Wegener granulomatosis

M13_WEGENER

Granulomatosis with Polyangiitis: A small-vessel necrotizing vasculitis characterised by the association of inflammation of the vessel wall and peri- and extravascular granulomatosis.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M31.3
  • Hospital discharge: ICD-9 4464
  • Hospital discharge: ICD-8 4462
  • Cause of death: ICD-10 M31.3
  • Cause of death: ICD-9 4464
  • Cause of death: ICD-8 4462

2 out of 7 registries used, show all original rules.

503

4. Check minimum number of events

None

503

5. Include endpoints

None

503

6. Filter based on genotype QC (FinnGen only)

486

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M31
Name in latin
Granulomatosis Wegener

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2962 1497 1441
Only index persons 2449 1266 1183
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 60.38 61.29 59.32
Only index persons 59.11 60.06 58.09

-FinnGen-

Key figures

All Female Male
Number of individuals 486 249 237
Unadjusted period prevalence (%) 0.11 0.10 0.12
Median age at first event (years) 55.29 54.44 56.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
503
Matched controls
5029
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
323.0
438
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
37.4
233.9
323
230
L04AX01
ATC
azathioprine; systemic
56.3
217.7
259
93
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
205.8
183
*
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
159.0
144
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
21.2
121.7
190
140
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
9.4
114.8
353
1004
L04AA06
ATC
mycophenolic acid; systemic
73.4
113.0
127
23
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
107.2
99
*
H02AB06
ATC
prednisolone; systemic
9.3
103.1
410
1620
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
16.4
89.4
152
129
L01AA01
ATC
cyclophosphamide; systemic
251.3
84.2
84
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
59.0
82.3
96
20
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.4
79.4
372
1539
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
78.2
73
*
M05BA04
ATC
alendronic acid; oral
11.4
75.4
153
185
DHA10
NOMESCO Finland
Biopsy of cavity of nose
67.9
74.6
85
15
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
16.4
70.5
118
92
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
10.4
68.6
146
190
UDH02
NOMESCO Finland
Rhinopharyngoscopy
10.7
63.8
132
161
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
56.3
53
*
TGC00
NOMESCO Finland
Bronchial lavation
21.4
55.5
83
46
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
24.0
52.9
76
37
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
25.0
52.8
75
35
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.4
51.7
107
127
H02AB04
ATC
methylprednisolone; systemic
5.8
49.8
164
387
ZX120
NOMESCO Finland
Intravenous
7.1
49.2
134
246
1XC02
NOMESCO Finland
NA
49.2
44.1
53
12
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
13.6
43.8
78
67
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
43.4
41
*
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
43.4
41
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.0
42.6
114
201
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
35.4
42.0
54
17
Z94.0
ICD-10 Finland
Kidney transplant status
35.2
37.4
48
15
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
36.9
35
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.9
36.7
113
236
A11CC03
ATC
alfacalcidol; systemic
14.9
36.6
62
47
KA1AE
NOMESCO Finland
Kidney ultrasound examination
14.6
36.2
62
48
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.7
35.0
192
713
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
34.8
33
*
R50.9
ICD-10 Finland
Fever, unspecified
4.6
33.8
134
368
A12AA04
ATC
calcium carbonate; oral
22.9
33.3
48
23
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
348.8
33.3
33
*
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
32.7
31
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
31.6
30
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
30.9
131
381
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.3
30.5
77
122
N18.8
ICD-10 Finland
Other chronic renal failure
13.3
30.0
53
44
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.0
29.8
105
252
A02BC02
ATC
pantoprazole; systemic
3.0
27.4
376
2492
TDM10
NOMESCO Finland
Puncture of maxillary antrum
8.8
26.8
59
75
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.8
26.8
55
62
B03XA02
ATC
darbepoetin alfa; parenteral
15.4
26.7
44
31
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
26.5
167
662
J31.0
ICD-10 Finland
Chronic rhinitis
5.4
26.4
84
179
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
26.3
25
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
13.2
26.1
46
38
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
11.9
25.9
48
44
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
142.3
25.9
27
*
127
Kela drug reimbursment
Transplant complication
19.1
25.7
39
22
GD1AD
NOMESCO Finland
Thorax CT examination
7.5
25.4
62
93
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
8.6
25.3
56
72
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.3
25.1
70
126
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
34.0
24.9
32
10
C03CA01
ATC
furosemide; systemic
2.9
24.9
194
885
TK800
NOMESCO Finland
Hemodialysis
12.9
24.8
44
37
4464A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Wegener's granulomatosis
+∞
24.2
23
*
N18.0
ICD-10 Finland
End-stage renal disease
18.0
23.9
37
22
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
9.0
23.8
51
62
J01MA12
ATC
levofloxacin; systemic
3.2
23.0
140
534
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
42.3
22.9
28
7
WW400
NOMESCO Finland
Plasmaferesis
240.5
22.8
23
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.7
22.2
66
129
Z49.1
ICD-10 Finland
Extracorporeal dialysis
15.4
22.0
36
25
ZX108
NOMESCO Finland
Inhalation
32.8
21.7
28
9
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.0
21.5
72
161
H02AB07
ATC
prednisone; oral
3.4
21.1
114
396
H65.3
ICD-10 Finland
Chronic mucoid otitis media
11.6
21.0
39
36
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
15.8
21.0
34
23
1AA01
NOMESCO Finland
NA
218.6
20.7
21
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.0
20.4
89
258
137
Kela drug reimbursment
Uraemia requiring dialysis
28.4
20.2
27
10
H65.2
ICD-10 Finland
Chronic serous otitis media
15.3
20.2
33
23
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
19.9
19
*
Z2446
NOMESCO Finland
Social worker
4.6
19.9
72
175
UDM02
NOMESCO Finland
Sinoscopy
9.6
19.5
40
45
M35.3
ICD-10 Finland
Polymyalgia rheumatica
15.6
19.2
31
21
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
6.3
18.9
51
88
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
18.9
18
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
18.9
18
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
18.1
290
1867
N085, M318
ICD-10 Finland
NA
+∞
17.8
17
*
Z49.2
ICD-10 Finland
Other dialysis
25.1
17.5
24
10
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
32.8
17.2
22
7
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.5
17.2
169
846
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.6
17.1
62
150
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.7
17.0
59
137
C08CA01
ATC
amlodipine; oral
2.3
16.9
211
1193
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
13.3
16.8
29
23
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
16.8
16
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.4
16.6
44
74
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.6
16.4
144
671
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
13.4
16.3
28
22
A02BC01
ATC
omeprazole; systemic
2.4
16.2
169
866
Z49.0
ICD-10 Finland
Preparatory care for dialysis
16.4
15.9
25
16
H26.3
ICD-10 Finland
Drug-induced cataract
62.1
15.9
18
*
M13.9
ICD-10 Finland
Arthritis, unspecified
4.4
15.8
59
147
Z3231
NOMESCO Finland
Registered nurse
2.4
15.6
172
905
L04AD01
ATC
ciclosporin; systemic
8.4
15.6
34
43
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
15.5
108
439
ZXA10
NOMESCO Finland
Bilateral
2.7
15.2
123
545
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.3
15.1
57
144
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
14.8
69
210
J01MA14
ATC
moxifloxacin; systemic
3.5
14.8
74
239
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
14.7
14
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
10.5
14.6
28
28
M05BB03
ATC
alendronic acid and colecalciferol; oral
8.6
14.5
31
38
Z2221
NOMESCO Finland
Medical doctor
2.3
14.4
171
926
WW200
NOMESCO Finland
Immunization
6.9
14.1
35
54
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.1
13.8
79
282
B03XA01
ATC
erythropoietin; parenteral
13.3
13.5
23
18
M30.0
ICD-10 Finland
Polyarteritis nodosa
143.7
13.5
14
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
11.9
13.4
24
21
B05DA
ATC
Isotonic solutions
21.9
13.4
19
9
TPX10
NOMESCO Finland
Implantation of vascular injection port
7.2
13.4
32
47
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
15.6
13.2
21
14
J34.8
ICD-10 Finland
Other specified disorders of nose and nasal sinuses
10.5
13.1
25
25
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.5
12.9
62
194
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
7.3
12.8
30
43
R04.0
ICD-10 Finland
Epistaxis
3.6
12.6
59
180
PAW37
NOMESCO Finland
Biopsy of temporal artery
33.0
12.6
16
5
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
7.2
12.6
30
44
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.4
12.6
46
113
J01FF01
ATC
clindamycin; systemic
2.2
12.5
154
838
P01BA02
ATC
hydroxychloroquine; oral
3.7
12.5
55
160
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
12.5
201
1229
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.3
12.3
63
207
J01CA04
ATC
amoxicillin; systemic
2.2
11.8
410
3355
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
11.8
99
444
WX892
NOMESCO Finland
Monitored bed care
3.3
11.8
60
196
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
19.5
11.7
17
9
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
122.7
11.5
12
*
ZXE00
NOMESCO Finland
One hour or less
2.0
11.4
217
1400
J05AB11
ATC
valaciclovir; oral
2.7
11.4
83
343
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.8
11.4
49
140
L04AA01
ATC
[U] ciclosporin; systemic
9.9
11.3
22
23
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.0
11.2
45
121
C09AA02
ATC
enalapril; systemic
2.3
11.1
119
601
UDC00
NOMESCO Finland
Ear microscopy
3.4
11.1
55
176
3AC01
NOMESCO Finland
NA
14.3
11.0
18
13
M05BA07
ATC
risedronic acid; oral
5.1
11.0
34
70
RS221
NOMESCO Finland
NA
8.1
11.0
24
31
Z3226
NOMESCO Finland
Physiotherapist
2.3
10.8
115
578
XG410
NOMESCO Finland
Flow-volume spirometry
4.4
10.8
39
95
V03AE02
ATC
sevelamer; oral
18.3
10.8
16
9
L88
ICPC
Rheumatoid/seropositive arthritis
5.0
10.6
33
69
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.2
10.6
55
183
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
10.4
10
*
B05DB
ATC
Hypertonic solutions
19.3
10.3
15
8
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
23.9
10.3
14
6
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.4
10.2
50
159
J01MA02
ATC
ciprofloxacin; systemic
1.9
10.2
203
1320
RD210
NOMESCO Finland
NA
6.7
10.1
25
39
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
6.7
10.1
25
39
B07.9
ICD-10 Finland
Verruca simplex
5.0
10.1
32
68
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
15.0
10.1
16
11
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
10.0
157
928
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
40.9
10.0
12
*
A41.9
ICD-10 Finland
Sepsis, unspecified
5.0
9.9
31
65
ZXA00
NOMESCO Finland
Right side
2.0
9.8
148
864
205
Kela drug reimbursment
Chronic hypertension
2.0
9.8
148
865
1CX01
NOMESCO Finland
NA
56.1
9.7
11
*
ZXD05
NOMESCO Finland
Urgent procedure
1.9
9.6
169
1042
C02CA01
ATC
prazosin; oral
9.4
9.6
19
21
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.2
9.6
29
59
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
15.4
9.6
15
10
R01AD08
ATC
fluticasone; nasal
2.0
9.5
155
928
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
6.8
9.5
23
35
DM1DG
NOMESCO Finland
Paranasal sinuses and face area very extensive MRI examination with high intensity magnet
101.9
9.4
10
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
30.7
9.4
12
*
M31.2
ICD-10 Finland
Lethal midline granuloma
+∞
9.4
9
*
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
9.4
9
*
TK820
NOMESCO Finland
Peritoneal dialysis
22.2
9.4
13
6
WX002
NOMESCO Finland
Sedation and analgesia
2.1
9.3
115
619
TAB00
NOMESCO Finland
Lumbar puncture
4.2
9.2
34
85
H65.0
ICD-10 Finland
Acute serous otitis media
8.0
9.2
20
26
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
6.5
9.2
23
37
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.7
9.1
39
112
TK810
NOMESCO Finland
Hemofiltration
15.9
9.1
14
9
J01DB01
ATC
cefalexin; oral
2.0
9.1
408
3436
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
37.4
9.0
11
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.0
9.0
35
92
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
9.0
208
1405
EB1WA
NOMESCO Finland
NA
19.0
9.0
13
7
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.7
8.9
38
109
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
8.9
59
231
H04.10
ICD-10 Finland
Dry eye syndrome
2.7
8.7
62
253
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
50.9
8.7
10
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
50.9
8.7
10
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
8.4
8
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.1
8.3
25
51
M05BA06
ATC
ibandronic acid; systemic
7.7
8.2
18
24
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
7.0
8.1
19
28
H02AB09
ATC
hydrocortisone; systemic
5.4
8.1
23
44
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
22.4
8.0
11
5
ZXA05
NOMESCO Finland
Left side
1.9
7.9
132
790
DFF00
NOMESCO Finland
Pure tone audiometry
2.7
7.9
56
226
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.9
7.9
49
183
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
7.7
55
222
DC1AD
NOMESCO Finland
Temporalbone CT
7.6
7.7
17
23
RS222
NOMESCO Finland
NA
8.2
7.6
16
20
6BA02
NOMESCO Finland
NA
18.7
7.6
11
6
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
12.1
7.6
13
11
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
25.4
7.6
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
7.6
112
643
R04.2
ICD-10 Finland
Haemoptysis
3.8
7.5
30
82
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.5
7.5
58
249
AA1AD
NOMESCO Finland
CT of head and brain
1.9
7.5
124
741
I77.6
ICD-10 Finland
Arteritis, unspecified
81.2
7.4
8
*
C08CA13
ATC
lercanidipine; oral
2.2
7.4
74
360
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
7.3
7
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
7.2
97
534
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
5.0
7.2
22
46
N25.0
ICD-10 Finland
Renal osteodystrophy
30.5
7.2
9
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
20.4
7.2
10
5
J05AB01
ATC
aciclovir; systemic
1.9
7.1
107
616
V03AE01
ATC
polystyrene sulfonate; oral
6.2
7.1
18
30
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.8
7.1
19
34
N19
ICD-10 Finland
Unspecified kidney failure
4.1
7.1
26
66
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.7
7.1
48
189
RS220
NOMESCO Finland
NA
7.1
7.0
16
23
D64.9
ICD-10 Finland
Anaemia, unspecified
2.4
7.0
57
250
J47
ICD-10 Finland
Bronchiectasis
6.0
7.0
18
31
R4110
NOMESCO Finland
Physiotherapy
1.8
6.9
141
897
I15.0
ICD-10 Finland
Renovascular hypertension
14.0
6.9
11
8
321
Kela drug reimbursment
Paricalcitol and cinacalcet
14.0
6.9
11
8
196
Kela drug reimbursment
Paricalcitol and cinacalcet
14.0
6.9
11
8
JN4AD
NOMESCO Finland
Body CT examination
2.7
6.9
47
186
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
11.1
6.8
12
11
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.3
6.8
33
106
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
6.8
41
153
R4190
NOMESCO Finland
Nutritional therapy
4.1
6.8
25
64
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.1
6.8
25
64
5AB14
NOMESCO Finland
NA
40.6
6.8
8
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
6.7
80
421
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
6.7
191
1346
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
8.0
6.7
14
18
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
6.6
50
213
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
4.8
6.5
20
43
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
70.7
6.4
7
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
14.5
6.4
10
7
JN4BD
NOMESCO Finland
Extensive body CT
2.2
6.4
61
291
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
6.7
6.4
15
23
J32.4
ICD-10 Finland
Chronic pansinusitis
6.1
6.3
16
27
K65.0
ICD-10 Finland
Acute peritonitis
6.1
6.3
16
27
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
9.4
6.3
12
13
K06.18
ICD-10 Finland
Another gingival hyperplasia
18.3
6.3
9
5
DHB10
NOMESCO Finland
Excision of lesion of internal nose
18.3
6.3
9
5
V03AE03
ATC
lanthanum carbonate; oral
18.3
6.3
9
5
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
6.3
6
*
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
27.0
6.2
8
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
27.0
6.2
8
*
R01AD09
ATC
mometasone; nasal
1.6
6.2
218
1613
H20.1
ICD-10 Finland
Chronic iridocyclitis
8.7
6.1
12
14
H15.1
ICD-10 Finland
Episcleritis
6.8
6.1
14
21
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
10.2
6.1
11
11
NF1AA
NOMESCO Finland
Hip X-ray examination
2.4
6.0
48
208
B01AA03
ATC
warfarin; systemic
1.9
6.0
98
577

Mortality – FinRegistry

Association

Association between endpoint M13_WEGENER and mortality.

Females

Parameter HR [95% CI] p-value
M13_WEGENER 2.443 [2.07, 2.88] < 0.001
Birth year 0.99 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 351 out of 1165 females with M13_WEGENER died.

Males

Parameter HR [95% CI] p-value
M13_WEGENER 2.398 [2.01, 2.86] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 368 out of 1088 males with M13_WEGENER died.

Mortality risk

Mortality risk for people of age

years, who have M13_WEGENER.

N-year risk Females Males
1 0.245% 0.406%
5 1.471% 2.311%
10 3.471% 6.235%
15 6.26% 11.394%
20 10.164% 18.006%

Relationships between endpoints

Index endpoint: M13_WEGENER – Wegener granulomatosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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