This is a non-core endpoint: only basic statistics are computed.
Kaschin-Beck disease
M13_KASHINBECK
skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
30 |
4. Check minimum number of eventsNone |
30 |
5. Include endpointsNone |
30 |
6. Filter based on genotype QC (FinnGen only) |
30 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M12
- Name in latin
- Morbus Kashin-Beck
Similar endpoints
↥List of similar endpoints to
Kaschin-Beck disease
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Anti-inflammatory and antirheumatic products, non-steroids
- Paracetamol of NSAID medication
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 287 | 187 | 100 |
| Only index persons | 269 | 177 | 92 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | - | 63.85 | 58.81 |
| Only index persons | 61.33 | 62.76 | 58.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 30 | 19 | 11 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | 61.10 | 57.60 | 67.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(40768804) Tissue Pathology biopsy report
19
95
3.73
2.98
2.6
2.2
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
5
9
6.40
2.30
1.4
1.2
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
8
26
3.81
2.20
2.5
1.5
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
5
11
5.21
2.02
5.6
2.7
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
16
93
2.54
1.64
3.6
3.8
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
12
64
2.46
1.43
2.3
3.6
—
—
—
0
0
(3026782) Osmolality of Urine
10
53
2.33
1.18
2.5
2.4
mosm/kgh2o
543.9
535.2
—
10
43
(3002256) Pathology report gross observation
7
32
2.54
1.17
1.7
1.3
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
9
50
2.14
1.09
3.3
3.6
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
11
63
2.18
1.08
1.7
1.7
mmol/l
1.6
1.4
0.27
11
46
(3015736) pH of Urine
14
89
2.07
1.06
4.1
3.1
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
15
100
2.00
0.98
1.7
2.2
pmol/l
101.1
95.6
—
7
49
(40758558) Short blood count panel - Blood
10
57
2.13
0.98
12.4
6.1
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
8
45
2.06
0.94
2.3
2.5
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
6
33
2.02
0.84
1.7
1.1
—
—
—
0
0
(3019060) Gas panel - Arterial blood
0
26
0.00
0.83
0.0
2.9
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
13
91
1.76
0.68
4.2
3.5
e6/l
7.1
125.8
—
8
59
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
21
0.00
0.62
0.0
2.0
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
10
67
1.74
0.59
2.7
2.2
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
19
157
1.57
0.47
4.5
4.2
—
—
—
0
0
(3044889) 12 lead EKG panel
20
168
1.57
0.45
4.5
3.9
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
13
100
1.53
0.43
5.5
4.7
g/l
37.7
36.0
0.75
13
90
(3023024) Carbon dioxide [Partial pressure] in Capillary blood
0
18
0.00
0.41
0.0
5.2
—
5.1
—
0
18
(3009542) Hematocrit [Volume Fraction] of Blood
24
213
1.63
0.40
24.0
14.1
%
37.8
39.8
0.38
18
133
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
9
73
1.33
0.29
3.8
2.3
u/l
121.3
118.4
—
9
67
(36304419) Bacteria [Presence] in Urine
9
73
1.33
0.29
4.0
2.7
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
11
89
1.37
0.25
3.4
3.0
—
—
—
0
0
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
5
40
1.30
0.24
4.2
3.5
ng/l
10.4
49.8
—
5
34
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
0
11
0.00
0.22
0.0
6.7
—
24.1
—
0
11
(3043409) Potassium [Moles/volume] in Arterial blood
0
11
0.00
0.22
0.0
1.5
—
3.9
—
0
11
(3018405) Lactate [Moles/volume] in Arterial blood
0
11
0.00
0.22
0.0
1.5
—
1.0
—
0
11
(40768793) Breast Pathology biopsy report
0
10
0.00
0.22
0.0
1.2
—
—
—
0
0
(3022313) Gas panel - Capillary blood
0
12
0.00
0.21
0.0
4.8
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
7
57
1.30
0.20
2.0
2.3
e6/l
5.7
3.8
—
7
46
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
25
233
1.44
0.19
18.1
13.5
mg/l
22.9
24.9
0.14
19
173
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
13
112
1.28
0.18
2.5
2.3
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
9
76
1.26
0.18
6.4
4.1
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
7
87
0.75
0.17
6.1
3.6
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
7
83
0.80
0.17
2.4
2.3
u/l
54.9
57.5
—
7
76
(3026008) Bacteria identified in Urine by Culture
10
85
1.26
0.15
3.1
3.3
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
5
46
1.10
0.10
5.4
4.6
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
5
61
0.78
0.09
1.2
1.3
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
15
155
0.94
0.00
3.0
3.9
mmol/l
6.1
6.6
1.02
15
147
(3041096) Erythrocytes [Presence] in Urine by Automated
6
64
0.92
0.00
5.8
3.1
—
—
—
0
0
(3007930) Methemoglobin/Hemoglobin.total in Blood
0
9
0.00
0.00
0.0
6.7
—
1.0
—
0
9
(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3018572) Chloride [Moles/volume] in Blood
0
8
0.00
0.00
0.0
6.4
—
104.8
—
0
8
(3029080) Hemoglobin [Entitic mass] in Reticulocytes
0
5
0.00
0.00
0.0
2.6
—
30.8
—
0
5
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
0
5
0.00
0.00
0.0
2.2
—
57.4
—
0
5
(3005570) Glucose [Moles/volume] in Urine
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
1.0
—
0
5
(3013512) EKG study
7
74
0.93
0.00
4.9
4.2
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3030905) Polymorphonuclear cells [#/volume] in Blood
0
5
0.00
0.00
0.0
1.8
—
5.7
—
0
5
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.9
—
0.0
—
0
8
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.9
—
0.0
—
0
8
(3032080) INR in Blood by Coagulation assay
9
94
0.94
0.00
3.6
8.3
—
1.4
—
0
30
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.9
—
37.0
—
0
8
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
13
130
1.00
0.00
8.8
5.7
umol/l
9.5
10.0
0.22
13
119
(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.9
—
0.0
—
0
8
(3028626) Oxygen [Partial pressure] in Capillary blood
0
7
0.00
0.00
0.0
3.7
—
8.3
—
0
7
(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood
0
9
0.00
0.00
0.0
6.3
—
1.9
—
0
9
(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
8
79
1.02
0.00
5.1
3.2
—
—
—
0
0
(3027456) Digoxin [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
5.8
—
0.8
—
0
6
(40768795) Lymph node Pathology biopsy report
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3003181) Sodium [Moles/volume] in Urine
0
9
0.00
0.00
0.0
1.1
—
50.6
—
0
9
(3039000) Anion gap in Blood
0
8
0.00
0.00
0.0
6.4
—
11.5
—
0
8
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3015235) Bicarbonate [Moles/volume] in Capillary blood
0
7
0.00
0.00
0.0
2.7
—
26.4
—
0
7
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.9
—
0.0
—
0
8
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
7
0.00
0.00
0.0
3.6
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.9
—
3.2
—
0
8
(4034850)
0
8
0.00
0.00
0.0
7.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_KASHINBECK and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_KASHINBECK | 1.032 [0.79, 1.34] | 0.813 |
| Birth year | 0.996 [0.99, 1.0] | 0.336 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 186 females with M13_KASHINBECK died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have M13_KASHINBECK.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | No data |
| 5 | 0.616% | No data |
| 10 | 1.581% | No data |
| 15 | 2.881% | No data |
| 20 | 5.35% | No data |
Relationships between endpoints
↥Index endpoint: M13_KASHINBECK – Kaschin-Beck disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data