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Other conditions originating in the perinatal period

P16_OTH_COND_ORIGINA_PERINA_PERIOD

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P96
  • Cause of death: ICD-10 P96

2 out of 7 registries used, show all original rules.

31

4. Check minimum number of events

None

31

5. Include endpoints

None

31

6. Filter based on genotype QC (FinnGen only)

31

Control definitions (FinnGen only)

Control exclude
P16_OTH_DISORD_ORIGINA_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P9
Name in latin
Aliae condiciones origine perinatales

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2012 927 1083
Only index persons 815 376 439
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 0.08 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 31 16 15
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 13.45 23.97 2.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
22
95
5.50
4.82
9.7
6.4
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
17
63
4.76
4.39
5.5
6.1
e6/l
1.4
0.4
0.69
12
47
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
17
65
4.58
4.17
5.4
5.2
e6/l
0.6
0.4
0.30
12
49
(36304419) Bacteria [Presence] in Urine
19
86
4.12
3.59
9.6
5.7
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
12
39
4.39
3.54
8.8
4.5
umol/l
10.2
15.2
2.11
12
39
(3042936) Bacteria identified in Isolate by Culture
11
35
4.32
3.31
2.6
2.0
—
—
—
0
0
(3000991) Gas panel - Venous blood
15
63
3.68
3.05
16.3
17.6
—
—
—
0
0
(3012544) pH of Venous blood
16
71
3.59
2.98
16.1
15.1
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
13
51
3.67
2.90
5.8
2.5
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
5
8
7.18
2.46
1.4
3.1
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
9
30
3.80
2.38
1.8
2.3
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
9
31
3.66
2.30
1.8
2.4
—
—
—
0
0
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
5
9
6.37
2.30
1.4
2.2
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
12
51
3.21
2.29
5.2
5.0
—
—
—
0
0
(3015736) pH of Urine
18
99
2.95
2.19
12.0
4.1
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
5
10
5.72
2.15
1.4
1.9
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
6
15
4.68
2.15
1.3
2.1
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
10
40
3.21
2.08
1.8
2.3
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
6
16
4.38
2.04
1.3
1.9
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
15
77
2.84
2.04
2.9
4.6
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
6
17
4.11
1.94
1.2
2.1
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
6
17
4.11
1.94
2.8
2.6
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
6
17
4.11
1.94
2.8
2.6
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
25
178
3.08
1.91
9.8
4.7
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
5
12
4.74
1.90
3.4
2.7
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
21
133
2.79
1.86
9.9
10.1
—
—
—
0
0
(3002256) Pathology report gross observation
7
24
3.46
1.85
1.0
1.2
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
5
13
4.36
1.79
1.4
1.8
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
7
27
3.04
1.63
1.6
1.2
nmol/l
20.1
17.5
—
7
21
(3030366) Cystatin C [Mass/volume] in Serum or Plasma
9
41
2.67
1.53
36.8
25.8
mg/l
2.2
1.2
—
9
41
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
9
41
2.67
1.53
1.3
2.8
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
18
117
2.28
1.36
7.3
3.8
ug/l
47.8
74.0
0.58
18
112
(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma
5
18
3.10
1.34
2.0
1.2
%
2.1
1.4
—
5
18
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
17
109
2.24
1.31
10.0
11.4
umol/l
20.4
27.2
0.28
17
102
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
6
26
2.61
1.25
1.2
2.0
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
5
20
2.78
1.20
3.0
2.6
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
7
31
2.62
1.20
1.7
1.3
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
10
53
2.31
1.17
2.2
1.6
—
—
—
0
0
(40758558) Short blood count panel - Blood
17
113
2.12
1.16
6.9
9.2
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
7
35
2.28
1.08
8.3
3.8
mg/mmol
15.8
508.4
—
7
23
(3041096) Erythrocytes [Presence] in Urine by Automated
9
51
2.07
1.06
10.1
2.9
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
7
37
2.15
1.01
1.3
2.8
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
7
37
2.15
1.01
1.9
2.1
—
—
—
0
0
(3003458) Phosphate [Moles/volume] in Serum or Plasma
13
82
2.01
0.98
35.2
13.1
mmol/l
1.3
1.4
0.41
13
75
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
16
109
1.97
0.98
9.4
4.1
nmol/l
87.6
72.5
1.61
16
103
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
24
191
2.13
0.93
4.0
3.6
pmol/l
14.4
14.3
0.13
24
180
(3021589) Normoblasts [#/volume] in Blood
22
172
1.96
0.89
16.2
11.1
e9/l
0.0
0.0
0.48
16
129
(3044640) Blood type and Crossmatch panel - Blood
13
85
1.91
0.87
3.7
3.2
—
—
—
0
0
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
6
32
2.08
0.87
1.7
4.6
u/l
302.0
261.3
—
6
32
(40760892) CBC W Ordered Manual Differential panel - Blood
9
54
1.94
0.85
23.9
6.7
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
6
33
2.01
0.84
1.0
1.5
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
20
155
1.82
0.75
11.7
4.3
mmol/mol
39.3
37.3
0.28
20
148
(3044889) 12 lead EKG panel
8
119
0.56
0.75
3.8
2.5
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
5
26
2.09
0.74
3.0
2.7
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
12
80
1.82
0.74
1.8
2.1
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
8
50
1.80
0.68
2.4
1.7
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
10
65
1.79
0.65
1.9
2.0
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
9
59
1.74
0.63
2.4
2.2
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
20
160
1.70
0.63
5.2
4.1
mmol/l
2.4
2.6
0.48
20
153
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
20
160
1.70
0.63
5.0
3.8
mmol/l
1.5
1.5
0.22
20
153
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
22
0.00
0.62
0.0
1.8
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
15
112
1.66
0.60
5.2
4.3
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
20
162
1.66
0.58
5.1
4.1
mmol/l
4.4
4.5
0.07
20
155
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
11
78
1.64
0.52
9.5
3.7
—
—
—
0
0
(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation
11
78
1.64
0.52
16.5
14.0
mmol/l
2.0
1.6
—
6
58
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
10
70
1.63
0.49
3.3
3.1
—
—
—
0
0
(3018677) aPTT in Platelet poor plasma by Coagulation assay
8
57
1.54
0.47
5.4
6.7
s
29.5
30.6
—
8
57
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
5
33
1.61
0.44
2.2
9.2
%
89.0
89.7
—
5
33
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
5
34
1.56
0.42
1.4
1.3
—
19.9
—
0
8
(3003327) Ova and parasites identified in Stool by Light microscopy
0
17
0.00
0.42
0.0
1.6
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
11
82
1.53
0.41
10.0
6.3
u/l
36.5
34.5
0.10
11
82
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
18
0.00
0.41
0.0
1.4
—
—
—
0
0
(3022313) Gas panel - Capillary blood
10
74
1.52
0.38
15.5
12.9
—
—
—
0
0
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
19
161
1.47
0.38
18.9
7.1
u/l
160.4
135.0
0.56
19
154
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
11
86
1.43
0.32
24.5
17.7
mmol/l
23.7
24.8
0.70
11
86
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
24
220
1.40
0.27
4.8
4.2
mu/l
1.9
2.1
0.22
24
208
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
41
1.26
0.23
1.8
1.5
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
11
0.00
0.22
0.0
1.4
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
11
0.00
0.22
0.0
1.4
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
0
10
0.00
0.22
0.0
1.4
—
—
—
0
0
(3042975) Streptococcus sp identified in Isolate by Organism specific culture
0
10
0.00
0.22
0.0
1.3
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
10
0.00
0.22
0.0
1.9
—
—
—
0
0
(3027901) Hemoglobin [Mass/volume] in Arterial cord blood
0
10
0.00
0.22
0.0
1.0
—
173.7
—
0
10
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
10
0.00
0.22
0.0
1.4
—
—
—
0
0
(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma
0
10
0.00
0.22
0.0
2.1
—
36.3
—
0
10
(3006245) CD3-CD19+ cells/100 cells in Blood
0
12
0.00
0.21
0.0
5.0
—
19.1
—
0
12
(3045414) Leukocytes [Presence] in Urine
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
7
57
1.29
0.20
2.3
2.3
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
10
82
1.32
0.20
13.5
2.8
mmol/l
2.4
2.4
—
10
73
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
26
244
1.41
0.19
4.2
4.2
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
10
114
0.82
0.12
1.2
2.3
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
26
250
1.25
0.09
41.4
13.5
umol/l
91.8
58.7
0.68
26
250
(3003694) ABO and Rh group [Type] in Blood
10
89
1.18
0.08
2.0
1.6
—
—
—
0
0
(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4062490)
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000093) Morphology [Interpretation] in Blood Narrative
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3011648) Oxygen content in Venous blood
0
6
0.00
0.00
0.0
30.7
—
11.7
—
0
6
(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(21494815) CD4 cells/100 lymphocytes in Specimen
0
7
0.00
0.00
0.0
5.0
—
—
—
0
0
(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3045683) HLA typing for celiac disease panel - Blood or Tissue
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
4.0
—
20.6
—
0
6
(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(1002224) Polysomnography panel
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3018405) Lactate [Moles/volume] in Arterial blood
0
7
0.00
0.00
0.0
3.6
—
1.8
—
0
7
(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.3
—
44.3
—
0
7
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation
0
5
0.00
0.00
0.0
1.4
—
258.8
—
0
5
(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
0
9
0.00
0.00
0.0
5.3
—
—
—
0
0
(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019060) Gas panel - Arterial blood
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
5
52
0.95
0.00
1.2
1.2
—
—
—
0
0
(3008757) Leukocyte morphology finding [Identifier] in Blood
0
5
0.00
0.00
0.0
9.0
—
—
—
0
0
(1175426) CD3 cells/100 lymphocytes in Blood
0
9
0.00
0.00
0.0
5.4
—
63.1
—
0
9
(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005082) Progesterone [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
34.2
—
0
5
(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3007566) Smooth muscle Ab [Titer] in Serum
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(40768443) Skin Pathology biopsy report
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3046279) Procalcitonin [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
3.4
—
2.6
—
0
5
(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood
0
9
0.00
0.00
0.0
5.4
—
26.9
—
0
9
(3027831) CD3-CD16+CD56+ (Natural killer) cells/100 cells in Blood
0
9
0.00
0.00
0.0
5.3
—
11.3
—
0
9
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.2
—
40.4
—
0
5
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood
0
6
0.00
0.00
0.0
5.7
—
—
—
0
0
(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011985) Renin [Units/volume] in Plasma
0
5
0.00
0.00
0.0
1.8
—
46.0
—
0
5
(3045424) Erythrocytes [Presence] in Urine
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_OTH_COND_ORIGINA_PERINA_PERIOD and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_OTH_COND_ORIGINA_PERINA_PERIOD.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: P16_OTH_COND_ORIGINA_PERINA_PERIOD – Other conditions originating in the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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