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Fitting and adjustment of external prosthetic device

Z21_FIT_ADJ_EXTER_PROSTHET_DEVICE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z44
  • Cause of death: ICD-10 Z44

2 out of 7 registries used, show all original rules.

97

4. Check minimum number of events

None

97

5. Include endpoints

None

97

6. Filter based on genotype QC (FinnGen only)

97

Control definitions (FinnGen only)

Control exclude
Z21_PERSONS_ENCOUNTERI_HEALTH_SERVI_SPECIFIC_PROCED_HEALTH_CARE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z4|Z5[0-4]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 97 61 36
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 66.53 65.95 67.51

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
92
Matched controls
921
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z44.1
ICD-10 Finland
Fitting and adjustment of artificial leg (complete)(partial)
+∞
48.2
42
*
Z44.3
ICD-10 Finland
Fitting and adjustment of external breast prosthesis
+∞
34.6
31
*
NGQ20
NOMESCO Finland
Amputation of lower leg
153.2
30.9
31
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
11.2
18.0
37
52
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
15.7
17.4
29
26
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
205.8
17.1
17
*
S97
ICPC
Chronic ulcer skin
19.7
16.6
25
17
N02AA05
ATC
oxycodone; systemic
9.9
16.4
36
56
XF600
NOMESCO Finland
Bloodpressure measurement
13.9
15.9
28
28
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
16.0
15.8
26
22
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
21.4
15.8
23
14
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
39.3
15.5
19
6
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
15.9
15.2
25
21
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
9.2
14.4
32
50
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
6.6
14.1
43
107
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
47.7
13.7
16
*
N03AX16
ATC
pregabalin; oral
6.2
13.5
44
118
A46
ICD-10 Finland
Erysipelas
7.2
13.3
36
75
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
31.8
12.5
16
6
NFQ20
NOMESCO Finland
Amputation of femur
35.3
12.1
15
5
NHQ40
NOMESCO Finland
Amputation of toe
20.5
11.7
17
10
ZZA00
NOMESCO Finland
Split skin graft
20.5
11.7
17
10
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
29.4
11.6
15
6
TPH07
NOMESCO Finland
Cathetrisation of artery
8.0
11.4
27
45
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
68.1
10.9
12
*
HAC20
NOMESCO Finland
Total mastectomy
12.3
10.6
19
19
Z89.5
ICD-10 Finland
Acquired absence of leg at or below knee
+∞
10.6
10
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
8.6
10.5
23
34
115
Kela drug reimbursment
Breast cancer
7.6
10.3
25
43
SPAT1229
SPAT
Assessment of need for aid
7.9
10.3
24
39
WX213
NOMESCO Finland
Lower leg blockade
29.9
10.1
13
5
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
29.9
10.1
13
5
SPAT1256
SPAT
Intramuscular and subcutaneous injection
4.3
10.0
58
262
SPAT1262
SPAT
Handing over of treatment supplies
5.0
10.0
37
109
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.7
9.7
23
38
TPH04
NOMESCO Finland
Cathetrisation of vein
4.9
9.7
36
106
C03CA01
ATC
furosemide; systemic
4.4
9.7
46
171
HA013
NOMESCO Finland
Radiotherapy after total ablation of mammary gland
24.9
9.7
13
6
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
9.5
9
*
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
4.3
9.4
45
166
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.5
9.4
30
74
J01FF01
ATC
clindamycin; systemic
4.2
9.1
44
163
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.3
9.1
25
51
WX306
NOMESCO Finland
Lumbar epidural anesthesy
16.2
9.0
14
10
ZXD05
NOMESCO Finland
Urgent procedure
4.1
8.9
44
168
SPAT1211
SPAT
Application of soft bandage
7.5
8.8
21
35
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
30.8
8.7
11
*
A10AE04
ATC
insulin glargine; parenteral
6.9
8.7
22
40
N03AX12
ATC
gabapentin; oral
5.7
8.7
26
59
SPAT1263
SPAT
Sampling
3.8
8.5
52
234
Z49.1
ICD-10 Finland
Extracorporeal dialysis
+∞
8.5
8
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
8.5
8
*
Z49.2
ICD-10 Finland
Other dialysis
+∞
8.5
8
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
36.9
8.3
10
*
SPAT1260
SPAT
Consultation of another employee
4.7
8.2
30
85
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.8
8.1
46
192
B01AB10
ATC
tinzaparin; parenteral
8.0
8.1
18
27
ZXE20
NOMESCO Finland
More than three and less than five hours
5.3
8.1
26
64
SPAT1249
SPAT
Treatment-related counselling outside office
3.6
8.0
52
242
SPAT1149
SPAT
Suture or treatment of traumatic wound
5.0
7.9
27
71
H3603, E103
ICD-10 Finland
NA
49.3
7.9
9
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
6.0
7.8
22
46
XX3DW
NOMESCO Finland
Time consuming IT work
5.8
7.7
22
47
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
9.7
7.7
15
18
L89
ICD-10 Finland
Decubitus ulcer and pressure area
15.1
7.6
12
9
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
7.2
7.6
18
30
L04AA06
ATC
mycophenolic acid; systemic
86.8
7.5
8
*
QXA20
NOMESCO Finland
Skin abrasion, unspecified location
86.8
7.5
8
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.5
7.4
46
205
N18.8
ICD-10 Finland
Other chronic renal failure
13.6
7.3
12
10
TPX10
NOMESCO Finland
Implantation of vascular injection port
22.1
7.3
10
5
J01DB01
ATC
cefalexin; oral
5.5
7.2
84
603
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.5
7.1
42
176
H02AB02
ATC
dexamethasone; systemic
6.2
7.1
19
37
SPAT1222
SPAT
Counselling/guidance promoting independent living
4.6
7.1
26
73
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.3
7.1
28
85
SPAT1312
SPAT
General health counselling
3.5
7.0
40
165
WX402
NOMESCO Finland
General anaesthesia
4.2
7.0
28
86
PE1AT
NOMESCO Finland
Femoral artery PTA
18.5
6.9
10
6
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
43.4
6.9
8
*
A04AA02
ATC
granisetron; systemic, transdermal
7.9
6.9
15
22
SPAT1215
SPAT
Assessment of need for medical rehabilitation
9.9
6.8
13
15
X76
ICPC
Malignant neoplasm breast female
24.6
6.8
9
*
B01AB05
ATC
enoxaparin; parenteral
3.4
6.8
43
190
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
3.4
6.8
39
162
WW200
SPAT
NA
4.8
6.7
23
60
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
8.5
6.7
14
19
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
6.9
6.7
16
27
J01MA02
ATC
ciprofloxacin; systemic
3.2
6.6
50
249
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
15.8
6.6
10
7
127
Kela drug reimbursment
Transplant complication
74.8
6.5
7
*
PF1BT
NOMESCO Finland
Extensive PTA of arteries of knee, lower leg and ankle
74.8
6.5
7
*
C50.00
ICD-10 Finland
Malignant tumor of nipple and areola, no histological veryfication
74.8
6.5
7
*
WX320
NOMESCO Finland
Spinalanesthesy
3.7
6.5
33
121
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
7.2
6.5
15
24
ZXE00
NOMESCO Finland
One hour or less
3.1
6.5
48
237
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
19.7
6.4
9
5
D64.9
ICD-10 Finland
Anaemia, unspecified
4.8
6.3
21
53
R50.9
ICD-10 Finland
Fever, unspecified
4.8
6.3
21
53
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
28.9
6.3
8
*
Z44.8
ICD-10 Finland
Fitting and adjustment of other external prosthetic devices
+∞
6.3
6
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
6.3
6
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
+∞
6.3
6
*
Z44.2
ICD-10 Finland
Fitting and adjustment of artificial eye
+∞
6.3
6
*
N02AX02
ATC
tramadol; systemic, rectal
3.1
6.3
52
273
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
16.4
6.0
9
6

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_FIT_ADJ_EXTER_PROSTHET_DEVICE – Fitting and adjustment of external prosthetic device

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).