Microscopic polyangiitis

M13_MICROPOLYANG

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M31.7
  • Cause of death: ICD-10 M31.7

2 out of 7 registries used, show all original rules.

171

4. Check minimum number of events

None

171

5. Include endpoints

None

171

6. Filter based on genotype QC (FinnGen only)

166

Control definitions (FinnGen only)

Control exclude
M13_NECROVASC

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M31

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 813 470 342
Only index persons 808 467 341
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 68.31 67.54 69.40
Only index persons 68.35 67.57 69.42

-FinnGen-

Key figures

All Female Male
Number of individuals 166 98 68
Unadjusted period prevalence (%) 0.04 0.04 0.03
Median age at first event (years) 65.68 65.11 66.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
171
Matched controls
1710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
164.1
130
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
123.3
103
*
L04AX01
ATC
azathioprine; systemic
98.0
98.6
105
27
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
75.8
67
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
171.3
71.5
71
7
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
19.8
58.5
100
113
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
42.5
39
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
20.9
39.1
60
43
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
39.1
36
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
51.8
39.0
46
12
L04AA06
ATC
mycophenolic acid; systemic
71.1
38.5
43
8
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
51.6
36.4
43
11
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
32.3
30
*
H02AB06
ATC
prednisolone; systemic
7.7
30.4
138
600
TK800
NOMESCO Finland
Hemodialysis
54.5
30.0
35
8
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.9
29.9
123
464
N17.9
ICD-10 Finland
Acute renal failure, unspecified
21.0
28.1
42
26
Z49.1
ICD-10 Finland
Extracorporeal dialysis
90.1
27.8
30
*
B03XA02
ATC
darbepoetin alfa; parenteral
53.6
26.6
31
7
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
25.7
24
*
N18.8
ICD-10 Finland
Other chronic renal failure
21.4
24.4
36
21
A11CC03
ATC
alfacalcidol; systemic
34.0
24.2
31
11
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
63.6
23.8
27
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.6
23.8
126
570
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.7
22.5
81
233
H02AB04
ATC
methylprednisolone; systemic
6.5
22.0
66
150
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
15.4
21.0
35
28
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.9
20.5
43
56
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
11.2
20.0
39
44
N085, M318
ICD-10 Finland
NA
+∞
19.1
18
*
C03CA01
ATC
furosemide; systemic
4.6
19.0
93
353
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.0
18.9
59
138
M05BA04
ATC
alendronic acid; oral
7.3
18.3
47
84
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
8.4
18.1
42
64
N18.0
ICD-10 Finland
End-stage renal disease
41.7
18.1
22
6
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.3
17.9
36
43
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
100.0
16.9
18
*
TGC00
NOMESCO Finland
Bronchial lavation
16.8
16.5
26
18
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.0
15.8
47
101
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
9.0
15.3
33
44
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
13.7
15.2
26
22
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.8
15.2
40
73
Z94.0
ICD-10 Finland
Kidney transplant status
87.8
14.8
16
*
ZX120
NOMESCO Finland
Intravenous
6.1
14.8
43
89
ZX108
NOMESCO Finland
Inhalation
39.9
14.8
18
5
L01AA01
ATC
cyclophosphamide; systemic
+∞
13.7
13
*
A02BC02
ATC
pantoprazole; systemic
4.1
13.5
140
901
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
12.7
12
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
12.7
12
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
139.8
12.6
13
*
A12AA04
ATC
calcium carbonate; oral
29.2
12.3
16
6
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
29.2
12.3
16
6
N19
ICD-10 Finland
Unspecified kidney failure
9.3
12.1
25
31
R50.9
ICD-10 Finland
Fever, unspecified
4.6
12.0
45
123
KA1AE
NOMESCO Finland
Kidney ultrasound examination
15.1
11.8
19
14
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.0
11.7
23
26
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
11.6
11
*
WW400
NOMESCO Finland
Plasmaferesis
128.3
11.6
12
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
128.3
11.6
12
*
127
Kela drug reimbursment
Transplant complication
27.2
11.3
15
6
Z49.0
ICD-10 Finland
Preparatory care for dialysis
27.2
11.3
15
6
C08CA01
ATC
amlodipine; oral
3.1
11.0
92
470
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.5
11.0
26
40
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
42.8
10.1
12
*
GD1AD
NOMESCO Finland
Thorax CT examination
8.0
9.9
22
31
137
Kela drug reimbursment
Uraemia requiring dialysis
58.4
9.8
11
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.5
9.7
29
61
N17.8
ICD-10 Finland
Other acute renal failure
16.3
9.7
15
10
R04.2
ICD-10 Finland
Haemoptysis
9.6
9.6
19
22
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
10.4
9.5
18
19
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
+∞
9.5
9
*
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
9.5
9
*
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
9.5
9
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
5.6
9.3
27
55
205
Kela drug reimbursment
Chronic hypertension
2.9
8.9
71
338
J01MA14
ATC
moxifloxacin; systemic
4.5
8.9
32
83
B03XA01
ATC
erythropoietin; parenteral
52.8
8.8
10
*
J01MA12
ATC
levofloxacin; systemic
3.2
8.7
51
200
D64.9
ICD-10 Finland
Anaemia, unspecified
4.2
8.7
34
96
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
8.6
57
242
H26.3
ICD-10 Finland
Drug-induced cataract
94.5
8.5
9
*
V03AE02
ATC
sevelamer; oral
+∞
8.4
8
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
8.4
8
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
8.4
8
*
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
8.4
8
*
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
8.4
8
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.2
8.4
32
88
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
47.2
7.8
9
*
PAW37
NOMESCO Finland
Biopsy of temporal artery
47.2
7.8
9
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.3
7.6
28
74
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.8
7.5
56
254
1AA01
NOMESCO Finland
NA
83.6
7.5
8
*
Z49.2
ICD-10 Finland
Other dialysis
83.6
7.5
8
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
83.6
7.5
8
*
R31
ICD-10 Finland
Unspecified haematuria
4.0
7.4
30
87
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.7
7.3
32
99
GD1UN
NOMESCO Finland
Lung circulation SPECT
+∞
7.3
7
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
7.3
7
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
7.2
44
176
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.0
7.0
45
183
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.9
6.8
16
25
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
41.8
6.8
8
*
B05DB
ATC
Hypertonic solutions
41.8
6.8
8
*
B05DA
ATC
Isotonic solutions
41.8
6.8
8
*
C08CA13
ATC
lercanidipine; oral
3.3
6.7
36
128
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.8
6.6
44
186
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.9
6.5
26
75
GD2SN
NOMESCO Finland
Lung ventilation SPECT
72.4
6.5
7
*
D638, N188
ICD-10 Finland
NA
+∞
6.3
6
*
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
+∞
6.3
6
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
+∞
6.3
6
*
J01CA04
ATC
amoxicillin; systemic
2.8
6.3
146
1158
J47
ICD-10 Finland
Bronchiectasis
8.2
6.2
13
17
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.3
6.2
32
113

Mortality – FinRegistry

Association

Association between endpoint M13_MICROPOLYANG and mortality.

Females

Parameter HR [95% CI] p-value
M13_MICROPOLYANG 2.749 [1.87, 4.04] < 0.001
Birth year 0.997 [0.99, 1.01] 0.51

During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 398 females with M13_MICROPOLYANG died.

Males

Parameter HR [95% CI] p-value
M13_MICROPOLYANG 2.227 [1.42, 3.48] < 0.001
Birth year 0.992 [0.98, 1.0] 0.08

During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 278 males with M13_MICROPOLYANG died.

Mortality risk

Mortality risk for people of age

years, who have M13_MICROPOLYANG.

N-year risk Females Males
1 0.3% 0.427%
5 1.814% 2.869%
10 4.159% 6.919%
15 8.407% 12.425%
20 14.379% 21.206%

Relationships between endpoints

Index endpoint: M13_MICROPOLYANG – Microscopic polyangiitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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