Risteys · PHLEBI_THROMBOP_FEMOR

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — I80.1# 1 out of 7 registries used, show all original rules.	23
4. Check minimum number of events None	23
5. Include endpoints None	23
6. Filter based on genotype QC (FinnGen only)	23

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	23	13	10
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	50.13	44.75	57.13

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

5.47

2.05

1.6

5.4

ng/l

174.2

96.3

—

(36304419) Bacteria [Presence] in Urine

2.56

1.23

4.0

3.3

—

(3033658) Prothrombin time (PT) actual/Normal

2.38

1.03

2.6

3.5

69.1

88.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.18

0.90

3.7

3.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

1.91

0.72

1.8

2.1

u/l

366.9

117.8

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

154

0.54

0.63

5.3

4.5

mmol/l

4.4

4.5

0.12

142

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.00

0.63

0.0

1.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

152

0.56

0.57

5.0

4.5

mmol/l

1.5

0.02

139

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

151

0.57

0.54

4.0

3.9

mmol/l

1.1

1.2

0.35

136

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

158

0.59

0.47

6.3

4.9

mmol/l

2.7

0.02

148

(40761511) CBC panel - Blood by Automated count

163

0.64

0.46

16.1

13.6

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.71

0.46

1.8

3.5

mmol/l

2.5

2.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

157

0.60

0.44

20.8

16.1

mg/l

28.2

19.0

0.45

130

(3003694) ABO and Rh group [Type] in Blood

1.60

0.43

1.4

1.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.43

0.0

2.0

—

2.0

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.43

0.0

3.1

—

50.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.43

0.0

2.9

—

24.9

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.42

0.0

2.7

—

131.1

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

0.42

0.0

4.2

—

32.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

115

1.55

0.42

3.1

4.2

pmol/l

13.6

15.1

1.79

105

(40758558) Short blood count panel - Blood

1.57

0.37

3.6

8.3

—

(42870588) Differential panel, method unspecified - Blood

1.42

0.35

4.4

6.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

153

0.65

0.33

4.8

5.1

mmol/l

6.0

5.9

0.18

146

(3020564) Creatinine [Moles/volume] in Serum or Plasma

167

0.71

0.33

22.9

18.7

umol/l

107.0

76.6

0.62

167

(3015736) pH of Urine

0.64

0.32

1.8

4.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.38

0.31

4.6

4.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

102

0.67

0.29

2.8

3.3

u/l

33.8

51.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.45

0.26

1.6

1.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.34

0.23

1.8

4.0

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.22

0.0

2.2

—

0.1

—

(4034850)

0.00

0.22

0.0

15.0

—

(3019225) pH of Specimen

0.00

0.22

0.0

3.1

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.22

0.0

1.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.22

0.0

1.3

—

(36660697) Celiac disease serology panel - Serum

0.00

0.22

0.0

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.00

0.22

0.0

1.5

—

(40768443) Skin Pathology biopsy report

0.00

0.22

0.0

1.1

—

(3023368) Bacteria identified in Blood by Culture

1.24

0.21

5.3

3.7

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.21

0.0

2.0

—

0.8

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.24

0.20

1.9

3.5

mmol/l

2.3

2.4

—

(40768804) Tissue Pathology biopsy report

1.30

0.20

2.3

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

0.73

0.19

2.1

2.7

—

(3022096) Basophils/100 leukocytes in Blood

1.23

0.19

4.8

6.2

0.9

0.7

—

(3044889) 12 lead EKG panel

116

1.28

0.13

4.2

3.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.24

0.11

2.2

1.8

mmol/l

0.9

1.2

—

(3009508) Creatinine [Moles/volume] in Urine

1.24

0.11

3.4

3.3

mmol/l

5.4

8.3

—

(3044640) Blood type and Crossmatch panel - Blood

1.18

0.10

1.8

1.9

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

148

0.86

0.09

4.1

4.8

mu/l

1.6

1.9

0.40

135

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

148

0.86

0.09

5.1

5.7

mmol/mol

38.6

40.0

0.43

138

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

130

1.20

0.08

4.8

8.8

u/l

68.8

78.4

0.72

124

(3013707) Erythrocyte sedimentation rate by Westergren method

119

0.86

0.05

3.5

4.4

mm/h

16.4

12.2

0.43

112

(3037467) Urinalysis macro (dipstick) panel - Urine

107

1.05

0.00

5.3

5.1

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

2.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.0

1.2

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.7

—

34.4

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

2.9

—

6.7

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.2

—

(3026008) Bacteria identified in Urine by Culture

0.98

0.00

6.0

4.0

—

(3039000) Anion gap in Blood

0.00

0.0

8.6

—

10.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.0

—

(4010399)

0.00

0.0

1.3

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.0

1.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.0

6.7

—

1.1

—

(3009343) pH of Capillary blood

0.00

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

1.7

—

109.9

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

2.9

—

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

1.7

—

3.9

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

8.6

—

106.8

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.0

9.5

—

1.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

2.7

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.3

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3002385) Erythrocyte distribution width [Ratio]

134

1.11

0.00

24.8

19.3

14.5

14.1

0.21

134

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

39.4

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

33.3

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

14.6

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

8.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

1.7

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.4

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.00

0.0

1.0

—

5.3

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.00

0.0

6.4

—

1.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: PHLEBI_THROMBOP_FEMOR_VEIN – Phlebitis and thrombophlebitis of femoral vein, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).

NAME	PHLEBI_THROMBOP_FEMOR_VEIN
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	I801
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Phlebitis and thrombophlebitis of femoral vein, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Phlebitis and thrombophlebitis of femoral vein, drug-induced (PHLEBI_THROMBOP_FEMOR_VEIN)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints