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Malignant neoplasm of liver and intrahepatic bile ducts

C3_LIVER_INTRAHEPATIC_BILE_DUCTS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C22
  • Cause of death: ICD-9 155
  • Cause of death: ICD-8 155
  • Cancer registry: Topography ICD-O-3 C22
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Malignant neoplasm of liver and intrahepatic bile ducts based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1005 205 800
Unadjusted period prevalence (%) 0.34 0.08 0.40
Median age at first event (years) 72.54 71.55 72.80

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1046
Matched controls
10460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
323.0
451
*
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
+∞
323.0
503
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
+∞
323.0
652
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
212.6
323.0
324
22
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
237.0
323.0
327
20
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
+∞
318.4
289
*
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
+∞
266.3
244
*
Z51.5
ICD-10 Finland
Palliative care
33.7
234.4
312
130
A03FA01
ATC
metoclopramide; systemic, rectal
12.7
191.7
378
446
198
Kela drug reimbursment
Sorafenib
+∞
170.6
159
*
8160/3-C22.1
ICD-O-3
Cholangiocarcinoma of intrahepatic bile duct
+∞
166.1
155
*
N02AA05
ATC
oxycodone; systemic
8.8
164.4
410
714
8000/3-C22.0
ICD-O-3
Neoplasm, malignant of liver
+∞
150.7
141
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
145.2
136
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
11.8
140.8
280
314
JN4CD
NOMESCO Finland
Very extensive body CT
33.5
139.2
184
66
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
40.5
121.2
153
44
L01XE05
ATC
[U] sorafenib; oral
+∞
120.1
113
*
A04AA02
ATC
granisetron; systemic, transdermal
421.8
115.9
114
*
H02AB02
ATC
dexamethasone; systemic
39.5
106.5
135
39
JN4BD
NOMESCO Finland
Extensive body CT
10.3
102.0
215
257
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
1053.5
99.8
96
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
95.3
90
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
329.9
90.3
90
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
19.0
90.0
141
85
R18
ICD-10 Finland
Ascites
32.6
89.8
119
41
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
933.7
89.1
86
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
26.6
78.6
110
46
WX302
NOMESCO Finland
Thoracal epidural anesthesy
18.7
76.4
120
72
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
34.7
75.2
98
31
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
34.7
75.2
98
31
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
12.3
74.4
140
130
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.2
72.7
256
613
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
261.1
72.3
73
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
25.0
70.3
100
44
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
69.5
66
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
10.6
68.6
139
149
PC2DT
NOMESCO Finland
Embolisation of lesion of liver
+∞
67.4
64
*
JN4AD
NOMESCO Finland
Body CT examination
10.2
66.6
138
154
L01BC06
ATC
capecitabine; oral
+∞
65.3
62
*
8000/3-C80.9
ICD-O-3
Neoplasm, malignant of unknown primary site
+∞
63.1
60
*
323
Kela drug reimbursment
Sorafenib
+∞
63.1
60
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
36.4
63.0
81
24
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.7
62.5
342
1224
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.1
59.9
157
255
C03DA01
ATC
spironolactone; oral
3.9
57.2
274
867
A04AA01
ATC
ondansetron; systemic, rectal
18.0
55.7
88
53
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
51.5
49
*
116
Kela drug reimbursment
Prostate cancer
+∞
51.5
49
*
WF002
NOMESCO Finland
Radical radiotherapy
113.7
50.3
54
5
Z94.4
ICD-10 Finland
Liver transplant status
56.7
50.2
59
11
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.8
48.7
178
429
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
48.5
402
1867
K83.1
ICD-10 Finland
Obstruction of bile duct
25.0
48.1
68
29
C24.9
ICD-10 Finland
Malignant neoplasm: Biliary tract, unspecified
+∞
47.2
45
*
JJ6LT
NOMESCO Finland
Coagulation of focal hepatic lesion under ultrasound guidance
+∞
46.2
44
*
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
16.8
45.9
74
47
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
22.3
45.8
67
32
PC2ET
NOMESCO Finland
Extensive embolisation of lesion of liver
+∞
44.1
42
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
65.5
43.6
50
8
D77
ICPC
Malignant digestive neopl other/NOS
229.2
43.2
44
*
127
Kela drug reimbursment
Transplant complication
20.9
42.3
63
32
K83.0
ICD-10 Finland
Cholangitis
15.6
41.7
69
47
N02AX02
ATC
tramadol; systemic, rectal
2.4
39.4
507
2930
8000/3-C22.1
ICD-O-3
Neoplasm, malignant of intrahepatic bile duct
+∞
38.8
37
*
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
44.6
38.4
47
11
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
72.6
37.2
42
6
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
103.8
37.0
40
*
WZC30
NOMESCO Finland
Teaching
4.2
36.8
152
408
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
42.7
36.5
45
11
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
131.2
35.9
38
*
UJK02
NOMESCO Finland
ERCP
8.3
34.7
79
102
A06AD11
ATC
lactulose; oral
2.8
34.6
273
1185
A05AA02
ATC
ursodeoxycholic acid; oral
17.9
33.9
53
31
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
29.3
33.5
45
16
JN3AD
NOMESCO Finland
Abdominal CT examination
4.5
33.1
124
301
JK3BT
NOMESCO Finland
Catherisation of bile duct with X-ray guidance
120.5
32.9
35
*
L02AE02
ATC
leuprorelin; implant, parenteral
90.4
31.9
35
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.5
31.5
97
190
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
31.4
30
*
B01AB05
ATC
enoxaparin; parenteral
2.4
30.8
325
1644
L04AA06
ATC
mycophenolic acid; systemic
13.9
30.7
53
40
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.8
30.4
90
168
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
30.3
29
*
3019
Kela drug reimbursment
Lenvatinib
+∞
30.3
29
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.2
30.3
422
2434
WW500
NOMESCO Finland
Blood transfusion
7.9
30.0
70
94
C03CA01
ATC
furosemide; systemic
2.1
29.8
513
3248
L01EX02
ATC
sorafenib; oral
+∞
29.3
28
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
29.3
28
*
1508
Kela drug reimbursment
Lenvatinib
+∞
28.2
27
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
33.8
27.9
36
11
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
43.8
27.9
34
8
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.2
27.7
371
2084
A10BA02
ATC
metformin; oral
2.1
27.5
416
2461
K76.9
ICD-10 Finland
Liver disease, unspecified
15.1
27.2
45
31
JKE25
NOMESCO Finland
Endoscopic external drainage of bile duct
63.8
27.1
31
5
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
16.8
26.4
42
26
A79
ICPC
Malignancy NOS
+∞
26.1
25
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
+∞
26.1
25
*
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
31.9
26.0
34
11
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
25.9
256
1234
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
25.6
252
1210
L03AA13
ATC
pegfilgrastim; parenteral
+∞
25.1
24
*
C22
ICD-10 Finland
Malignant neoplasm of liver and intrahepatic bile ducts
+∞
25.1
24
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
25.1
24
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
24.9
471
3022
J01MA12
ATC
levofloxacin; systemic
2.4
24.7
249
1206
JJB50
NOMESCO Finland
Excision of segments V, VI, VII and VIII of liver
+∞
24.0
23
*
B01AB10
ATC
tinzaparin; parenteral
4.7
23.7
84
192
L04AD01
ATC
ciclosporin; systemic
9.8
23.2
47
50
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
23.1
172
702
176
Kela drug reimbursment
Regorafenib
+∞
23.0
22
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
23.0
22
*
JK4ZT
NOMESCO Finland
Percutaneous transhepatic implantation of bile duct prothesis
+∞
23.0
22
*
JK3NB
NOMESCO Finland
Percutaneous transhepatic cholangiography
66.5
22.9
26
*
L03AA02
ATC
filgrastim; parenteral
41.1
22.7
28
7
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
11.8
22.3
41
36
I81
ICD-10 Finland
Portal vein thrombosis
35.9
22.1
28
8
JJB30
NOMESCO Finland
Excision of two segments of liver
+∞
21.9
21
*
L01EX08
ATC
lenvatinib; oral
+∞
21.9
21
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
21.9
21
*
L02BB03
ATC
bicalutamide; oral
+∞
21.9
21
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
18.9
21.8
33
18
A07AA11
ATC
rifaximin; oral
44.3
21.5
26
6
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
17.9
21.4
33
19
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
21.4
168
707
JJB10
NOMESCO Finland
Atypcal resection of liver
+∞
20.9
20
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
20.9
20
*
C22.7
ICD-10 Finland
Malignant neoplasm: Other specified carcinomas of liver
+∞
20.9
20
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
213.9
20.6
21
*
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
30.7
20.6
27
9
K92.0
ICD-10 Finland
Haematemesis
4.9
20.5
68
145
WX402
NOMESCO Finland
General anaesthesia
2.9
20.3
136
517
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
7.8
20.0
46
61
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
19.8
19
*
R50.9
ICD-10 Finland
Fever, unspecified
2.5
19.5
174
785
A10AE04
ATC
insulin glargine; parenteral
2.7
19.4
146
599
KCD02
NOMESCO Finland
Transurethral resection of bladder
23.0
19.1
27
12
A10BB12
ATC
glimepiride; oral
2.6
19.0
154
657
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
18.9
125
472
ZX120
NOMESCO Finland
Intravenous
3.2
18.8
106
360
XJA00
NOMESCO Finland
Intraoperative abdominal ultrasonography
+∞
18.8
18
*
JJB71
NOMESCO Finland
Laparoscopic resection of liver
+∞
18.8
18
*
JJ7LT
NOMESCO Finland
Coagulation of focal hepatic lesion under CT guidance
+∞
18.8
18
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
18.8
18
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
19.1
18.7
28
15
N02AA01
ATC
morphine; systemic, rectal
12.6
18.7
33
27
ZXE40
NOMESCO Finland
More than seven and less than nine hours
7.0
18.2
45
67
B18.2
ICD-10 Finland
Chronic viral hepatitis C
15.6
18.0
29
19
D97
ICPC
Liver disease NOS
33.5
18.0
23
7
D13.4
ICD-10 Finland
Benign neoplasm: Liver
27.2
17.9
24
9
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
14.0
17.8
30
22
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.8
17.8
119
453
JJA44
NOMESCO Finland
Laparoscopic destruction of lesion of liver
+∞
17.8
17
*
1550A
ICD-9 Finland
Malignant neoplasm of liver and intrahepatic bile ducts, Liver, primary
+∞
17.8
17
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
17.8
17
*
A02BC02
ATC
pantoprazole; systemic
1.8
17.7
605
4565
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
96.6
17.6
19
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
96.6
17.6
19
*
UJF32
NOMESCO Finland
Coloscopy
2.0
17.6
266
1518
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
182.8
17.6
18
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
32.0
17.1
22
7
JJA20
NOMESCO Finland
Open biopsy of liver
50.9
17.0
20
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
7.2
17.0
41
59
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.5
17.0
44
70
A06AH03
ATC
naloxegol; oral
17.7
17.0
26
15
9680/3-C22.0
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of liver
+∞
16.7
16
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
16.7
16
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
16.7
16
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
+∞
16.7
16
*
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
+∞
16.7
16
*
TJA10
NOMESCO Finland
Laparocentesis
172.5
16.5
17
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.8
16.5
71
196
JJ5AT
NOMESCO Finland
NA
40.7
16.4
20
5
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
7.0
16.3
40
59
R4110
NOMESCO Finland
Physiotherapy
1.9
16.2
264
1545
A10BH01
ATC
sitagliptin; oral
2.5
16.0
136
592
TK800
NOMESCO Finland
Hemodialysis
5.7
16.0
46
84
8160/3-C24.9
ICD-O-3
Cholangiocarcinoma of billiary tract, NOS
+∞
15.7
15
*
JN3GE
NOMESCO Finland
Intraoperative ultrasound examination of abdomen
+∞
15.7
15
*
K72.1
ICD-10 Finland
Chronic hepatic failure
38.6
15.4
19
5
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
15.4
159
765
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
7.4
15.3
36
50
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.9
15.1
284
1742
L01XE21
ATC
[U] regorafenib; oral
+∞
14.6
14
*
XQ902
NOMESCO Finland
Other photography
36.6
14.5
18
5
A98
ICPC
Health maint/preventive medicine
0.6
14.4
597
7238
T90
ICPC
Diabetes non-insulin dependent
1.8
14.1
276
1711
SPAT1262
SPAT
Handing over of treatment supplies
2.0
14.0
216
1229
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
14.0
297
1888
J01MA02
ATC
ciprofloxacin; systemic
1.7
13.8
402
2813
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
13.6
202
1132
C24.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of biliary tract
+∞
13.6
13
*
369
Kela drug reimbursment
Regorafenib
+∞
13.6
13
*
PC2SC
NOMESCO Finland
Liver angiography with X-ray
+∞
13.6
13
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
141.7
13.5
14
*
JK3FT
NOMESCO Finland
Exchange of bile duct catheter with radiological guidance
141.7
13.5
14
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
141.7
13.5
14
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
5.7
13.4
38
69
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.6
12.8
58
168
205
Kela drug reimbursment
Chronic hypertension
1.7
12.8
405
2883
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.4
12.6
37
70
XX4BW
NOMESCO Finland
NA
32.4
12.6
16
5
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.7
12.6
54
150
8140/3-C22.0
ICD-O-3
Adenocarcinoma, NOS, of liver
+∞
12.5
12
*
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
+∞
12.5
12
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
12.5
12
*
JJB40
NOMESCO Finland
Excision of segments II, III and IV of liver
+∞
12.5
12
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
12.5
12
*
8010/3-C22.0
ICD-O-3
Carcinoma, NOS, of liver
+∞
12.5
12
*
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
5.5
12.5
36
67
JK3NT
NOMESCO Finland
Percutaneous transhepatic dilatation of bileducts
131.4
12.5
13
*
PJA12
NOMESCO Finland
Sentinel node biopsy
131.4
12.5
13
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
12.3
178
984
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
10.7
12.3
23
22
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
38.0
12.2
15
*
R4190
NOMESCO Finland
Nutritional therapy
6.5
12.2
31
49
K92.1
ICD-10 Finland
Melaena
2.7
12.2
86
337
D70.82
ICD-10 Finland
Drug-induced neutropenia
21.6
12.0
17
8
D64.9
ICD-10 Finland
Anaemia, unspecified
2.1
12.0
143
733
1552X
ICD-9 Finland
Malignant neoplasm of liver and intrahepatic bile ducts, Liver, not specified as primary or secondary[NEOPLASMA MALIGNUMHEPATIS, NON DEFINITUM PRIM/SEC]
+∞
11.5
11
*
C22.2
ICD-10 Finland
Malignant neoplasm: Hepatoblastoma
+∞
11.5
11
*
A04AD12
ATC
aprepitant; systemic
+∞
11.5
11
*
115
Kela drug reimbursment
Breast cancer
+∞
11.5
11
*
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
+∞
11.5
11
*
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
13.8
11.5
19
14
Y77
ICPC
Malignant neoplasm prostate
121.2
11.4
12
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.0
11.2
64
220
A10AE05
ATC
insulin detemir; parenteral
2.8
11.2
74
281
JAH00
NOMESCO Finland
Laparotomy
4.0
11.2
44
114
Z2446
NOMESCO Finland
Social worker
2.9
11.2
69
251
ZXC40
NOMESCO Finland
Use of ultrasound
20.3
11.1
16
8
SPAT1109
SPAT
Analgesia with portable analgesic pump
14.1
11.0
18
13
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.4
10.8
52
1171
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
18.0
10.7
16
9
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.1
10.6
58
196
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.8
10.5
186
1103
JJB20
NOMESCO Finland
Excision of single segment of liver
+∞
10.4
10
*
8140/3-C80.9
ICD-O-3
Adenocarcinoma, NOS, of unknown primary site
+∞
10.4
10
*
JJA43
NOMESCO Finland
Destruction of lesion of liver
+∞
10.4
10
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
10.4
10
*
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
+∞
10.4
10
*
L01XE29
ATC
[U] lenvatinib; oral
+∞
10.4
10
*
C23
ICD-10 Finland
Malignant neoplasm of gallbladder
+∞
10.4
10
*
C24.00
ICD-10 Finland
Hepatic duct
+∞
10.4
10
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.1
10.4
119
598
UJK12
NOMESCO Finland
Peroral cholangioscopy
19.0
10.3
15
8
A41.8
ICD-10 Finland
Other specified sepsis
5.0
10.3
32
66
N05CF01
ATC
zopiclone; oral
1.6
10.2
331
2339
JKA20
NOMESCO Finland
Cholecystectomy
3.1
10.0
53
175
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.5
10.0
78
327
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.2
10.0
51
164
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
4.7
9.9
32
69
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
13.5
9.7
16
12
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.0
9.7
136
743
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.0
9.6
130
701
K70.4
ICD-10 Finland
Alcoholic hepatic failure
11.5
9.6
17
15
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
100.8
9.4
10
*
L04AA10
ATC
sirolimus; oral
100.8
9.4
10
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
100.8
9.4
10
*
WW200
SPAT
NA
0.2
9.4
11
484
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
+∞
9.4
9
*
JJB60
NOMESCO Finland
Other excsion of three or more segments of liver
+∞
9.4
9
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
9.4
9
*
TJA40
NOMESCO Finland
Percutaneous local drainage of peritoneal cavity
+∞
9.4
9
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
9.4
9
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
9.4
9
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
9.2
337
2444
C10AA05
ATC
atorvastatin; oral
0.6
9.2
227
3205
SPAT1053
SPAT
Memory test
0.5
9.2
77
1434
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.6
9.1
65
258
SPAT1255
SPAT
Intravenous administration of medicine
2.4
9.1
77
336
ZX050
NOMESCO Finland
Stereotactic radiotherapy
37.0
9.0
11
*
N06DX01
ATC
memantine; oral
0.3
9.0
24
693
RS220
NOMESCO Finland
NA
6.6
9.0
22
34
WX002
NOMESCO Finland
Sedation and analgesia
1.8
8.9
178
1094
ZXE00
NOMESCO Finland
One hour or less
1.5
8.7
325
2359
L04AX01
ATC
azathioprine; systemic
3.1
8.6
45
148
C24.09
ICD-10 Finland
Biliary duct or passage NOS
90.7
8.4
9
*
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
+∞
8.3
8
*
JJB53
NOMESCO Finland
Excision of segments IV,V, VI, VII and VIII of liver
+∞
8.3
8
*
YJ1BD
NOMESCO Finland
Extensive CT examination of abdomen for dose design of radiotherapy
+∞
8.3
8
*
L01EX05
ATC
regorafenib; oral
+∞
8.3
8
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
8.3
8
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
8.3
8
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
8.3
8
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.4
8.3
47
998
Z3226
NOMESCO Finland
Physiotherapist
1.7
8.2
170
1056
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
14.6
8.2
13
9
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
14.6
8.2
13
9
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
3.3
8.2
40
126
J94.8
ICD-10 Finland
Other specified pleural conditions
4.7
8.1
26
56
K70.2
ICD-10 Finland
Alcoholic fibrosis and sclerosis of liver
33.6
8.1
10
*
K76.89
ICD-10 Finland
Other specified diseases of liver
33.6
8.1
10
*
PC1BC
NOMESCO Finland
Extensive angiography of aorta and abdominal arteries
11.8
8.1
14
12
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
17.3
8.1
12
7
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
17.3
8.1
12
7
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.3
8.1
23
642
B01AF01
ATC
rivaroxaban; oral
0.4
8.1
32
778
E66.00
ICD-10 Finland
Metabolic syndrome
2.6
8.0
56
222
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
7.3
8.0
18
25
C07AA05
ATC
propranolol; systemic
1.8
7.9
138
809
K70.0
ICD-10 Finland
Alcoholic fatty liver
6.2
7.9
20
33
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
10.9
7.8
14
13
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.1
7.8
29
73
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
5.1
7.7
23
46
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
15.1
7.7
12
8
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
45.3
7.7
9
*
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.1
7.6
40
133
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
18.5
7.6
11
6
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
25.2
7.6
10
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
25.2
7.6
10
*
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
8.9
7.6
15
17
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
6.5
7.4
18
28
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
80.6
7.4
8
*
N40
ICD-10 Finland
Hyperplasia of prostate
0.6
7.4
188
2662
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
5.3
7.4
21
40
Z2221
NOMESCO Finland
Medical doctor
1.6
7.3
227
1569
A10BB01
ATC
glibenclamide; oral
2.0
7.3
97
518
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.6
7.3
51
202
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
7.3
301
2221
C25.9
ICD-10 Finland
Malignant neoplasm: Pancreas, unspecified
+∞
7.3
7
*
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
+∞
7.3
7
*
2BB01
NOMESCO Finland
NA
+∞
7.3
7
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
7.3
7
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
7.3
7
*
K76.6
ICD-10 Finland
Portal hypertension
+∞
7.3
7
*
6603
FHL
Delete a block
+∞
7.3
7
*
8310/3-C64.9
ICD-O-3
Clear cell adenocarcinoma, NOS, of kidney, NOS
+∞
7.3
7
*
YJ1CD
NOMESCO Finland
Very extensive CT examination of abdomen for dose design of radiotherapy
+∞
7.3
7
*
8140/3-C22.1
ICD-O-3
Adenocarcinoma, NOS, of intrahepatic bile duct
+∞
7.3
7
*
JJ1AT
NOMESCO Finland
Puncture of lesion of liver with ultrasound guidance
+∞
7.3
7
*
HA1AA
NOMESCO Finland
X-ray mammography
5.5
7.2
20
37
NK6AN
NOMESCO Finland
Total body bone isotope imaging
15.9
7.2
11
7
JAH01
NOMESCO Finland
Laparoscopy
3.7
7.2
29
79
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
7.2
86
443
G04CA52
ATC
tamsulosin and dutasteride; systemic
0.5
7.1
54
1042
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.0
7.1
91
480
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
7.1
136
2048
K70.1
ICD-10 Finland
Alcoholic hepatitis
5.9
6.9
18
31
M04AA01
ATC
allopurinol; systemic
1.6
6.9
183
1213
B01AF02
ATC
apixaban; oral
0.4
6.9
30
703
R83
ICPC
Respiratory infection other
0.4
6.9
29
688
B01AB04
ATC
dalteparin; parenteral
2.6
6.8
47
184
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
40.3
6.8
8
*
K74.0
ICD-10 Finland
Hepatic fibrosis
40.3
6.8
8
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
3.4
6.8
30
89
A10BG03
ATC
pioglitazone; oral
2.9
6.8
39
138
E83.1
ICD-10 Finland
Disorders of iron metabolism
16.8
6.7
10
6
HAB40
NOMESCO Finland
Wedge excision of mammary gland
16.8
6.7
10
6
D41.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bladder
7.2
6.7
15
21
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
22.7
6.7
9
*
K51.8
ICD-10 Finland
Other ulcerative colitis
5.9
6.6
17
29
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.6
6.6
46
181
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
0.3
6.6
19
528
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.4
6.6
29
86
SPAT1088
SPAT
Blood transfusion
10.1
6.5
12
12
ZZR00
NOMESCO Finland
Flap of skin
6.9
6.5
15
22
K51.5
ICD-10 Finland
Left sided colitis
3.9
6.5
25
66
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.9
6.5
37
130
WX882
NOMESCO Finland
High dependency care
3.0
6.4
34
115
HAC20
NOMESCO Finland
Total mastectomy
70.2
6.4
7
*
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
70.2
6.4
7
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
14.4
6.4
10
7
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
6.6
6.3
15
23
XF612
NOMESCO Finland
Measurement of central venous pressure
18.1
6.3
9
5
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
18.1
6.3
9
5
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
0.4
6.3
23
575
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
+∞
6.3
6
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
6.3
6
*
L01BC04
ATC
carmofur; oral
+∞
6.3
6
*
C22.3
ICD-10 Finland
Malignant neoplasm: Angiosarcoma of liver
+∞
6.3
6
*
C80.90
ICD-10 Finland
Malignant tumor without specified localization without histology
+∞
6.3
6
*
C67.0
ICD-10 Finland
Malignant neoplasm: Trigone of bladder
+∞
6.3
6
*
C24.0
ICD-10 Finland
Malignant neoplasm: Extrahepatic bile duct
+∞
6.3
6
*
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
+∞
6.3
6
*
C80.92
ICD-10 Finland
Malignant tumor without specified localization adenocarcinoma
+∞
6.3
6
*
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
+∞
6.3
6
*
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
+∞
6.3
6
*
V03AF03
ATC
calcium folinate; systemic
+∞
6.3
6
*
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
+∞
6.3
6
*
1551A
ICD-9 Finland
Malignant neoplasm of liver and intrahepatic bile ducts, Intrahepatic bile ducts
+∞
6.3
6
*
C22.4
ICD-10 Finland
Malignant neoplasm: Other sarcomas of liver
+∞
6.3
6
*
SPAT1122
SPAT
Ascites puncture
+∞
6.3
6
*
C82.00
ICD-10 Finland
Follicular nodular non-Hodgkin's lymphoma, ungraded
+∞
6.3
6
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.6
6.2
145
2100
A41.9
ICD-10 Finland
Sepsis, unspecified
2.5
6.2
47
195
UJD02
NOMESCO Finland
Gastroscopy
2.2
6.1
56
259
K76.7
ICD-10 Finland
Hepatorenal syndrome
12.6
6.1
10
8
K50.8
ICD-10 Finland
Other Crohn disease
6.7
6.0
14
21
I25.1
ICD-10 Finland
Atherosclerotic heart disease
0.7
6.0
206
2771
160
Kela drug reimbursment
exenatide
3.7
6.0
24
66

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_LIVER_INTRAHEPATIC_BILE_DUCTS_EXALLC – Malignant neoplasm of liver and intrahepatic bile ducts

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).