Rheumatoid lung disease

RHEUMAT_LUNG

adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J99.0, J99.0M05.1, M05.1+J99.0 Cause of death: ICD-10 — J99.0, J99.0M05.1, M05.1+J99.0 2 out of 7 registries used, show all original rules.	135
4. Check minimum number of events None	135
5. Include endpoints None	135
6. Filter based on genotype QC (FinnGen only)	135

Control definitions (FinnGen only)

Control exclude: ILD_SYST_AUTO_DISEASES

Extra metadata

First used in FinnGen datafreeze: DF2

NAME	RHEUMAT_LUNG
CONTROL_EXCLUDE	ILD_SYST_AUTO_DISEASES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M051\|J990
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M051\|J990
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Rheumatoid lung disease based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	998	519	473
Only index persons	705	370	335
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	70.83	71.81	69.83
Only index persons	70.05	70.59	69.45

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	135	59	76
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	71.11	70.62	71.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
114: Matched controls
1139

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

206.8

98.1

J99.0*M05.1

ICD-10 Finland

Rheumatoid lung disease

+∞

88.4

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

105.1

83.4

100

A07EC01

ATC

sulfasalazine; oral, rectal

57.3

60.9

P01BA02

ATC

hydroxychloroquine; oral

41.6

58.1

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

37.9

51.7

J99.0

ICD-10 Finland

Rheumatoid lung disease

+∞

44.8

M05.9

ICD-10 Finland

Seropositive rheumatoid arthritis, unspecified

75.2

39.1

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

58.5

38.2

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

43.3

38.1

H02AB06

ATC

prednisolone; systemic

33.2

37.3

108

400

L04AA13

ATC

leflunomide; oral

56.3

37.1

M05.1

ICD-10 Finland

Rheumatoid lung disease

+∞

35.2

J84.1

ICD-10 Finland

Other interstitial pulmonary diseases with fibrosis

129.7

35.1

J84.9

ICD-10 Finland

Interstitial pulmonary disease, unspecified

59.8

27.2

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

17.6

26.8

L04AX01

ATC

azathioprine; systemic

38.0

26.3

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

21.3

24.7

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

17.0

24.2

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

7.4

21.8

283

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

53.9

19.0

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

50.8

18.0

L88

ICPC

Rheumatoid/seropositive arthritis

20.6

17.6

J18.9

ICD-10 Finland

Pneumonia, unspecified

5.5

16.1

236

7140A

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]

29.9

15.3

UGC12

NOMESCO Finland

Flexible bronchoscopy

7.6

15.0

L04AA06

ATC

mycophenolic acid; systemic

92.3

15.0

M01CB01

ATC

sodium aurothiomalate; parenteral

26.6

14.8

TGC00

NOMESCO Finland

Bronchial lavation

17.8

14.3

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

18.4

13.2

J84.8

ICD-10 Finland

Other specified interstitial pulmonary diseases

52.7

12.2

M05

ICD-10 Finland

Seropositive rheumatoid arthritis

39.5

11.6

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

9.6

11.3

71238

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita

48.5

11.2

TND11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in joint, wrist or hand

24.4

11.0

L04AA01

ATC

[U] ciclosporin; systemic

66.4

10.8

M01CB03

ATC

auranofin; oral

66.4

10.8

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

12.4

10.8

TNB11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in shoulder joint

44.2

10.2

M05BA04

ATC

alendronic acid; oral

6.2

10.0

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

24.2

9.6

ND2DA

NOMESCO Finland

Bilateral hand X-ray examination

20.7

9.2

H02AB07

ATC

prednisone; oral

4.7

9.0

L04AB01

ATC

etanercept; parenteral

54.3

8.8

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

6.4

8.7

ZX120

NOMESCO Finland

Intravenous

6.1

8.7

NDL52

NOMESCO Finland

Tenosynovectomy of hand

96.9

8.5

L04AB04

ATC

adalimumab; parenteral

96.9

8.5

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

4.3

8.5

102

R06.0

ICD-10 Finland

Dyspnoea

3.5

8.4

200

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

4.0

8.3

123

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

36.2

8.2

ND2BA

NOMESCO Finland

Hand and fingers extensive X-ray examination

24.1

8.2

R50.9

ICD-10 Finland

Fever, unspecified

4.5

8.0

M80.4

ICD-10 Finland

Drug-induced osteoporosis with pathological fracture

85.4

7.5

NDG30

NOMESCO Finland

Fusion of wrist, total

85.4

7.5

L04AD01

ATC

ciclosporin; systemic

85.4

7.5

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

17.2

7.4

GX1K5

NOMESCO Finland

Diffusion capacity

+∞

7.4

M01AC06

ATC

meloxicam; systemic, rectal

3.1

7.2

266

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.0

7.2

418

XG410

NOMESCO Finland

Flow-volume spirometry

6.7

6.9

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

7.3

6.9

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

5.4

6.8

XG412

NOMESCO Finland

Flow-volume spirometry with bronchospasmolysis

5.5

6.6

NHG76

NOMESCO Finland

Arthroplasty of other tarsometatarsal joint

19.3

6.4

NHM20

NOMESCO Finland

Excision of synovial ganglion of ankle or foot

19.3

6.4

SPAT1292

SPAT

Other function in accordance with SHToL (Finnish classification of nursing interventions)

4.9

6.3

J990, M058

ICD-10 Finland

+∞

6.3

L40.5

ICD-10 Finland

Arthropathic psoriasis

+∞

6.3

WZC30

NOMESCO Finland

Teaching

3.9

6.3

GD1AD

NOMESCO Finland

Thorax CT examination

7.4

6.3

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

2.7

6.1

366

J90

ICD-10 Finland

Pleural effusion, not elsewhere classified

7.1

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3005719) IgG [Mass/volume] in Serum or Plasma

12.78

43.45

5.2

2.2

g/l

9.1

10.5

1.24

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

19.27

41.54

1.7

1.4

iu/ml

0.2

0.1

—

(3037522) Nuclear Ab [Titer] in Serum

111

7.44

27.70

1.6

1.3

titre

702.0

515.4

0.25

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

8.24

21.59

3.4

3.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

216

5.17

20.14

12.6

5.2

—

(3020891) Body temperature

8.29

20.06

9.3

4.6

—

(3019060) Gas panel - Arterial blood

6.25

19.84

6.0

4.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

11.23

19.31

1.4

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

18.02

18.81

1.5

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

6.42

18.63

1.2

1.6

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

152

5.09

18.10

1.5

1.2

u/ml

107.5

25.4

2.61

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

5.91

17.11

1.2

1.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

166

4.61

15.97

1.4

1.2

iu/ml

129.5

39.6

1.29

(3017181) Myelocytes/100 leukocytes in Blood

5.25

15.55

6.5

3.6

1.1

1.0

0.10

(40761535) Cells panel - Urine sediment

5.29

15.10

8.9

3.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

8.86

14.84

1.5

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

7.50

14.62

2.4

1.5

—

(3021440) Promyelocytes/100 leukocytes in Blood

5.15

14.37

6.4

3.7

0.2

0.10

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

9.29

13.97

1.5

1.6

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

9.29

13.97

1.2

1.1

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

8.68

13.93

1.5

1.6

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

10.54

13.71

2.6

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

10.54

13.71

2.6

1.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

10.54

13.71

2.6

1.5

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

5.83

13.55

2.6

1.8

ug/l

2.7

5.6

0.25

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

7.11

13.40

3.2

1.5

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

8.03

13.06

1.4

1.3

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

9.12

13.05

1.6

—

(3002179) Metamyelocytes/100 leukocytes in Blood

4.87

12.31

6.2

3.6

0.3

0.5

0.28

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

9.65

11.32

3.6

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

107

4.22

11.24

1.2

1.6

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

7.06

10.55

3.5

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

189

3.50

10.42

3.3

1.9

—

(3023368) Bacteria identified in Blood by Culture

354

3.22

10.21

6.4

4.3

—

(3043409) Potassium [Moles/volume] in Arterial blood

5.40

10.18

8.4

3.8

mmol/l

4.0

3.9

0.58

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

132

3.75

10.07

2.1

1.8

—

(3025159) Blasts/100 leukocytes in Blood

4.31

10.06

7.3

3.9

0.0

0.3

0.49

(44806118)

8.88

9.91

1.5

1.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

8.88

9.91

3.8

1.4

—

(44790047)

8.88

9.91

1.5

1.6

—

(44790049)

8.88

9.91

1.5

1.6

—

(44790048)

8.88

9.91

1.5

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

134

3.69

9.83

2.3

1.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

5.03

9.77

1.1

1.4

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

4.33

9.59

5.9

3.7

ml/min/173m2

54.2

58.4

0.32

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

7.21

9.57

1.3

1.1

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

8.68

9.00

1.0

—

(3042631) Mycobacterium sp identified in Specimen

7.46

8.60

3.8

4.6

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

5.92

8.43

1.4

1.2

g/l

1.2

0.01

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

5.90

7.92

1.4

1.2

g/l

0.2

0.3

2.08

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

6.74

7.87

1.9

1.5

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

420

2.77

7.79

2.9

2.3

nmol/l

84.7

77.0

1.30

362

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

582

2.92

7.78

7.1

7.2

mmol/l

1.2

0.09

489

(3042936) Bacteria identified in Isolate by Culture

173

3.07

7.75

2.7

1.9

—

(3029937) Albumin [Presence] in Urine by Test strip

302

2.78

7.64

10.0

3.8

estimate

0.0

0.00

(42870588) Differential panel, method unspecified - Blood

336

2.72

7.47

14.6

5.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

4.26

7.41

4.3

2.8

1.5

1.0

2.32

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

483

2.69

7.26

5.1

4.0

ng/l

56.3

36.6

0.49

362

(3014576) Chloride [Moles/volume] in Serum or Plasma

155

3.02

7.07

7.8

6.9

mmol/l

102.4

104.2

1.20

150

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

418

2.63

7.05

6.5

3.2

—

(3035350) Ketones [Presence] in Urine by Test strip

526

2.66

6.96

8.8

3.8

estimate

0.0

0.00

100

(3009261) Glucose [Presence] in Urine by Test strip

537

2.66

6.89

8.7

3.8

estimate

0.0

0.00

(3000494) Fungus identified in Specimen by Culture

130

3.04

6.48

2.0

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

239

2.65

6.46

10.0

3.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

531

2.54

6.37

10.1

5.2

estimate

0.0

0.00

100

(3020630) Protein [Mass/volume] in Serum or Plasma

113

3.13

6.35

1.7

2.4

g/l

64.4

65.1

0.18

(3000850) Epithelial cells [#/volume] in Urine

243

2.60

6.21

4.3

2.7

e6/l

3.8

4.6

0.35

216

(4034850)

4.40

6.09

16.4

13.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.19

5.87

1.4

2.4

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

3.40

5.86

5.4

4.0

mmol/l

3.1

2.3

0.57

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

6.27

5.71

4.1

2.8

58.8

60.5

—

(3021788) Differential panel - Synovial fluid

6.27

5.71

1.3

1.6

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

6.27

5.71

3.7

2.8

e9/l

4.6

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

101

2.95

5.18

4.4

6.5

mmol/l

1.6

1.4

0.62

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.27

5.14

4.5

3.9

g/l

133.4

127.1

0.63

(3037467) Urinalysis macro (dipstick) panel - Urine

100

724

2.47

5.10

10.2

4.6

—

(4062490)

12.04

4.85

1.4

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

417

2.20

4.83

9.7

4.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

190

2.39

4.57

3.5

2.8

e6/l

1.0

0.01

107

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

4.00

4.48

1.5

1.4

—

(36304419) Bacteria [Presence] in Urine

308

2.19

4.46

4.5

3.0

—

(3004616) Nuclear Ab [Presence] in Serum

7.94

4.43

1.6

1.1

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

12.20

4.32

1.1

1.0

—

(3045414) Leukocytes [Presence] in Urine

3.69

4.31

3.4

2.0

—

(3018418) pH of Serum or Plasma

354

2.12

4.27

3.8

4.4

7.4

0.03

(3030467) Casts [#/volume] in Urine by Automated count

321

2.14

4.26

4.8

3.1

e6/l

0.5

0.00

242

(3024561) Albumin [Mass/volume] in Serum or Plasma

505

2.09

4.25

4.6

4.4

g/l

32.4

34.7

2.47

471

(3021901) Oxygen saturation in Capillary blood

4.42

3.96

4.4

3.3

—

(3044941) Cell count panel - Synovial fluid

7.65

3.92

1.5

1.7

—

(3000093) Morphology [Interpretation] in Blood Narrative

6.46

3.55

1.3

1.5

—

(3027945) Reticulocytes/100 erythrocytes in Blood

150

2.29

3.55

5.9

3.3

1.9

1.8

0.22

134

(3045716) Anion gap in Serum or Plasma

10.38

3.53

3.2

3.3

mmol/l

6.6

7.8

—

(40757494) Bilirubin.total [Moles/volume] in Blood

10.38

3.53

3.8

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.46

3.43

1.5

1.4

—

(3022313) Gas panel - Capillary blood

2.89

3.36

7.3

4.0

—

(3023419) Bacteria identified in Sputum by Culture

4.99

3.30

2.8

3.3

—

(3005322) IgE [Units/volume] in Serum or Plasma

3.01

3.19

1.7

1.2

u/ml

208.4

136.2

0.28

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.60

2.94

1.9

1.3

—

(40758558) Short blood count panel - Blood

265

1.91

2.90

11.5

7.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

6.91

2.90

4.3

1.2

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

6.91

2.90

4.3

1.2

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

6.91

2.90

4.3

1.2

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

6.91

2.90

4.3

1.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

241

1.94

2.89

2.8

1.7

mg/l

2.7

1.6

0.46

193

(3018095) Leukocytes [#/volume] in Urine

414

1.81

2.83

5.7

3.9

e6/l

28.7

76.7

1.15

308

(3024263) Appearance of Synovial fluid

8.59

2.77

1.6

1.2

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

114

2.23

2.76

4.1

2.4

ug/l

3.5

5.3

1.21

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.06

2.65

1.8

1.7

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

4.18

2.61

7.9

4.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

5.65

2.57

1.0

1.1

—

(3023420) DNA double strand Ab [Units/volume] in Serum

7.36

2.57

1.2

1.1

—

(3037756) Immunofixation for Serum or Plasma

3.10

2.47

1.2

1.3

—

(1761868) Lipid panel - Serum or Plasma

325

0.45

2.45

3.2

3.4

—

(3000991) Gas panel - Venous blood

2.24

2.41

5.0

8.6

—

(3026389) Candida sp identified in Specimen by Organism specific culture

4.77

2.29

1.0

1.1

—

(3002582) Erythrocytes [#/volume] in Urine

364

1.70

2.23

5.2

3.3

e6/l

21.5

226.6

0.63

286

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

503

1.66

2.19

7.2

4.0

—

(3032080) INR in Blood by Coagulation assay

503

1.66

2.19

7.0

9.6

inr

1.2

1.3

0.74

150

(40760888) Immunoglobulin light chains.free panel - Serum

3.14

2.19

1.2

6.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

4.43

2.17

2.0

1.4

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

384

1.68

2.17

2.6

3.3

mmol/l

2.3

0.12

332

(3012544) pH of Venous blood

120

2.00

2.08

2.5

4.2

—

(1616796) Gas panel - Central venous blood

3.20

2.05

5.3

3.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.69

1.97

1.4

1.3

—

(3026008) Bacteria identified in Urine by Culture

357

1.64

1.94

4.9

3.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

139

1.88

1.91

12.7

8.8

—

(3014051) Protein [Presence] in Urine by Test strip

3.30

1.90

4.7

2.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.30

1.90

1.3

1.4

—

(3044927) Protein electrophoresis panel - Urine

4.28

1.84

1.0

1.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

250

1.66

1.76

1.8

nmol/l

1646.9

1163.8

0.87

182

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

3.95

1.73

2.6

1.0

—

(3052851) Hemolysis interference index of Serum or Plasma

2.68

1.69

2.6

4.3

—

(21494434) Karyotype in Bone marrow

3.67

1.63

1.4

1.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

3.67

1.63

4.8

3.9

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.09

1.60

1.5

1.4

—

(3045424) Erythrocytes [Presence] in Urine

3.42

1.53

2.4

1.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.94

1.52

1.0

1.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

498

1.50

1.49

3.1

2.4

—

(3007566) Smooth muscle Ab [Titer] in Serum

3.20

1.45

1.0

1.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.27

1.44

5.4

1.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.91

1.38

1.9

1.6

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.36

0.0

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

873

0.68

1.35

30.0

18.3

39.3

38.0

0.92

560

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.03

1.32

3.3

1.8

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.57

1.32

1.3

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

132

1.70

1.30

3.0

1.7

—

(3034770) Mitochondria Ab [Titer] in Serum

2.69

1.22

1.0

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.17

1.20

1.6

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.17

1.20

1.6

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.17

1.20

1.6

1.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.37

1.20

1.0

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.18

0.0

1.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

120

1.68

1.16

4.5

3.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.07

1.07

3.4

1.6

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.32

1.04

1.4

1.6

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.32

1.04

1.4

1.6

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.98

0.0

2.2

—

2.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

102

1.65

0.95

3.1

4.1

mmol/l

1.2

0.00

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

102

0.47

0.94

1.6

2.6

u/l

41.4

30.4

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.78

0.82

1.1

1.2

—

(1002224) Polysomnography panel

0.00

0.79

0.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.80

0.77

1.2

1.6

—

(3003694) ABO and Rh group [Type] in Blood

259

1.36

0.75

1.3

—

(3000330) Specific gravity of Urine by Test strip

1.67

0.74

4.3

5.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

469

1.29

0.71

2.1

pmol/l

87.2

95.4

0.85

230

(3020961) Endomysium IgA Ab [Titer] in Serum

1.75

0.71

1.1

1.0

—

(3019225) pH of Specimen

103

1.51

0.68

5.3

4.1

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

200

1.37

0.67

1.3

1.2

u/ml

0.6

0.9

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

275

1.32

0.64

1.4

1.9

pmol/l

624.1

438.3

1.49

231

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.5

—

14.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.57

0.60

1.6

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

250

1.31

0.60

4.3

2.3

—

(40768797) Stomach Pathology biopsy report

142

1.39

0.58

1.2

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

114

1082

1.34

0.56

40.9

19.8

umol/l

79.8

83.3

0.74

114

1082

(3004789) Transferrin [Mass/volume] in Serum or Plasma

183

1.31

0.49

1.9

2.5

g/l

2.2

2.3

0.18

165

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

105

1.37

0.43

1.1

1.4

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.40

0.42

1.8

2.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.41

0.0

1.3

—

(40761511) CBC panel - Blood by Automated count

111

1062

1.25

0.41

28.4

16.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.41

0.0

1.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

3.4

—

3.9

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.39

0.39

2.1

2.3

—

(3025941) Bacteria identified in Stool by Culture

1.39

0.39

1.4

1.2

—

(3026782) Osmolality of Urine

246

1.23

0.38

3.2

mosm/kgh2o

524.8

543.2

0.19

209

(3013512) EKG study

373

1.18

0.35

4.6

4.2

—

(40768804) Tissue Pathology biopsy report

428

0.84

0.34

2.4

2.2

—

(40768443) Skin Pathology biopsy report

1.35

0.34

1.3

1.2

—

(4010399)

1.35

0.33

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

934

1.18

0.33

5.0

4.7

mu/l

1.9

2.0

0.49

813

(3044640) Blood type and Crossmatch panel - Blood

347

1.17

0.32

4.6

2.3

—

(3024731) MCV [Entitic volume]

115

1116

1.21

0.27

54.4

24.3

93.7

91.5

3.61

115

1096

(3000963) Hemoglobin [Mass/volume] in Blood

115

1117

1.20

0.26

55.0

24.5

g/l

128.7

133.5

3.13

115

1094

(3035941) MCH [Entitic mass]

115

1117

1.20

0.26

54.2

24.3

30.6

30.4

0.47

115

1097

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.29

0.23

1.0

1.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.23

0.22

1.0

1.9

—

(4035726)

101

0.78

0.22

1.4

1.3

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

1.2

—

(4281824)

0.00

0.21

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.5

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3016879) Cocaine [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3027008) Opiates [Presence] in Urine

0.00

0.21

0.0

1.3

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

1.2

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.21

0.0

1.3

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

1.1

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

271.4

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.1

—

39.0

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

534.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

362

0.88

0.21

4.4

4.6

21.4

22.0

0.08

185

(3049717) Cytology report of Urine Cyto stain

1.26

0.20

1.7

2.7

—

(36660697) Celiac disease serology panel - Serum

1.14

0.17

1.3

1.1

—

(3022621) pH of Urine by Test strip

1.12

0.15

3.9

2.9

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

993

0.92

0.13

4.6

4.7

mmol/l

1.4

1.5

0.17

892

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

980

0.93

0.10

25.7

16.1

ml/min/173m2

74.2

73.7

0.08

811

(3041096) Erythrocytes [Presence] in Urine by Automated

302

1.08

0.09

7.5

3.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.04

0.09

1.6

1.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

997

0.94

0.08

4.6

4.8

mmol/l

4.4

4.5

0.53

907

(3002256) Pathology report gross observation

137

1.11

0.08

1.2

1.3

—

(3022145) Colonoscopy Study observation

112

0.88

0.07

1.3

1.2

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.09

0.07

4.4

3.3

e6/l

0.2

0.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

375

0.95

0.06

3.1

4.1

mg/mmol

3.3

6.5

1.07

241

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

955

0.95

0.06

4.3

mmol/l

1.4

1.3

1.60

852

(40761536) Microorganisms panel - Urine sediment

1.12

0.05

9.7

4.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

191

1.06

0.03

4.3

3.1

e6/l

10.0

3.0

0.42

112

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

101

1001

1.04

0.02

4.8

5.1

mmol/l

6.1

0.03

894

(3044889) 12 lead EKG panel

754

1.02

0.00

5.4

4.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

103

1025

1.02

0.00

5.1

5.4

mmol/l

2.5

2.6

0.54

922

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.9

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.4

—

113.5

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.6

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

0.0

1.0

—

57.0

—

(3044007) Cell count panel - Peritoneal fluid

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

4.4

—

75.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

0.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.93

0.00

3.5

8.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.3

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.2

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

83.5

—

(3000012) Reticulocyte production index

0.00

0.0

1.4

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.9

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

2.0

—

(44806420)

0.00

0.0

2.2

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.2

—

117.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.1

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

7.7

—

(4027681)

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.9

—

(3000492) Spirometry study

1.01

0.00

2.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint RHEUMAT_LUNG and mortality.

Females

Parameter	HR [95% CI]	p-value
RHEUMAT_LUNG	4.335 [3.39, 5.55]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.19

During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 379 females with RHEUMAT_LUNG died.

Males

Parameter	HR [95% CI]	p-value
RHEUMAT_LUNG	3.125 [2.41, 4.05]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.015

During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 351 males with RHEUMAT_LUNG died.

Mortality risk

Mortality risk for people of age

years, who have RHEUMAT_LUNG.

N-year risk	Females	Males
1	0.334%	0.578%
5	2.191%	3.843%
10	5.284%	9.686%
15	10.592%	17.551%
20	19.317%	28.326%

Relationships between endpoints

↥

Index endpoint: RHEUMAT_LUNG – Rheumatoid lung disease

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Rheumatoid lung disease

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints