No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
178 |
4. Check minimum number of eventsNone |
178 |
5. Include endpointsNone |
178 |
6. Filter based on genotype QC (FinnGen only) |
178 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Other specified acquired deformities of limbs
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1624 | 978 | 639 |
| Only index persons | 1493 | 897 | 596 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 32.12 | 39.17 | 21.06 |
| Only index persons | 31.42 | 38.34 | 21.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 178 | 119 | 59 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 39.75 | 39.35 | 40.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 158
- Matched controls
- 1579
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.8
ICD-10 Finland
Other specified acquired deformities of limbs
1081.3
72.1
65
*
M21.9
ICD-10 Finland
Acquired deformity of limb, unspecified
+∞
54.4
49
*
7368X
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformities of other parts of limbs
+∞
39.2
36
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
240.4
21.1
21
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
19.1
18
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
17.8
17.4
27
18
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
16.0
16.7
27
20
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
15.9
15
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
13.7
13
*
9115
FHL
Epiphysiodesis (in hip luxation trokanter 9408)
152.6
13.7
14
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
25.2
13.2
18
8
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
50.9
12.1
14
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.4
11.9
84
396
WX320
NOMESCO Finland
Spinalanesthesy
4.6
11.8
45
126
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
11.6
11
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
38.1
11.5
14
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
12.5
11.4
20
18
9102
FHL
Trepanation or removal of the local bone process
117.5
10.6
11
*
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
10.5
10
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
58.7
9.8
11
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
23.4
9.5
13
6
7369X
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformity of limb, site unspecified
+∞
9.5
9
*
9271
FHL
Hallux surgery
+∞
9.5
9
*
B01AB05
ATC
enoxaparin; parenteral
3.4
9.4
53
204
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
12.6
8.8
15
13
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
35.3
8.2
10
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
6.6
8.0
20
34
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
11.7
8.0
14
13
M01AH05
ATC
etoricoxib; oral
2.6
8.0
92
545
M25.5
ICD-10 Finland
Pain in joint
3.3
7.9
43
160
NH3EA
NOMESCO Finland
Feet X-ray examination with load
47.4
7.8
9
*
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
47.4
7.8
9
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
7.5
66
333
ZXA05
NOMESCO Finland
Left side
3.2
7.5
42
159
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
14.3
7.5
12
9
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
83.9
7.5
8
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.9
7.4
20
38
S18
ICPC
Laceration/cut
2.6
7.3
68
354
N02AX02
ATC
tramadol; systemic, rectal
2.7
7.3
64
321
L13
ICPC
Hip symptom/complaint
4.2
7.2
27
73
L15
ICPC
Knee symptom/complaint
3.6
7.1
33
108
X59
ICD-10 Finland
Exposure to unspecified factor
3.2
7.0
39
146
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
17.7
6.8
10
6
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
41.9
6.8
8
*
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
72.7
6.5
7
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
7.6
6.4
14
20
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
6.3
6
*
M21.5
ICD-10 Finland
Acquired clawhand, clubhand, clawfoot and clubfoot
+∞
6.3
6
*
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
6.3
6
*
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
+∞
6.3
6
*
M79.6
ICD-10 Finland
Pain in limb
2.5
6.0
58
301
Mortality – FinRegistry
↥Association
Association between endpoint M13_LIMBDEFORM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_LIMBDEFORM | 1.57 [1.14, 2.17] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.203 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 621 females with M13_LIMBDEFORM died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have M13_LIMBDEFORM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.187% | No data |
| 5 | 0.894% | No data |
| 10 | 2.358% | No data |
| 15 | 4.271% | No data |
| 20 | 7.636% | No data |
Relationships between endpoints
↥Index endpoint: M13_LIMBDEFORM – Other specified acquired deformities of limbs
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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