gas panel - Capillary blood

3.02

1.54

3.8

2.4

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.32

1.54

2.0

2.1

g/l

9.3

10.3

0.35

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.75

1.40

1.3

2.3

—

(3022621) pH of Urine by Test strip

0.00

1.39

0.0

2.3

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.26

1.35

7.5

4.4

0.0

0.3

—

(40758558) Short blood count panel - Blood

160

1.76

1.33

17.5

7.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.02

1.30

4.3

2.7

e6/l

3.0

5.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.75

1.23

1.6

1.2

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.17

1.23

8.1

2.7

kpa

3.6

3.9

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

2.24

1.23

2.5

3.9

pmol/l

4.0

4.6

—

(3032080) INR in Blood by Coagulation assay

236

1.66

1.22

14.4

9.0

inr

1.6

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.91

1.20

1.3

1.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

1.19

0.0

1.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.61

1.17

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.48

1.16

7.7

2.9

1.1

1.4

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.32

1.12

3.9

2.5

mmol/l

1.0

2.4

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.11

1.03

4.1

2.4

kpa

4.8

5.1

—

(40768804) Tissue Pathology biopsy report

244

1.57

1.03

2.8

2.1

—

(3017181) Myelocytes/100 leukocytes in Blood

1.95

0.98

7.5

4.1

0.4

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.83

0.96

1.2

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

230

1.53

0.92

2.0

pmol/l

86.7

95.0

0.39

107

(3019060) Gas panel - Arterial blood

1.83

0.86

2.8

4.3

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.89

0.81

6.8

3.2

mmol/l

23.3

24.7

—

(3002385) Erythrocyte distribution width [Ratio]

488

1.59

0.80

31.5

17.9

14.2

13.7

2.00

473

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.65

0.80

2.0

1.9

—

(3026008) Bacteria identified in Urine by Culture

182

1.48

0.75

4.1

2.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.75

0.73

6.7

3.5

—

(1761868) Lipid panel - Serum or Plasma

208

0.65

0.73

2.9

3.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

575

0.68

0.61

4.9

4.5

mmol/l

4.8

4.7

0.14

525

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.83

0.60

7.0

6.9

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.78

0.59

8.0

3.0

g/l

119.7

129.9

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.59

0.0

2.4

—

(3031040) Bacteria [#/volume] in Urine by Automated count

376

1.37

0.57

6.0

4.3

—

41.4

—

(4010399)

1.68

0.57

1.7

1.4

—

(3026782) Osmolality of Urine

110

1.46

0.54

4.7

2.7

mosm/kgh2o

527.3

565.8

0.32

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

590

0.68

0.54

5.7

5.0

mmol/l

2.8

0.03

536

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

570

0.71

0.50

4.9

4.5

mmol/l

1.4

1.5

1.12

514

(3019225) pH of Specimen

1.44

0.46

10.1

3.5

—

(40768797) Stomach Pathology biopsy report

1.46

0.46

1.2

1.3

—

(3000494) Fungus identified in Specimen by Culture

1.47

0.44

2.5

1.5

—

(3026361) Erythrocytes [#/volume] in Blood

641

0.71

0.43

47.4

21.3

e12/l

4.2

4.5

2.47

617

(3010813) Leukocytes [#/volume] in Blood

641

0.71

0.43

47.3

21.4

e9/l

6.8

6.5

0.76

617

(3035941) MCH [Entitic mass]

641

0.71

0.43

46.9

21.2

30.3

0.03

625

(3024731) MCV [Entitic volume]

641

0.71

0.43

47.0

21.2

92.0

91.0

1.29

625

(3007461) Platelets [#/volume] in Blood

641

0.71

0.43

47.5

21.3

e9/l

237.6

250.9

0.79

621

(3000963) Hemoglobin [Mass/volume] in Blood

641

0.71

0.43

47.4

21.4

g/l

127.3

134.5

2.87

626

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

134

1.35

0.42

1.5

1.7

pmol/l

439.9

474.5

0.24

108

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.42

0.0

1.6

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.42

0.0

2.6

—

(4094501)

0.00

0.42

0.0

1.2

—

(3008898) HLA-B27 [Presence]

0.00

0.41

0.0

1.3

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.41

0.0

6.2

—

27.8

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.41

0.0

1.8

—

1.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

126

1.35

0.40

7.2

3.8

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.39

0.0

1.3

—

292.4

—

(3003694) ABO and Rh group [Type] in Blood

145

1.32

0.39

1.7

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

155

1.31

0.38

6.7

4.3

estimate

0.0

—

(40761536) Microorganisms panel - Urine sediment

1.51

0.37

4.2

4.3

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.43

0.36

1.3

1.7

g/l

0.9

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

162

0.76

0.33

4.2

3.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

518

1.29

0.31

29.8

14.7

38.9

39.7

0.45

357

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

550

0.79

0.30

6.7

6.0

mmol/mol

43.2

40.4

0.95

509

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

400

0.84

0.24

3.5

3.1

u/l

110.6

50.5

0.92

371

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.38

0.24

1.6

2.5

e6/l

0.1

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

599

1.31

0.23

39.6

16.4

mmol/l

139.1

139.7

0.80

581

(3007164) IgA [Mass/volume] in Serum or Plasma

123

0.78

0.22

1.1

1.4

g/l

2.8

2.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.20

0.22

1.2

2.4

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.20

0.22

1.2

1.1

—

157.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

2.1

—

(3025941) Bacteria identified in Stool by Culture

1.30

0.21

1.3

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.21

0.0

2.0

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.20

0.0

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.20

0.0

1.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.20

0.0

1.4

—

(3015736) pH of Urine

216

1.17

0.19

6.4

3.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.13

0.16

19.4

7.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

348

1.13

0.15

2.5

3.2

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

601

1.28

0.14

39.5

16.4

mmol/l

4.1

4.0

3.50

582

(3035350) Ketones [Presence] in Urine by Test strip

279

1.13

0.14

5.8

3.9

estimate

0.0

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

548

0.86

0.14

4.8

4.1

mmol/l

1.6

1.3

1.45

494

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.12

0.10

1.8

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.07

0.09

3.0

1.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

284

1.10

0.09

7.2

5.1

estimate

0.0

—

(3022145) Colonoscopy Study observation

1.10

0.08

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

394

0.92

0.07

6.2

4.0

—

(40761511) CBC panel - Blood by Automated count

613

0.96

0.07

23.5

13.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

102

0.87

0.07

1.7

—

(3013512) EKG study

178

1.09

0.06

7.5

3.8

—

(3009261) Glucose [Presence] in Urine by Test strip

289

1.07

0.05

5.8

3.9

estimate

0.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

101

1.11

0.04

1.1

1.3

u/ml

1.1

14.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

568

1.02

0.00

5.6

4.6

mmol/l

6.2

5.9

0.63

515

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

223

0.98

0.00

6.7

4.1

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(4211845)

0.00

0.0

1.5

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.0

—

3.9

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.4

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

10.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.2

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(4062490)

0.00

0.0

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.00

0.00

3.2

2.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.4

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.5

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.3

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

613

1.10

0.00

41.5

16.7

umol/l

84.9

75.7

1.30

613

(3000492) Spirometry study

1.00

0.00

2.3

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.2

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

2.2

—

2.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.1

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.2

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.91

0.00

1.5

1.4

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

6.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.6

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS and mortality.

Females

Parameter	HR [95% CI]	p-value
CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS	5.804 [3.29, 10.24]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.04

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 160 females with CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS died.

Males

Parameter	HR [95% CI]	p-value
CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS	4.335 [2.25, 8.34]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.118

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 136 males with CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS died.

Mortality risk

Mortality risk for people of age

years, who have CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS.

N-year risk	Females	Males
1	0.329%	0.929%
5	2.531%	5.604%
10	7.054%	13.748%
15	13.192%	25.687%
20	21.35%	40.197%

Relationships between endpoints

↥

Index endpoint: CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS – Cardiomyopathy due to drugs and other external agents

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cardiomyopathy due to drugs and other external agents

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints