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Malignant neoplasm of intrahepatic ducts, biliary tract and gallbladder

C3_BILIARY_GALLBLADDER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C22, C23&, C24
  • Cause of death: ICD-9 155|156
  • Cause of death: ICD-8 155|156
  • Cancer registry: Topography ICD-O-3 C2[2-4]
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

1683

4. Check minimum number of events

None

1683

5. Include endpoints

1683

6. Filter based on genotype QC (FinnGen only)

1683

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Malignant neoplasm of intrahepatic ducts, biliary tract and gallbladder based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1683 504 1179
Unadjusted period prevalence (%) 0.42 0.17 0.52
Median age at first event (years) 72.26 71.45 72.60

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1517
Matched controls
15170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
+∞
323.0
503
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
2957.1
323.0
666
*
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
1923.9
323.0
304
*
130
Kela drug reimbursment
Malignant tumour
14.3
323.0
726
912
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
92.5
323.0
437
66
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
60.6
323.0
387
85
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
326.7
317.6
312
12
Z51.5
ICD-10 Finland
Palliative care
11.1
219.8
457
565
C24.9
ICD-10 Finland
Malignant neoplasm: Biliary tract, unspecified
954.4
176.8
170
*
N02AA05
ATC
oxycodone; systemic
5.6
170.2
620
1667
A03FA01
ATC
metoclopramide; systemic, rectal
5.4
168.6
641
1807
8160/3-C22.1
ICD-O-3
Cholangiocarcinoma of intrahepatic bile duct
+∞
164.6
155
*
198
Kela drug reimbursment
Sorafenib
360.7
161.3
160
5
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
8.2
156.4
388
613
K83.1
ICD-10 Finland
Obstruction of bile duct
31.7
150.7
202
73
8000/3-C22.0
ICD-O-3
Neoplasm, malignant of liver
+∞
149.5
141
*
C23
ICD-10 Finland
Malignant neoplasm of gallbladder
514.6
143.9
141
*
UJK02
NOMESCO Finland
ERCP
14.7
128.3
224
177
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
16.2
126.6
212
151
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
21.0
123.4
187
101
JN4CD
NOMESCO Finland
Very extensive body CT
9.8
122.8
265
322
L01XE05
ATC
[U] sorafenib; oral
407.1
115.1
114
*
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
33.8
114.0
150
49
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
22.1
113.0
168
85
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
24.9
107.0
153
68
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
9.7
101.8
218
257
WX302
NOMESCO Finland
Thoracal epidural anesthesy
8.0
99.5
241
349
K83.0
ICD-10 Finland
Cholangitis
23.6
99.2
144
67
8140/3-C23.9
ICD-O-3
Adenocarcinoma, NOS, of gallbladder
+∞
93.7
89
*
A04AA02
ATC
granisetron; systemic, transdermal
6.9
92.3
249
420
JLC30
NOMESCO Finland
Pancreatoduodenectomy
56.3
88.7
105
20
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
16.4
85.6
141
94
R18
ICD-10 Finland
Ascites
14.8
83.2
143
106
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
8.1
80.6
192
267
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
18.7
80.5
126
73
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
80.2
372
1134
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
18.1
80.2
127
76
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
12.8
80.2
147
126
JN4BD
NOMESCO Finland
Extensive body CT
4.3
79.2
340
964
8160/3-C24.9
ICD-O-3
Cholangiocarcinoma of billiary tract, NOS
+∞
78.8
75
*
C24.1
ICD-10 Finland
Malignant neoplasm: Ampulla of Vater
786.6
77.0
75
*
H02AB02
ATC
dexamethasone; systemic
4.6
76.0
295
755
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.6
75.8
239
487
JK3BT
NOMESCO Finland
Catherisation of bile duct with X-ray guidance
46.5
75.2
92
21
L01BC06
ATC
capecitabine; oral
8.4
74.9
173
228
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
14.7
69.4
119
87
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
24.0
68.9
99
44
C24.0
ICD-10 Finland
Malignant neoplasm: Extrahepatic bile duct
341.4
66.0
66
*
PC2DT
NOMESCO Finland
Embolisation of lesion of liver
665.8
65.4
64
*
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
12.2
63.8
119
105
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
7.5
63.6
158
232
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
5.1
62.1
212
468
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.9
62.0
292
882
C24.00
ICD-10 Finland
Hepatic duct
+∞
61.9
59
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
8.8
60.2
134
165
C24.09
ICD-10 Finland
Biliary duct or passage NOS
611.4
60.1
59
*
323
Kela drug reimbursment
Sorafenib
314.5
59.7
60
*
8140/3-C24.1
ICD-O-3
Adenocarcinoma, NOS, of ampulla of Vater
+∞
57.7
55
*
Z94.4
ICD-10 Finland
Liver transplant status
65.6
54.7
63
10
C24.02
ICD-10 Finland
Common bile duct
269.5
51.4
52
*
JN4AD
NOMESCO Finland
Body CT examination
4.0
51.2
226
638
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
5.4
50.2
160
324
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
5.7
48.3
147
281
8160/3-C24.0
ICD-O-3
Cholangiocarcinoma of extrahepatic bile duct
+∞
48.2
46
*
8000/3-C24.9
ICD-O-3
Neoplasm, malignant of billiary tract, NOS
+∞
48.2
46
*
C03DA01
ATC
spironolactone; oral
3.0
48.0
318
1224
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
4.6
48.0
179
429
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.4
47.1
539
2845
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
12.1
46.8
87
76
JJC00
NOMESCO Finland
Allogenic transplantation of liver
68.5
46.4
53
8
A05AA02
ATC
ursodeoxycholic acid; oral
15.9
46.2
76
50
JK3NB
NOMESCO Finland
Percutaneous transhepatic cholangiography
42.3
45.9
57
14
A09AA02
ATC
multienzymes (lipase, protease etc.)
8.4
45.8
104
132
PC2ET
NOMESCO Finland
Extensive embolisation of lesion of liver
+∞
45.0
43
*
D77
ICPC
Malignant digestive neopl other/NOS
25.8
44.4
62
25
C24.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of biliary tract
429.1
42.4
42
*
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
33.5
42.2
55
17
JK4ZT
NOMESCO Finland
Percutaneous transhepatic implantation of bile duct prothesis
80.9
42.1
47
6
JJ6LT
NOMESCO Finland
Coagulation of focal hepatic lesion under ultrasound guidance
94.8
42.0
46
5
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
41.5
197
587
8000/3-C80.9
ICD-O-3
Neoplasm, malignant of unknown primary site
22.3
41.2
60
28
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
9.0
41.1
89
104
8140/3-C24.0
ICD-O-3
Adenocarcinoma, NOS, of extrahepatic bile duct
+∞
40.8
39
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
14.5
39.9
68
49
A04AA01
ATC
ondansetron; systemic, rectal
4.1
39.4
163
430
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
52.6
38.7
46
9
8000/3-C22.1
ICD-O-3
Neoplasm, malignant of intrahepatic bile duct
+∞
38.7
37
*
R50.9
ICD-10 Finland
Fever, unspecified
2.7
38.1
299
1263
127
Kela drug reimbursment
Transplant complication
13.7
37.9
66
50
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
37.9
409
2054
8000/3-C24.0
ICD-O-3
Neoplasm, malignant of extrahepatic bile duct
+∞
37.7
36
*
JKE25
NOMESCO Finland
Endoscopic external drainage of bile duct
40.4
37.6
47
12
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
35.2
531
3087
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
35.2
282
1202
JK3FT
NOMESCO Finland
Exchange of bile duct catheter with radiological guidance
68.3
35.1
40
6
WZC30
NOMESCO Finland
Teaching
2.8
34.6
257
1045
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
16.9
33.9
54
33
A06AD11
ATC
lactulose; oral
2.3
33.8
385
1964
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
24.9
32.8
46
19
B01AB05
ATC
enoxaparin; parenteral
2.1
32.7
520
3071
N02AX02
ATC
tramadol; systemic, rectal
1.9
32.2
708
4729
JJB30
NOMESCO Finland
Excision of two segments of liver
73.5
32.0
36
5
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
115.8
31.8
34
*
K76.9
ICD-10 Finland
Liver disease, unspecified
11.3
30.7
58
53
3019
Kela drug reimbursment
Lenvatinib
308.2
29.9
30
*
JKA20
NOMESCO Finland
Cholecystectomy
4.6
29.4
106
244
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
24.7
29.3
41
17
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
28.8
550
3446
J01MA12
ATC
levofloxacin; systemic
2.1
28.3
368
1975
1508
Kela drug reimbursment
Lenvatinib
286.5
27.8
28
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
14.2
27.7
47
34
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.2
27.3
108
272
JAH01
NOMESCO Finland
Laparoscopy
4.8
26.8
91
197
L01EX02
ATC
sorafenib; oral
142.5
26.7
28
*
L04AA06
ATC
mycophenolic acid; systemic
9.2
26.6
56
63
C22
ICD-10 Finland
Malignant neoplasm of liver and intrahepatic bile ducts
+∞
25.1
24
*
JJB50
NOMESCO Finland
Excision of segments V, VI, VII and VIII of liver
59.1
25.1
29
5
B01AB10
ATC
tinzaparin; parenteral
3.1
25.0
147
509
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.9
24.9
481
2993
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
21.7
24.8
36
17
A06AH03
ATC
naloxegol; oral
8.8
24.6
53
62
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
10.7
24.4
47
45
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
24.3
215
953
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.8
24.2
70
126
A98
ICPC
Health maint/preventive medicine
0.6
24.2
891
10881
L04AD01
ATC
ciclosporin; systemic
9.4
24.1
50
55
8000/3-C23.9
ICD-O-3
Neoplasm, malignant of gallbladder
+∞
24.0
23
*
8140/3-C24.9
ICD-O-3
Adenocarcinoma, NOS, of billiary tract, NOS
+∞
24.0
23
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.2
23.9
76
153
A04AA55
ATC
palonosetron, combinations; systemic
8.5
23.7
52
63
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
17.2
23.6
37
22
JAH00
NOMESCO Finland
Laparotomy
4.6
23.4
83
188
UJK12
NOMESCO Finland
Peroral cholangioscopy
28.7
23.2
31
11
I81
ICD-10 Finland
Portal vein thrombosis
25.1
23.1
32
13
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
13.2
23.0
40
31
L01EX08
ATC
lenvatinib; oral
+∞
23.0
22
*
C22.7
ICD-10 Finland
Malignant neoplasm: Other specified carcinomas of liver
233.3
22.7
23
*
WW500
NOMESCO Finland
Blood transfusion
3.6
22.4
105
307
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
22.4
407
2457
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.3
22.4
232
1113
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
17.0
22.3
35
21
WX402
NOMESCO Finland
General anaesthesia
2.3
22.2
230
1101
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
29.5
21.9
29
10
A10BA02
ATC
metformin; oral
1.8
21.9
523
3459
A07AA11
ATC
rifaximin; oral
39.2
21.8
27
7
C03CA01
ATC
furosemide; systemic
1.7
21.2
656
4681
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
4.9
21.1
70
148
JJB10
NOMESCO Finland
Atypcal resection of liver
21.8
20.8
30
14
JJA20
NOMESCO Finland
Open biopsy of liver
30.5
20.6
27
9
JK3NT
NOMESCO Finland
Percutaneous transhepatic dilatation of bileducts
42.3
20.5
25
6
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
8.6
19.5
42
50
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
8.9
19.4
41
47
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
19.4
304
1726
B18.2
ICD-10 Finland
Chronic viral hepatitis C
15.8
19.3
31
20
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
17.0
19.2
30
18
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
15.0
18.9
31
21
XJA00
NOMESCO Finland
Intraoperative abdominal ultrasonography
28.2
18.7
25
9
JJ5AT
NOMESCO Finland
NA
101.3
18.6
20
*
JN3GE
NOMESCO Finland
Intraoperative ultrasound examination of abdomen
101.3
18.6
20
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
5.2
18.5
58
116
R4190
NOMESCO Finland
Nutritional therapy
4.4
18.2
67
159
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.5
17.9
148
630
1550A
ICD-9 Finland
Malignant neoplasm of liver and intrahepatic bile ducts, Liver, primary
+∞
17.7
17
*
JJA44
NOMESCO Finland
Laparoscopic destruction of lesion of liver
+∞
17.7
17
*
K92.0
ICD-10 Finland
Haematemesis
3.7
17.7
79
223
JJB71
NOMESCO Finland
Laparoscopic resection of liver
96.2
17.6
19
*
D13.4
ICD-10 Finland
Benign neoplasm: Liver
18.9
17.3
26
14
176
Kela drug reimbursment
Regorafenib
31.9
17.0
22
7
A10BB12
ATC
glimepiride; oral
2.2
17.0
193
959
D97
ICPC
Liver disease NOS
22.1
16.9
24
11
A02BC02
ATC
pantoprazole; systemic
1.6
16.8
916
7424
9680/3-C22.0
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of liver
+∞
16.7
16
*
JK3SB
NOMESCO Finland
Endoscopic retrorade cholangiography
35.4
16.7
21
6
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
10.2
16.4
32
32
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
4.6
16.4
57
128
A10AE04
ATC
insulin glargine; parenteral
2.1
15.8
185
928
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
15.8
676
5126
JJ7LT
NOMESCO Finland
Coagulation of focal hepatic lesion under CT guidance
60.7
15.8
18
*
R4110
NOMESCO Finland
Physiotherapy
1.7
15.6
385
2520
ZX120
NOMESCO Finland
Intravenous
2.2
15.6
162
772
K72.1
ICD-10 Finland
Chronic hepatic failure
26.6
15.6
21
8
TJA10
NOMESCO Finland
Laparocentesis
19.4
15.6
23
12
XX4BW
NOMESCO Finland
NA
38.5
15.4
19
5
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
8.8
15.2
32
37
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
8.2
15.1
33
41
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
14.7
255
1491
PC2SC
NOMESCO Finland
Liver angiography with X-ray
+∞
14.6
14
*
SPAT1262
SPAT
Handing over of treatment supplies
1.7
14.0
302
1889
C10AA05
ATC
atorvastatin; oral
0.6
13.9
334
4757
TK800
NOMESCO Finland
Hemodialysis
4.1
13.9
54
136
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
5.2
13.8
42
82
WX004
NOMESCO Finland
Patient-controlled sedation
11.5
13.8
25
22
XQ902
NOMESCO Finland
Other photography
11.5
13.8
25
22
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
4.8
13.7
45
96
JJB40
NOMESCO Finland
Excision of segments II, III and IV of liver
75.8
13.6
15
*
C24.01
ICD-10 Finland
Cystic duct
+∞
13.6
13
*
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
5.5
13.5
39
72
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
8.8
13.0
27
31
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.5
12.9
88
1767
A10BH01
ATC
sitagliptin; oral
2.0
12.9
176
942
WF049
NOMESCO Finland
Radiotherapy of metastasis
3.0
12.7
74
256
XX3DW
NOMESCO Finland
Time consuming IT work
2.0
12.7
159
820
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
12.6
433
3069
8140/3-C22.0
ICD-O-3
Adenocarcinoma, NOS, of liver
+∞
12.5
12
*
8010/3-C22.0
ICD-O-3
Carcinoma, NOS, of liver
+∞
12.5
12
*
A41.8
ICD-10 Finland
Other specified sepsis
4.1
12.4
48
121
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
3.3
12.4
62
194
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.0
12.1
150
773
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
3.4
12.0
57
171
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
12.0
369
2542
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
14.8
11.8
19
13
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
11.8
251
1558
N40
ICD-10 Finland
Hyperplasia of prostate
0.6
11.7
259
3781
JJB53
NOMESCO Finland
Excision of segments IV,V, VI, VII and VIII of liver
+∞
11.5
11
*
C22.2
ICD-10 Finland
Malignant neoplasm: Hepatoblastoma
+∞
11.5
11
*
L01XE29
ATC
[U] lenvatinib; oral
+∞
11.5
11
*
1552X
ICD-9 Finland
Malignant neoplasm of liver and intrahepatic bile ducts, Liver, not specified as primary or secondary[NEOPLASMA MALIGNUMHEPATIS, NON DEFINITUM PRIM/SEC]
120.9
11.4
12
*
B01AF01
ATC
rivaroxaban; oral
0.4
11.3
48
1145
ZXC40
NOMESCO Finland
Use of ultrasound
10.6
11.3
21
20
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
3.9
11.2
45
118
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
7.1
11.1
26
37
T90
ICPC
Diabetes non-insulin dependent
1.6
11.0
355
2464
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.5
11.0
78
1551
WX892
NOMESCO Finland
Monitored bed care
2.1
10.9
131
664
205
Kela drug reimbursment
Chronic hypertension
1.5
10.8
542
4152
C25.9
ICD-10 Finland
Malignant neoplasm: Pancreas, unspecified
4.8
10.8
35
75
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
28.2
10.7
14
5
JKC30
NOMESCO Finland
Partial excision of bile duct and anastomosis to jejunum
60.4
10.6
12
*
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
10.6
188
2900
A41.9
ICD-10 Finland
Sepsis, unspecified
2.5
10.6
79
321
JJA43
NOMESCO Finland
Destruction of lesion of liver
+∞
10.4
10
*
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
6.8
10.4
25
37
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.4
10.3
89
389
WX002
NOMESCO Finland
Sedation and analgesia
1.6
10.2
278
1846
J01MA02
ATC
ciprofloxacin; systemic
1.4
10.2
593
4668
B01AB04
ATC
dalteparin; parenteral
2.4
10.0
84
363
C17.0
ICD-10 Finland
Malignant neoplasm: Duodenum
26.2
9.8
13
5
L01XE21
ATC
[U] regorafenib; oral
20.2
9.8
14
7
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
4.3
9.8
35
83
SPAT1255
SPAT
Intravenous administration of medicine
2.1
9.8
107
520
SPAT1053
SPAT
Memory test
0.5
9.8
110
1905
R83
ICPC
Respiratory infection other
0.4
9.6
42
990
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
10.1
9.5
18
18
JDE00
NOMESCO Finland
Gastrojejunostomy
15.1
9.5
15
10
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
100.6
9.4
10
*
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
12.4
9.4
16
13
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
4.3
9.3
33
78
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.7
9.3
62
234
A04AD12
ATC
aprepitant; systemic
4.7
9.2
30
65
N02AA01
ATC
morphine; systemic, rectal
3.3
9.1
44
136
K72.9
ICD-10 Finland
Hepatic failure, unspecified
10.1
9.0
17
17
JK3MB
NOMESCO Finland
Postoperative cholangiography
36.9
9.0
11
*
C10AA07
ATC
rosuvastatin; oral
0.6
8.9
151
2360
JJB60
NOMESCO Finland
Other excsion of three or more segments of liver
24.2
8.9
12
5
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
24.2
8.9
12
5
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
3.2
8.9
44
139
SPAT1109
SPAT
Analgesia with portable analgesic pump
6.9
8.8
21
31
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.5
8.8
100
1727
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.5
8.7
69
287
A79
ICPC
Malignancy NOS
3.7
8.6
36
100
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
8.5
191
1199
K92.1
ICD-10 Finland
Melaena
2.0
8.5
105
542
L04AA10
ATC
sirolimus; oral
27.7
8.5
11
*
WX882
NOMESCO Finland
High dependency care
2.7
8.4
57
218
K70.4
ICD-10 Finland
Alcoholic hepatic failure
8.6
8.3
17
20
UJF32
NOMESCO Finland
Coloscopy
1.5
8.2
366
2710
369
Kela drug reimbursment
Regorafenib
14.5
8.2
13
9
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
8.2
8.1
17
21
K70.2
ICD-10 Finland
Alcoholic fibrosis and sclerosis of liver
33.5
8.1
10
*
N06DX01
ATC
memantine; oral
0.4
8.1
35
827
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
11.8
8.1
14
12
K75.0
ICD-10 Finland
Abscess of liver
10.1
8.0
15
15
L03AA02
ATC
filgrastim; parenteral
2.8
8.0
48
173
WW200
SPAT
NA
0.3
8.0
19
579
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.7
8.0
165
1013
L04AX01
ATC
azathioprine; systemic
2.5
7.9
58
235
XF612
NOMESCO Finland
Measurement of central venous pressure
10.9
7.8
14
13
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.8
7.8
140
824
A10AE05
ATC
insulin detemir; parenteral
2.1
7.7
90
451
K76.89
ICD-10 Finland
Other specified diseases of liver
15.1
7.7
12
8
TJA40
NOMESCO Finland
Percutaneous local drainage of peritoneal cavity
18.4
7.6
11
6
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
25.1
7.6
10
*
WX419
NOMESCO Finland
Other general anesthesy
5.4
7.5
21
39
P20
ICPC
Memory disturbance
0.6
7.5
87
1498
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.0
7.4
90
459
L01EX05
ATC
regorafenib; oral
80.5
7.4
8
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
13.4
7.4
12
9
YJ1BD
NOMESCO Finland
Extensive CT examination of abdomen for dose design of radiotherapy
13.4
7.4
12
9
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
5.6
7.4
20
36
L82
ICD-10 Finland
Seborrhoeic keratosis
0.5
7.3
72
1301
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.1
7.3
78
378
8140/3-C22.1
ICD-O-3
Adenocarcinoma, NOS, of intrahepatic bile duct
+∞
7.3
7
*
6603
FHL
Delete a block
+∞
7.3
7
*
1551A
ICD-9 Finland
Malignant neoplasm of liver and intrahepatic bile ducts, Intrahepatic bile ducts
+∞
7.3
7
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.4
7.2
35
795
C80.92
ICD-10 Finland
Malignant tumor without specified localization adenocarcinoma
15.8
7.2
11
7
RS220
NOMESCO Finland
NA
4.3
7.2
25
59
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.6
7.2
108
1742
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
1.9
7.2
110
612
K51.5
ICD-10 Finland
Left sided colitis
3.2
7.2
36
116
K51.8
ICD-10 Finland
Other ulcerative colitis
4.4
7.1
24
55
K70.1
ICD-10 Finland
Alcoholic hepatitis
5.6
7.1
19
34
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
10.1
7.0
13
13
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
10.1
7.0
13
13
K70.0
ICD-10 Finland
Alcoholic fatty liver
4.9
7.0
21
43
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.2
6.9
20
39
207
Kela drug reimbursment
Chronic arrhythmias
0.6
6.9
122
1896
WX704
NOMESCO Finland
Intubation
2.0
6.9
84
433
XKD00
NOMESCO Finland
Uroflowmetry
0.6
6.8
164
2384
JJB20
NOMESCO Finland
Excision of single segment of liver
16.8
6.7
10
6
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
0.4
6.7
32
731
K81.0
ICD-10 Finland
Acute cholecystitis
2.7
6.7
43
162
N02AJ06
ATC
codeine and paracetamol; systemic
0.7
6.6
231
3140
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
0.7
6.6
255
3399
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.5
6.6
72
1260
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
8.7
6.6
13
15
D76
ICPC
Malignant neoplasm pancreas
8.7
6.6
13
15
XJD02
NOMESCO Finland
Peroral endoscopic ultrasonography
4.8
6.5
20
42
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
0.3
6.5
17
498
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
0.7
6.5
197
2740
K90.3
ICD-10 Finland
Pancreatic steatorrhoea
6.2
6.5
16
26
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.5
6.5
47
192
2BB01
NOMESCO Finland
NA
70.1
6.4
7
*
K85.8
ICD-10 Finland
Other acute pancreatitis
4.9
6.4
19
39
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
5.2
6.3
18
35
K76.7
ICD-10 Finland
Hepatorenal syndrome
11.1
6.3
11
10
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
2.6
6.3
42
164
C22.3
ICD-10 Finland
Malignant neoplasm: Angiosarcoma of liver
+∞
6.3
6
*
C22.4
ICD-10 Finland
Malignant neoplasm: Other sarcomas of liver
+∞
6.3
6
*
8163/3-C24.1
ICD-O-3
Pancreatobiliary type carcinoma of ampulla of Vater
+∞
6.3
6
*
JJ2CT
NOMESCO Finland
Biopsy of liver with CT guidance
+∞
6.3
6
*
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
+∞
6.3
6
*
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.5
6.2
232
1647
YJ1CD
NOMESCO Finland
Very extensive CT examination of abdomen for dose design of radiotherapy
26.8
6.2
8
*
N02BE01
ATC
paracetamol; systemic, rectal
0.8
6.2
951
10467
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
0.6
6.2
116
1779
G04CA52
ATC
tamsulosin and dutasteride; systemic
0.6
6.2
77
1298
AA1BD
NOMESCO Finland
Extensive CT of head and brain
2.6
6.1
41
160
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
4.2
6.1
21
50
PJD99
NOMESCO Finland
Excision of other lymph nodes
12.6
6.1
10
8
PC1BC
NOMESCO Finland
Extensive angiography of aorta and abdominal arteries
6.7
6.0
14
21
E83.1
ICD-10 Finland
Disorders of iron metabolism
10.1
6.0
11
11

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_BILIARY_GALLBLADDER – Malignant neoplasm of intrahepatic ducts, biliary tract and gallbladder

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).