Vascular dementia (sudden onset)

VD_SO

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F01.0 Cause of death: ICD-10 — F01.0 2 out of 7 registries used, show all original rules.	193
4. Check minimum number of events None	193
5. Include endpoints None	193
6. Filter based on genotype QC (FinnGen only)	193

Control definitions (FinnGen only)

Control exclude: F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: F01
Name in latin: Dementia vascularis subito incipiens

NAME	VD_SO
CONTROL_EXCLUDE	F5_DEMENTIA\|G6_ALZHEIMER\|G6_AD_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F010
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F010
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Vascular dementia (sudden onset) based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3652	1906	1688
Only index persons	2020	1098	922
Unadjusted period prevalence (%)
Whole population	0.05	0.05	0.05
Only index persons	0.04	0.04	0.04
Median age at first event (years)
Whole population	80.97	82.95	78.80
Only index persons	81.43	83.51	78.96

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	193	53	140
Unadjusted period prevalence (%)	0.05	0.02	0.06
Median age at first event (years)	78.01	79.12	77.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
182: Matched controls
1818

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

F01.0

ICD-10 Finland

Vascular dementia of acute onset

+∞

260.0

181

F01.9

ICD-10 Finland

Vascular dementia, unspecified

1369.8

88.4

F03

ICD-10 Finland

Unspecified dementia

53.1

47.5

F01.10

ICD-10 Finland

Multi-infarct dementia without additional symptoms

+∞

25.6

N05AX08

ATC

risperidone; systemic

12.5

25.2

307

Kela drug reimbursment

Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease

+∞

22.3

N06DA02

ATC

donepezil; oral

+∞

21.2

F01.19

ICD-10 Finland

Multi-infarct dementia without information on additional symptoms

+∞

18.0

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

5.6

17.7

140

N06DX01

ATC

memantine; oral

55.7

17.4

G30.1

ICD-10 Finland

Alzheimer disease with late onset

70.1

17.1

N05AH04

ATC

quetiapine; oral

7.5

16.2

F01.1

ICD-10 Finland

Multi-infarct dementia

+∞

14.8

N06DA03

ATC

rivastigmine; oral, transdermal

+∞

13.7

G30.9

ICD-10 Finland

Alzheimer disease, unspecified

139.0

12.6

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

3.5

11.3

227

F01.20

ICD-10 Finland

Subcortical vascular dementia without additional symptoms

+∞

10.5

WYA20

NOMESCO Finland

Home visit

16.2

9.7

N06DA04

ATC

galantamine; oral

+∞

9.4

F01.29

ICD-10 Finland

Subcortical vascular dementia without information on additional symptoms

+∞

9.4

N06AB04

ATC

citalopram; systemic

3.3

9.4

195

R41.0

ICD-10 Finland

Disorientation, unspecified

8.2

9.2

F01

ICD-10 Finland

Vascular dementia

29.0

8.6

N05AD03

ATC

melperone; systemic

10.8

8.2

F00.10*G30.1

ICD-10 Finland

Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms

35.0

8.2

R56.8

ICD-10 Finland

Other and unspecified convulsions

6.9

8.0

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

4.3

7.9

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.5

7.9

507

A28

ICPC

Limited function/disability NOS

3.0

7.6

193

G30.8

ICD-10 Finland

Other Alzheimer disease

83.3

7.5

E11.00

ICD-10 Finland

Non-insulin dependent diabetes diabetic hypoglycaemic coma

4.7

7.5

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

6.1

7.3

Z75.5

ICD-10 Finland

Holiday relief care

9.4

7.2

N05AH03

ATC

olanzapine; systemic

12.7

7.2

N30.0

ICD-10 Finland

Acute cystitis

3.4

7.0

114

B01AC07

ATC

dipyridamole; systemic

3.0

6.8

159

G45.9

ICD-10 Finland

Transient cerebral ischaemic attack, unspecified

3.4

6.8

111

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

2.4

6.7

382

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

4.6

6.4

N05BA04

ATC

oxazepam; oral

2.6

6.4

242

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.7

6.3

195

F05.1

ICD-10 Finland

Delirium superimposed on dementia

+∞

6.3

G40.9

ICD-10 Finland

Epilepsy, unspecified

8.1

6.2

N06AB10

ATC

escitalopram; oral

3.8

6.1

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

3.3

6.0

103

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

738

0.48

4.50

4.4

5.0

mmol/l

2.2

2.3

0.33

651

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

704

0.48

4.21

4.0

4.5

mmol/l

1.2

1.4

1.92

623

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

686

0.50

3.78

3.8

4.0

mmol/l

1.3

1.2

0.37

601

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

736

0.52

3.68

4.9

5.2

mmol/l

6.3

6.2

0.22

641

(40768804) Tissue Pathology biopsy report

307

0.35

3.31

1.6

2.4

—

(3044889) 12 lead EKG panel

536

0.52

2.96

4.2

4.7

—

(3021589) Normoblasts [#/volume] in Blood

328

0.44

2.61

10.2

10.3

e9/l

0.0

—

259

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

533

0.58

2.23

3.1

3.5

pmol/l

14.4

15.4

1.23

462

(3020682) Albumin/Creatinine [Ratio] in Urine

278

0.50

1.83

3.3

3.8

mg/mmol

11.6

12.8

—

188

(3047181) Lactate [Moles/volume] in Blood

2.83

1.81

3.4

5.4

mmol/l

1.1

1.6

—

(40761511) CBC panel - Blood by Automated count

785

0.67

1.76

26.3

18.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

698

0.67

1.71

26.5

19.5

ml/min/173m2

64.1

64.6

0.05

572

(1761868) Lipid panel - Serum or Plasma

175

0.43

1.67

2.8

3.7

—

(3026008) Bacteria identified in Urine by Culture

328

1.53

1.64

4.7

4.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

817

0.69

1.61

34.8

23.3

umol/l

102.8

93.8

0.36

817

(40758558) Short blood count panel - Blood

203

0.46

1.59

4.2

5.9

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

1.54

0.0

2.5

—

0.0

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

1.53

0.0

2.4

—

35.3

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

1.52

0.0

2.5

—

1.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

344

0.59

1.50

3.0

2.9

ug/l

96.0

155.2

1.30

317

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.99

1.48

1.3

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

348

0.62

1.38

5.2

4.6

19.3

23.2

—

182

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

0.00

1.36

0.0

3.7

—

31.8

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

0.00

1.36

0.0

3.7

—

112.4

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

1.36

0.0

2.6

—

0.0

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

1.34

0.0

2.5

—

0.0

—

(3025941) Bacteria identified in Stool by Culture

0.00

1.33

0.0

1.3

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

2.15

1.32

3.3

4.0

0.9

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.82

1.29

1.0

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

236

0.56

1.27

1.8

pmol/l

465.8

432.1

0.23

197

(3001604) Monocytes [#/volume] in Blood

389

0.67

1.13

4.4

5.0

e9/l

0.6

0.32

327

(3015736) pH of Urine

319

0.65

1.09

5.8

4.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

588

0.73

1.04

6.4

5.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

459

0.71

1.03

7.6

7.4

e9/l

5.1

4.5

0.59

396

(42870588) Differential panel, method unspecified - Blood

269

0.64

1.03

5.1

4.9

—

(3022621) pH of Urine by Test strip

1.82

1.03

7.3

3.7

—

(3013115) Eosinophils [#/volume] in Blood

402

0.70

1.00

4.0

5.2

e9/l

0.2

0.32

354

(1616796) Gas panel - Central venous blood

0.00

0.98

0.0

3.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

144

0.54

0.98

1.4

4.9

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

654

0.76

0.94

7.3

6.4

u/l

82.1

85.9

0.25

606

(3007164) IgA [Mass/volume] in Serum or Plasma

102

0.48

0.92

1.2

1.3

g/l

3.8

2.8

—

(3006315) Basophils [#/volume] in Blood

393

0.72

0.88

5.0

5.1

e9/l

0.0

0.04

335

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

813

0.78

0.87

31.8

19.5

mg/l

32.7

30.1

0.27

686

(3019198) Lymphocytes [#/volume] in Blood

401

0.73

0.84

5.8

5.2

e9/l

1.5

1.7

0.90

354

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.76

0.81

2.9

1.6

—

(40768797) Stomach Pathology biopsy report

0.50

0.80

1.0

1.3

—

(4034850)

0.00

0.79

0.0

12.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.78

0.0

4.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.87

0.69

1.0

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.87

0.69

1.0

1.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

409

0.77

0.67

4.2

g/l

33.0

33.6

0.26

376

(3052851) Hemolysis interference index of Serum or Plasma

1.81

0.66

4.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.59

0.61

3.0

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

317

0.76

0.60

7.6

5.3

—

(3005322) IgE [Units/volume] in Serum or Plasma

0.00

0.58

0.0

1.2

—

266.4

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.50

0.54

2.8

1.4

nmol/l

417.7

402.9

—

(3018010) Neutrophils/100 leukocytes in Blood

376

0.79

0.54

5.9

5.4

66.0

60.5

1.57

343

(3020630) Protein [Mass/volume] in Serum or Plasma

0.61

0.53

1.7

2.6

g/l

63.8

66.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

386

0.80

0.53

4.9

5.5

18.6

23.9

2.01

349

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.40

0.51

4.1

5.0

mmol/l

25.3

23.7

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

106

0.65

0.50

2.7

4.6

33.7

33.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

191

1.29

0.49

32.8

34.9

inr

2.0

1.5

1.51

(3041096) Erythrocytes [Presence] in Urine by Automated

228

0.77

0.44

6.8

4.8

—

(3042936) Bacteria identified in Isolate by Culture

149

0.72

0.42

1.5

2.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.41

0.0

1.8

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

2.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

188

1.25

0.40

2.5

1.8

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.44

0.39

1.4

1.3

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.39

0.0

1.4

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

0.00

0.39

0.0

1.5

—

221.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.39

0.0

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

114

0.69

0.38

1.5

2.0

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.63

0.36

2.2

u/l

27.8

34.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

644

0.88

0.32

29.8

21.9

34.6

35.5

0.13

361

(3011397) Hemoglobin [Presence] in Urine by Test strip

174

0.79

0.31

6.1

4.6

—

(3012544) pH of Venous blood

111

1.28

0.31

4.1

3.3

—

(3023368) Bacteria identified in Blood by Culture

347

1.16

0.30

5.1

4.0

—

(3013512) EKG study

288

0.85

0.28

5.7

5.0

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.21

0.0

1.4

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(3014271) Vancomycin [Susceptibility]

0.00

0.21

0.0

2.5

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.0

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

2.2

—

64.2

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

3.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

3.0

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

1.5

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.21

0.0

3.8

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

2.1

—

5.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.8

—

73.3

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

2.1

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.21

0.0

1.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

2.0

—

62.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.21

0.0

1.3

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

2.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.20

0.0

1.4

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.20

0.0

4.0

—

216.2

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.20

0.0

3.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.23

0.20

3.3

7.1

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

234

1.13

0.18

3.2

2.5

u/l

35.6

34.1

0.05

227

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

379

0.91

0.16

3.9

4.6

—

(3018095) Leukocytes [#/volume] in Urine

362

1.10

0.16

4.4

e6/l

90.5

267.8

0.51

283

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.79

0.16

2.5

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

418

0.92

0.15

2.2

2.3

pmol/l

83.9

88.9

0.49

229

(3002582) Erythrocytes [#/volume] in Urine

334

1.10

0.15

3.6

3.9

e6/l

130.1

313.2

0.41

270

(3019060) Gas panel - Arterial blood

1.10

0.15

2.4

3.2

—

(3000991) Gas panel - Venous blood

0.81

0.15

1.9

5.8

—

(3023520) Reticulocytes [#/volume] in Blood

0.83

0.14

1.4

2.4

e9/l

79.1

67.0

—

(3019150) Specific gravity of Urine by Refractometry

180

1.12

0.13

7.2

5.2

kg/l

1.0

—

(3016502) Oxygen saturation in Arterial blood

107

0.83

0.13

2.7

5.1

96.1

93.0

—

100

(3003694) ABO and Rh group [Type] in Blood

167

0.89

0.11

1.1

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

125

1.13

0.10

1.7

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.14

0.10

5.6

6.6

—

(3044640) Blood type and Crossmatch panel - Blood

292

1.07

0.09

2.0

3.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.14

0.09

5.0

4.1

—

(3022313) Gas panel - Capillary blood

0.83

0.08

11.6

3.8

—

(3032080) INR in Blood by Coagulation assay

438

0.95

0.08

19.0

12.7

inr

2.0

1.5

—

114

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.85

0.07

3.0

3.2

ng/l

81.6

94.1

—

(3019225) pH of Specimen

1.07

0.07

3.4

2.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

364

1.05

0.07

3.5

3.9

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

545

0.96

0.05

5.1

4.5

mmol/l

7.2

6.9

0.34

520

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

303

0.95

0.05

3.0

2.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

424

0.96

0.05

5.8

4.9

ng/l

44.3

62.7

0.69

349

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

269

0.96

0.02

3.1

2.2

u/l

50.7

54.9

0.53

240

(3027801) Oxygen [Partial pressure] in Arterial blood

124

0.97

0.00

2.8

4.6

kpa

11.5

11.0

0.16

116

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

126

1.03

0.00

1.8

1.7

—

(36304419) Bacteria [Presence] in Urine

266

1.02

0.00

3.2

3.9

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

123

0.97

0.00

2.8

4.6

kpa

5.2

5.1

0.19

114

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

218

1.01

0.00

1.8

2.8

—

(3000330) Specific gravity of Urine by Test strip

1.02

0.00

3.1

5.8

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

6.9

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(44806118)

0.00

0.0

1.6

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

4.9

—

187.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.3

—

10.2

—

(4211845)

0.00

0.0

2.4

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.01

0.00

2.9

5.7

g/l

113.8

114.8

—

(3009343) pH of Capillary blood

1.01

0.00

6.9

3.3

—

7.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.4

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.3

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

2.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

6.8

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

2.6

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

5.7

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(44790048)

0.00

0.0

1.6

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.8

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.4

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.3

—

(4146454)

0.00

0.0

3.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

5.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.7

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(44790047)

0.00

0.0

1.6

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

6.7

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

2.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.0

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.1

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

2.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3014891) Appearance of Pleural fluid

0.00

0.0

2.2

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.1

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

1.9

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.3

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.6

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.6

—

31.3

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

114.8

—

(3006571) Polymorphonuclear cells/100 leukocytes in Synovial fluid

0.00

0.0

1.3

—

57.4

—

(44790049)

0.00

0.0

1.6

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.6

—

62.8

—

(4281824)

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint VD_SO and mortality.

Females

Parameter	HR [95% CI]	p-value
VD_SO	2.85 [2.38, 3.42]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.079

During the follow-up period (1.1.1998 — 31.12.2019), 1283 out of 1533 females with VD_SO died.

Males

Parameter	HR [95% CI]	p-value
VD_SO	3.491 [2.72, 4.49]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 1130 out of 1336 males with VD_SO died.

Mortality risk

Mortality risk for people of age

years, who have VD_SO.

N-year risk	Females	Males
1	0.215%	0.773%
5	1.352%	4.001%
10	3.941%	9.908%
15	7.694%	18.216%
20	12.433%	28.948%

Relationships between endpoints

↥

Index endpoint: VD_SO – Vascular dementia (sudden onset)

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Vascular dementia (sudden onset)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints