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Donors of organs and tissues

Z21_DONORS_ORGANS_TISSU

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z52
  • Cause of death: ICD-10 Z52

2 out of 7 registries used, show all original rules.

503

4. Check minimum number of events

None

503

5. Include endpoints

None

503

6. Filter based on genotype QC (FinnGen only)

503

Control definitions (FinnGen only)

Control exclude
Z21_PERSONS_ENCOUNTERI_HEALTH_SERVI_SPECIFIC_PROCED_HEALTH_CARE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z4|Z5[0-4]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 503 290 213
Unadjusted period prevalence (%) 0.10 0.10 0.09
Median age at first event (years) 48.62 47.20 50.56

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
445
Matched controls
4449
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z52.4
ICD-10 Finland
Kidney donor
+∞
183.3
163
*
Z52.89
ICD-10 Finland
Donor of other organ or tissue
+∞
134.3
122
*
Z00.5
ICD-10 Finland
Examination of potential donor of organ and tissue
+∞
123.9
113
*
WW409
NOMESCO Finland
Other aferesis
312.9
100.1
98
*
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
458.9
79.5
77
*
L03AA02
ATC
filgrastim; parenteral
56.9
77.6
91
20
Z52.9
ICD-10 Finland
Donor of unspecified organ or tissue
+∞
76.3
71
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
24.5
71.4
103
54
WW300
NOMESCO Finland
Transfer of autologic stem cells
145.0
70.2
73
6
Z52.3
ICD-10 Finland
Bone marrow donor
+∞
68.5
64
*
YKA01
NOMESCO Finland
Percutaneous endoscopic excision of kidney from living donor
+∞
56.5
53
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
28.4
49.8
68
28
C90.0
ICD-10 Finland
Multiple myeloma
39.0
46.1
58
17
XW000
NOMESCO Finland
Bone marrow biopsy
13.5
44.6
80
71
153
Kela drug reimbursment
Lenalidomid
69.4
38.9
44
7
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
6.3
37.6
111
224
YNB00
NOMESCO Finland
Excision of bone marrow for transplantation
+∞
35.9
34
*
L04AX04
ATC
lenalidomide; oral
64.2
35.8
41
7
WW500
NOMESCO Finland
Blood transfusion
19.2
34.6
53
31
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
47.3
29.1
35
8
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
11.9
28.9
54
51
M04AA01
ATC
allopurinol; systemic
6.5
28.4
78
140
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
50.7
27.8
33
7
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
103.1
27.0
29
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.6
26.8
60
79
H02AB02
ATC
dexamethasone; systemic
5.9
26.7
80
160
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
29.1
26.2
35
13
J05AB11
ATC
valaciclovir; oral
4.6
25.6
97
252
329
Kela drug reimbursment
Lenalidomide
53.4
25.6
30
6
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
26.2
24.7
34
14
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
18.2
24.0
37
22
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
22.3
197
975
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.0
21.9
56
90
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.5
21.1
115
407
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
26.0
19.8
27
11
A04AA01
ATC
ondansetron; systemic, rectal
5.9
18.4
53
100
L03AA13
ATC
pegfilgrastim; parenteral
8.6
17.9
39
49
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
99.0
17.7
19
*
AA1AA
NOMESCO Finland
Head X-ray examination
26.8
17.1
23
9
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
11.4
15.7
29
27
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
20.9
15.2
22
11
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.0
15.1
42
76
Z52.8
ICD-10 Finland
Donor of other organs and tissues
+∞
14.7
14
*
JN4ED
NOMESCO Finland
Body CT examination with specail preparation
82.8
14.7
16
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
77.5
13.7
15
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
35.2
13.6
17
5
KA1FN
NOMESCO Finland
Isotope renography
17.4
13.1
20
12
N02AA05
ATC
oxycodone; systemic
3.7
13.0
59
177
OAB38
NOMESCO Finland
Psychosocial guidance and counselling
71.9
12.7
14
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
25.1
12.5
17
7
JN4AD
NOMESCO Finland
Body CT examination
4.5
12.5
45
109
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
12.3
54
157
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.3
12.0
26
33
JN4BD
NOMESCO Finland
Extensive body CT
3.6
11.4
53
162
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
7.9
10.8
24
32
PJA10
NOMESCO Finland
Exploration of lymph nodes
12.4
10.4
18
15
PD1BD
NOMESCO Finland
Extensive CT of abdominal aorta and branches
13.5
10.2
17
13
WX1CG
NOMESCO Finland
Extensive total body MRI with high intensity magnet
41.0
10.0
12
*
B03XA02
ATC
darbepoetin alfa; parenteral
26.7
9.9
13
5
J01MA12
ATC
levofloxacin; systemic
2.6
9.9
79
346
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
9.7
61
232
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.0
9.4
54
193
Z52.2
ICD-10 Finland
Bone donor
+∞
9.4
9
*
YKA00
NOMESCO Finland
Excision of kidney from living donor
+∞
9.4
9
*
R4110
NOMESCO Finland
Physiotherapy
2.2
9.0
103
537
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
6.3
9.0
23
38
WF049
NOMESCO Finland
Radiotherapy of metastasis
12.9
8.9
15
12
WX1DG
NOMESCO Finland
Very extensive total body MRI with high intensity magnet
51.0
8.7
10
*
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
8.4
85
418
J02AC03
ATC
voriconazole; systemic
91.7
8.4
9
*
YN7AD
NOMESCO Finland
CT examination of spine for dose design of radiotherapy
91.7
8.4
9
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.8
8.4
17
20
WX1BG
NOMESCO Finland
Total body MRI with high intensity magnet
+∞
8.4
8
*
R50.9
ICD-10 Finland
Fever, unspecified
2.4
7.9
67
302
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
6.6
7.8
19
30
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.1
7.7
29
75
ZXF99
NOMESCO Finland
Other r3eason to interrupt procedure
25.5
7.6
10
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.5
7.5
25
58
L04AX02
ATC
thalidomide; oral
81.3
7.4
8
*
J05AB01
ATC
aciclovir; systemic
2.0
7.2
93
508
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
30.5
7.2
9
*
C83.1
ICD-10 Finland
Mantle cell lymphoma
30.5
7.2
9
*
NB6AA
NOMESCO Finland
Humerus X-ray examination
9.0
7.1
14
16
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.1
6.9
25
63
JN6AD
NOMESCO Finland
CT of torso and neck
8.5
6.9
14
17
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
6.9
53
227
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
6.5
34
116
JN4DD
NOMESCO Finland
Scout CT scan of torso
70.8
6.4
7
*
Z51.6
ICD-10 Finland
Desensitization to allergens
+∞
6.3
6
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
+∞
6.3
6
*
C90.2
ICD-10 Finland
Extramedullary plasmacytoma
27.1
6.2
8
*
TGC00
NOMESCO Finland
Bronchial lavation
5.3
6.1
17
33
127
Kela drug reimbursment
Transplant complication
10.2
6.1
11
11

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_DONORS_ORGANS_TISSU – Donors of organs and tissues

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).