Other specific arthropathies

M13_OTERSPECARTHR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M12.8
  • Hospital discharge: ICD-9 7164
  • Cause of death: ICD-10 M12.8
  • Cause of death: ICD-9 7164

2 out of 7 registries used, show all original rules.

66

4. Check minimum number of events

None

66

5. Include endpoints

None

66

6. Filter based on genotype QC (FinnGen only)

65

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M12
Name in latin
Aliae arthropathiae specificae non alibi classificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 538 264 268
Only index persons 487 239 248
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 43.11 48.62 37.31
Only index persons 39.19 46.04 32.59

-FinnGen-

Key figures

All Female Male
Number of individuals 65 36 29
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 47.57 49.10 45.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
66
Matched controls
661
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.8
ICD-10 Finland
Other specific arthropathies, not elsewhere classified
+∞
67.8
53
*
7164A
ICD-9 Finland
Other and unspecified arthropathies, Transient arthropathy
+∞
14.0
13
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
24.0
12.9
18
10
M19.0
ICD-10 Finland
Primary arthrosis of other joints
79.2
12.1
13
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
24.8
10.3
14
7
A07EC01
ATC
sulfasalazine; oral, rectal
24.8
10.3
14
7
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
17.1
9.7
15
11
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
+∞
9.6
9
*
M13.9
ICD-10 Finland
Arthritis, unspecified
19.7
9.0
13
8
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
102.3
8.6
9
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
102.3
8.6
9
*
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
102.3
8.6
9
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
38.5
8.3
10
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
25.8
8.3
11
5
M25.5
ICD-10 Finland
Pain in joint
6.3
8.1
23
51
P01BA02
ATC
hydroxychloroquine; oral
21.5
7.9
11
6
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
+∞
7.4
7
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
+∞
7.4
7
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
34.0
7.3
9
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
76.7
6.5
7
*
L88
ICPC
Rheumatoid/seropositive arthritis
29.7
6.4
8
*
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
29.7
6.4
8
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
11.7
6.3
11
11

Mortality – FinRegistry

Association

Association between endpoint M13_OTERSPECARTHR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_OTERSPECARTHR.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: M13_OTERSPECARTHR – Other specific arthropathies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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