This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Microcephaly
Q17_MICROCEPHALY
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
24 |
4. Check minimum number of eventsNone |
24 |
5. Include endpointsNone |
24 |
6. Filter based on genotype QC (FinnGen only) |
24 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_NERVOUS_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q0
- Name in latin
- Microcephalia
Similar endpoints
↥List of similar endpoints to
Microcephaly
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the nervous system
- Congenital malformations, deformations and chromosomal abnormalities
- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 952 | 472 | 480 |
| Only index persons | 434 | 219 | 215 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | - | 1.81 | 2.39 |
| Only index persons | 4.68 | 4.37 | 4.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 24 | 14 | 10 |
| Unadjusted period prevalence (%) | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | 4.54 | 6.57 | 1.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3007164) IgA [Mass/volume] in Serum or Plasma
15
110
1.96
0.86
1.7
1.8
g/l
1.6
1.4
—
8
58
(3007853) Bacteria identified in Skin by Aerobe culture
6
33
2.08
0.86
2.5
1.6
—
—
—
0
0
(40758558) Short blood count panel - Blood
14
98
2.03
0.82
4.6
10.2
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
18
143
2.03
0.73
5.8
3.2
pmol/l
15.1
14.6
0.34
18
135
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
6
35
1.95
0.64
2.5
3.0
u/l
103.5
147.5
—
6
35
(3002256) Pathology report gross observation
0
19
0.00
0.63
0.0
1.2
—
—
—
0
0
(3020961) Endomysium IgA Ab [Titer] in Serum
6
36
1.88
0.62
1.2
1.3
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
0
23
0.00
0.61
0.0
1.8
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
0
23
0.00
0.61
0.0
1.9
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
7
45
1.78
0.56
1.1
1.3
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
16
127
1.78
0.55
3.6
7.2
mm/h
6.9
9.0
0.80
16
121
(3044889) 12 lead EKG panel
5
76
0.57
0.45
1.4
2.2
—
—
—
0
0
(3023410) Appearance of Cerebral spinal fluid
0
15
0.00
0.43
0.0
4.6
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
15
0.00
0.43
0.0
2.1
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
0
16
0.00
0.43
0.0
5.7
—
—
—
0
0
(3000991) Gas panel - Venous blood
5
69
0.65
0.32
7.0
13.5
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
18
158
1.55
0.30
6.1
3.8
mu/l
2.3
2.2
0.20
18
149
(3005322) IgE [Units/volume] in Serum or Plasma
5
37
1.44
0.25
3.2
1.4
u/ml
5761.0
180.7
—
5
32
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
5
37
1.44
0.25
1.0
1.1
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
6
48
1.33
0.22
4.0
3.9
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
11
0.00
0.22
0.0
3.3
—
5.5
—
0
11
(3011648) Oxygen content in Venous blood
0
11
0.00
0.22
0.0
44.0
—
10.6
—
0
11
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
11
0.00
0.22
0.0
1.5
—
—
—
0
0
(3014148) Varicella zoster virus Ab [Titer] in Serum
0
11
0.00
0.22
0.0
1.4
—
—
—
0
0
(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay
0
11
0.00
0.22
0.0
2.0
—
—
—
0
0
(3010375) cycloSPORINE [Mass/volume] in Blood
0
10
0.00
0.22
0.0
31.4
—
168.9
—
0
10
(3023511) Choriogonadotropin [Units/volume] in Urine
0
10
0.00
0.22
0.0
1.6
—
—
—
0
0
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.22
0.0
1.6
—
—
—
0
0
(3016018) Differential panel - Cerebral spinal fluid
0
10
0.00
0.22
0.0
8.1
—
—
—
0
0
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
0
10
0.00
0.22
0.0
1.3
—
—
—
0
0
(3008757) Leukocyte morphology finding [Identifier] in Blood
0
12
0.00
0.22
0.0
3.9
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
12
0.00
0.22
0.0
1.5
—
—
—
0
0
(40761535) Cells panel - Urine sediment
0
12
0.00
0.22
0.0
4.0
—
—
—
0
0
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
0
12
0.00
0.22
0.0
2.1
—
—
—
0
0
(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma
0
12
0.00
0.22
0.0
4.4
—
283.2
—
0
12
(3022313) Gas panel - Capillary blood
10
82
1.38
0.21
7.7
13.6
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
(3007566) Smooth muscle Ab [Titer] in Serum
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
0
13
0.00
0.21
0.0
43.8
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
0
13
0.00
0.21
0.0
2.3
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(3019230) Fractional oxyhemoglobin in Venous blood
0
14
0.00
0.20
0.0
35.6
—
73.4
—
0
14
(3003694) ABO and Rh group [Type] in Blood
7
60
1.23
0.20
1.4
1.8
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
7
86
0.74
0.18
2.0
2.0
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
8
95
0.76
0.18
2.1
3.5
mmol/l
2.7
2.6
—
8
86
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
8
94
0.78
0.18
2.0
3.4
mmol/l
1.4
1.4
—
8
84
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
10
85
1.30
0.15
8.3
13.5
mmol/l
24.4
24.0
—
10
85
(3026008) Bacteria identified in Urine by Culture
5
44
1.17
0.11
1.4
4.0
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
5
60
0.79
0.09
3.2
4.1
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
7
63
1.16
0.09
2.6
4.4
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
7
66
1.09
0.09
3.6
7.4
—
—
—
0
0
(3015736) pH of Urine
8
75
1.10
0.09
3.1
4.3
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
9
84
1.11
0.08
3.8
4.7
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
13
123
1.12
0.02
3.9
5.3
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
10
94
1.11
0.01
3.7
5.1
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
14
134
1.11
0.01
5.0
16.1
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
10
98
1.03
0.00
2.1
2.7
mmol/l
5.4
5.3
—
10
90
(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3024932) HLA-DR beta [Type]
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3017115) Methotrexate [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
32.7
—
0.6
—
0
6
(3045414) Leukocytes [Presence] in Urine
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3016845) Adenovirus Ag [Presence] in Specimen by Immunofluorescence
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3024471) HLA-A [Type]
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
2.2
—
215.7
—
0
6
(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3022229) Phosphate [Moles/volume] in Urine
0
6
0.00
0.00
0.0
4.0
—
14.0
—
0
6
(3012336) Haptoglobin [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
4.5
—
1.0
—
0
6
(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3050129) First trimester maternal screen panel - Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting
0
6
0.00
0.00
0.0
2.3
—
0.3
—
0
6
(3001788) Aldosterone [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
1767.2
—
0
6
(4034850)
0
6
0.00
0.00
0.0
7.0
—
—
—
0
0
(3032352) Blasts [#/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
4.3
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
9
96
0.90
0.00
2.0
3.7
mmol/l
4.1
4.3
—
9
89
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
6
67
0.86
0.00
2.0
2.2
—
—
—
0
0
(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3011985) Renin [Units/volume] in Plasma
0
5
0.00
0.00
0.0
1.8
—
1701.4
—
0
5
(3040151) Glucose [Moles/volume] in Capillary blood
0
9
0.00
0.00
0.0
1.7
—
5.4
—
0
9
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3016038) Potassium [Moles/volume] in Urine
0
7
0.00
0.00
0.0
2.0
—
33.0
—
0
7
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
5.0
—
4.6
—
0
5
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3022621) pH of Urine by Test strip
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
9
92
0.97
0.00
1.9
3.5
mmol/l
1.2
1.1
—
9
86
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay
0
9
0.00
0.00
0.0
5.0
—
98.0
—
0
9
(3047181) Lactate [Moles/volume] in Blood
0
5
0.00
0.00
0.0
15.0
—
1.1
—
0
5
(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(21494434) Karyotype in Bone marrow
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3029080) Hemoglobin [Entitic mass] in Reticulocytes
0
5
0.00
0.00
0.0
6.2
—
32.4
—
0
5
(3022493) Free Hemoglobin [Mass/volume] in Plasma
0
5
0.00
0.00
0.0
3.4
—
183.8
—
0
5
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3045142) Bone marrow Pathology biopsy report
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
9
93
0.95
0.00
12.1
23.1
mmol/l
24.9
24.3
—
9
93
(21494755) Public health laboratory ask at order entry panel
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
8
0.00
0.00
0.0
1.7
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
(3029634) Reagin Ab [Titer] in Serum by VDRL
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020891) Body temperature
0
8
0.00
0.00
0.0
14.3
—
—
—
0
0
(3029493) Herpes virus 6 DNA [Presence] in Blood by NAA with probe detection
0
8
0.00
0.00
0.0
5.5
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3003752) BK virus DNA [Units/volume] (viral load) in Urine by NAA with probe detection
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
(3051611) Lipemic interference index of Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
855.2
—
0
5
(3051651) Icteric interference index of Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
7
0.00
0.00
0.0
4.4
—
—
—
0
0
(3045781) Inhibin B [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
141.8
—
0
5
(3026250) Tacrolimus [Mass/volume] in Blood
0
5
0.00
0.00
0.0
67.6
—
6.3
—
0
5
(3018405) Lactate [Moles/volume] in Arterial blood
0
7
0.00
0.00
0.0
6.7
—
1.8
—
0
7
(3035933) Granulocytes/100 leukocytes in Blood
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3032390) JC virus DNA [#/volume] (viral load) in Urine by NAA with probe detection
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
8
85
0.91
0.00
5.1
3.6
mmol/mol
33.8
35.8
—
8
79
(3016650) Hepatitis A virus Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
9
0.00
0.00
0.0
2.9
—
—
—
0
0
(3016914) Bacteria identified in Cerebral spinal fluid by Culture
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_MICROCEPHALY and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have Q17_MICROCEPHALY.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: Q17_MICROCEPHALY – Microcephaly
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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