Risteys · M13_OSTEOPATHYINOTH

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M90, M90.6C40.99, M90.6C41.99 Cause of death:* ICD-10 — M90, M90.6C40.99, M90.6*C41.99 2 out of 7 registries used, show all original rules.	234
4. Check minimum number of events None	234
5. Include endpoints None	234
6. Filter based on genotype QC (FinnGen only)	234

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1723	895	807
Only index persons	1430	752	678
Unadjusted period prevalence (%)
Whole population	0.02	0.03	0.02
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	67.00	67.82	66.10
Only index persons	66.54	67.84	65.10

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	234	127	107
Unadjusted period prevalence (%)	0.05	0.04	0.05
Median age at first event (years)	65.52	64.46	66.78

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
218: Matched controls
2181

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M90.7*C90.0

ICD-10 Finland

Pathological fracture in multiple myeloma

+∞

106.1

H02AB02

ATC

dexamethasone; systemic

21.9

73.9

119

113

WF049

NOMESCO Finland

Radiotherapy of metastasis

43.3

71.6

N02AA05

ATC

oxycodone; systemic

18.0

71.5

129

162

C90.0

ICD-10 Finland

Multiple myeloma

187.9

66.1

M90.7

ICD-10 Finland

Fracture of bone in neoplastic disease

+∞

55.6

L04AX04

ATC

lenalidomide; oral

297.7

48.1

9732/3-C42.1

ICD-O-3

Plasma cell myeloma of bone marrow

297.7

48.1

153

Kela drug reimbursment

Lenalidomid

203.8

48.0

C79.5

ICD-10 Finland

Secondary malignant neoplasm of bone and bone marrow

41.0

46.6

NF3AA

NOMESCO Finland

Femur X-ray examination

50.7

42.9

WF004

NOMESCO Finland

Palliative radiotherapy

40.7

42.6

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

21.1

41.6

M05BX04

ATC

denosumab; parenteral

20.8

39.5

L03AA02

ATC

filgrastim; parenteral

32.1

39.4

M84.4

ICD-10 Finland

Pathological fracture, not elsewhere classified

+∞

38.7

NE1AA

NOMESCO Finland

Pelvis X-ray examination

13.8

36.8

NFB60

NOMESCO Finland

Demanding prosthetic replacement of hip

71.6

36.7

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

6.4

35.6

138

464

Z51.5

ICD-10 Finland

Palliative care

13.7

35.3

A04AA01

ATC

ondansetron; systemic, rectal

12.4

35.0

C79.8

ICD-10 Finland

Secondary malignant neoplasm of other specified sites

17.7

31.3

329

Kela drug reimbursment

Lenalidomide

111.0

27.4

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

10.6

27.4

A49.9

ICD-10 Finland

Bacterial infection, unspecified

8.1

27.2

113

A03FA01

ATC

metoclopramide; systemic, rectal

5.8

27.0

242

NFR20

NOMESCO Finland

Incomplete excision of soft tissue tumour of hip or thigh

+∞

26.6

WD105

NOMESCO Finland

Cystostatic therapy of methastized malignancy

12.4

24.8

JN4BD

NOMESCO Finland

Extensive body CT

7.0

24.1

128

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

25.6

23.9

B03XA02

ATC

darbepoetin alfa; parenteral

22.6

23.0

ZXD05

NOMESCO Finland

Urgent procedure

4.3

21.8

110

417

ZX120

NOMESCO Finland

Intravenous

6.6

21.7

121

WX212

NOMESCO Finland

Femoral plexus blockade

20.6

21.6

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

10.8

21.3

WW300

NOMESCO Finland

Transfer of autologic stem cells

231.2

21.0

NFJ60

NOMESCO Finland

Internal fixation of fracture of other parts of femur with intramedullary nail

53.6

20.6

B01AB10

ATC

tinzaparin; parenteral

8.1

20.4

Z94.8

ICD-10 Finland

Other transplanted organ and tissue status

115.6

19.9

NBJ60

NOMESCO Finland

Internal fixation of fracture of shoulder or upper arm using intramedullary nail, humerus

219.1

19.9

TPH04

NOMESCO Finland

Cathetrisation of vein

4.4

19.6

286

WW500

NOMESCO Finland

Blood transfusion

12.1

19.6

ZX112

NOMESCO Finland

Subcutaneous

18.1

19.5

NJ3DA

NOMESCO Finland

Long bones of extremities X-ray examination

60.8

19.3

XW000

NOMESCO Finland

Bone marrow biopsy

10.9

19.1

M907, C6488

ICD-10 Finland

+∞

19.0

YN7BD

NOMESCO Finland

Extensive CT examination of spine for dose design of radiotherapy

109.6

18.9

393

Kela drug reimbursment

Pomalidomide

207.1

18.8

D48.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage

28.0

18.7

B01AB05

ATC

enoxaparin; parenteral

3.8

18.7

109

452

YL1BD

NOMESCO Finland

Extensive CT examination of pelvis for dose design of radiotherapy

15.6

18.4

A04AA02

ATC

granisetron; systemic, transdermal

9.9

18.1

WD515

NOMESCO Finland

Demanding therapy of malignancy with enzyme inhibitors and similar treatments

103.6

17.9

L04AX06

ATC

pomalidomide; oral

195.2

17.8

C03CA01

ATC

furosemide; systemic

3.7

17.7

103

421

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

13.2

17.7

AA1AA

NOMESCO Finland

Head X-ray examination

54.7

17.3

R4110

NOMESCO Finland

Physiotherapy

3.8

17.3

369

M04AA01

ATC

allopurinol; systemic

5.1

17.1

147

WD305

NOMESCO Finland

Simple therapy of methastized malignancy with biomodifiers

22.3

16.8

TPX10

NOMESCO Finland

Implantation of vascular injection port

16.0

16.8

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

3.5

16.3

104

450

M90.8*N25.0

ICD-10 Finland

Osteopathy in renal osteodystrophy

+∞

15.8

JN4AD

NOMESCO Finland

Body CT examination

5.9

15.1

A06AH03

ATC

naloxegol; oral

34.5

15.1

S42.3

ICD-10 Finland

Fracture of shaft of humerus

34.5

15.1

ZX090

NOMESCO Finland

Other technic of radiotherapy

10.6

15.0

WW402

NOMESCO Finland

Leucoferesis

+∞

14.7

YNB10

NOMESCO Finland

Collection of stem cells for transplant

+∞

14.7

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

6.4

14.7

1507

Kela drug reimbursment

Pomalidomide

160.3

14.6

XX3DW

NOMESCO Finland

Time consuming IT work

5.3

14.5

108

S72.3

ICD-10 Finland

Fracture of shaft of femur

45.9

14.3

J01MA12

ATC

levofloxacin; systemic

3.9

14.3

228

C64.88

ICD-10 Finland

Other malignant neoplasm of kidney, except renal pelvis

14.0

14.3

ZXE10

NOMESCO Finland

More than one and less than three hours

3.2

14.3

110

532

A79

ICPC

Malignancy NOS

19.2

14.1

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

3.9

14.1

212

WX402

NOMESCO Finland

General anaesthesia

4.0

14.1

200

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

6.3

13.8

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

5.4

13.8

WD325

NOMESCO Finland

Demanding therapy of methastized malignancy with biomodifiers

27.8

13.6

A02BC02

ATC

pantoprazole; systemic

3.3

13.6

168

1104

NB6AA

NOMESCO Finland

Humerus X-ray examination

15.1

13.6

130

Kela drug reimbursment

Malignant tumour

5.3

13.3

A06AD11

ATC

lactulose; oral

4.1

13.3

173

M05BA02

ATC

clodronic acid; systemic

30.5

13.2

115

Kela drug reimbursment

Breast cancer

5.5

13.1

NF1AA

NOMESCO Finland

Hip X-ray examination

5.4

13.1

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

6.6

13.1

WD415

NOMESCO Finland

Demanding antibody therapy of methastized malignancy

16.8

12.9

L03AA13

ATC

pegfilgrastim; parenteral

8.3

12.7

NF3AD

NOMESCO Finland

Femur CT

+∞

12.6

NK6CT

NOMESCO Finland

Bone biopsy with CT guidance

137.6

12.6

WD405

NOMESCO Finland

Simple antiboidy therapy of methastized malignancy

14.5

12.2

ZXE20

NOMESCO Finland

More than three and less than five hours

3.9

12.2

168

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.8

12.2

186

A28

ICPC

Limited function/disability NOS

3.8

12.2

186

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

11.5

12.1

TNE25

NOMESCO Finland

Drill biopsy of bone marrow, pelvis

17.7

11.9

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.2

11.7

308

R50.9

ICD-10 Finland

Fever, unspecified

4.1

11.6

140

197

Kela drug reimbursment

Sunitinib

126.4

11.5

398

Kela drug reimbursment

Ixazomib

126.4

11.5

YN1BD

NOMESCO Finland

Extensive CT examination of extremities for dose design of radiotherapy

126.4

11.5

WD125

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

6.2

11.4

WW200

NOMESCO Finland

Immunization

10.4

11.0

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.7

11.0

120

686

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

29.7

10.9

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

6.1

10.7

1XX32

NOMESCO Finland

+∞

10.5

A11CC03

ATC

alfacalcidol; systemic

9.9

10.3

ZXE00

NOMESCO Finland

One hour or less

2.6

10.2

107

588

TPH07

NOMESCO Finland

Cathetrisation of artery

4.0

10.2

122

X59

ICD-10 Finland

Exposure to unspecified factor

3.3

10.1

218

L02BA03

ATC

fulvestrant; parenteral

21.2

9.9

C64

ICD-10 Finland

Malignant neoplasm of kidney, except renal pelvis

57.6

9.7

JN4CD

NOMESCO Finland

Very extensive body CT

7.2

9.7

L02BA01

ATC

tamoxifen; oral

6.8

9.7

N03AX16

ATC

pregabalin; oral

2.9

9.7

291

ZXA00

NOMESCO Finland

Right side

2.7

9.6

369

1505

Kela drug reimbursment

Ixazomib

104.4

9.5

L01AA03

ATC

melphalan; systemic

104.4

9.5

YG1BD

NOMESCO Finland

Extensive CT examination of thorax for dose design of radiotherapy

7.9

9.5

L02BG04

ATC

letrozole; oral

5.2

9.5

X76

ICPC

Malignant neoplasm breast female

22.9

9.5

NEK99

NOMESCO Finland

Other operation on bone of pelvis

+∞

9.4

L01XX50

ATC

[U] ixazomib; oral

+∞

9.4

M49.5*C90.0

ICD-10 Finland

Vertebral fracture due to multiple myeloma

+∞

9.4

WZC30

NOMESCO Finland

Teaching

3.5

9.4

160

1501

Kela drug reimbursment

Palbociclib

38.4

9.1

192

Kela drug reimbursment

Fulvestrant

19.6

9.0

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

11.4

8.9

L01BC06

ATC

capecitabine; oral

6.7

8.9

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

2.6

8.8

369

ZX070

NOMESCO Finland

Intensity modified radiotherapy

14.9

8.8

WD505

NOMESCO Finland

Simple enzyme inhibitor or similar therapy of methastized malignancy

14.9

8.8

WX2DD

NOMESCO Finland

Low-dose CT of skeleton in whole body

52.1

8.7

1502

Kela drug reimbursment

Cabozantinib

52.1

8.7

3012

Kela drug reimbursment

Cabozantinib

52.1

8.7

TK800

NOMESCO Finland

Hemodialysis

9.6

8.7

ZX080

NOMESCO Finland

Image guided radiotherapy

10.7

8.7

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.3

8.6

169

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

8.4

8.6

TKC20

NOMESCO Finland

Catheterisation of bladder

4.6

8.5

N02AX02

ATC

tramadol; systemic, rectal

2.4

8.5

107

633

J05AB01

ATC

aciclovir; systemic

2.8

8.4

260

L01XE26

ATC

[U] cabozantinib; oral

+∞

8.4

M907, C61

ICD-10 Finland

+∞

8.4

C50.4

ICD-10 Finland

Malignant neoplasm: Upper-outer quadrant of breast

18.0

8.2

L01XE33

ATC

[U] palbociclib; oral

34.8

8.1

394

Kela drug reimbursment

Palbociclib

34.8

8.1

J01MA14

ATC

moxifloxacin; systemic

4.0

8.1

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

5.3

8.1

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

9.0

8.0

PJD52

NOMESCO Finland

Block dissection of axillary lymph nodes

5.7

7.9

N02BE01

ATC

paracetamol; systemic, rectal

3.3

7.9

197

1616

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.6

7.8

285

5BA08

NOMESCO Finland

46.7

7.8

AA1BD

NOMESCO Finland

Extensive CT of head and brain

8.5

7.7

N18.0

ICD-10 Finland

End-stage renal disease

12.5

7.7

WD135

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

19.2

7.7

WX320

NOMESCO Finland

Spinalanesthesy

2.6

7.7

308

J05AB11

ATC

valaciclovir; oral

3.2

7.7

151

NE1AD

NOMESCO Finland

Pelvis and hip bones CT examination

7.6

YA1BD

NOMESCO Finland

Extensive CT examination of head and neck for dose design of radiotherapy

26.1

7.6

WX002

NOMESCO Finland

Sedation and analgesia

2.7

7.6

260

Z3226

NOMESCO Finland

Physiotherapist

2.7

7.5

241

M80.9

ICD-10 Finland

Unspecified osteoporosis with pathological fracture

82.8

7.5

158

Kela drug reimbursment

Everolimus

+∞

7.3

M87.1

ICD-10 Finland

Osteonecrosis due to drugs

+∞

7.3

ZXE04

NOMESCO Finland

Procedure duration 30 to 39 minutes

4.3

7.3

D41.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Kidney

6.4

7.2

159

Kela drug reimbursment

Pazopanib

31.1

7.2

8312/3-C64.9

ICD-O-3

Renal cell carcinoma, NOS, of kidney, NOS

31.1

7.2

L28

ICPC

Limited function/disability (L)

2.8

7.2

211

WD115

NOMESCO Finland

Multiple cystostatic therapy of methastized malignancy

9.3

7.2

HAC20

NOMESCO Finland

Total mastectomy

5.8

7.1

WX200

NOMESCO Finland

Interscalenous plexus blockade

8.0

7.0

HA1AA

NOMESCO Finland

X-ray mammography

3.9

7.0

127

Kela drug reimbursment

Transplant complication

9.8

6.9

A12AA04

ATC

calcium carbonate; oral

11.5

6.9

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

4.6

6.9

C90.2

ICD-10 Finland

Extramedullary plasmacytoma

41.4

6.8

NFJ62

NOMESCO Finland

Internal fixation of fracture of other parts of femur with plate

41.4

6.8

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

4.3

6.7

S72.4

ICD-10 Finland

Fracture of lower end of femur

23.4

6.7

L01AA01

ATC

cyclophosphamide; systemic

23.4

6.7

XF400

NOMESCO Finland

ECG with 12 standard connections

2.7

6.7

219

Z2446

NOMESCO Finland

Social worker

4.2

6.6

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

3.0

6.5

137

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

3.6

6.5

N17.9

ICD-10 Finland

Acute renal failure, unspecified

5.5

6.5

M49.5*C79.5

ICD-10 Finland

Metastatic fracture of vertebra

71.9

6.5

L01XE04

ATC

[U] sunitinib; oral

71.9

6.5

KAC10

NOMESCO Finland

Total nephrectomy with capsule

14.9

6.5

ZXD10

NOMESCO Finland

Scheduled procedure

2.1

6.4

589

Z49.1

ICD-10 Finland

Extracorporeal dialysis

9.7

6.4

WD205

NOMESCO Finland

Therapy of methastized malignancy with hormones

11.5

6.4

AA3AI

NOMESCO Finland

Cone beam CT of facial bones

18.7

6.3

L02BB04

ATC

enzalutamide; oral

18.7

6.3

NK6AN

NOMESCO Finland

Total body bone isotope imaging

5.7

6.3

M907, C5041

ICD-10 Finland

+∞

6.3

G62.0

ICD-10 Finland

Drug-induced polyneuropathy

+∞

6.3

M907, C795

ICD-10 Finland

+∞

6.3

S72.0

ICD-10 Finland

Fracture of neck of femur

5.5

6.2

V03AE01

ATC

polystyrene sulfonate; oral

10.5

6.1

SPAT1222

SPAT

Counselling/guidance promoting independent living

2.8

6.1

157

Mortality – FinRegistry

↥

Association

Association between endpoint M13_OSTEOPATHYINOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_OSTEOPATHYINOTH	9.092 [6.48, 12.75]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.114

During the follow-up period (1.1.1998 — 31.12.2019), 430 out of 733 females with M13_OSTEOPATHYINOTH died.

Males

Parameter	HR [95% CI]	p-value
M13_OSTEOPATHYINOTH	7.116 [4.53, 11.17]	< 0.001
Birth year	0.985 [0.98, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 356 out of 636 males with M13_OSTEOPATHYINOTH died.

Mortality risk

Mortality risk for people of age

years, who have M13_OSTEOPATHYINOTH.

N-year risk	Females	Males
1	0.763%	1.031%
5	4.847%	6.694%
10	12.775%	16.411%
15	22.181%	29.36%
20	35.371%	45.528%

Relationships between endpoints

↥

Index endpoint: M13_OSTEOPATHYINOTH – Osteopathy in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	M13_OSTEOPATHYINOTH
CONTROL_EXCLUDE	M13_OSTEOCHONDRO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M90
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M90
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Osteopathy in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints