No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
416 |
4. Check minimum number of eventsNone |
416 |
5. Include endpointsNone |
416 |
6. Filter based on genotype QC (FinnGen only) |
416 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M21
- Name in latin
- Deformitas membri vara non alibi classificata
Similar endpoints
↥List of similar endpoints to
Varus deformity, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3785 | 2650 | 1120 |
| Only index persons | 3415 | 2455 | 960 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.08 | 0.03 |
| Only index persons | 0.08 | 0.09 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 51.91 | 55.37 | 43.69 |
| Only index persons | 51.77 | 54.93 | 43.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 416 | 329 | 87 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.04 |
| Median age at first event (years) | 51.39 | 51.96 | 49.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 368
- Matched controls
- 3678
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.1
ICD-10 Finland
Varus deformity, not elsewhere classified
+∞
323.0
316
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
182.0
212.6
208
26
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
1746.0
130.4
119
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
109.6
66.6
71
8
M17.1
ICD-10 Finland
Other primary gonarthrosis
22.5
63.3
94
55
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
682.4
60.5
58
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
47.6
57.9
70
18
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
56.0
55.4
65
14
ZXA00
NOMESCO Finland
Right side
5.8
46.9
168
465
ZXA05
NOMESCO Finland
Left side
5.9
45.0
155
405
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
468.7
43.1
42
*
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
42.5
40
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
42.5
40
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
61.0
41.6
48
9
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
17.9
36.7
58
38
NHL20
NOMESCO Finland
Myotomy or tenotomy of foot
+∞
33.9
32
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
12.8
32.9
60
55
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
18.3
32.7
51
32
73803
ICD-8 Finland
Other deformities, Genu varum
+∞
31.7
30
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
14.7
28.3
48
37
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
291.0
27.1
27
*
M25.5
ICD-10 Finland
Pain in joint
4.2
26.8
119
372
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
26.4
25
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
100.7
26.0
28
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
255.8
23.9
24
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
+∞
23.2
22
*
M77.4
ICD-10 Finland
Metatarsalgia
8.4
22.6
51
69
N02AX02
ATC
tramadol; systemic, rectal
3.1
22.1
169
789
9271
FHL
Hallux surgery
+∞
22.1
21
*
WX320
NOMESCO Finland
Spinalanesthesy
4.3
22.0
91
260
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
10.3
22.0
44
48
M20.2
ICD-10 Finland
Hallux rigidus
122.2
21.8
23
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
18.9
21.8
33
19
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.0
21.4
182
906
M16.1
ICD-10 Finland
Other primary coxarthrosis
18.7
20.4
31
18
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
22.3
18.9
27
13
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
199.6
18.7
19
*
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
17.8
17
*
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
188.6
17.7
18
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.8
17.5
82
258
L17
ICPC
Foot/toe symptom/complaint
3.1
17.2
117
487
R4110
NOMESCO Finland
Physiotherapy
3.0
17.2
122
523
M01AH05
ATC
etoricoxib; oral
2.6
17.0
223
1371
NHG82
NOMESCO Finland
Fusion of other tarsal joint
94.4
16.7
18
*
Z20.9
ICD-10 Finland
Contact with and exposure to unspecified communicable disease
8.8
15.9
34
42
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
3.5
15.8
82
280
M01AX05
ATC
glucosamine; oral
3.8
15.7
72
222
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
14.9
141
710
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
19.4
14.9
22
12
M54.5
ICD-10 Finland
Low back pain
2.6
14.5
133
655
M22.4
ICD-10 Finland
Chondromalacia patellae
44.3
14.2
17
*
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
14.3
13.9
23
17
Z25.1
ICD-10 Finland
Need for immunization against influenza
5.3
13.8
43
90
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
8.0
13.8
31
42
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
13.6
13
*
73799
ICD-8 Finland
Hallux valgus and varus
+∞
13.6
13
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
145.0
13.5
14
*
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
145.0
13.5
14
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.1
13.2
36
64
M01AC06
ATC
meloxicam; systemic, rectal
2.4
12.7
144
781
73801
ICD-8 Finland
Other deformities, Coxa vara
+∞
12.6
12
*
M79.6
ICD-10 Finland
Pain in limb
2.4
12.1
132
699
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
48.3
12.0
14
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
11.6
113
562
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
+∞
11.5
11
*
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
123.6
11.5
12
*
N03AX16
ATC
pregabalin; oral
2.6
11.2
93
421
SPAT1229
SPAT
Assessment of need for aid
4.5
11.0
39
94
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
6.8
11.0
27
42
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
44.7
11.0
13
*
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
5.0
10.9
35
76
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
22.2
10.8
15
7
M21.0
ICD-10 Finland
Valgus deformity, not elsewhere classified
+∞
10.5
10
*
M13.9
ICD-10 Finland
Arthritis, unspecified
10.0
10.4
20
21
N03AX12
ATC
gabapentin; oral
3.2
10.3
57
200
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
4.6
10.2
35
82
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
8.8
10.2
21
25
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
9.8
136
790
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
56.5
9.7
11
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.0
9.4
37
99
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
+∞
9.4
9
*
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
+∞
9.4
9
*
P01BA02
ATC
hydroxychloroquine; oral
6.3
9.4
24
40
R51.80
ICD-10 Finland
Headache
2.7
9.1
67
283
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
16.1
9.1
14
9
G57.6
ICD-10 Finland
Lesion of plantar nerve
16.1
9.1
14
9
M23.8
ICD-10 Finland
Other internal derangements of knee
13.0
8.9
15
12
B01AB05
ATC
enoxaparin; parenteral
2.2
8.8
100
527
NF1AA
NOMESCO Finland
Hip X-ray examination
5.3
8.8
26
52
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.8
8.8
24
44
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.4
8.7
81
386
Z48.0
ICD-10 Finland
Attention to surgical dressings and sutures
5.4
8.6
25
49
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
9.3
8.6
17
19
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.4
8.5
41
131
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.4
8.4
41
132
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
8.4
8
*
7364B
ICD-9 Finland
Other acquired deformities of limbs, Genu valgum or varum (acquired)[GENU VARUM ACQUISITUM]
+∞
8.4
8
*
TQW40
NOMESCO Finland
Remowal of suture of skin
3.9
8.3
33
90
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
8.2
135
829
R4110
SPAT
NA
6.5
8.1
20
32
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.6
8.1
36
108
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
8.1
68
309
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
6.8
8.0
19
29
M01AH01
ATC
celecoxib; oral (coxibs)
2.6
7.9
59
251
L15
ICPC
Knee symptom/complaint
2.5
7.8
66
297
NH3EA
NOMESCO Finland
Feet X-ray examination with load
45.9
7.7
9
*
R5110
SPAT
NA
6.9
7.7
18
27
Z29.8
ICD-10 Finland
Other specified prophylactic measures
6.9
7.7
18
27
ZXC84
NOMESCO Finland
Bloodless operation space
18.8
7.6
11
6
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
25.6
7.6
10
*
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
81.6
7.4
8
*
N02BE01
ATC
paracetamol; systemic, rectal
2.1
7.3
305
2565
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
+∞
7.3
7
*
M22.1
ICD-10 Finland
Recurrent subluxation of patella
+∞
7.3
7
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
7.3
7
*
M03BC51
ATC
orphenadrine, combinations; systemic
2.0
7.3
110
646
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
16.1
7.3
11
7
NF1DA
NOMESCO Finland
X-ray of hips
30.6
7.2
9
*
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.3
7.1
25
61
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
4.3
7.1
25
61
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
7.1
73
364
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
4.8
7.0
22
48
B01AF01
ATC
rivaroxaban; oral
3.6
7.0
30
88
L88
ICPC
Rheumatoid/seropositive arthritis
14.1
6.9
11
8
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
14.1
6.9
11
8
EB1CA
NOMESCO Finland
Tooth X-ray additional picture
2.7
6.9
45
178
TNX39
NOMESCO Finland
Other orthopedic bandage, unspecified region
11.2
6.8
12
11
M01AB05
ATC
diclofenac; systemic, rectal
1.8
6.7
227
1745
J01DA01
ATC
[U] cefalexin; systemic
1.8
6.6
222
1695
R52.9
ICD-10 Finland
Pain, unspecified
3.2
6.6
34
115
L89
ICPC
Osteoarthrosis of hip
12.5
6.6
11
9
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.9
6.5
17
30
NJ3NA
NOMESCO Finland
Measurement of difference in extremity lengty with X-ray
71.0
6.4
7
*
SPAT1153
SPAT
Removal of sutures
1.9
6.4
104
626
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
11.3
6.3
11
10
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
9.5
6.3
12
13
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
18.4
6.3
9
5
M25.2
ICD-10 Finland
Flail joint
+∞
6.3
6
*
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
+∞
6.3
6
*
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
27.2
6.2
8
*
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
27.2
6.2
8
*
L90
ICPC
Osteoarthrosis of knee
6.5
6.2
15
24
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
3.5
6.2
27
81
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
12.8
6.1
10
8
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
6.1
78
426
Mortality – FinRegistry
↥Association
Association between endpoint M13_VARUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VARUS | 0.983 [0.85, 1.14] | 0.816 |
| Birth year | 0.994 [0.99, 1.0] | 0.151 |
During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 2081 females with M13_VARUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VARUS | 0.887 [0.73, 1.08] | 0.242 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 763 males with M13_VARUS died.
Mortality risk
Mortality risk for people of age
years, who have M13_VARUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.182% |
| 5 | 0.453% | 1.075% |
| 10 | 1.299% | 2.474% |
| 15 | 2.626% | 4.632% |
| 20 | 4.587% | 7.824% |
Relationships between endpoints
↥Index endpoint: M13_VARUS – Varus deformity, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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