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This is a non-core endpoint: only basic statistics are computed.

Toxic effect of metals

ST19_TOXIC_EFFECT_METALS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 T56
  • Cause of death: ICD-10 T56

2 out of 7 registries used, show all original rules.

23

4. Check minimum number of events

None

23

5. Include endpoints

None

23

6. Filter based on genotype QC (FinnGen only)

23

Control definitions (FinnGen only)

Control exclude
ST19_TOXIC_EFFEC_SUBST_CHIEF_NONME_SOURCE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
T5[1-9]|T6[0-5]
Name in latin
Effectus toxicus metallorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 23 8 15
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 47.14 38.30 51.85

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3022145) Colonoscopy Study observation
5
17
3.45
1.44
1.0
1.5
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
6
26
2.75
1.28
1.2
1.7
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
0
30
0.00
1.06
0.0
1.7
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
10
57
2.33
1.04
3.0
1.6
u/l
307.7
222.9
—
10
51
(3023368) Bacteria identified in Blood by Culture
8
43
2.31
1.01
3.0
4.4
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
0
24
0.00
0.85
0.0
1.7
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
7
41
2.01
0.79
4.1
7.6
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
14
105
1.85
0.72
4.6
4.0
mmol/l
7.9
6.4
0.83
14
99
(3011397) Hemoglobin [Presence] in Urine by Test strip
6
35
1.96
0.64
4.3
3.5
—
—
—
0
0
(3013512) EKG study
8
56
1.65
0.50
2.0
6.5
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
0
16
0.00
0.43
0.0
1.7
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
15
124
1.60
0.42
2.5
2.9
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
18
0.00
0.41
0.0
1.6
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
6
43
1.53
0.39
4.7
1.5
mg/l
6.7
3.6
—
6
37
(3001122) Ferritin [Mass/volume] in Serum or Plasma
9
71
1.44
0.32
4.7
2.0
ug/l
111.8
96.9
—
9
60
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
9
71
1.44
0.32
2.1
2.9
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
5
40
1.32
0.24
3.4
3.2
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
12
101
1.39
0.23
4.2
4.1
—
—
—
0
0
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
0
11
0.00
0.22
0.0
2.3
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
0
11
0.00
0.22
0.0
6.1
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
12
0.00
0.22
0.0
1.4
—
—
—
0
0
(3002256) Pathology report gross observation
0
12
0.00
0.22
0.0
1.2
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
0
12
0.00
0.22
0.0
1.7
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
0
13
0.00
0.21
0.0
4.1
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
7
57
1.33
0.21
2.0
2.5
—
—
—
0
0
(3030981) Hyaline casts [#/volume] in Urine by Automated count
0
14
0.00
0.21
0.0
2.4
—
0.1
—
0
14
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
5
42
1.24
0.11
2.6
3.4
—
—
—
0
0
(40758558) Short blood count panel - Blood
5
44
1.17
0.11
13.4
7.1
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
6
52
1.21
0.10
1.8
2.7
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
7
64
1.13
0.09
4.1
2.8
mmol/l
2.4
2.3
—
7
55
(3015736) pH of Urine
7
66
1.09
0.09
3.9
3.9
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
8
74
1.12
0.09
2.3
2.6
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
8
87
0.88
0.08
3.5
4.2
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
12
115
1.09
0.00
3.7
4.5
—
—
—
0
0
(3044889) 12 lead EKG panel
11
112
0.97
0.00
4.1
3.7
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
6
57
1.07
0.00
2.2
3.4
—
—
—
0
0
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
0
7
0.00
0.00
0.0
1.3
—
0.0
—
0
7
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.2
—
3.1
—
0
5
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
8.0
—
1.5
—
0
8
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.0
—
0.0
—
0
6
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
0
8
0.00
0.00
0.0
8.3
—
—
—
0
0
(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
0
5
0.00
0.00
0.0
6.8
—
—
—
0
0
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3005895) Myoglobin [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
2.3
—
310.1
—
0
6
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3020961) Endomysium IgA Ab [Titer] in Serum
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3012110) Lysozyme [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.3
—
11.3
—
0
7
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
7
73
0.94
0.00
3.6
4.1
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
6.4
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
8.0
—
6.6
—
0
8
(3041354) Potassium [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
6.4
—
3.9
—
0
5
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.0
—
0.0
—
0
6
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.0
—
38.0
—
0
6
(3019473) Protein [Mass/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.3
—
370.0
—
0
6
(3035285) Chloride [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
6.4
—
106.2
—
0
5
(1761482) Bacteria [#/volume] in Urine by Culture
0
9
0.00
0.00
0.0
5.8
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3012336) Haptoglobin [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.7
—
1.6
—
0
7
(3020044) Glucose [Moles/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.3
—
3.8
—
0
6
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
2.2
—
182.4
—
0
9
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(40768443) Skin Pathology biopsy report
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_TOXIC_EFFECT_METALS – Toxic effect of metals

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).