Risteys · PHLEBI_THROMBOP_UNSPE

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — I80.9# 1 out of 7 registries used, show all original rules.	23
4. Check minimum number of events None	23
5. Include endpoints None	23
6. Filter based on genotype QC (FinnGen only)	23

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	23	16	7
Unadjusted period prevalence (%)	0.00	0.01	0.00
Median age at first event (years)	52.21	50.20	56.79

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

9.63

6.52

3.5

2.4

e6/l

2.3

4.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

6.31

4.20

3.7

2.3

e6/l

1.7

0.5

—

(3003396) Base excess in Arterial blood by calculation

5.54

2.89

9.4

4.8

mmol/l

0.2

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

4.19

2.84

3.8

2.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

5.25

2.77

2.8

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

8.70

2.68

5.4

4.4

mmol/l

27.5

24.2

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

8.70

2.68

5.4

5.0

mmol/l

24.4

24.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.99

2.66

2.8

1.8

—

(3012544) pH of Venous blood

5.42

2.60

7.1

3.2

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

5.42

2.60

2.4

1.9

u/l

18.7

31.2

—

(36304419) Bacteria [Presence] in Urine

3.73

2.37

3.8

2.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

6.72

2.34

2.6

1.6

—

(3000991) Gas panel - Venous blood

6.03

2.19

18.0

6.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.56

2.10

3.1

1.7

—

(3023368) Bacteria identified in Blood by Culture

3.44

2.01

10.9

5.4

—

(3022096) Basophils/100 leukocytes in Blood

3.02

1.89

8.5

6.6

0.6

0.7

0.29

(3000494) Fungus identified in Specimen by Culture

4.12

1.89

1.2

1.3

—

(40768797) Stomach Pathology biopsy report

3.40

1.88

1.3

1.4

—

(3026008) Bacteria identified in Urine by Culture

3.16

1.85

3.4

3.1

—

(3006504) Eosinophils/100 leukocytes in Blood

2.80

1.63

8.5

6.3

3.6

3.0

0.35

(3022145) Colonoscopy Study observation

3.95

1.61

1.0

1.2

—

(3018010) Neutrophils/100 leukocytes in Blood

2.74

1.61

8.4

6.2

61.3

56.9

0.71

(3019069) Monocytes/100 leukocytes in Blood

2.74

1.61

8.5

6.4

8.7

8.8

0.06

(42870588) Differential panel, method unspecified - Blood

2.77

1.49

7.4

5.9

—

(3000850) Epithelial cells [#/volume] in Urine

2.70

1.49

1.9

2.6

e6/l

6.6

3.2

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

3.16

1.48

1.5

3.2

33.7

28.5

—

(40758558) Short blood count panel - Blood

2.70

1.36

17.1

9.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

2.55

1.36

8.5

6.3

23.1

28.4

0.94

(3032080) INR in Blood by Coagulation assay

2.63

1.36

14.2

9.3

inr

1.1

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.07

1.29

3.8

3.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.69

1.21

4.6

3.5

ng/l

21.3

59.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

1.05

0.0

4.6

—

32.4

—

(40768804) Tissue Pathology biopsy report

2.30

1.05

1.7

2.0

—

(3044889) 12 lead EKG panel

127

2.29

0.92

6.2

4.0

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

2.09

0.85

6.2

4.0

g/l

34.0

35.0

0.28

(3019225) pH of Specimen

0.00

0.85

0.0

4.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.84

0.0

9.6

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.37

0.80

4.6

2.7

23.4

18.3

—

(3042936) Bacteria identified in Isolate by Culture

2.27

0.78

1.8

1.7

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.27

0.78

2.4

2.6

umol/l

3.2

14.5

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

103

1.91

0.73

7.3

4.5

mmol/l

6.4

6.5

0.12

(21494755) Public health laboratory ask at order entry panel

0.00

0.63

0.0

1.2

—

(3015736) pH of Urine

1.83

0.60

3.1

3.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

128

1.82

0.57

4.4

4.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.60

0.43

4.2

6.7

—

(3017732) Neutrophils [#/volume] in Blood

0.00

0.43

0.0

2.1

—

4.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.43

0.0

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.67

0.41

3.2

3.6

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

1.59

0.40

19.5

6.3

mmol/l

1.2

0.28

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

104

1.57

0.38

4.3

2.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.45

0.37

2.7

2.1

—

(3044640) Blood type and Crossmatch panel - Blood

1.48

0.34

4.5

2.2

—

(1761868) Lipid panel - Serum or Plasma

1.44

0.33

2.9

3.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.32

0.24

1.4

1.5

nmol/l

1055.8

1056.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.22

0.0

2.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.22

0.0

1.3

—

(1002224) Polysomnography panel

0.00

0.22

0.0

1.0

—

(3022621) pH of Urine by Test strip

0.00

0.22

0.0

2.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.1

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.8

—

24.6

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.22

0.0

2.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.21

0.0

1.8

—

(3013707) Erythrocyte sedimentation rate by Westergren method

146

1.31

0.19

7.6

4.1

mm/h

19.3

11.5

1.22

130

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.34

0.18

5.2

3.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.21

0.10

4.0

3.9

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

0.81

0.09

4.7

3.6

ng/l

2172.3

1161.8

—

(3003338) MCHC [Mass/volume]

149

1.24

0.09

55.8

19.3

g/l

326.7

331.3

0.99

149

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

85.4

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

2.8

—

44.5

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.04

0.00

3.7

4.3

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

2.3

—

230.8

—

(4034850)

0.00

0.0

47.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

3.7

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3020891) Body temperature

0.00

0.0

5.5

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.8

—

30.2

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.7

—

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: PHLEBI_THROMBOP_UNSPE_SITE – Phlebitis and thrombophlebitis of unspecified site, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).

NAME	PHLEBI_THROMBOP_UNSPE_SITE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	I809
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Phlebitis and thrombophlebitis of unspecified site, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Phlebitis and thrombophlebitis of unspecified site, drug-induced (PHLEBI_THROMBOP_UNSPE_SITE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints