Risteys · ST19_TOXIC_EFFECT_SOAPS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — T55 Cause of death: ICD-10 — T55 2 out of 7 registries used, show all original rules.	14
4. Check minimum number of events None	14
5. Include endpoints None	14
6. Filter based on genotype QC (FinnGen only)	14

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	14	9	5
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	32.93	32.13	34.38

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3033658) Prothrombin time (PT) actual/Normal

0.00

1.13

0.0

1.8

—

96.6

—

(3019198) Lymphocytes [#/volume] in Blood

3.02

1.09

5.4

5.7

e9/l

2.1

1.8

—

(3003338) MCHC [Mass/volume]

108

0.40

0.95

16.3

9.3

g/l

336.5

333.7

—

108

(3015736) pH of Urine

2.76

0.94

4.9

3.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.88

0.0

1.7

—

(3013512) EKG study

2.66

0.85

7.4

4.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

2.46

0.84

2.1

4.4

umol/l

6.4

9.4

—

(3001604) Monocytes [#/volume] in Blood

2.31

0.81

5.9

5.7

e9/l

0.6

0.5

—

(3006315) Basophils [#/volume] in Blood

2.31

0.81

5.9

5.7

e9/l

0.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.31

0.77

4.2

7.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.32

0.71

1.7

2.1

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.66

0.0

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.24

0.64

5.9

4.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.93

0.63

1.7

2.3

—

(3013115) Eosinophils [#/volume] in Blood

2.05

0.59

5.9

5.6

e9/l

0.1

0.2

—

(3002030) Lymphocytes/100 leukocytes in Blood

2.05

0.59

4.5

4.6

31.8

30.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

1.95

0.56

5.9

6.2

e9/l

3.7

3.6

—

(42870588) Differential panel, method unspecified - Blood

1.94

0.50

1.8

4.0

—

(3026008) Bacteria identified in Urine by Culture

1.79

0.47

4.2

2.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.79

0.47

1.8

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.73

0.46

4.0

3.9

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.44

0.0

2.1

—

(36660697) Celiac disease serology panel - Serum

0.00

0.43

0.0

1.2

—

(3006504) Eosinophils/100 leukocytes in Blood

1.64

0.40

4.9

4.4

1.8

2.9

—

(3019069) Monocytes/100 leukocytes in Blood

1.59

0.39

5.0

4.9

7.4

7.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.49

0.27

2.0

2.2

—

(3003694) ABO and Rh group [Type] in Blood

1.44

0.26

1.8

1.5

—

(3022096) Basophils/100 leukocytes in Blood

1.48

0.25

5.5

4.6

0.4

0.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.48

0.25

2.0

2.1

nmol/l

64.0

70.9

—

(1761868) Lipid panel - Serum or Plasma

1.43

0.25

5.3

2.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.22

0.0

1.8

—

(3002256) Pathology report gross observation

0.00

0.22

0.0

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.8

—

(3022621) pH of Urine by Test strip

0.00

0.22

0.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.22

0.0

1.9

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.00

0.22

0.0

1.2

—

25.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

1.39

0.11

6.0

4.0

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

1.35

0.11

6.2

5.4

u/l

68.7

73.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

1.29

0.11

5.3

2.5

mmol/l

7.2

6.3

—

(3044889) 12 lead EKG panel

0.73

0.11

4.2

2.7

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

0.97

0.00

4.6

3.7

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.0

1.3

—

0.1

—

(4010399)

0.00

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

1.09

0.00

7.1

3.8

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

1.0

—

104.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.1

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

1.06

0.00

5.6

4.2

mm/h

10.6

9.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.1

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.1

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

0.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.0

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

6.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

22.6

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

3.2

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.00

0.0

5.6

—

41.0

—

(3027945) Reticulocytes/100 erythrocytes in Blood

0.00

0.0

4.0

—

1.8

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: ST19_TOXIC_EFFECT_SOAPS_DETERG – Toxic effect of soaps and detergents

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

NAME	ST19_TOXIC_EFFECT_SOAPS_DETERG
CONTROL_EXCLUDE	ST19_TOXIC_EFFEC_SUBST_CHIEF_NONME_SOURCE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	T55
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	T55
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Toxic effect of soaps and detergents

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Case counts by code for Toxic effect of soaps and detergents (ST19_TOXIC_EFFECT_SOAPS_DETERG)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints