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Loose body in joint

EFO MESH Endpoint Browser PheWeb

M13_LOOSEJOINT

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M24.0
  • Hospital discharge: ICD-9 — 7181
  • Hospital discharge: ICD-8 — 72901
  • Cause of death: ICD-10 — M24.0
  • Cause of death: ICD-9 — 7181
  • Cause of death: ICD-8 — 72901

2 out of 7 registries used, show all original rules.

941

4. Check minimum number of events

None

941

5. Include endpoints

None

941

6. Filter based on genotype QC (FinnGen only)

941

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M24
Name in latin
Corpus liberum articulationis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7793 2490 5243
Only index persons 6900 2215 4685
Unadjusted period prevalence (%)
Whole population 0.12 0.07 0.15
Only index persons 0.15 0.08 0.18
Median age at first event (years)
Whole population 39.44 43.27 37.54
Only index persons 37.78 41.19 36.17

-FinnGen-

Key figures

All Female Male
Number of individuals 941 342 599
Unadjusted period prevalence (%) 0.21 0.12 0.26
Median age at first event (years) 38.93 39.19 38.78

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
835
Matched controls
8350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
72901
ICD-8 Finland
Other diseases of joint, Corpus liberum articuli
+∞
323.0
295
*
M24.0
ICD-10 Finland
Loose body in joint
8837.4
323.0
451
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
50.9
252.9
305
93
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
66.3
151.6
174
33
M19.0
ICD-10 Finland
Primary arthrosis of other joints
51.3
132.4
159
38
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
116.8
128.5
137
14
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
124.1
116
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
31.4
116.8
157
61
M25.5
ICD-10 Finland
Pain in joint
6.2
90.9
288
653
NCF25
NOMESCO Finland
Operation for osteochondritis of elbow joint, arthroscopic
232.9
82.9
84
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
60.6
79.0
92
17
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
13.9
78.0
139
118
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
196.5
70.2
72
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
15.1
67.9
116
88
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
+∞
67.6
64
*
9254
FHL
Arthrotomy (includes biopsy, revision, loose removal, fixation, and similar procedures)
187.6
67.1
69
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
31.2
61.5
82
29
1220
FHL
Arthroscopy
24.1
59.3
85
39
M01AX05
ATC
glucosamine; oral
5.9
59.2
183
378
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
152.6
54.6
57
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
52.6
50
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.1
51.7
436
2168
WX320
NOMESCO Finland
Spinalanesthesy
4.4
51.6
217
619
7181B
ICD-9 Finland
Other derangement of joint, Loose body in joint[NIVELHIIRI,KYYNÄRNIVEL]
+∞
51.6
49
*
M01AH05
ATC
etoricoxib; oral
3.0
50.9
504
2785
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
9.5
50.3
108
129
N02AX02
ATC
tramadol; systemic, rectal
3.1
49.7
398
1896
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
48.4
46
*
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
135.5
48.3
51
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
127.1
45.2
48
*
ZXA05
NOMESCO Finland
Left side
3.5
44.0
253
929
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
56.4
40.9
48
9
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
39.9
39.2
49
13
L15
ICPC
Knee symptom/complaint
4.1
38.2
166
476
N02BE01
ATC
paracetamol; systemic, rectal
3.2
38.0
709
5323
ZXA00
NOMESCO Finland
Right side
3.2
37.6
244
963
NCF20
NOMESCO Finland
Operation for osteochondritis of elbow joint, open
372.5
36.3
36
*
1224
FHL
Arthroscopy and loose removal
372.5
36.3
36
*
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
6.8
36.2
95
154
M22.4
ICD-10 Finland
Chondromalacia patellae
193.2
36.0
37
*
1221
FHL
Arthroscopy and meniscus surgery
39.5
35.9
45
12
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
35.7
321
1556
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
7.6
34.7
84
121
NHF25
NOMESCO Finland
Operation for debridement of ankle joint, arthroscopic
59.8
34.5
40
7
M09AX01
ATC
hyaluronic acid; parenteral
16.0
33.0
54
36
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
121.5
32.9
35
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
19.2
32.2
49
27
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
22.6
31.2
45
21
M20.1
ICD-10 Finland
Hallux valgus (acquired)
14.9
31.0
52
37
M23.8
ICD-10 Finland
Other internal derangements of knee
25.1
30.8
43
18
7181F
ICD-9 Finland
NA
+∞
30.4
29
*
M13.9
ICD-10 Finland
Arthritis, unspecified
13.4
30.2
53
42
B01AB05
ATC
enoxaparin; parenteral
2.7
30.1
250
1132
NCA30
NOMESCO Finland
Exploration of joint of elbow or forearm, arthroscopic
313.0
30.0
30
*
M01AH01
ATC
celecoxib; oral (coxibs)
3.3
27.4
151
517
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
55.3
27.3
32
6
M01AC06
ATC
meloxicam; systemic, rectal
2.4
27.2
295
1530
L90
ICPC
Osteoarthrosis of knee
13.4
26.9
47
37
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.9
26.5
117
334
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.8
26.3
197
830
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
25.1
24
*
M01AE03
ATC
ketoprofen; systemic, rectal
2.3
25.0
323
1812
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
+∞
24.1
23
*
M01AB05
ATC
diclofenac; systemic, rectal
2.1
23.8
544
3897
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
6.8
23.4
60
94
M93.2
ICD-10 Finland
Osteochondritis dissecans
85.8
22.8
25
*
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
236.0
22.7
23
*
H02AB06
ATC
prednisolone; systemic
2.1
22.7
359
2181
M79.6
ICD-10 Finland
Pain in limb
2.3
22.6
266
1412
M24.2
ICD-10 Finland
Disorder of ligament
46.4
22.5
27
6
M02AA07
ATC
piroxicam; topical
2.2
22.0
285
1579
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
22.0
21
*
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
+∞
22.0
21
*
1223
FHL
Arthroscopy and articular cartilage surgery
118.0
21.7
23
*
M01AX17
ATC
nimesulide; oral
2.5
21.7
198
922
X58
ICD-10 Finland
Exposure to other specified factors
3.0
21.3
132
484
M23.4
ICD-10 Finland
Loose body in knee
+∞
20.9
20
*
1225
FHL
Arthroscopy and other therapeutic procedure
30.9
20.7
27
9
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
19.9
19
*
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
9.0
19.8
42
49
X59
ICD-10 Finland
Exposure to unspecified factor
2.7
19.8
154
650
B01AX06
ATC
[U] rivaroxaban; oral
75.3
19.8
22
*
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
204.5
19.6
20
*
S83.2
ICD-10 Finland
Tear of meniscus, current
4.5
19.3
70
166
72221
ICD-8 Finland
Osteochondrosis, Dissecans
71.5
18.8
21
*
M03BX02
ATC
tizanidine; oral
1.9
18.7
493
3563
M01AE01
ATC
ibuprofen; systemic, rectal
2.4
18.5
727
6156
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
4.7
18.4
64
145
M20.2
ICD-10 Finland
Hallux rigidus
45.0
18.3
22
5
M01AE02
ATC
naproxen; oral, rectal
1.9
18.2
432
2993
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.2
17.8
37
42
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
17.8
17
*
R03AC02
ATC
salbutamol; inhalant
1.9
17.8
399
2700
M22.0
ICD-10 Finland
Recurrent dislocation of patella
183.6
17.6
18
*
S18
ICPC
Laceration/cut
2.0
17.5
313
1943
ACC51
NOMESCO Finland
Release of median nerve
4.5
17.5
63
148
M24.4
ICD-10 Finland
Recurrent dislocation and subluxation of joint
+∞
16.7
16
*
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
40.9
16.4
20
5
J01DA01
ATC
[U] cefalexin; systemic
1.8
16.4
489
3615
M03BC01
ATC
orphenadrine (citrate); systemic
2.2
16.2
193
1007
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
30.7
16.2
21
7
N03AX16
ATC
pregabalin; oral
2.3
16.1
169
833
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.0
16.0
52
110
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
5.3
16.0
49
97
A07EC01
ATC
sulfasalazine; oral, rectal
6.1
15.9
43
73
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
8.2
15.9
35
44
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
15.8
220
1227
NGF20
NOMESCO Finland
Operation for osteochondritis of knee, open
61.2
15.8
18
*
L89
ICPC
Osteoarthrosis of hip
16.0
15.8
25
16
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
86.7
15.6
17
*
M19.9
ICD-10 Finland
Arthrosis, unspecified
10.3
15.5
30
30
M17.5
ICD-10 Finland
Other secondary gonarthrosis
162.8
15.5
16
*
9271
FHL
Hallux surgery
162.8
15.5
16
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.7
15.5
115
471
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.8
15.4
52
115
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
15.3
223
1263
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.3
14.8
78
255
NHA30
NOMESCO Finland
Exploration of joint of ankle or foot, arthroscopic
32.3
14.8
19
6
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
21.5
14.7
21
10
7174A
ICD-9 Finland
Internal derangement of knee, Derangement of lateral meniscus
+∞
14.6
14
*
7327A
ICD-9 Finland
Osteochondropathies, Osteochondritis dissecans[OSTEOCHONDRITIS DISSECANS GENUS]
152.5
14.5
15
*
NF1AA
NOMESCO Finland
Hip X-ray examination
4.6
14.3
50
115
WX002
NOMESCO Finland
Sedation and analgesia
2.3
14.2
150
735
M01AH02
ATC
rofecoxib; oral
2.7
14.1
100
395
N03AX12
ATC
gabapentin; oral
2.6
14.1
106
435
M54.5
ICD-10 Finland
Low back pain
1.9
14.0
238
1426
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
4.1
13.9
54
138
P01BA02
ATC
hydroxychloroquine; oral
6.2
13.6
36
60
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
13.6
13
*
M24.8
ICD-10 Finland
Other specific joint derangements, not elsewhere classified
142.1
13.5
14
*
M01AB01
ATC
indometacin; systemic, rectal
3.4
13.3
65
201
SPAT1153
SPAT
Removal of sutures
1.9
13.2
224
1333
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.4
13.2
116
520
R4110
NOMESCO Finland
Physiotherapy
2.0
12.9
199
1143
NG1EA
NOMESCO Finland
Knee X-ray examination with wrench
50.8
12.9
15
*
J01AA02
ATC
doxycycline; systemic
1.8
12.7
597
4888
M18.1
ICD-10 Finland
Other primary arthrosis of first carpometacarpal joint
32.6
12.6
16
5
72908
ICD-8 Finland
Other diseases of joint, Alii definiti
32.6
12.6
16
5
NBF25
NOMESCO Finland
Operation for humeroscapular osteochondritis, arthroscopic
7.5
12.6
29
40
WX200
NOMESCO Finland
Interscalenous plexus blockade
9.2
12.3
25
28
M54.4
ICD-10 Finland
Lumbago with sciatica
2.3
12.1
119
565
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.7
12.1
52
146
M16
ICD-10 Finland
Coxarthrosis [arthrosis of hip]
6.6
11.9
30
47
J01FA10
ATC
azithromycin; systemic
1.7
11.9
419
3126
M01AE11
ATC
tiaprofenic acid; oral, rectal
4.9
11.9
38
80
M48.0
ICD-10 Finland
Spinal stenosis
2.6
11.6
84
339
NHE15
NOMESCO Finland
Suture or reinsertion of ligament of ankle
19.2
11.6
17
9
NG2AA
NOMESCO Finland
Patella X-ray examination
23.2
11.6
16
7
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
11.5
11
*
7151B
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, KYYNÄRNIVEL]
+∞
11.5
11
*
A02BC02
ATC
pantoprazole; systemic
1.7
11.5
471
3653
NHF20
NOMESCO Finland
Operation for debridement of ankle joint, open
121.5
11.4
12
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
11.4
178
1023
L08
ICPC
Shoulder symptom/complaint
2.1
11.3
131
667
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
15.3
11.3
18
12
M67.4
ICD-10 Finland
Ganglion
3.5
11.3
53
160
NG1DA
NOMESCO Finland
X-ray of knees
35.5
11.3
14
*
WX110
NOMESCO Finland
Local anesthesy
1.7
11.0
518
4148
B01AF01
ATC
rivaroxaban; oral
2.7
11.0
75
290
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
43.9
10.9
13
*
WX702
NOMESCO Finland
Supraglottic ventilation device
3.7
10.7
46
130
J01DB01
ATC
cefalexin; oral
1.7
10.6
629
5342
M22.1
ICD-10 Finland
Recurrent subluxation of patella
111.3
10.4
11
*
9521
FHL
Arthrotomy (eg loose removal)
+∞
10.4
10
*
7151E
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, LONKKANIVEL]
+∞
10.4
10
*
ND1CG
NOMESCO Finland
Wrist and hand extensive MRI examination with high intensity magnet
32.9
10.3
13
*
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
10.3
207
1293
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.1
10.3
55
184
M18.0
ICD-10 Finland
Primary arthrosis of first carpometacarpal joints, bilateral
23.7
10.3
14
6
A02BC05
ATC
esomeprazole; systemic
1.7
10.2
276
1889
G56.2
ICD-10 Finland
Lesion of ulnar nerve
4.0
9.9
39
102
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
3.1
9.8
54
184
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
26.3
9.8
13
5
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
20.3
9.8
14
7
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
10.8
9.8
18
17
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
10.8
9.8
18
17
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
3.7
9.7
42
119
R03DC03
ATC
montelukast; oral
2.1
9.6
109
550
NC1BG
NOMESCO Finland
Elbow MRI examination with high intensity magnet
30.4
9.4
12
*
73799
ICD-8 Finland
Hallux valgus and varus
+∞
9.4
9
*
NGC00
NOMESCO Finland
Exchange of a loose part of prosthesis in knee joint
+∞
9.4
9
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
22.0
9.4
13
6
A02BC03
ATC
lansoprazole; oral
1.7
9.3
201
1280
S83.0
ICD-10 Finland
Dislocation of patella
7.4
9.3
21
29
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.6
9.1
65
261
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
18.8
8.9
13
7
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
8.9
71
303
M94.2
ICD-10 Finland
Chondromalacia
24.3
8.9
12
5
M15
ICD-10 Finland
Polyarthrosis
4.8
8.8
28
60
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
6.2
8.7
22
36
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
16.5
8.6
13
8
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
9.1
8.6
17
19
L01
ICPC
Neck symptom/complaint
2.2
8.5
86
412
L16
ICPC
Ankle symptom/complaint
2.6
8.5
62
253
M01AB55
ATC
diclofenac, combinations; oral
3.0
8.5
48
166
M23.5
ICD-10 Finland
Chronic instability of knee
90.9
8.4
9
*
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
4.9
8.4
26
54
WZA90
NOMESCO Finland
Other doctors statement
1.8
8.4
152
911
NBE45
NOMESCO Finland
Plastic repair of ligament of shoulder not using prosthetic material, arthroscopic
12.9
8.4
14
11
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
12.9
8.4
14
11
7176A
ICD-9 Finland
Internal derangement of knee, Loose body in knee
+∞
8.3
8
*
7152F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, secondary[OSTEORTHROSIS SECUNDARIA,POLVI]
+∞
8.3
8
*
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
9.6
8.3
16
17
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.3
8.2
77
358
M19.8
ICD-10 Finland
Other specified arthrosis
6.1
8.2
21
35
R06AE09
ATC
levocetirizine; oral
2.0
8.1
100
521
M54.2
ICD-10 Finland
Cervicalgia
2.8
8.1
51
190
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
5.1
8.1
24
48
WZA00
NOMESCO Finland
Short statement of of health and health related matters
3.2
8.0
40
129
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
13.2
7.9
13
10
WX204
NOMESCO Finland
Axillary plexus blockaced
4.4
7.9
27
63
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.3
7.8
38
120
8360A
ICD-9 Finland
Dislocation of knee, Tear of medial cartilage or meniscus of knee, current
10.9
7.8
14
13
M23.3
ICD-10 Finland
Other meniscus derangements
15.2
7.7
12
8
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
45.4
7.7
9
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
45.4
7.7
9
*
NGT60
NOMESCO Finland
Forcible manipulation of knee joint
45.4
7.7
9
*
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
4.0
7.7
29
74
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
7.5
7.7
17
23
S83.4
ICD-10 Finland
Sprain and strain involving (fibular)(tibial) collateral ligament of knee
4.3
7.6
27
65
R05FB02
ATC
cough suppressants and expectorants
1.6
7.6
260
1865
T93.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of lower limb
10.1
7.5
14
14
M01AB08
ATC
etodolac; oral
2.7
7.5
49
188
NG1AA
SPAT
NA
3.5
7.5
33
97
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
80.7
7.4
8
*
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
80.7
7.4
8
*
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
80.7
7.4
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
7.4
289
2135
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.1
7.4
39
131
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
7.3
71
335
SFA00
NOMESCO Finland
Small filling
2.0
7.3
92
484
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
7.3
7
*
212
Kela drug reimbursment
Gout
+∞
7.3
7
*
9314
FHL
Total knee endoprosthesis (also includes patellar part)
+∞
7.3
7
*
M25.8
ICD-10 Finland
Other specified joint disorders
+∞
7.3
7
*
NG2CA
NOMESCO Finland
X-ray of patella with specialised projection
+∞
7.3
7
*
NCF10
NOMESCO Finland
Synovectomy of elbow joint, open
+∞
7.3
7
*
NGB10
NOMESCO Finland
Primary partial prosthetic replacement of knee joint, demi prosthesis
+∞
7.3
7
*
M17.2
ICD-10 Finland
Post-traumatic gonarthrosis, bilateral
+∞
7.3
7
*
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
+∞
7.3
7
*
NH1AD
NOMESCO Finland
Ankle and foot CT
6.3
7.3
18
29
9255
FHL
Joint auger removal
15.9
7.2
11
7
9243
FHL
Plastic of the patella and its tendons
15.9
7.2
11
7
84400
ICD-8 Finland
Sprains and strains of knee and leg
7.4
7.2
16
22
S93.2
ICD-10 Finland
Rupture of ligaments at ankle and foot level
7.4
7.2
16
22
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
7.2
185
1233
NFB50
NOMESCO Finland
Primary total prosthetic replacement of hip joint using cement
30.3
7.2
9
*
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
20.2
7.1
10
5
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
3.6
7.0
30
86
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.5
7.0
378
2988
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
7.0
503
4220
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
6.9
278
2059
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
6.9
117
686
ACC53
NOMESCO Finland
Release of ulnar nerve
5.9
6.9
18
31
L10
ICPC
Elbow symptom/complaint
3.0
6.9
37
126
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
6.9
118
693
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.7
6.9
136
839
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
6.8
6.8
16
24
SPAT1210
SPAT
Application of cast or individual aid
3.7
6.8
28
78
S53.4
ICD-10 Finland
Sprain and strain of elbow
11.0
6.8
12
11
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
6.8
265
1950
M25.2
ICD-10 Finland
Flail joint
40.4
6.8
8
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
40.4
6.8
8
*
L04AA13
ATC
leflunomide; oral
16.8
6.8
10
6
Z50.1
ICD-10 Finland
Other physical therapy
3.1
6.7
35
117
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
6.7
193
1317
S93.4
ICD-10 Finland
Sprain and strain of ankle
2.2
6.7
67
322
R06.0
ICD-10 Finland
Dyspnoea
1.7
6.7
154
991
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
6.7
335
2603
M35.7
ICD-10 Finland
Hypermobility syndrome
12.4
6.6
11
9
H02BX01
ATC
methylprednisolone, combinations; systemic
3.0
6.6
36
125
M77.1
ICD-10 Finland
Lateral epicondylitis
2.4
6.6
53
230
E883A
ICD-9 Finland
Fall into hole or other opening in surface
2.7
6.5
42
159
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
6.5
266
1970
R06AE07
ATC
cetirizine; oral
1.5
6.5
283
2124
L88
ICPC
Rheumatoid/seropositive arthritis
6.9
6.5
15
22
R05
ICPC
Cough
1.7
6.4
132
821
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
70.3
6.4
7
*
TNX30
NOMESCO Finland
Soft bandage, unspecified region
7.5
6.4
14
19
L12
ICPC
Hand/finger symptom/complaint
2.0
6.4
82
436
UJF32
NOMESCO Finland
Coloscopy
1.6
6.4
162
1071
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
14.4
6.4
10
7
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.4
354
2797
J01FA06
ATC
roxithromycin; oral
1.5
6.4
274
2056
NBL22
NOMESCO Finland
Myotomy, tenotomy or excision of tendon of upper arm
6.6
6.3
15
23
G47.3
ICD-10 Finland
Sleep apnoea
1.6
6.3
157
1032
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
6.3
108
635
M65.3
ICD-10 Finland
Trigger finger
3.4
6.3
28
84
1222
FHL
Arthroscopy and synovial surgery
18.2
6.3
9
5
NDA30
NOMESCO Finland
Exploration of joint of wrist or hand, arthroscopic
18.2
6.3
9
5
S22.3
ICD-10 Finland
Fracture of rib
2.3
6.3
53
234
RF210
NOMESCO Finland
NA
4.4
6.3
21
49
NGC60
NOMESCO Finland
Exchange or addition of patellar part
+∞
6.3
6
*
71308
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) alia (spinali excepta)
+∞
6.3
6
*
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
+∞
6.3
6
*
7183F
ICD-9 Finland
Other derangement of joint, Recurrent dislocation of joint[LUXATIO HABITUALIS, POLVI]
+∞
6.3
6
*
NCF15
NOMESCO Finland
Synovectomy of elbow joint, arthroscopic
+∞
6.3
6
*
M79.7
ICD-10 Finland
Fibromyalgia
4.8
6.2
19
40
M23
ICD-10 Finland
Internal derangement of knee
4.8
6.2
19
40
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
6.2
139
889
WX290
NOMESCO Finland
Other blockade of nerve
1.5
6.1
308
2382
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.1
384
3102
S89.9
ICD-10 Finland
Unspecified injury of lower leg
3.8
6.1
24
65
M35.3
ICD-10 Finland
Polymyalgia rheumatica
3.8
6.1
24
65
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
6.1
105
620
M01AC01
ATC
piroxicam; systemic, rectal
1.9
6.1
94
533
R06AX27
ATC
desloratadine; oral
1.6
6.1
174
1183
Z01.2
ICD-10 Finland
Dental examination
1.5
6.1
274
2068
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.6
6.1
40
156
9057A
ICD-9 Finland
Late effects of musculoskeletal and connective tissue injuries, Late effect of sprain and strain without mention of tendon injury
10.1
6.0
11
11
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
4.2
6.0
21
51
H02AB04
ATC
methylprednisolone; systemic
1.9
6.0
92
523
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
6.0
444
3695

Mortality – FinRegistry

↥

Association

Association between endpoint M13_LOOSEJOINT and mortality.

Females

Parameter HR [95% CI] p-value
M13_LOOSEJOINT 0.759 [0.58, 0.99] 0.038
Birth year 0.999 [0.99, 1.01] 0.773

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 1209 females with M13_LOOSEJOINT died.

Males

Parameter HR [95% CI] p-value
M13_LOOSEJOINT 0.783 [0.66, 0.94] 0.007
Birth year 0.985 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 138 out of 2346 males with M13_LOOSEJOINT died.

Mortality risk

Mortality risk for people of age

years, who have M13_LOOSEJOINT.

N-year risk Females Males
1 0.081% 0.149%
5 0.524% 0.934%
10 1.311% 2.189%
15 2.421% 4.269%
20 4.278% 7.068%

Relationships between endpoints

↥

Index endpoint: M13_LOOSEJOINT – Loose body in joint

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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