panniculitis: a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the fatty layer under the skin - panniculus adiposus). Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
375 |
4. Check minimum number of eventsNone |
375 |
5. Include endpointsNone |
375 |
6. Filter based on genotype QC (FinnGen only) |
375 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M79
- Name in latin
- Panniculitis non specificata
Similar endpoints
↥List of similar endpoints to
Panniculitis, unspecified
based on the number of shared cases.
Similar with more cases:
- Other soft tissue disorders, not elsewhere classified
- Soft tissue disorders
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2209 | 1489 | 709 |
| Only index persons | 2001 | 1370 | 631 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.09 | 58.14 | 57.96 |
| Only index persons | 57.31 | 57.27 | 57.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 375 | 251 | 124 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.05 |
| Median age at first event (years) | 57.53 | 54.83 | 63.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 342
- Matched controls
- 3420
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M79.3
ICD-10 Finland
Panniculitis, unspecified
4503599627370496.0
323.0
330
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.3
53.7
110
138
L52
ICD-10 Finland
Erythema nodosum
244.9
42.9
43
*
M79.6
ICD-10 Finland
Pain in limb
4.1
28.1
139
487
H02AB06
ATC
prednisolone; systemic
3.2
22.7
197
1030
A46
ICD-10 Finland
Erysipelas
4.7
21.8
81
210
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
6.0
21.4
62
121
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.9
20.6
73
179
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
20.1
179
925
P01BA02
ATC
hydroxychloroquine; oral
5.9
20.0
59
117
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.2
19.1
79
226
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
18.5
77
221
M79.0
ICD-10 Finland
Rheumatism, unspecified
52.9
17.2
20
*
N02AX02
ATC
tramadol; systemic, rectal
2.7
16.8
163
853
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.5
16.6
89
314
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
16.0
122
549
E66.8
ICD-10 Finland
Other obesity
7.4
15.8
38
57
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.2
15.7
64
178
7293X
ICD-9 Finland
Other disorders of soft tissues, Panniculitis, unspecified[PANNICULITIS NUD]
+∞
15.7
15
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
15.4
144
730
N03AX12
ATC
gabapentin; oral
3.9
15.0
67
203
A02BC02
ATC
pantoprazole; systemic
2.6
14.8
235
1581
D07AC01
ATC
betamethasone; topical
2.6
14.6
141
721
J01FF01
ATC
clindamycin; systemic
2.8
14.1
108
480
R50.9
ICD-10 Finland
Fever, unspecified
3.7
14.0
66
208
J01DB01
ATC
cefalexin; oral
2.9
13.7
287
2200
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
4.4
13.6
51
131
M79.7
ICD-10 Finland
Fibromyalgia
19.2
13.5
20
11
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
13.5
139
732
E0000UV
ATC
NA
2.4
13.1
159
907
M25.5
ICD-10 Finland
Pain in joint
2.7
12.7
103
469
N03AX16
ATC
pregabalin; oral
2.9
12.7
90
377
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
4.1
12.2
49
134
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
12.2
132
706
M13.9
ICD-10 Finland
Arthritis, unspecified
5.1
12.1
38
81
X59
ICD-10 Finland
Exposure to unspecified factor
3.1
12.1
74
281
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
11.1
11.9
22
21
C03CA01
ATC
furosemide; systemic
2.5
11.8
111
548
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
14.3
11.6
19
14
L88
ICD-10 Finland
Pyoderma gangrenosum
+∞
11.5
11
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.2
11.5
65
235
ZXA00
NOMESCO Finland
Right side
2.5
11.3
102
489
L04AX01
ATC
azathioprine; systemic
5.7
11.2
32
61
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.3
11.1
41
104
TQW80
NOMESCO Finland
Local dermatologic skincare
8.2
11.1
24
31
J01DA01
ATC
[U] cefalexin; systemic
2.2
11.0
224
1578
D07AD01
ATC
clobetasol; topical
2.9
11.0
73
293
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.2
11.0
42
110
J01MA02
ATC
ciprofloxacin; systemic
2.3
10.9
145
842
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
10.1
10.9
21
22
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.7
10.9
37
86
R03AC02
ATC
salbutamol; inhalant
2.2
10.8
183
1187
P01AB01
ATC
metronidazole; oral, rectal
2.2
10.7
147
866
SPAT1263
SPAT
Sampling
2.2
10.7
154
928
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
62.0
10.7
12
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.2
10.6
152
912
SPAT1153
SPAT
Removal of sutures
2.3
10.4
121
659
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
13.7
10.3
17
13
S18
ICPC
Laceration/cut
2.2
10.2
149
896
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.8
10.1
69
281
S97
ICPC
Chronic ulcer skin
4.8
10.0
33
75
A18.4
ICD-10 Finland
Tuberculosis of skin and subcutaneous tissue
+∞
9.4
9
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
9.4
72
311
UJF32
NOMESCO Finland
Coloscopy
2.3
9.4
103
542
R51.80
ICD-10 Finland
Headache
3.0
9.4
56
207
ZXA05
NOMESCO Finland
Left side
2.3
9.3
97
497
T90
ICPC
Diabetes non-insulin dependent
2.4
9.3
91
452
M01AC06
ATC
meloxicam; systemic, rectal
2.1
9.1
123
710
L17
ICPC
Foot/toe symptom/complaint
2.3
9.0
93
474
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
9.0
84
405
N06AX21
ATC
duloxetine; oral
3.5
8.9
42
132
M79.1
ICD-10 Finland
Myalgia
3.4
8.9
43
138
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
8.9
79
370
UJF30
NOMESCO Finland
Ileoscopy through colon
3.2
8.7
48
167
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.2
8.6
45
153
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.2
8.6
45
153
M01AH05
ATC
etoricoxib; oral
2.0
8.6
193
1353
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
7.7
8.6
19
26
B01AB05
ATC
enoxaparin; parenteral
2.1
8.4
112
634
J01MA12
ATC
levofloxacin; systemic
2.5
8.4
72
333
PH2DE
NOMESCO Finland
Ultrasound examination of bloodflow in veins of lower extremity with Doppler method
7.9
8.3
18
24
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.3
8.3
90
467
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
8.2
47
170
M79.9
ICD-10 Finland
Soft tissue disorder, unspecified
34.2
8.1
10
*
R42
ICD-10 Finland
Dizziness and giddiness
2.3
8.1
81
403
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
8.1
199
1430
M67.4
ICD-10 Finland
Ganglion
5.7
8.0
22
41
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.4
7.9
69
320
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
7.9
130
804
Z3231
NOMESCO Finland
Registered nurse
2.2
7.9
95
516
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
7.7
90
481
M76.6
ICD-10 Finland
Achilles tendinitis
6.0
7.6
20
35
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
12.2
7.6
13
11
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.9
7.6
30
82
H02AB07
ATC
prednisone; oral
2.7
7.5
53
217
A02BC01
ATC
omeprazole; systemic
2.1
7.5
99
555
WX002
NOMESCO Finland
Sedation and analgesia
2.3
7.5
73
358
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
7.5
92
501
J45.8
ICD-10 Finland
Mixed asthma
7.1
7.4
17
25
A08
ICPC
Swelling
5.4
7.4
21
41
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.6
7.4
32
95
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.1
7.3
100
570
D07AC13
ATC
mometasone; topical
2.0
7.1
106
624
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
5.4
7.1
20
39
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
7.0
41
151
A02BC05
ATC
esomeprazole; systemic
1.9
7.0
140
918
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.6
7.0
23
53
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.4
7.0
24
58
E66.9
ICD-10 Finland
Obesity, unspecified
5.2
6.9
20
40
E000001
ATC
NA
2.2
6.9
81
430
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.3
6.8
24
59
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.3
6.8
33
107
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
40.9
6.8
8
*
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
40.9
6.8
8
*
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
17.1
6.8
10
6
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
17.1
6.8
10
6
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.4
6.8
32
102
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.4
6.7
19
37
J01FA06
ATC
roxithromycin; oral
1.9
6.7
139
917
M01AE01
ATC
ibuprofen; systemic, rectal
2.3
6.7
301
2611
L08
ICPC
Shoulder symptom/complaint
2.4
6.7
59
275
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.8
6.7
27
76
M02AA07
ATC
piroxicam; topical
1.9
6.6
123
783
R03BA02
ATC
budesonide; inhalant
2.3
6.6
65
319
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
6.5
96
559
A01AB09
ATC
miconazole; local oral
2.9
6.5
39
147
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
6.5
65
323
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
6.5
58
273
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
5.4
6.4
18
35
L86
ICPC
Back syndrome with radiating pain
4.8
6.4
20
44
SPAT1262
SPAT
Handing over of treatment supplies
2.2
6.4
70
361
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.1
6.4
34
119
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
6.4
55
254
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
9.5
6.3
12
13
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.8
6.3
38
144
C07AB07
ATC
bisoprolol; oral
1.8
6.3
151
1043
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.2
6.3
68
350
N06AA09
ATC
amitriptyline; systemic
2.8
6.2
39
148
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
6.2
82
456
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
6.2
82
458
A10AE04
ATC
insulin glargine; parenteral
2.8
6.2
39
150
J01DA09
ATC
[U] cefadroxil; inhalant, oral
2.0
6.2
92
539
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
6.2
59
287
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
6.2
49
217
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
6.1
40
159
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
6.1
96
571
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
6.1
90
525
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
12.8
6.1
10
8
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
6.1
53
245
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
6.2
6.1
15
25
M48.0
ICD-10 Finland
Spinal stenosis
2.7
6.0
40
161
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.0
6.0
32
112
Mortality – FinRegistry
↥Association
Association between endpoint M13_PANNICULITISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PANNICULITISNAS | 1.38 [1.15, 1.66] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.527 |
During the follow-up period (1.1.1998 — 31.12.2019), 280 out of 1244 females with M13_PANNICULITISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PANNICULITISNAS | 1.738 [1.29, 2.34] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 552 males with M13_PANNICULITISNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_PANNICULITISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.178% | 0.309% |
| 5 | 0.897% | 1.926% |
| 10 | 2.107% | 4.525% |
| 15 | 4.121% | 8.675% |
| 20 | 7.064% | 14.637% |
Relationships between endpoints
↥Index endpoint: M13_PANNICULITISNAS – Panniculitis, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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