No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
284 |
4. Check minimum number of eventsNone |
284 |
5. Include endpointsNone |
284 |
6. Filter based on genotype QC (FinnGen only) |
284 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M21
- Name in latin
- Deformitas membri valga non alibi classificata
Similar endpoints
↥List of similar endpoints to
Valgus deformity, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2937 | 1838 | 1089 |
| Only index persons | 2579 | 1613 | 966 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 35.31 | 47.23 | 14.96 |
| Only index persons | 34.02 | 45.33 | 15.13 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 284 | 201 | 83 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | 40.54 | 45.50 | 28.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 255
- Matched controls
- 2549
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.0
ICD-10 Finland
Valgus deformity, not elsewhere classified
+∞
250.0
197
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
131.8
72.6
75
8
M17.1
ICD-10 Finland
Other primary gonarthrosis
38.8
47.6
60
20
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
191.0
46.5
47
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
45.2
42
*
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
39.6
37
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
21.4
37.6
56
33
M19.0
ICD-10 Finland
Primary arthrosis of other joints
80.9
37.2
41
6
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
27.6
26
*
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
27.6
26
*
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
52.0
27.2
32
7
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
22.5
25.7
37
19
M25.5
ICD-10 Finland
Pain in joint
5.7
25.3
83
199
73802
ICD-8 Finland
Other deformities, Genu valgum
+∞
21.1
20
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
227.8
20.9
21
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
10.6
20.8
41
45
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
52.7
20.5
24
5
M01AX05
ATC
glucosamine; oral
5.8
19.7
60
128
ZXA00
NOMESCO Finland
Right side
4.1
19.0
88
291
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
35.9
18.3
23
7
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
17.9
17
*
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
+∞
17.9
17
*
N02AX02
ATC
tramadol; systemic, rectal
3.4
17.9
114
484
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
15.6
17.3
28
20
M20.2
ICD-10 Finland
Hallux rigidus
+∞
16.9
16
*
M13.9
ICD-10 Finland
Arthritis, unspecified
19.6
16.8
25
14
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
181.4
16.7
17
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
43.2
16.6
20
5
WX320
NOMESCO Finland
Spinalanesthesy
4.6
16.2
62
168
M79.6
ICD-10 Finland
Pain in limb
3.3
16.1
106
452
L15
ICPC
Knee symptom/complaint
4.3
15.9
65
188
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
90.8
15.8
17
*
N03AX12
ATC
gabapentin; oral
5.0
15.6
54
131
M01AH05
ATC
etoricoxib; oral
3.0
15.6
149
817
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.1
15.5
123
595
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
10.4
14.9
29
31
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
20.6
14.5
21
11
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
32.1
14.1
18
6
ZXA05
NOMESCO Finland
Left side
3.5
13.9
75
272
73800
ICD-8 Finland
Other deformities, Coxa valga
+∞
13.7
13
*
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
+∞
13.7
13
*
9271
FHL
Hallux surgery
+∞
13.7
13
*
NFK20
NOMESCO Finland
Epiphysiodesis of femur
+∞
13.7
13
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
9.9
13.1
26
29
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
25.9
12.6
17
7
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
12.6
12
*
7364A
ICD-9 Finland
Other acquired deformities of limbs, Genu valgum or varum (acquired)[GENU VALGUM ACQUISITUM]
+∞
12.6
12
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.2
12.4
39
85
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
39.7
12.3
15
*
L17
ICPC
Foot/toe symptom/complaint
3.0
11.8
81
343
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
11.5
11
*
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
125.4
11.5
12
*
N03AX16
ATC
pregabalin; oral
3.3
11.5
66
246
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
45.4
11.0
13
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
10.9
94
453
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.7
10.5
48
150
NHG82
NOMESCO Finland
Fusion of other tarsal joint
114.5
10.5
11
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
114.5
10.5
11
*
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
10.5
10
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
10.5
10
*
M21.1
ICD-10 Finland
Varus deformity, not elsewhere classified
+∞
10.5
10
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
+∞
10.5
10
*
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
6.5
10.1
26
44
NH3EA
NOMESCO Finland
Feet X-ray examination with load
27.3
9.9
13
5
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
5.4
9.8
29
59
B01AF01
ATC
rivaroxaban; oral
5.2
9.7
30
64
M18.1
ICD-10 Finland
Other primary arthrosis of first carpometacarpal joint
57.2
9.7
11
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
15.8
9.6
15
10
S18
ICPC
Laceration/cut
2.4
9.6
105
570
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
+∞
9.4
9
*
J01FF01
ATC
clindamycin; systemic
2.7
9.4
75
341
L28
ICPC
Limited function/disability (L)
3.6
9.4
43
135
WX702
NOMESCO Finland
Supraglottic ventilation device
6.0
9.3
25
45
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
8.5
9.0
19
24
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.6
9.0
76
359
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
7.7
8.9
20
28
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
11.3
8.9
16
15
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
6.1
8.7
23
41
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
93.0
8.5
9
*
M22.0
ICD-10 Finland
Recurrent dislocation of patella
93.0
8.5
9
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
93.0
8.5
9
*
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
93.0
8.5
9
*
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
+∞
8.4
8
*
NG1DA
NOMESCO Finland
X-ray of knees
+∞
8.4
8
*
B01AB05
ATC
enoxaparin; parenteral
2.6
8.3
69
320
P01BA02
ATC
hydroxychloroquine; oral
7.2
8.2
19
28
N02BE01
ATC
paracetamol; systemic, rectal
2.5
8.2
209
1645
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
34.5
8.1
10
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
22.9
8.1
11
5
N06AX21
ATC
duloxetine; oral
3.7
8.1
35
105
M54.5
ICD-10 Finland
Low back pain
2.4
8.0
80
407
1221
FHL
Arthroscopy and meniscus surgery
46.4
7.8
9
*
M67.0
ICD-10 Finland
Short Achilles tendon (acquired)
46.4
7.8
9
*
E66.00
ICD-10 Finland
Metabolic syndrome
5.5
7.8
22
43
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.9
7.6
24
53
M01AB05
ATC
diclofenac; systemic, rectal
2.1
7.5
154
1076
H02AB06
ATC
prednisolone; systemic
2.1
7.5
108
651
N06AA09
ATC
amitriptyline; systemic
3.9
7.4
30
85
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
6.6
7.4
18
29
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
7.3
7
*
Q74.1
ICD-10 Finland
Congenital malformation of knee
+∞
7.3
7
*
7363A
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformities of hip[COXA VALGA ACQUISITA]
+∞
7.3
7
*
M23.3
ICD-10 Finland
Other meniscus derangements
+∞
7.3
7
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
+∞
7.3
7
*
7360A
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformities of forearm, excluding fingers[CUBITUS VALGUS ACQUISITUS]
+∞
7.3
7
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
7.3
7
*
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
+∞
7.3
7
*
M70.6
ICD-10 Finland
Trochanteric bursitis
3.6
7.1
32
99
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.9
7.1
28
78
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
7.0
96
562
L13
ICPC
Hip symptom/complaint
3.3
7.0
34
112
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
14.3
7.0
11
8
9165
FHL
Removal of osteosynthesis material
14.3
7.0
11
8
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.6
6.9
23
54
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
41.2
6.8
8
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
41.2
6.8
8
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
41.2
6.8
8
*
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
41.2
6.8
8
*
R03BA01
ATC
beclometasone; inhalant
2.8
6.8
43
170
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.8
6.8
28
81
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.8
6.8
16
25
G57.6
ICD-10 Finland
Lesion of plantar nerve
12.7
6.6
11
9
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
5.3
6.6
19
38
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
6.6
50
217
TQW40
NOMESCO Finland
Remowal of suture of skin
4.5
6.6
22
52
M01AC06
ATC
meloxicam; systemic, rectal
2.2
6.6
82
458
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
4.4
6.5
22
53
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
6.5
71
375
SAA01
NOMESCO Finland
Simple examination of mouth
2.1
6.5
186
1444
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.6
6.5
49
213
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
8.5
6.4
13
16
M19.8
ICD-10 Finland
Other specified arthrosis
11.4
6.4
11
10
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
11.4
6.4
11
10
J01DA01
ATC
[U] cefalexin; systemic
2.0
6.3
155
1129
SPAT1153
SPAT
Removal of sutures
2.2
6.3
72
387
NH1EA
NOMESCO Finland
Ankle X-ray examination with load or wrench
+∞
6.3
6
*
NHK68
NOMESCO Finland
Shortening or lengthening osteotomy of ankle or foot
+∞
6.3
6
*
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
6.3
6
*
Q66.0
ICD-10 Finland
Talipes equinovarus
+∞
6.3
6
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.3
6.3
31
104
A02BC01
ATC
omeprazole; systemic
2.2
6.2
66
343
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
12.9
6.1
10
8
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
10.4
6.1
11
11
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
6.0
108
697
Mortality – FinRegistry
↥Association
Association between endpoint M13_VALGUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VALGUS | 0.979 [0.79, 1.21] | 0.846 |
| Birth year | 0.994 [0.99, 1.0] | 0.186 |
During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 1234 females with M13_VALGUS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have M13_VALGUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.108% | No data |
| 5 | 0.609% | No data |
| 10 | 1.436% | No data |
| 15 | 2.867% | No data |
| 20 | 4.812% | No data |
Relationships between endpoints
↥Index endpoint: M13_VALGUS – Valgus deformity, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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