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Other specified/unspecified necrotizing vasculopathies

EFO MESH Endpoint Browser PheWeb

M13_NECROVASCNAS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M31.8, M31.9
  • Hospital discharge: ICD-9 — 447[5-6]
  • Hospital discharge: ICD-8 — 4469
  • Cause of death: ICD-10 — M31.8, M31.9
  • Cause of death: ICD-9 — 447[5-6]
  • Cause of death: ICD-8 — 4469

2 out of 7 registries used, show all original rules.

491

4. Check minimum number of events

None

491

5. Include endpoints

None

491

6. Filter based on genotype QC (FinnGen only)

491

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3624 1976 1609
Only index persons 2728 1510 1218
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.05 0.06 0.05
Median age at first event (years)
Whole population 61.78 62.38 60.96
Only index persons 59.20 59.37 58.98

-FinnGen-

Key figures

All Female Male
Number of individuals 491 264 227
Unadjusted period prevalence (%) 0.09 0.09 0.10
Median age at first event (years) 57.30 54.54 60.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
442
Matched controls
4419
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
301.9
254
*
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
133.2
121
*
L04AX01
ATC
azathioprine; systemic
35.8
111.8
146
60
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
12.1
86.2
175
226
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
79.6
74
*
H02AB06
ATC
prednisolone; systemic
7.0
74.6
338
1396
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.4
59.9
266
961
4476A
ICD-9 Finland
Other disorders of arteries and arterioles, Arteritis, unspecified
+∞
58.7
55
*
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
47.8
45
*
L04AA06
ATC
mycophenolic acid; systemic
28.0
46.0
63
26
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
+∞
44.5
42
*
M05BA04
ATC
alendronic acid; oral
6.8
41.1
114
214
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
8.4
36.1
84
120
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
8.2
36.0
85
124
L01AA01
ATC
cyclophosphamide; systemic
+∞
35.9
34
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
35.9
34
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
35.9
34
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
35.4
281
1445
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
34.8
33
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
6.7
34.8
96
176
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
11.1
34.2
67
70
PAW37
NOMESCO Finland
Biopsy of temporal artery
97.8
33.3
36
*
44698
ICD-8 Finland
Polyarteritis nodosa and allied conditions, Other
+∞
32.7
31
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.8
32.7
179
672
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.2
31.9
111
269
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.5
28.6
65
88
C03CA01
ATC
furosemide; systemic
3.3
28.3
201
899
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
27.5
28.0
38
15
R50.9
ICD-10 Finland
Fever, unspecified
4.4
27.9
115
328
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
27.4
26
*
H02AB07
ATC
prednisone; oral
4.1
26.6
119
365
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
26.3
25
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.1
25.8
66
107
N085, M318
ICD-10 Finland
NA
+∞
25.2
24
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
25.2
24
*
H02AB04
ATC
methylprednisolone; systemic
3.9
24.9
116
366
J01MA12
ATC
levofloxacin; systemic
3.5
24.3
139
518
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.1
24.0
44
40
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
8.9
24.0
52
65
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.2
23.7
67
124
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
32.0
23.1
30
10
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
11.0
22.9
44
44
M35.3
ICD-10 Finland
Polymyalgia rheumatica
13.8
21.6
37
29
J01FF01
ATC
clindamycin; systemic
2.9
21.3
166
757
P01BA02
ATC
hydroxychloroquine; oral
5.4
21.3
67
141
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.3
21.2
85
231
D69.0
ICD-10 Finland
Allergic purpura
31.8
20.8
27
9
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.4
20.4
80
213
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
9.8
19.3
39
43
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
19.0
102
354
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.5
18.9
71
180
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
18.9
18
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
18.8
134
568
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
104.5
18.7
20
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
198.0
18.7
19
*
TK800
NOMESCO Finland
Hemodialysis
10.8
18.2
35
35
ZX120
NOMESCO Finland
Intravenous
4.0
18.2
78
224
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
17.8
17
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.6
17.6
87
282
A11CC03
ATC
alfacalcidol; systemic
9.2
17.3
36
42
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
18.3
17.1
26
15
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.6
17.0
51
101
TGC00
NOMESCO Finland
Bronchial lavation
9.9
17.0
34
37
I77.6
ICD-10 Finland
Arteritis, unspecified
93.6
16.7
18
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.4
16.2
43
73
Z49.1
ICD-10 Finland
Extracorporeal dialysis
15.3
16.0
26
18
A12AA04
ATC
calcium carbonate; oral
11.0
15.9
30
29
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.7
15.9
37
52
N18.0
ICD-10 Finland
End-stage renal disease
16.5
15.9
25
16
L95.8
ICD-10 Finland
Other vasculitis limited to skin
62.3
15.9
18
*
H26.3
ICD-10 Finland
Drug-induced cataract
62.3
15.9
18
*
M31.6
ICD-10 Finland
Other giant cell arteritis
+∞
15.7
15
*
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
15.7
15
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.4
15.5
59
151
M13.9
ICD-10 Finland
Arthritis, unspecified
4.5
15.5
57
141
A02BC02
ATC
pantoprazole; systemic
2.4
15.5
311
2220
N18.8
ICD-10 Finland
Other chronic renal failure
8.0
15.5
35
47
J01MA14
ATC
moxifloxacin; systemic
3.8
15.3
69
206
A46
ICD-10 Finland
Erysipelas
3.1
15.0
91
339
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
14.7
101
411
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
14.7
14
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
14.7
14
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
10.6
14.2
27
27
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.7
14.0
113
505
B03XA02
ATC
darbepoetin alfa; parenteral
9.6
13.9
28
31
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
12.0
13.5
24
21
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.7
13.4
60
178
S97
ICPC
Chronic ulcer skin
4.7
13.3
46
107
A02BC01
ATC
omeprazole; systemic
2.3
13.2
151
809
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.4
12.8
65
213
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.0
12.7
52
143
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
12.6
12
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
13.7
12.5
21
16
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
20.8
12.5
18
9
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.3
12.5
33
56
N02AX02
ATC
tramadol; systemic, rectal
2.1
12.5
216
1383
ZXA10
NOMESCO Finland
Bilateral
2.5
12.5
109
505
N02AA05
ATC
oxycodone; systemic
2.7
12.3
90
376
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.8
12.2
41
93
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
5.3
12.2
37
75
C08CA05
ATC
nifedipine; systemic
4.1
11.9
47
125
TDM10
NOMESCO Finland
Puncture of maxillary antrum
5.4
11.8
35
69
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
11.8
118
587
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
11.5
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.9
11.4
48
135
KA1AE
NOMESCO Finland
Kidney ultrasound examination
6.5
11.4
29
47
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.1
11.4
161
936
Z94.0
ICD-10 Finland
Kidney transplant status
11.0
11.4
21
20
ZX108
NOMESCO Finland
Inhalation
25.8
11.2
15
6
TPX10
NOMESCO Finland
Implantation of vascular injection port
7.7
11.1
25
34
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
11.1
70
265
V03AE01
ATC
polystyrene sulfonate; oral
14.4
11.1
18
13
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.0
11.1
44
118
NHQ40
NOMESCO Finland
Amputation of toe
7.2
11.0
26
38
Z2446
NOMESCO Finland
Social worker
3.9
11.0
45
124
V03AE02
ATC
sevelamer; oral
44.5
11.0
13
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.8
10.9
46
130
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
10.8
85
371
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.2
10.6
40
102
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
10.6
146
836
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.3
10.5
39
98
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
10.5
184
1160
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
6.3
10.5
27
45
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
10.5
10
*
ZZA00
NOMESCO Finland
Split skin graft
6.0
10.4
28
49
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.4
10.3
51
164
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
10.2
118
621
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.6
10.2
78
331
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.2
10.2
54
183
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.1
10.1
57
202
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.4
10.0
92
434
J01MA02
ATC
ciprofloxacin; systemic
1.9
9.9
193
1259
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.3
9.9
51
170
ZXD05
NOMESCO Finland
Urgent procedure
2.0
9.8
156
941
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
9.4
9
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
9.4
9
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
9.4
9
*
J01DB01
ATC
cefalexin; oral
2.1
9.4
361
2995
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
9.4
86
405
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.3
9.3
24
40
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.9
9.3
57
212
A41.9
ICD-10 Finland
Sepsis, unspecified
4.5
9.3
32
75
N03AX16
ATC
pregabalin; oral
2.2
9.2
113
607
GD1AD
NOMESCO Finland
Thorax CT examination
4.3
9.2
33
81
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.2
9.1
103
537
J45.1
ICD-10 Finland
Nonallergic asthma
3.3
8.9
44
142
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
7.4
8.8
20
28
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
14.4
8.7
14
10
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
14.4
8.7
14
10
UJF32
NOMESCO Finland
Coloscopy
2.0
8.7
130
756
XG410
NOMESCO Finland
Flow-volume spirometry
4.6
8.7
29
66
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
10.3
8.6
16
16
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
10.3
8.6
16
16
DHA10
NOMESCO Finland
Biopsy of cavity of nose
10.3
8.6
16
16
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.8
8.5
56
218
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
8.5
89
446
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
8.4
8
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
8.4
8
*
127
Kela drug reimbursment
Transplant complication
7.3
8.3
19
27
205
Kela drug reimbursment
Chronic hypertension
1.9
8.2
142
874
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
7.0
8.1
19
28
JN4AD
NOMESCO Finland
Body CT examination
3.0
8.1
47
170
1XC02
NOMESCO Finland
NA
17.6
8.1
12
7
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
34.0
8.1
10
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.3
8.1
78
374
H02AB09
ATC
hydrocortisone; systemic
6.5
8.1
20
32
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
9.2
8.1
16
18
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.3
8.1
39
124
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
10.3
8.1
15
15
M04AA01
ATC
allopurinol; systemic
2.3
8.1
76
362
R06.0
ICD-10 Finland
Dyspnoea
2.0
8.0
122
712
NF1AA
NOMESCO Finland
Hip X-ray examination
2.8
8.0
53
206
B01AA03
ATC
warfarin; systemic
2.0
8.0
112
634
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.5
8.0
36
109
UDM02
NOMESCO Finland
Sinoscopy
6.3
7.9
20
33
J01AA02
ATC
doxycycline; systemic
1.9
7.9
340
2813
137
Kela drug reimbursment
Uraemia requiring dialysis
11.1
7.8
14
13
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
9.7
7.8
15
16
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
5.2
7.8
23
46
C08CA01
ATC
amlodipine; oral
1.8
7.8
167
1100
NGQ20
NOMESCO Finland
Amputation of lower leg
18.7
7.6
11
6
A02BC03
ATC
lansoprazole; oral
1.9
7.6
143
902
Z49.0
ICD-10 Finland
Preparatory care for dialysis
10.3
7.6
14
14
B99
ICD-10 Finland
Other and unspecified infectious diseases
7.3
7.5
17
24
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
6.7
7.5
18
28
J01FA06
ATC
roxithromycin; oral
1.8
7.5
176
1192
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
5.8
7.5
20
36
L95.0
ICD-10 Finland
Livedoid vasculitis
81.4
7.4
8
*
L88
ICPC
Rheumatoid/seropositive arthritis
4.4
7.3
25
59
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
11.1
7.3
13
12
Z3231
NOMESCO Finland
Registered nurse
1.9
7.2
130
803
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
7.2
83
434
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.3
7.2
35
113
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
20.4
7.2
10
5
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
7.2
85
450
I50.0
ICD-10 Finland
Congestive heart failure
2.9
7.1
42
154
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
5.8
7.1
19
34
AA1AD
NOMESCO Finland
CT of head and brain
1.9
7.1
117
702
ZXA00
NOMESCO Finland
Right side
1.8
7.1
135
851
J05AB11
ATC
valaciclovir; oral
2.3
7.1
68
327
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
7.1
57
249
H04.10
ICD-10 Finland
Dry eye syndrome
2.6
7.0
52
219
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.2
7.0
69
336
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
7.7
6.9
15
20
3AC01
NOMESCO Finland
NA
8.5
6.9
14
17
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
8.5
6.9
14
17
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
8.5
6.9
14
17
R04.0
ICD-10 Finland
Epistaxis
2.7
6.9
45
177
L04AA01
ATC
[U] ciclosporin; systemic
6.3
6.8
17
28
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.0
6.8
38
133
L93.0
ICD-10 Finland
Discoid lupus erythematosus
40.7
6.8
8
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
40.7
6.8
8
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
6.6
6.7
16
25
R53
ICD-10 Finland
Malaise and fatigue
2.0
6.7
99
569
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
12.5
6.6
11
9
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
12.5
6.6
11
9
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
12.5
6.6
11
9
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
10.2
6.6
12
12
WW200
NOMESCO Finland
Immunization
4.6
6.6
21
47
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
5.5
6.5
18
34
GD2SN
NOMESCO Finland
Lung ventilation SPECT
14.6
6.4
10
7
B05DA
ATC
Isotonic solutions
14.6
6.4
10
7
M05BA07
ATC
risedronic acid; oral
3.8
6.4
25
68
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
3.5
6.4
28
84
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.5
6.3
47
197
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
3.7
6.3
26
74
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.2
6.3
22
54
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
18.3
6.3
9
5
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
18.3
6.3
9
5
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
18.3
6.3
9
5
A41.8
ICD-10 Finland
Other specified sepsis
7.2
6.3
14
20
N085, M319
ICD-10 Finland
NA
+∞
6.3
6
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
6.3
6
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
6.3
6
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
+∞
6.3
6
*
J01DA01
ATC
[U] cefalexin; systemic
1.7
6.2
272
2169
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
6.2
38
144
TAB00
NOMESCO Finland
Lumbar puncture
3.6
6.2
26
75
J31.0
ICD-10 Finland
Chronic rhinitis
2.7
6.2
40
156
N19
ICD-10 Finland
Unspecified kidney failure
4.2
6.2
22
55
H65.2
ICD-10 Finland
Chronic serous otitis media
7.8
6.2
13
17
J32.4
ICD-10 Finland
Chronic pansinusitis
7.8
6.2
13
17
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
12.7
6.1
10
8
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.1
6.1
65
328
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
6.1
63
314
J01CF05
ATC
flucloxacillin; systemic
3.6
6.0
25
72
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.6
6.0
25
72

Mortality – FinRegistry

↥

Association

Association between endpoint M13_NECROVASCNAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_NECROVASCNAS 2.738 [2.25, 3.33] < 0.001
Birth year 0.994 [0.99, 1.0] 0.152

During the follow-up period (1.1.1998 — 31.12.2019), 421 out of 1141 females with M13_NECROVASCNAS died.

Males

Parameter HR [95% CI] p-value
M13_NECROVASCNAS 2.719 [2.19, 3.38] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 382 out of 930 males with M13_NECROVASCNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_NECROVASCNAS.

N-year risk Females Males
1 0.155% 0.461%
5 1.405% 3.089%
10 3.493% 7.542%
15 7.111% 14.245%
20 12.552% 22.975%

Relationships between endpoints

↥

Index endpoint: M13_NECROVASCNAS – Other specified/unspecified necrotizing vasculopathies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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