Rheumatoid lung disease

RHEUMAT_LUNG

adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

114

4. Check minimum number of events

None

114

5. Include endpoints

None

114

6. Filter based on genotype QC (FinnGen only)

111

Control definitions (FinnGen only)

Control exclude
ILD_SYST_AUTO_DISEASES

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 998 519 473
Only index persons 705 370 335
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 70.83 71.81 69.83
Only index persons 70.05 70.59 69.45

-FinnGen-

Key figures

All Female Male
Number of individuals 111 48 63
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 70.59 70.41 70.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
114
Matched controls
1139
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
206.8
98.1
97
30
J99.0*M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
88.4
73
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
105.1
83.4
100
72
A07EC01
ATC
sulfasalazine; oral, rectal
57.3
60.9
73
34
P01BA02
ATC
hydroxychloroquine; oral
41.6
58.1
78
56
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
37.9
51.7
69
44
J99.0
ICD-10 Finland
Rheumatoid lung disease
+∞
44.8
40
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
75.2
39.1
43
9
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
58.5
38.2
44
12
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
43.3
38.1
47
18
H02AB06
ATC
prednisolone; systemic
33.2
37.3
108
400
L04AA13
ATC
leflunomide; oral
56.3
37.1
43
12
M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
35.2
32
*
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
129.7
35.1
36
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
59.8
27.2
31
7
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
17.6
26.8
44
39
L04AX01
ATC
azathioprine; systemic
38.0
26.3
33
12
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
21.3
24.7
37
25
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
17.0
24.2
40
35
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.4
21.8
81
283
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
53.9
19.0
22
5
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
50.8
18.0
21
5
L88
ICPC
Rheumatoid/seropositive arthritis
20.6
17.6
26
16
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.5
16.1
67
236
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
29.9
15.3
20
8
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.6
15.0
38
70
L04AA06
ATC
mycophenolic acid; systemic
92.3
15.0
16
*
M01CB01
ATC
sodium aurothiomalate; parenteral
26.6
14.8
20
9
TGC00
NOMESCO Finland
Bronchial lavation
17.8
14.3
22
15
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
18.4
13.2
20
13
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
52.7
12.2
14
*
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
39.5
11.6
14
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.6
11.3
23
29
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
48.5
11.2
13
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
24.4
11.0
15
7
M01CB03
ATC
auranofin; oral
66.4
10.8
12
*
L04AA01
ATC
[U] ciclosporin; systemic
66.4
10.8
12
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
12.4
10.8
19
18
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
44.2
10.2
12
*
M05BA04
ATC
alendronic acid; oral
6.2
10.0
28
57
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
24.2
9.6
13
6
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
20.7
9.2
13
7
H02AB07
ATC
prednisone; oral
4.7
9.0
33
91
L04AB01
ATC
etanercept; parenteral
54.3
8.8
10
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
6.4
8.7
23
43
ZX120
NOMESCO Finland
Intravenous
6.1
8.7
24
48
NDL52
NOMESCO Finland
Tenosynovectomy of hand
96.9
8.5
9
*
L04AB04
ATC
adalimumab; parenteral
96.9
8.5
9
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.3
8.5
34
102
R06.0
ICD-10 Finland
Dyspnoea
3.5
8.4
49
200
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.0
8.3
37
123
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
36.2
8.2
10
*
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
24.1
8.2
11
5
R50.9
ICD-10 Finland
Fever, unspecified
4.5
8.0
30
84
L04AD01
ATC
ciclosporin; systemic
85.4
7.5
8
*
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
85.4
7.5
8
*
NDG30
NOMESCO Finland
Fusion of wrist, total
85.4
7.5
8
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
17.2
7.4
11
7
GX1K5
NOMESCO Finland
Diffusion capacity
+∞
7.4
7
*
M01AC06
ATC
meloxicam; systemic, rectal
3.1
7.2
55
266
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
7.2
72
418
XG410
NOMESCO Finland
Flow-volume spirometry
6.7
6.9
17
29
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
7.3
6.9
16
25
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.4
6.8
20
43
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.5
6.6
19
40
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
19.3
6.4
9
5
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
19.3
6.4
9
5
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
4.9
6.3
20
47
J990, M058
ICD-10 Finland
NA
+∞
6.3
6
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
+∞
6.3
6
*
WZC30
NOMESCO Finland
Teaching
3.9
6.3
26
80
GD1AD
NOMESCO Finland
Thorax CT examination
7.4
6.3
14
21
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.7
6.1
64
366
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
7.1
6.1
14
22

Mortality – FinRegistry

Association

Association between endpoint RHEUMAT_LUNG and mortality.

Females

Parameter HR [95% CI] p-value
RHEUMAT_LUNG 4.335 [3.39, 5.55] < 0.001
Birth year 0.994 [0.99, 1.0] 0.19

During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 379 females with RHEUMAT_LUNG died.

Males

Parameter HR [95% CI] p-value
RHEUMAT_LUNG 3.125 [2.41, 4.05] < 0.001
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 351 males with RHEUMAT_LUNG died.

Mortality risk

Mortality risk for people of age

years, who have RHEUMAT_LUNG.

N-year risk Females Males
1 0.334% 0.578%
5 2.191% 3.843%
10 5.284% 9.686%
15 10.592% 17.551%
20 19.317% 28.326%

Relationships between endpoints

Index endpoint: RHEUMAT_LUNG – Rheumatoid lung disease

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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