mixed connective tissue disease: Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus , scleroderma , and polymyositis . Some affected people may also have symptoms of rheumatoid arthritis . Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) , corticosteroids and immunosuppresivedrugsmay help manage the symptoms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
667 |
4. Check minimum number of eventsNone |
667 |
5. Include endpointsNone |
667 |
6. Filter based on genotype QC (FinnGen only) |
667 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M35
- Name in latin
- Alia syndromata mixta
Similar endpoints
↥List of similar endpoints to
Other overlap syndromes
based on the number of shared cases.
Similar with more cases:
- Mixed connective tissue disease
- Other systemic involvement of connective tissue (FG)
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3427 | 2668 | 727 |
| Only index persons | 3153 | 2488 | 665 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.08 | 0.02 |
| Only index persons | 0.08 | 0.09 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 55.82 | 55.40 | 57.44 |
| Only index persons | 55.07 | 54.63 | 56.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 667 | 514 | 153 |
| Unadjusted period prevalence (%) | 0.15 | 0.18 | 0.07 |
| Median age at first event (years) | 52.71 | 50.78 | 59.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 605
- Matched controls
- 6048
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P01BA02
ATC
hydroxychloroquine; oral
55.3
323.0
412
224
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
323.0
605
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
44.2
312.2
417
288
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
370.5
169.0
163
6
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
2100.6
167.8
155
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
19.2
165.5
275
251
H02AB06
ATC
prednisolone; systemic
10.0
128.9
501
1972
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
18.6
126.9
207
164
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.6
100.2
402
1400
L04AX01
ATC
azathioprine; systemic
21.3
98.6
150
92
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
92.1
86
*
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
455.7
82.0
80
*
C08CA05
ATC
nifedipine; systemic
12.7
81.2
154
158
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
11.8
80.0
158
176
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
13.2
61.4
112
102
XX9XE
NOMESCO Finland
Other ultrasound examination
76.3
60.6
68
10
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.0
59.6
135
186
H02AB07
ATC
prednisone; oral
5.7
57.9
194
463
M35.3
ICD-10 Finland
Polymyalgia rheumatica
23.8
56.2
81
39
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
55.1
364
1677
L88
ICPC
Rheumatoid/seropositive arthritis
14.1
52.9
93
77
PAW37
NOMESCO Finland
Biopsy of temporal artery
482.2
45.9
45
*
M05BA04
ATC
alendronic acid; oral
6.0
43.7
132
268
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
8.1
42.8
102
148
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
6.0
42.6
128
257
L04AA06
ATC
mycophenolic acid; systemic
22.5
41.9
61
30
I73.0
ICD-10 Finland
Raynaud syndrome
25.6
38.7
54
23
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
37.9
36
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
35.3
251
1098
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.0
31.9
75
105
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
30.5
29
*
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
+∞
29.4
28
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.3
28.7
175
669
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
28.3
27
*
R50.9
ICD-10 Finland
Fever, unspecified
3.6
27.2
140
467
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
25.0
169
682
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
12.1
24.1
44
39
XPX04
NOMESCO Finland
Angioscopy
56.4
23.2
27
5
A02BC02
ATC
pantoprazole; systemic
2.5
23.1
435
3071
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
23.1
22
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
23.1
22
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
22.3
308
1848
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.7
21.6
47
58
M13.9
ICD-10 Finland
Arthritis, unspecified
4.7
21.5
76
178
R4120
NOMESCO Finland
Occupational therapy
4.5
20.9
77
188
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
5.0
20.7
69
152
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
7.8
20.6
48
66
H04.10
ICD-10 Finland
Dry eye syndrome
3.6
20.3
99
312
ZX120
NOMESCO Finland
Intravenous
3.7
20.0
94
287
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.8
19.1
86
253
SBA10
NOMESCO Finland
Measurement of excretion of saliva
16.5
19.0
30
19
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
9.6
18.6
38
42
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
8.4
18.6
41
52
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.8
18.3
134
556
M35.5
ICD-10 Finland
Multifocal fibrosclerosis
+∞
17.8
17
*
7108X
ICD-9 Finland
Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue
+∞
17.8
17
*
A02BC03
ATC
lansoprazole; oral
2.3
17.6
214
1168
E0000UV
ATC
NA
2.1
17.1
273
1680
XG410
NOMESCO Finland
Flow-volume spirometry
5.8
17.0
49
91
M05BA07
ATC
risedronic acid; oral
5.8
17.0
49
91
R06.0
ICD-10 Finland
Dyspnoea
2.4
16.8
182
935
L04AA13
ATC
leflunomide; oral
7.1
16.8
41
61
M33.2
ICD-10 Finland
Polymyositis
+∞
16.7
16
*
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
+∞
16.7
16
*
H02AB04
ATC
methylprednisolone; systemic
2.8
16.7
123
513
C08CA02
ATC
felodipine; oral
3.5
16.4
80
251
A02BC01
ATC
omeprazole; systemic
2.3
16.4
198
1073
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
16.3
105
402
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
15.7
84
282
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.5
15.6
135
613
I77.6
ICD-10 Finland
Arteritis, unspecified
87.4
15.6
17
*
L04AD01
ATC
ciclosporin; systemic
11.2
15.6
29
27
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
39.1
15.5
19
5
A07EC01
ATC
sulfasalazine; oral, rectal
3.5
15.3
75
236
N02AX02
ATC
tramadol; systemic, rectal
2.0
15.2
271
1723
L04AA01
ATC
[U] ciclosporin; systemic
10.4
15.1
29
29
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.6
14.6
69
211
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
14.4
148
734
A07AA02
ATC
nystatin; oral
3.8
14.3
63
181
J01FF01
ATC
clindamycin; systemic
2.2
14.2
184
1017
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.1
13.9
82
294
TGC00
NOMESCO Finland
Bronchial lavation
7.9
13.8
31
41
WZA10
NOMESCO Finland
Long statement of health and health related matters
12.4
13.7
24
20
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
13.6
13
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
13.6
13
*
M35
ICD-10 Finland
Other systemic involvement of connective tissue
143.0
13.5
14
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
13.4
80
290
TEA00
NOMESCO Finland
Biopsy of lip
19.6
13.0
19
10
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
5.6
12.9
37
69
NH3EA
NOMESCO Finland
Feet X-ray examination with load
6.7
12.8
32
50
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.1
12.8
74
263
M35.7
ICD-10 Finland
Hypermobility syndrome
32.8
12.6
16
5
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.0
12.6
77
284
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
12.5
12
*
P01BA01
ATC
chloroquine; systemic
24.9
12.5
17
7
A02BC05
ATC
esomeprazole; systemic
1.9
12.1
265
1769
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.7
12.1
54
158
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.5
11.9
42
99
J01MA14
ATC
moxifloxacin; systemic
3.2
11.7
65
222
C03CA01
ATC
furosemide; systemic
2.0
11.7
167
949
C08CA01
ATC
amlodipine; oral
1.9
11.7
210
1303
NXL00
NOMESCO Finland
Biopsy of muscle
66.2
11.6
13
*
L01AA01
ATC
cyclophosphamide; systemic
66.2
11.6
13
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
6.9
11.6
28
42
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.4
11.5
56
175
J01MA12
ATC
levofloxacin; systemic
2.3
11.5
120
594
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.8
11.5
38
84
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
8.1
11.5
25
32
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
11.2
152
844
M01AH01
ATC
celecoxib; oral (coxibs)
2.2
11.2
131
682
M05BX04
ATC
denosumab; parenteral
3.7
11.1
48
137
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.1
11.0
62
216
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
7.1
11.0
26
38
A02BA02
ATC
ranitidine; systemic
2.1
10.9
135
719
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.1
10.8
60
206
J01DB01
ATC
cefalexin; oral
2.0
10.7
499
4232
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.8
10.7
45
125
M60.9
ICD-10 Finland
Myositis, unspecified
21.9
10.7
15
7
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
13.2
10.7
18
14
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
9.4
10.6
21
23
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
111.8
10.4
11
*
M33.9
ICD-10 Finland
Dermatopolymyositis, unspecified
+∞
10.4
10
*
G73.7*M35.0
ICD-10 Finland
Myopathy in sicca syndrome [Sjögren]
+∞
10.4
10
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
10.4
10
*
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
+∞
10.4
10
*
M31.6
ICD-10 Finland
Other giant cell arteritis
+∞
10.4
10
*
M13.0
ICD-10 Finland
Polyarthritis, unspecified
9.8
10.3
20
21
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
9.8
10.3
20
21
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.2
10.2
53
175
D07AC01
ATC
betamethasone; topical
1.8
10.2
222
1458
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
10.1
58
205
M01AC06
ATC
meloxicam; systemic, rectal
1.8
10.1
235
1578
UJF32
NOMESCO Finland
Coloscopy
2.0
10.1
157
917
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
6.1
9.9
26
44
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
9.9
170
1028
L93.0
ICD-10 Finland
Discoid lupus erythematosus
20.4
9.8
14
7
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
9.8
88
403
G04BE03
ATC
sildenafil; oral
13.6
9.7
16
12
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.9
9.7
39
105
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.8
9.6
31
67
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
9.5
79
348
D64.9
ICD-10 Finland
Anaemia, unspecified
2.6
9.4
67
272
M33.1
ICD-10 Finland
Other dermatomyositis
+∞
9.4
9
*
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
9.4
9
*
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
9.4
9
*
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
9.4
9
*
L20
ICPC
Joint symptom/complaint NOS
4.4
9.3
33
79
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
7.5
9.3
21
29
UJF30
NOMESCO Finland
Ileoscopy through colon
2.6
9.3
69
287
TNG10
NOMESCO Finland
Puncture of knee
11.7
9.1
16
14
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.5
9.0
31
72
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
7.6
9.0
20
27
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
6.1
8.8
23
39
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
9.7
8.8
17
18
A01AB04
ATC
amphotericin B; local oral
3.3
8.7
43
137
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
8.7
180
1148
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.8
8.7
55
207
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
5.2
8.7
26
52
M25.5
ICD-10 Finland
Pain in joint
1.8
8.7
181
1161
K11.2
ICD-10 Finland
Sialoadenitis
4.0
8.7
33
85
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
8.6
251
1783
L99
ICPC
Musculoskeletal disease other
6.4
8.4
21
34
M01AH02
ATC
rofecoxib; oral
2.2
8.4
92
462
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
8.7
8.3
17
20
J02AC01
ATC
fluconazole; systemic
1.7
8.3
275
2017
N03AX16
ATC
pregabalin; oral
1.8
8.3
154
948
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
14.7
8.2
13
9
M05BB03
ATC
alendronic acid and colecalciferol; oral
4.8
8.2
26
56
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.6
8.1
27
61
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.6
8.1
35
101
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
8.1
58
235
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
5.4
8.1
23
44
GD1AD
NOMESCO Finland
Thorax CT examination
4.0
8.1
31
81
J01MA02
ATC
ciprofloxacin; systemic
1.7
8.0
221
1535
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
7.9
110
611
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.3
7.8
37
116
ELA30
NOMESCO Finland
Biopsy of salivary gland
45.6
7.7
9
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.1
7.7
28
70
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
7.7
85
428
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.5
7.6
34
101
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
18.6
7.6
11
6
K11.70
ICD-10 Finland
Hypoptyalism
12.0
7.6
13
11
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.4
7.6
35
107
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
6.6
7.5
18
28
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
7.4
54
221
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
81.0
7.4
8
*
C02KX01
ATC
bosentan; oral
81.0
7.4
8
*
C02KX04
ATC
macitentan; oral
81.0
7.4
8
*
R1250
NOMESCO Finland
Evaluation of functional capability
5.7
7.4
20
36
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
5.7
7.4
20
36
D68.8
ICD-10 Finland
Other specified coagulation defects
8.5
7.4
15
18
M01AB55
ATC
diclofenac, combinations; oral
2.7
7.3
50
198
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
7.3
7
*
M35.2
ICD-10 Finland
Behçet disease
+∞
7.3
7
*
M01AH05
ATC
etoricoxib; oral
1.6
7.3
344
2733
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
7.3
59
256
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
7.2
209
1462
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.3
7.2
34
106
R4110
NOMESCO Finland
Physiotherapy
1.7
7.2
157
1010
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
20.3
7.1
10
5
H02AB09
ATC
hydrocortisone; systemic
4.6
7.1
23
51
N06AX21
ATC
duloxetine; oral
2.2
7.1
71
342
N03AX12
ATC
gabapentin; oral
2.0
7.1
99
548
B99
ICD-10 Finland
Other and unspecified infectious diseases
6.1
7.1
18
30
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
12.2
7.1
12
10
ZX140
NOMESCO Finland
Intra articular
8.9
7.1
14
16
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
7.1
79
400
A01AB09
ATC
miconazole; local oral
2.2
7.1
70
335
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
7.7
6.9
15
20
J05AB11
ATC
valaciclovir; oral
2.0
6.8
86
459
L04.0
ICD-10 Finland
Acute lymphadenitis of face, head and neck
9.5
6.8
13
14
NF1AA
NOMESCO Finland
Hip X-ray examination
2.4
6.8
56
245
NK6PA
NOMESCO Finland
Measurement of bone density from one location with X-ray
40.5
6.8
8
*
J05AB01
ATC
aciclovir; systemic
1.8
6.8
137
861
N06AA09
ATC
amitriptyline; systemic
2.2
6.8
68
327
E000001
ATC
NA
1.8
6.7
126
771
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.2
6.7
66
316
M06
ICD-10 Finland
Other rheumatoid arthritis
22.8
6.7
9
*
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
6.0
6.6
17
29
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
12.4
6.6
11
9
H25.8
ICD-10 Finland
Other senile cataract
2.2
6.6
65
312
E000002
ATC
NA
2.1
6.5
71
354
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
6.3
6.5
16
26
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.5
6.5
48
199
S01XA18
ATC
ciclosporin; ophthalmic
14.5
6.4
10
7
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
6.4
102
594
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
5.3
6.4
18
35
NDL52
NOMESCO Finland
Tenosynovectomy of hand
8.3
6.4
13
16
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
8.3
6.4
13
16
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.4
6.3
21
49
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
18.2
6.3
9
5
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
6.3
212
1531
7109X
ICD-9 Finland
Diffuse diseases of connective tissue, Unspecified diffuse connective tissue disease
+∞
6.3
6
*
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
6.3
6
*
N35.1
ICD-10 Finland
Postinfective urethral stricture, not elsewhere classified
+∞
6.3
6
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
6.2
58
272
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
5.4
6.2
17
32
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
6.2
62
300
TAB00
NOMESCO Finland
Lumbar puncture
3.4
6.2
28
86
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.7
6.1
19
41
H05AA02
ATC
teriparatide; parenteral
10.2
6.0
11
11
WX002
NOMESCO Finland
Sedation and analgesia
1.8
6.0
114
700
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.0
6.0
22
56
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.0
6.0
22
56
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.2
6.0
63
309
Mortality – FinRegistry
↥Association
Association between endpoint M13_OVERLAP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OVERLAP | 1.678 [1.46, 1.93] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 518 out of 2397 females with M13_OVERLAP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OVERLAP | 1.774 [1.42, 2.21] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 661 males with M13_OVERLAP died.
Mortality risk
Mortality risk for people of age
years, who have M13_OVERLAP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.263% |
| 5 | 1.046% | 1.899% |
| 10 | 2.575% | 4.915% |
| 15 | 4.769% | 8.96% |
| 20 | 8.273% | 15.286% |
Relationships between endpoints
↥Index endpoint: M13_OVERLAP – Other overlap syndromes
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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