No definition available.
Allergic contact dermatitis due to drugs in contact with skin
ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
808 |
4. Check minimum number of eventsNone |
808 |
5. Include endpointsNone |
808 |
6. Filter based on genotype QC (FinnGen only) |
808 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Allergic contact dermatitis due to drugs in contact with skin
based on the number of shared cases.
Similar with more cases:
- Allergic contact dermatitis
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5347 | 3692 | 1635 |
| Only index persons | 5018 | 3503 | 1515 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.05 |
| Only index persons | 0.11 | 0.13 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 53.77 | 53.75 | 53.80 |
| Only index persons | 53.05 | 52.95 | 53.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 808 | 572 | 236 |
| Unadjusted period prevalence (%) | 0.17 | 0.19 | 0.10 |
| Median age at first event (years) | 55.26 | 52.96 | 60.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 724
- Matched controls
- 7240
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
4503599627370496.0
323.0
722
*
XQ802
NOMESCO Finland
Epicutan test
44.3
272.8
343
144
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
18.6
213.6
368
381
XQ800
NOMESCO Finland
Prick test
13.9
139.9
263
286
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
71.8
119.2
135
23
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
68.2
117.4
134
24
L30.9
ICD-10 Finland
Dermatitis, unspecified
6.8
101.1
314
736
E0000UV
ATC
NA
4.4
75.6
463
2093
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
53.7
64.9
77
16
D07AC13
ATC
mometasone; topical
4.0
64.6
367
1473
D07AC01
ATC
betamethasone; topical
3.8
60.9
391
1716
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
12.3
59.1
111
105
L20.0
ICD-10 Finland
Besnier prurigo
7.7
58.7
147
232
R06AE07
ATC
cetirizine; oral
3.4
54.3
447
2308
D07AB08
ATC
desonide; topical
5.5
52.1
173
392
E000001
ATC
NA
3.8
49.6
269
981
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
40.0
47.1
59
16
L23.1
ICD-10 Finland
Allergic contact dermatitis due to adhesives
71.3
46.8
53
8
L23.8
ICD-10 Finland
Allergic contact dermatitis due to other agents
46.6
46.1
56
13
L30.3
ICD-10 Finland
Infective dermatitis
10.2
41.7
85
93
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.0
38.8
179
551
D07AD01
ATC
clobetasol; topical
3.6
36.8
195
671
H02AB06
ATC
prednisolone; systemic
2.7
36.4
430
2526
D07AB02
ATC
hydrocortisone butyrate; topical
2.9
36.3
302
1432
D07CC01
ATC
betamethasone and antibiotics; topical
3.6
31.8
162
533
D07BC01
ATC
betamethasone and antiseptics; topical
3.5
29.0
150
497
D02AE01
ATC
carbamide; topical
4.7
27.4
99
236
E000006
ATC
NA
4.0
25.8
110
307
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.8
25.8
119
356
R06AX27
ATC
desloratadine; oral
2.4
24.0
259
1347
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
11.1
23.6
45
43
D09AB01
ATC
zinc bandage without supplements; topical
9.8
23.1
47
51
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
22.6
218
1063
R06AE09
ATC
levocetirizine; oral
2.9
22.4
156
629
D02AX
ATC
Other emollients and protectives
6.0
22.1
63
114
XQ899
NOMESCO Finland
Other assessment of skin
32.3
21.6
28
9
L23
ICD-10 Finland
Allergic contact dermatitis
44.8
21.5
26
6
T78.4
ICD-10 Finland
Allergy, unspecified
5.1
21.3
69
146
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
6.2
21.2
58
100
TQW80
NOMESCO Finland
Local dermatologic skincare
7.5
20.7
49
69
D07XC01
ATC
betamethasone, combinations; topical
3.1
19.9
121
444
L30.8
ICD-10 Finland
Other specified dermatitis
8.9
19.7
42
50
E000002
ATC
NA
2.9
19.6
130
503
N05BB01
ATC
hydroxyzine; systemic
4.0
19.2
81
223
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
11.8
19.2
35
31
D07AA02
ATC
hydrocortisone; topical
2.8
19.1
138
564
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.1
18.6
109
389
C01CA24
ATC
epinephrine; parenteral
3.8
17.8
80
232
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.5
17.5
85
263
L30.0
ICD-10 Finland
Nummular dermatitis
5.7
16.9
49
91
D11AH01
ATC
tacrolimus; topical
13.1
16.8
29
23
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
4.5
16.0
57
134
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
10.1
15.8
31
32
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.5
15.5
129
569
R06AX22
ATC
ebastine; oral
2.3
15.3
158
778
E000003
ATC
NA
4.0
15.0
61
163
ZXX04
NOMESCO Finland
Extent of procedure, 4 units
25.6
14.7
20
8
H02AB07
ATC
prednisone; oral
2.4
14.7
134
620
J01FF01
ATC
clindamycin; systemic
2.0
14.5
216
1248
L50.0
ICD-10 Finland
Allergic urticaria
5.4
12.4
37
72
R03AC02
ATC
salbutamol; inhalant
1.8
12.4
391
2893
J01DB01
ATC
cefalexin; oral
2.0
12.2
593
5038
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
10.3
12.1
23
23
XQ801
NOMESCO Finland
Intracutantest
23.3
11.6
16
7
S01GX01
ATC
cromoglicic acid; ophthalmic
2.0
11.6
172
979
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
11.0
303
2124
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
5.0
10.9
34
70
S29
ICPC
Skin symptom/complaint other
2.1
10.9
140
751
R06AX13
ATC
loratadine; oral
2.1
10.7
128
666
H02AB04
ATC
methylprednisolone; systemic
2.1
10.5
128
668
L23.7
ICD-10 Finland
Allergic contact dermatitis due to plants, except food
+∞
10.4
10
*
XQ820
NOMESCO Finland
Exposure to medicinal substance
19.1
10.3
15
8
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.8
10.3
42
114
C05AA08
ATC
fluocortolone; rectal, topical
2.2
9.9
112
566
E000007
ATC
NA
2.9
9.9
61
223
J02AC02
ATC
itraconazole; systemic
2.0
9.7
143
807
E000004
ATC
NA
4.7
9.7
32
71
J01DA01
ATC
[U] cefalexin; systemic
1.7
9.6
453
3639
L29.9
ICD-10 Finland
Pruritus, unspecified
5.4
9.6
28
54
H01.0
ICD-10 Finland
Blepharitis
3.3
9.6
47
148
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.4
9.6
83
372
L50.9
ICD-10 Finland
Urticaria, unspecified
3.6
9.4
41
118
L20
ICD-10 Finland
Atopic dermatitis
4.2
9.4
34
83
ZXX05
NOMESCO Finland
Extent of procedure, 5 units
22.0
9.4
13
6
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
5.6
9.0
25
46
L26
ICD-10 Finland
Exfoliative dermatitis
50.6
8.7
10
*
J02AC01
ATC
fluconazole; systemic
1.6
8.6
309
2284
SPAT1263
SPAT
Sampling
1.6
8.6
310
2294
S88
ICPC
Dermatitis contact/allergic
4.8
8.5
27
58
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
8.5
280
2022
D11AX14
ATC
[U] tacrolimus; topical
10.9
8.3
15
14
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
8.3
128
732
R01AD08
ATC
fluticasone; nasal
1.7
8.2
205
1368
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
6.1
8.2
21
35
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.2
8.2
42
138
A46
ICD-10 Finland
Erysipelas
2.0
8.2
102
538
ZXX03
NOMESCO Finland
Extent of procedure, 3 units
10.2
8.1
15
15
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.3
8.1
77
360
R03DC03
ATC
montelukast; oral
1.9
7.9
122
695
S87
ICPC
Dermatitis/atopic eczema
4.2
7.8
28
69
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
7.7
153
952
R03BA05
ATC
fluticasone; inhalant
1.8
7.6
135
808
J01AA04
ATC
lymecycline; systemic
2.0
7.6
96
509
L17
ICPC
Foot/toe symptom/complaint
1.7
7.6
180
1183
L50.8
ICD-10 Finland
Other urticaria
4.7
7.6
24
52
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
3.8
7.4
30
82
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
5.4
7.4
21
40
A02BC05
ATC
esomeprazole; systemic
1.6
7.4
284
2112
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
7.4
247
1773
L01
ICPC
Neck symptom/complaint
2.0
7.4
100
545
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
4.2
7.4
26
63
D07AB01
ATC
clobetasone; topical
3.2
7.4
36
115
D11AH04
ATC
alitretinoin; oral
+∞
7.3
7
*
D07XB05
ATC
dexamethasone, combinations; topical
3.7
7.2
30
84
J01CF05
ATC
flucloxacillin; systemic
3.3
7.2
34
106
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
7.2
116
674
L24.0
ICD-10 Finland
Irritant contact dermatitis due to detergents
20.2
7.1
10
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
7.0
199
1367
L30.1
ICD-10 Finland
Dyshidrosis [pompholyx]
13.9
6.9
11
8
D07AC14
ATC
methylprednisolone aceponate; topical
2.6
6.7
47
188
L23.4
ICD-10 Finland
Allergic contact dermatitis due to dyes
22.7
6.7
9
*
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
6.5
6.7
16
25
A92
ICPC
Allergy/allergic reaction NOS
3.8
6.5
26
71
M54.5
ICD-10 Finland
Low back pain
1.6
6.4
226
1636
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.4
598
5377
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.5
6.4
48
201
D05BB02
ATC
acitretin; oral
3.9
6.3
24
63
L56.4
ICD-10 Finland
Polymorphous light eruption
11.1
6.3
11
10
Z09.8
ICD-10 Finland
Follow-up examination after other treatment for other conditions
2.9
6.3
36
127
XG410
NOMESCO Finland
Flow-volume spirometry
2.8
6.3
37
135
D07AC03
ATC
desoximetasone; topical
4.8
6.3
19
40
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.3
6.3
54
244
WQ007
NOMESCO Finland
NA
26.9
6.2
8
*
J30.3
ICD-10 Finland
Other allergic rhinitis
3.1
6.2
31
102
D07XB02
ATC
triamcinolone, combinations; topical
5.4
6.2
17
32
XQ848
NOMESCO Finland
Dermatological photography
3.8
6.1
24
65
A02BC02
ATC
pantoprazole; systemic
1.5
6.1
445
3756
J01DC02
ATC
cefuroxime; systemic
2.6
6.1
43
174
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.1
95
544
L25.9
ICD-10 Finland
Unspecified contact dermatitis, unspecified cause
6.8
6.1
14
21
S01ED02
ATC
betaxolol; ophthalmic
6.8
6.1
14
21
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
4.2
6.0
21
51
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
6.0
80
430
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
6.0
95
549
Mortality – FinRegistry
↥Association
Association between endpoint ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN | 1.27 [1.11, 1.45] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 3292 females with ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN | 1.183 [1.01, 1.38] | 0.037 |
| Birth year | 0.988 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 1473 males with ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN died.
Mortality risk
Mortality risk for people of age
years, who have ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.111% | 0.179% |
| 5 | 0.634% | 1.323% |
| 10 | 1.575% | 3.396% |
| 15 | 3.293% | 6.513% |
| 20 | 5.733% | 11.263% |
Relationships between endpoints
↥Index endpoint: ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN – Allergic contact dermatitis due to drugs in contact with skin
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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