Multifocal fibrosclerosis

M13_MULTIFIBRO

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M35.5 Cause of death: ICD-10 — M35.5 2 out of 7 registries used, show all original rules.	224
4. Check minimum number of events None	224
5. Include endpoints None	224
6. Filter based on genotype QC (FinnGen only)	224

Control definitions (FinnGen only)

Control exclude: M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M35
Name in latin: Fibrosclerosis multifocalis

NAME	M13_MULTIFIBRO
CONTROL_EXCLUDE	M13_SYSTCONNECT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M355
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M355
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Multifocal fibrosclerosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1805	1278	511
Only index persons	1554	1106	448
Unadjusted period prevalence (%)
Whole population	0.03	0.04	0.01
Only index persons	0.03	0.04	0.02
Median age at first event (years)
Whole population	72.13	72.44	71.18
Only index persons	70.74	71.06	69.95

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	224	151	73
Unadjusted period prevalence (%)	0.05	0.05	0.03
Median age at first event (years)	63.18	61.22	67.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
201: Matched controls
2009

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M35.5

ICD-10 Finland

Multifocal fibrosclerosis

+∞

291.0

201

M35.3

ICD-10 Finland

Polymyalgia rheumatica

191.6

122.9

119

H02AB06

ATC

prednisolone; systemic

8.4

38.3

163

679

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

9.9

33.0

109

M35.9

ICD-10 Finland

Systemic involvement of connective tissue, unspecified

+∞

29.9

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

310.3

27.4

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

5.2

26.7

134

557

M31.5

ICD-10 Finland

Giant cell arteritis with polymyalgia rheumatica

271.0

24.2

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

8.5

22.8

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

10.9

20.9

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

8.7

20.4

P01BA02

ATC

hydroxychloroquine; oral

8.1

20.2

H02AB07

ATC

prednisone; oral

5.1

18.3

176

PAW37

NOMESCO Finland

Biopsy of temporal artery

196.6

17.8

L88

ICPC

Rheumatoid/seropositive arthritis

12.0

16.9

M35.1

ICD-10 Finland

Other overlap syndromes

+∞

16.9

M05BA04

ATC

alendronic acid; oral

4.7

12.6

120

M25.5

ICD-10 Finland

Pain in joint

3.2

12.2

364

N03AX16

ATC

pregabalin; oral

3.2

11.5

323

N02AX02

ATC

tramadol; systemic, rectal

2.8

10.9

109

599

M79.1

ICD-10 Finland

Myalgia

4.1

10.2

122

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

9.5

10.1

L04AX01

ATC

azathioprine; systemic

7.8

9.8

M13.9

ICD-10 Finland

Arthritis, unspecified

5.2

9.6

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.6

9.5

112

661

R70.0

ICD-10 Finland

Elevated erythrocyte sedimentation rate

11.5

9.5

A02BC02

ATC

pantoprazole; systemic

2.8

9.5

155

1097

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

5.4

9.4

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.5

9.1

111

659

M05BA07

ATC

risedronic acid; oral

6.8

8.6

H04.10

ICD-10 Finland

Dry eye syndrome

4.1

8.5

M35.7

ICD-10 Finland

Hypermobility syndrome

+∞

8.4

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.4

8.3

108

653

H02AB04

ATC

methylprednisolone; systemic

3.1

7.8

175

M01AE02

ATC

naproxen; oral, rectal

2.3

7.6

124

823

J01DB01

ATC

cefalexin; oral

2.9

7.6

172

1357

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

6.0

7.6

A07EC01

ATC

sulfasalazine; oral, rectal

4.2

7.3

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.8

7.3

219

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.2

7.1

141

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

4.6

7.1

M03BC51

ATC

orphenadrine, combinations; systemic

2.5

7.1

338

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

3.7

7.0

J01FA10

ATC

azithromycin; systemic

2.2

6.8

118

792

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

3.7

6.7

A46

ICD-10 Finland

Erysipelas

2.9

6.6

169

M54.5

ICD-10 Finland

Low back pain

2.3

6.6

462

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

4.3

6.4

M79.7

ICD-10 Finland

Fibromyalgia

6.7

6.3

H35.5

ICD-10 Finland

Hereditary retinal dystrophy

+∞

6.3

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.2

6.2

506

J45.9

ICD-10 Finland

Asthma, unspecified

2.6

6.1

223

R07.4

ICD-10 Finland

Chest pain, unspecified

2.3

6.1

377

R50.9

ICD-10 Finland

Fever, unspecified

2.9

6.1

151

Mortality – FinRegistry

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Association

Association between endpoint M13_MULTIFIBRO and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_MULTIFIBRO	1.619 [1.38, 1.9]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.019

During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 1187 females with M13_MULTIFIBRO died.

Males

Parameter	HR [95% CI]	p-value
M13_MULTIFIBRO	1.371 [1.09, 1.72]	0.006
Birth year	0.988 [0.98, 1.0]	0.015

During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 481 males with M13_MULTIFIBRO died.

Mortality risk

Mortality risk for people of age

years, who have M13_MULTIFIBRO.

N-year risk	Females	Males
1	0.105%	0.27%
5	0.745%	1.63%
10	1.866%	3.975%
15	3.45%	7.504%
20	6.278%	13.11%

Relationships between endpoints

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Index endpoint: M13_MULTIFIBRO – Multifocal fibrosclerosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Multifocal fibrosclerosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints