Risteys · M13_JUVOSTEOCHONRHIP

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M91, M92 Hospital discharge: ICD-9 — 7321X\|732[3-6] Hospital discharge: ICD-8 — 72209\|7222[8-9] Cause of death: ICD-10 — M91, M92 Cause of death: ICD-9 — 7321X\|732[3-6] Cause of death: ICD-8 — 72209\|7222[8-9] 2 out of 7 registries used, show all original rules.	1348
4. Check minimum number of events None	1348
5. Include endpoints None	1348
6. Filter based on genotype QC (FinnGen only)	1348

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	17161	7115	10008
Only index persons	15939	6633	9306
Unadjusted period prevalence (%)
Whole population	0.25	0.20	0.28
Only index persons	0.31	0.24	0.36
Median age at first event (years)
Whole population	14.72	14.39	14.83
Only index persons	14.83	14.62	14.98

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	1348	762	586
Unadjusted period prevalence (%)	0.26	0.26	0.26
Median age at first event (years)	19.44	18.39	20.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1214: Matched controls
12140

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M92.5

ICD-10 Finland

Juvenile osteochondrosis of tibia and fibula

594.3

291.5

278

M92.6

ICD-10 Finland

Juvenile osteochondrosis of tarsus

2454.4

205.1

193

M92.7

ICD-10 Finland

Juvenile osteochondrosis of metatarsus

656.3

122.5

119

M91.1

ICD-10 Finland

Juvenile osteochondrosis of head of femur [Legg-Calvé-Perthes]

1194.5

113.5

109

72209

ICD-8 Finland

Osteochondrosis, spinalis juvenilis (Scheuermann) NUD

+∞

101.5

7324B

ICD-9 Finland

Osteochondropathies, Juvenile osteochondrosis of lower extremity, excluding foot[OSTEOCHONDROSIS JUVENILIS TUBEROSITATIS TIBIAE]

+∞

98.3

M92.4

ICD-10 Finland

Juvenile osteochondrosis of patella

584.3

57.1

M93.2

ICD-10 Finland

Osteochondritis dissecans

+∞

46.1

9102

FHL

Trepanation or removal of the local bone process

33.8

44.5

NGK05

NOMESCO Finland

Partial or total excision of bone of lower leg

99.9

44.1

NHK99

NOMESCO Finland

Other operation on bone of ankle or foot

14.3

39.7

M91.2

ICD-10 Finland

Coxa plana

+∞

38.7

NHK10

NOMESCO Finland

Incision or excision of metatarsal or tarsal bone

21.2

35.9

M92.3

ICD-10 Finland

Other juvenile osteochondrosis of upper limb

+∞

28.2

M25.5

ICD-10 Finland

Pain in joint

2.2

28.2

370

2029

7323B

ICD-9 Finland

Osteochondropathies, Juvenile osteochondrosis of upper extremity[OSTEOCHONDROSIS JUVENILIS OSSIS LUNATUM CARPI]

+∞

26.1

7325X

ICD-9 Finland

Osteochondropathies, Juvenile osteochondrosis of foot

+∞

25.1

7321A

ICD-9 Finland

Osteochondropathies, Juvenile osteochondrosis of hip and pelvis[COXA PLANA (LEGG-CALVô-PERTHES)]

+∞

25.1

M79.6

ICD-10 Finland

Pain in limb

2.0

25.0

410

2446

M92.9

ICD-10 Finland

Juvenile osteochondrosis, unspecified

+∞

24.0

7324X

ICD-9 Finland

Osteochondropathies, Juvenile osteochondrosis of lower extremity, excluding foot[OSTEOCHONDROSIS JUVENILIS EXTREMITATIS INFER ALIA]

+∞

24.0

NGK99

NOMESCO Finland

Other operation on bone of knee or lower leg

42.3

23.7

M16.7

ICD-10 Finland

Other secondary coxarthrosis

18.5

23.6

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

4.3

23.4

218

M91.9

ICD-10 Finland

Juvenile osteochondrosis of hip and pelvis, unspecified

+∞

23.0

M01AH05

ATC

etoricoxib; oral

1.8

22.4

626

4474

M92.0

ICD-10 Finland

Juvenile osteochondrosis of humerus

+∞

21.9

NHK40

NOMESCO Finland

Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone

9.7

21.7

M91.0

ICD-10 Finland

Juvenile osteochondrosis of pelvis

+∞

19.8

M92.2

ICD-10 Finland

Juvenile osteochondrosis of hand

+∞

19.8

N02AX02

ATC

tramadol; systemic, rectal

1.9

19.8

415

2656

NFU20

NOMESCO Finland

Removal of internal fixation device from femur

15.6

19.8

M92.8

ICD-10 Finland

Other specified juvenile osteochondrosis

203.1

19.6

N02BE01

ATC

paracetamol; systemic, rectal

1.9

19.3

950

7969

ZXA05

NOMESCO Finland

Left side

2.1

18.1

240

1288

NFB30

NOMESCO Finland

Primary total prosthetic replacement of hip joint not using cement

4.0

17.9

191

B01AB05

ATC

enoxaparin; parenteral

2.0

16.7

259

1475

72228

ICD-8 Finland

Osteochondrosis, Juvenilis, alia definita

+∞

16.7

M16.3

ICD-10 Finland

Other dysplastic coxarthrosis

10.6

15.7

M01AE02

ATC

naproxen; oral, rectal

1.6

15.6

684

5338

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.7

15.4

480

3410

M16.1

ICD-10 Finland

Other primary coxarthrosis

3.0

15.4

330

NFK30

NOMESCO Finland

Angulation, rotation or displacement osteotomy of femur

32.1

14.8

M01AB05

ATC

diclofenac; systemic, rectal

1.6

14.5

685

5405

NGK00

NOMESCO Finland

Partial or total excision of bone of patella

151.7

14.5

NF1AA

NOMESCO Finland

Hip X-ray examination

3.1

14.4

272

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

3.1

14.0

274

M01AE03

ATC

ketoprofen; systemic, rectal

1.7

13.7

333

2182

R4110

NOMESCO Finland

Physiotherapy

1.8

13.6

265

1621

M92.1

ICD-10 Finland

Juvenile osteochondrosis of radius and ulna

+∞

13.6

ZXA00

NOMESCO Finland

Right side

1.9

13.5

232

1361

Z3226

NOMESCO Finland

Physiotherapist

1.9

13.4

204

1145

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.5

13.4

104

431

NHG76

NOMESCO Finland

Arthroplasty of other tarsometatarsal joint

11.6

13.3

M01AE01

ATC

ibuprofen; systemic, rectal

1.9

13.2

1060

9538

N02AJ06

ATC

codeine and paracetamol; systemic

1.6

12.9

415

2936

L13

ICPC

Hip symptom/complaint

2.2

12.7

136

659

M54.5

ICD-10 Finland

Low back pain

1.6

12.6

368

2532

M02AA07

ATC

piroxicam; topical

1.7

12.2

295

1922

M01AC06

ATC

meloxicam; systemic, rectal

1.7

11.8

317

2124

NFB60

NOMESCO Finland

Demanding prosthetic replacement of hip

23.1

11.6

NHF25

NOMESCO Finland

Operation for debridement of ankle joint, arthroscopic

7.2

11.5

72211

ICD-8 Finland

Osteochondrosis, Coxae planae

+∞

11.5

9103

FHL

Partial or complete bone removal

121.1

11.4

NG1BG

NOMESCO Finland

Knee and lower leg MRI examination with high intensity magnet

3.1

11.3

203

M22.4

ICD-10 Finland

Chondromalacia patellae

3.3

11.2

176

WX320

NOMESCO Finland

Spinalanesthesy

1.8

11.2

200

1181

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.0

11.0

143

756

NGF40

NOMESCO Finland

Repair of defect of cartilage in the knee joint with transplant

43.7

10.9

NF1DA

NOMESCO Finland

X-ray of hips

5.6

10.9

M03BX02

ATC

tizanidine; oral

1.5

10.8

641

5176

N02AA05

ATC

oxycodone; systemic

2.3

10.8

100

455

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.6

10.7

409

2991

M93.1

ICD-10 Finland

Kienböck disease of adults

+∞

10.4

M19.0

ICD-10 Finland

Primary arthrosis of other joints

2.5

10.4

351

NGL30

NOMESCO Finland

Plastic repair or reinsertation of tendon of patella

32.8

10.3

N03AX16

ATC

pregabalin; oral

1.7

10.3

212

1309

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

2.3

10.3

405

NGF20

NOMESCO Finland

Operation for osteochondritis of knee, open

13.2

10.2

R03AC02

ATC

salbutamol; inhalant

1.5

10.2

581

4633

ZXD10

NOMESCO Finland

Scheduled procedure

1.6

10.0

357

2558

M23.8

ICD-10 Finland

Other internal derangements of knee

3.2

9.9

165

M89.0

ICD-10 Finland

Algoneurodystrophy

20.2

9.8

X58

ICD-10 Finland

Exposure to other specified factors

1.8

9.7

178

1060

M77.4

ICD-10 Finland

Metatarsalgia

2.7

9.7

255

J01DB01

ATC

cefalexin; oral

1.6

9.7

938

8327

H02AB06

ATC

prednisolone; systemic

1.5

9.5

434

3282

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.1

9.4

111

562

7324A

ICD-9 Finland

Osteochondropathies, Juvenile osteochondrosis of lower extremity, excluding foot[TIBIA VARA (BLOUNT)]

+∞

9.4

NE1AA

NOMESCO Finland

Pelvis X-ray examination

2.8

9.1

208

1220

FHL

Arthroscopy

3.3

9.1

136

J01DA01

ATC

[U] cefalexin; systemic

1.4

9.1

660

5474

M21.4

ICD-10 Finland

Flat foot [pes planus] (acquired)

3.9

9.1

M17.1

ICD-10 Finland

Other primary gonarthrosis

1.9

9.0

130

713

NEK20

NOMESCO Finland

Fenestration or forage of bone of pelvis

18.7

8.9

ZXD20

NOMESCO Finland

Day surgery

1.9

8.9

138

775

S18

ICPC

Laceration/cut

1.5

8.9

391

2924

SAA01

NOMESCO Finland

Simple examination of mouth

1.5

8.9

854

7476

RF420

NOMESCO Finland

8.0

8.9

A02BC02

ATC

pantoprazole; systemic

1.4

8.8

582

4725

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.6

8.7

271

1870

N03AX12

ATC

gabapentin; oral

1.8

8.6

141

806

L15

ICPC

Knee symptom/complaint

1.7

8.6

201

1288

J01FA10

ATC

azithromycin; systemic

1.4

8.6

728

6191

NFK20

NOMESCO Finland

Epiphysiodesis of femur

27.7

8.5

M01AH03

ATC

valdecoxib; oral

2.6

8.4

227

M93.9

ICD-10 Finland

Osteochondropathy, unspecified

+∞

8.3

M19.1

ICD-10 Finland

Post-traumatic arthrosis of other joints

4.1

8.3

ZXE10

NOMESCO Finland

More than one and less than three hours

1.5

8.3

325

2366

9165

FHL

Removal of osteosynthesis material

4.3

8.2

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

2.1

8.2

479

SPAT1153

SPAT

Removal of sutures

1.5

8.2

277

1951

R51.80

ICD-10 Finland

Headache

1.7

8.1

192

1233

ZXE00

NOMESCO Finland

One hour or less

1.5

8.1

398

3038

RF410

NOMESCO Finland

7.3

8.0

J01FF01

ATC

clindamycin; systemic

1.6

8.0

260

1811

N06AX21

ATC

duloxetine; oral

1.9

7.9

112

610

M75.1

ICD-10 Finland

Rotator cuff syndrome

1.6

7.9

194

1257

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

1.8

7.8

131

755

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

2.8

7.8

181

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.4

7.7

484

3859

X59

ICD-10 Finland

Exposure to unspecified factor

1.6

7.7

201

1322

WX408

NOMESCO Finland

General anesthesy, balanced

1.5

7.6

264

1864

NCF25

NOMESCO Finland

Operation for osteochondritis of elbow joint, arthroscopic

11.9

7.6

M03BC01

ATC

orphenadrine (citrate); systemic

1.6

7.5

243

1686

M01AH02

ATC

rofecoxib; oral

2.1

7.5

444

R06.0

ICD-10 Finland

Dyspnoea

1.6

7.4

200

1328

9527

FHL

Alloarthroplasty, implant or endoprosthesis

80.5

7.4

NG1CG

NOMESCO Finland

Knee and lower leg extensive MRI examination with high intensity magnet

3.1

7.3

120

72220

ICD-8 Finland

Osteochondrosis, Malacia ossia lunati (Kienböck)

+∞

7.3

7327A

ICD-9 Finland

Osteochondropathies, Osteochondritis dissecans[OSTEOCHONDRITIS DISSECANS GENUS]

+∞

7.3

72219

ICD-8 Finland

Osteochondrosis, Coxae juvenilis NUD

+∞

7.3

M01AX17

ATC

nimesulide; oral

1.7

7.3

170

1084

M20.1

ICD-10 Finland

Hallux valgus (acquired)

2.4

7.3

267

L17

ICPC

Foot/toe symptom/complaint

1.5

7.2

247

1737

EBA05

NOMESCO Finland

Complicated extraction of tooth

1.6

7.2

194

1288

NGF30

NOMESCO Finland

Fixation of loose body of joint of knee

30.2

7.2

9407

FHL

Osteotomy of the upper femur

30.2

7.2

NHG77

NOMESCO Finland

Arthroplasty of interphalangeal tarsal joint(s)

5.3

7.1

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.2

6.9

294

M01AH01

ATC

celecoxib; oral (coxibs)

1.7

6.9

130

782

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

2.1

6.8

339

W19

ICD-10 Finland

Unspecified fall

1.9

6.7

534

A02BC01

ATC

omeprazole; systemic

1.5

6.7

230

1614

L03

ICPC

Low back symptom/complaint

1.5

6.6

253

1817

M19.2

ICD-10 Finland

Other secondary arthrosis

5.9

6.6

J45.9

ICD-10 Finland

Asthma, unspecified

1.6

6.6

162

1048

R03AK07

ATC

formoterol and budesonide; inhalant

1.6

6.6

187

1255

R09

ICPC

Sinus symptom/complaint

1.9

6.6

516

72880

ICD-8 Finland

Vertebrogenic pain syndrome, Radicula syndrome of lower limbs

8.7

6.6

E66.01

ICD-10 Finland

Obesity due to excess calories

1.9

6.5

509

WX110

NOMESCO Finland

Local anesthesy

1.4

6.5

812

7208

L16

ICPC

Ankle symptom/complaint

1.7

6.5

123

742

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.5

6.5

277

2039

72870

ICD-8 Finland

Vertebrogenic pain syndrome, Lumbalgia

5.7

6.5

NG1BA

NOMESCO Finland

Knee extensive X-ray examination

3.8

6.4

ZZH21

NOMESCO Finland

Graft of patients own bone, small pieces

3.8

6.4

NHK30

NOMESCO Finland

Osteotomy or rotation osteotomy of first metatarsal or tarsal bone

3.1

6.3

106

7326A

ICD-9 Finland

Osteochondropathies, Other juvenile osteochondrosis

+∞

6.3

7323X

ICD-9 Finland

Osteochondropathies, Juvenile osteochondrosis of upper extremity[OSTEOCHONDROSIS JUVENILIS EXTREMITATIS SUPER ALIA]

+∞

6.3

M91.3

ICD-10 Finland

Pseudocoxalgia

+∞

6.3

RF210

NOMESCO Finland

3.1

6.2

101

NHL68

NOMESCO Finland

Tenodesis, shortening or lengthening of tendon of foot

5.1

6.2

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.4

6.1

348

2708

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.5

6.0

241

1748

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

2.9

6.0

125

Mortality – FinRegistry

↥

Association

Association between endpoint M13_JUVOSTEOCHONRHIP and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_JUVOSTEOCHONRHIP	1.541 [1.25, 1.9]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.049

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 5170 females with M13_JUVOSTEOCHONRHIP died.

Males

Parameter	HR [95% CI]	p-value
M13_JUVOSTEOCHONRHIP	1.025 [0.85, 1.23]	0.794
Birth year	0.99 [0.98, 1.0]	0.047

During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 6552 males with M13_JUVOSTEOCHONRHIP died.

Mortality risk

Mortality risk for people of age

years, who have M13_JUVOSTEOCHONRHIP.

N-year risk	Females	Males
1	0.154%	0.218%
5	0.888%	1.206%
10	2.037%	3.102%
15	3.735%	6.01%
20	6.754%	10.274%

Relationships between endpoints

↥

Index endpoint: M13_JUVOSTEOCHONRHIP – Juvenile osteochondrosis

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	M13_JUVOSTEOCHONRHIP
CONTROL_EXCLUDE	M13_OTHERBONE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M9[1-2]
HD_ICD_9	7321X\|732[3-6]
HD_ICD_8	72209\|7222[8-9]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M9[1-2]
COD_ICD_9	7321X\|732[3-6]
COD_ICD_8	72209\|7222[8-9]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Juvenile osteochondrosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints