Unequal limb length (acquired)

M13_LIMBLENGTH

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M21.7 Cause of death: ICD-10 — M21.7 2 out of 7 registries used, show all original rules.	357
4. Check minimum number of events None	357
5. Include endpoints None	357
6. Filter based on genotype QC (FinnGen only)	357

Control definitions (FinnGen only)

Control exclude: M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M21
Name in latin: Inaequalitas hongitudinis membrorum (acquisita)

NAME	M13_LIMBLENGTH
CONTROL_EXCLUDE	M13_ARTHROPATHIES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M217
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M217
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Unequal limb length (acquired) based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	5169	2272	2894
Only index persons	4933	2151	2782
Unadjusted period prevalence (%)
Whole population	0.07	0.07	0.08
Only index persons	0.09	0.08	0.11
Median age at first event (years)
Whole population	13.10	12.57	13.51
Only index persons	13.24	12.74	13.63

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	357	218	139
Unadjusted period prevalence (%)	0.07	0.07	0.06
Median age at first event (years)	14.20	14.08	14.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
316: Matched controls
3159

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M21.7

ICD-10 Finland

Unequal limb length (acquired)

+∞

323.0

316

NFK20

NOMESCO Finland

Epiphysiodesis of femur

413.4

37.9

NGK20

NOMESCO Finland

Epiphysiodesis of knee or lower leg

345.2

31.4

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

141.1

25.0

M16.1

ICD-10 Finland

Other primary coxarthrosis

82.5

21.0

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

24.5

19.4

M17.1

ICD-10 Finland

Other primary gonarthrosis

24.5

18.0

M41.1

ICD-10 Finland

Juvenile idiopathic scoliosis

15.8

18.0

NFU20

NOMESCO Finland

Removal of internal fixation device from femur

39.2

17.8

M25.5

ICD-10 Finland

Pain in joint

3.8

16.2

243

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

28.0

15.8

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

7.5

15.2

NF1AA

NOMESCO Finland

Hip X-ray examination

15.2

14.8

NFB30

NOMESCO Finland

Primary total prosthetic replacement of hip joint not using cement

78.6

13.7

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

146.0

13.6

NK6JD

NOMESCO Finland

Ortopaedic measurement of extemities with CT

+∞

12.6

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

135.1

12.5

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

135.1

12.5

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

7.6

12.1

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

7.1

12.1

N03AX12

ATC

gabapentin; oral

4.2

10.5

105

M70.6

ICD-10 Finland

Trochanteric bursitis

5.7

10.3

N02AX02

ATC

tramadol; systemic, rectal

2.6

10.2

397

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

8.0

9.6

M19.0

ICD-10 Finland

Primary arthrosis of other joints

31.1

9.5

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

31.1

9.5

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

103.0

9.5

M08.4

ICD-10 Finland

Pauciarticular juvenile arthritis

+∞

9.4

ZXA00

NOMESCO Finland

Right side

2.8

9.4

254

NK6MA

NOMESCO Finland

Measurement of bone age from hand and elbow using X-ray

7.1

9.3

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.3

9.0

105

570

M21.4

ICD-10 Finland

Flat foot [pes planus] (acquired)

19.3

9.0

L13

ICPC

Hip symptom/complaint

4.2

9.0

WX320

NOMESCO Finland

Spinalanesthesy

3.1

8.6

178

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.7

8.5

110

NJ3NA

NOMESCO Finland

Measurement of difference in extremity lengty with X-ray

92.4

8.5

Q72.88

ICD-10 Finland

Other reduction defects of lower himb(s)

92.4

8.5

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

10.4

8.1

N03AX16

ATC

pregabalin; oral

3.0

8.1

184

M75.1

ICD-10 Finland

Rotator cuff syndrome

3.2

8.0

153

S82.2

ICD-10 Finland

Fracture of shaft of tibia

8.1

8.0

M13.9

ICD-10 Finland

Arthritis, unspecified

9.8

7.9

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

5.0

7.8

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

4.8

7.8

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.3

7.7

379

M15.9

ICD-10 Finland

Polyarthrosis, unspecified

18.9

7.7

B01AB05

ATC

enoxaparin; parenteral

2.6

7.6

259

NFK50

NOMESCO Finland

Shortening osteotomy of femur

+∞

7.3

M21.0

ICD-10 Finland

Valgus deformity, not elsewhere classified

+∞

7.3

NJ3MA

NOMESCO Finland

Measurement of extremity length with X-ray

+∞

7.3

NFC20

NOMESCO Finland

Secondary implantation of hip prosthesis

+∞

7.3

NGU20

NOMESCO Finland

Removal of internal fixation device from knee or lower leg

12.4

7.1

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

6.6

7.0

NG1BG

NOMESCO Finland

Knee and lower leg MRI examination with high intensity magnet

9.6

6.8

M41.9

ICD-10 Finland

Scoliosis, unspecified

9.6

6.8

S72.3

ICD-10 Finland

Fracture of shaft of femur

17.1

6.8

NFK30

NOMESCO Finland

Angulation, rotation or displacement osteotomy of femur

40.9

6.8

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

4.1

6.8

M54.4

ICD-10 Finland

Lumbago with sciatica

2.9

6.7

151

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

3.7

6.5

M79.6

ICD-10 Finland

Pain in limb

2.1

6.5

499

M20.4

ICD-10 Finland

Other hammer toe(s) (acquired)

71.2

6.4

9165

FHL

Removal of osteosynthesis material

14.7

6.4

NE1AA

NOMESCO Finland

Pelvis X-ray examination

6.8

6.4

L04AA13

ATC

leflunomide; oral

+∞

6.3

M22.0

ICD-10 Finland

Recurrent dislocation of patella

+∞

6.3

NF1DA

NOMESCO Finland

X-ray of hips

27.3

6.3

ZXA05

NOMESCO Finland

Left side

2.5

6.2

216

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

4.9

6.2

N02BE01

ATC

paracetamol; systemic, rectal

1.9

6.2

224

1787

P01BA02

ATC

hydroxychloroquine; oral

7.9

6.2

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

5.1

6.1

M43.1

ICD-10 Finland

Spondylolisthesis

8.9

6.1

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.0

6.1

496

M01AH05

ATC

etoricoxib; oral

1.9

6.1

117

754

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

6.2

6.1

Mortality – FinRegistry

↥

Association

Association between endpoint M13_LIMBLENGTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_LIMBLENGTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_LIMBLENGTH – Unequal limb length (acquired)

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Unequal limb length (acquired)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints