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Omphalitis of newborn with or without mild haemorrhage

P16_OMPHA_NEWBO_W_WO_MILD_HAEMORRHAGE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P38
  • Cause of death: ICD-10 P38

2 out of 7 registries used, show all original rules.

7

4. Check minimum number of events

None

7

5. Include endpoints

None

7

6. Filter based on genotype QC (FinnGen only)

7

Control definitions (FinnGen only)

Control exclude
P16_INFECTIONS_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P3
Name in latin
Omphalitis neonatalis cum/sine haemorrhagia levi

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 677 296 381
Only index persons 339 154 185
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population - 0.03 0.03
Only index persons 0.03 0.04 0.03

-FinnGen-

Key figures

All Female Male
Number of individuals 7 - 5
Unadjusted period prevalence (%) 0.00 - 0.00
Median age at first event (years) 0.36 - 0.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3007164) IgA [Mass/volume] in Serum or Plasma
0
26
0.00
1.05
0.0
1.6
—
1.3
—
0
13
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
0
26
0.00
1.05
0.0
1.5
—
0.4
—
0
6
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
0
14
0.00
0.47
0.0
1.8
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
0
14
0.00
0.47
0.0
1.7
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
0
11
0.00
0.23
0.0
1.9
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
0
11
0.00
0.23
0.0
1.9
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
0
11
0.00
0.23
0.0
1.9
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
0
11
0.00
0.23
0.0
1.3
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
0
11
0.00
0.23
0.0
4.0
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
0
11
0.00
0.23
0.0
2.0
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
0
11
0.00
0.23
0.0
1.9
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
0
10
0.00
0.23
0.0
1.9
—
3.0
—
0
10
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
10
0.00
0.23
0.0
1.7
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
0
12
0.00
0.23
0.0
2.2
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
0
9
0.00
0.23
0.0
1.3
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
9
0.00
0.23
0.0
3.1
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
0
13
0.00
0.23
0.0
1.4
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
0
13
0.00
0.23
0.0
1.3
—
2.4
—
0
13
(3021706) Oxygen [Partial pressure] in Arterial cord blood
0
8
0.00
0.00
0.0
1.0
—
2.9
—
0
8
(3003932) Carbon dioxide [Partial pressure] in Arterial cord blood
0
8
0.00
0.00
0.0
1.0
—
7.6
—
0
8
(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood
0
8
0.00
0.00
0.0
1.0
—
20.1
—
0
8
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
4.5
—
36.5
—
0
8
(3006598) pH of Arterial cord blood
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
0
6
0.00
0.00
0.0
2.3
—
35.7
—
0
6
(3023511) Choriogonadotropin [Units/volume] in Urine
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
2.2
—
606.2
—
0
6
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(3028026) IgM [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
3.2
—
0.8
—
0
5
(3017732) Neutrophils [#/volume] in Blood
0
7
0.00
0.00
0.0
2.9
—
3.2
—
0
7
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3017446) Testosterone [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
3.0
—
12.9
—
0
7
(3020961) Endomysium IgA Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
3.4
—
36.4
—
0
5
(3026008) Bacteria identified in Urine by Culture
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(3009214) Lutropin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
3.8
—
7.0
—
0
5
(3004789) Transferrin [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.6
—
2.5
—
0
5
(3022948) Iron [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.4
—
17.9
—
0
5
(3007853) Bacteria identified in Skin by Aerobe culture
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_OMPHA_NEWBO_W_WO_MILD_HAEMORRHAGE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_OMPHA_NEWBO_W_WO_MILD_HAEMORRHAGE.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: P16_OMPHA_NEWBO_W_WO_MILD_HAEMORRHAGE – Omphalitis of newborn with or without mild haemorrhage

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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