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Type 2 diabetes, definitions combined

DOID EFO PheWeb

T2D

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

  • not E4_DM1
417843

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

67620

6. Filter based on genotype QC (FinnGen only)

65083

Control definitions (FinnGen only)

Control exclude DIABETES_FG
Control conditions not E4_DM1

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 672907 323104 343619
Only index persons 555680 265660 290020
Unadjusted prevalence (%)
Whole population 9.41 9.25 9.60
Only index persons 10.45 9.77 11.07
Median age at first event (years)
Whole population 63.87 66.12 61.70
Only index persons 62.04 63.76 60.46

-FinnGen-

Key figures

All Female Male
Number of individuals 65083 28926 36157
Unadjusted prevalence (%) 16.63 12.56 19.89
Median age at first event (years) 60.57 59.68 61.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: T2D – Type 2 diabetes, definitions combined

GWS hits: 245

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