Other infective (teno)synovitis

M13_INFTENOSYNOVITIS

synovitis: ['Inflammation of the SYNOVIAL MEMBRANE [ MeSH ]']

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M65.1 Cause of death: ICD-10 — M65.1 2 out of 7 registries used, show all original rules.	147
4. Check minimum number of events None	147
5. Include endpoints None	147
6. Filter based on genotype QC (FinnGen only)	147

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M65
Name in latin: [Teno]synovitis infectiosa

NAME	M13_INFTENOSYNOVITIS
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M651
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M651
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other infective (teno)synovitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1009	530	477
Only index persons	967	512	455
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	50.52	51.73	49.28
Only index persons	50.64	51.52	49.64

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	147	93	54
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	52.56	50.28	56.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
133: Matched controls
1329

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M65.1

ICD-10 Finland

Other infective (teno)synovitis

+∞

186.1

131

NDM40

NOMESCO Finland

Discission of sheath of tendon of wrist or hand

+∞

19.2

M65.9

ICD-10 Finland

Synovitis and tenosynovitis, unspecified

41.2

14.9

G56.0

ICD-10 Finland

Carpal tunnel syndrome

7.1

14.5

M79.6

ICD-10 Finland

Pain in limb

4.5

13.2

189

M25.5

ICD-10 Finland

Pain in joint

4.1

11.9

198

ZXA00

NOMESCO Finland

Right side

4.3

11.8

173

N03AX16

ATC

pregabalin; oral

4.4

10.9

139

NBG15

NOMESCO Finland

Acromioplastia, arthroscopic

22.1

10.0

NDS00

NOMESCO Finland

Incision and debridement of infection of tendon of wrist or hand

+∞

9.5

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

8.1

9.5

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.2

9.4

334

M65.8

ICD-10 Finland

Other synovitis and tenosynovitis

21.8

8.6

M75.1

ICD-10 Finland

Rotator cuff syndrome

4.1

8.2

103

L03.0

ICD-10 Finland

Cellulitis of finger and toe

7.0

7.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.0

7.8

310

NHL50

NOMESCO Finland

Tenolysis or tenosynovectomy of foot

47.8

7.8

X59

ICD-10 Finland

Exposure to unspecified factor

3.8

7.6

110

N02BE01

ATC

paracetamol; systemic, rectal

4.4

7.6

121

928

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

5.2

7.5

H02AB06

ATC

prednisolone; systemic

2.8

7.5

376

NBG10

NOMESCO Finland

Acromioplastia

84.5

7.5

M65.0

ICD-10 Finland

Abscess of tendon sheath

+∞

7.4

M65.3

ICD-10 Finland

Trigger finger

13.0

7.2

NBL00

NOMESCO Finland

Suture or reinsertation of rotator cuff of shoulder

10.9

7.2

M19.0

ICD-10 Finland

Primary arthrosis of other joints

6.0

7.1

N02AX02

ATC

tramadol; systemic, rectal

2.7

6.8

306

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.8

6.6

233

M13.9

ICD-10 Finland

Arthritis, unspecified

5.8

6.6

NDL52

NOMESCO Finland

Tenosynovectomy of hand

73.2

6.5

A02BC03

ATC

lansoprazole; oral

2.9

6.5

200

Z3226

NOMESCO Finland

Physiotherapist

3.4

6.4

113

M01AE03

ATC

ketoprofen; systemic, rectal

2.7

6.4

300

J01DB01

ATC

cefalexin; oral

3.1

6.4

113

854

A02BC02

ATC

pantoprazole; systemic

2.6

6.2

610

M76.6

ICD-10 Finland

Achilles tendinitis

10.8

6.2

ACC51

NOMESCO Finland

Release of median nerve

5.6

6.1

R52.9

ICD-10 Finland

Pain, unspecified

5.9

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

163

3.32

9.16

1.4

1.2

u/ml

22.8

8.9

0.48

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

174

2.98

7.57

1.4

1.2

iu/ml

28.7

31.8

0.10

(3013115) Eosinophils [#/volume] in Blood

578

2.58

7.11

7.6

5.4

e9/l

0.2

0.50

521

(42870588) Differential panel, method unspecified - Blood

362

2.49

6.73

7.1

5.1

—

(3001604) Monocytes [#/volume] in Blood

561

2.42

6.31

7.6

5.0

e9/l

0.6

0.04

496

(3006315) Basophils [#/volume] in Blood

562

2.41

6.27

7.7

5.0

e9/l

0.0

0.24

497

(3026493) Urate [Moles/volume] in Serum or Plasma

272

2.48

6.14

2.9

2.8

umol/l

362.7

8887.8

2.06

232

(3007853) Bacteria identified in Skin by Aerobe culture

110

3.04

6.01

2.3

1.4

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

493

2.30

5.79

6.0

5.9

mmol/l

1.2

0.25

443

(3019198) Lymphocytes [#/volume] in Blood

576

2.31

5.74

7.9

5.0

e9/l

1.8

2.1

0.82

521

(3042936) Bacteria identified in Isolate by Culture

158

2.69

5.70

3.1

2.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

141

1207

5.12

5.68

21.6

11.8

mg/l

25.9

23.4

0.38

122

919

(3013707) Erythrocyte sedimentation rate by Westergren method

116

863

2.63

5.56

5.7

3.4

mm/h

12.2

11.3

0.30

110

781

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

121

919

2.79

5.56

8.9

7.0

u/l

82.4

79.3

0.27

113

854

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

432

2.24

5.43

2.0

1.8

pmol/l

92.7

97.1

0.31

216

(3026008) Bacteria identified in Urine by Culture

326

2.29

5.36

4.3

2.8

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

674

2.29

5.32

9.4

e9/l

4.4

4.0

0.73

601

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

547

2.19

5.12

7.6

6.9

mmol/l

1.2

0.03

468

(3023368) Bacteria identified in Blood by Culture

272

2.27

4.93

6.0

3.9

—

(3032080) INR in Blood by Coagulation assay

442

2.06

4.39

6.6

6.5

inr

1.2

1.1

0.32

122

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

4.80

4.37

1.4

1.1

u/ml

10.8

1.2

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

675

2.09

4.36

4.4

mmol/l

6.8

6.7

0.17

628

(3031040) Bacteria [#/volume] in Urine by Automated count

739

2.04

3.95

6.1

3.7

—

5046.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

103

782

2.06

3.89

5.8

3.9

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

115

911

2.21

3.86

3.9

3.7

pmol/l

14.5

14.7

0.34

104

820

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

250

2.08

3.77

1.6

1.5

mg/l

1.1

0.03

194

(3009261) Glucose [Presence] in Urine by Test strip

554

1.92

3.69

5.8

3.2

estimate

0.0

0.00

(3021601) Nitrite [Presence] in Urine by Test strip

550

1.89

3.53

7.6

4.5

estimate

0.0

0.00

(3022217) INR in Platelet poor plasma by Coagulation assay

130

2.32

3.45

22.9

20.7

—

1.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

611

1.87

3.41

5.8

6.2

umol/l

11.7

11.0

0.28

585

(3049717) Cytology report of Urine Cyto stain

3.63

3.40

1.7

3.4

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

367

1.90

3.38

2.2

2.1

u/l

55.8

57.1

0.11

335

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.97

3.29

1.8

1.4

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

479

1.83

3.19

3.4

2.5

ug/l

216.5

114.0

0.45

435

(4306422)

4.91

2.96

1.3

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.29

2.93

2.1

1.6

—

(3035350) Ketones [Presence] in Urine by Test strip

555

1.76

2.89

5.6

3.1

estimate

0.0

0.00

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

8.57

2.77

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

6.20

2.72

1.0

1.7

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.28

2.70

1.2

1.5

—

(3037756) Immunofixation for Serum or Plasma

3.76

2.62

1.1

2.3

—

(3018418) pH of Serum or Plasma

331

1.77

2.61

3.7

7.4

—

(3000093) Morphology [Interpretation] in Blood Narrative

7.34

2.57

1.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

257

1.83

2.56

4.0

4.5

—

(40758558) Short blood count panel - Blood

308

1.77

2.53

6.7

6.9

—

(3021589) Normoblasts [#/volume] in Blood

525

1.68

2.46

12.9

9.0

e9/l

0.0

0.52

434

(3019309) Folate [Moles/volume] in Red Blood Cells

180

1.92

2.44

1.7

1.6

nmol/l

1117.5

1168.0

0.11

129

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.48

2.44

1.7

1.4

—

(3020630) Protein [Mass/volume] in Serum or Plasma

2.27

2.40

1.3

3.2

g/l

65.9

67.3

0.39

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

3.78

2.40

1.0

1.1

—

(4268621)

4.03

2.28

2.6

2.1

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

127

1118

2.00

2.21

5.0

4.4

mu/l

1.9

0.00

120

1011

(3022948) Iron [Moles/volume] in Serum or Plasma

155

1.91

2.19

2.7

2.1

umol/l

13.7

13.5

0.04

144

(3015377) Calcium [Moles/volume] in Serum or Plasma

373

1.66

2.17

2.7

3.5

mmol/l

2.4

0.12

334

(3020682) Albumin/Creatinine [Ratio] in Urine

339

1.67

2.13

4.1

3.8

mg/mmol

10.6

9.5

0.07

206

(36660697) Celiac disease serology panel - Serum

2.10

2.12

1.3

1.1

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

4.12

2.06

1.2

1.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.24

2.00

1.2

2.8

—

(40768804) Tissue Pathology biopsy report

471

1.59

1.99

2.0

2.1

—

(3044941) Cell count panel - Synovial fluid

4.66

1.95

1.8

1.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

392

1.60

1.91

4.7

2.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

211

1.73

1.90

1.4

1.5

—

(3013512) EKG study

331

1.62

1.88

5.2

3.7

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.61

1.88

1.2

g/l

3.3

3.4

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.61

1.88

1.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

133

1206

2.08

1.87

4.7

4.2

mmol/l

1.4

1.5

1.40

125

1114

(3041096) Erythrocytes [Presence] in Urine by Automated

314

1.62

1.87

5.1

3.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

4.27

1.84

1.2

1.1

—

(3044640) Blood type and Crossmatch panel - Blood

378

1.58

1.82

2.4

2.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

103

1.97

1.82

5.4

3.0

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

135

1235

2.14

1.78

5.3

4.7

mmol/l

2.8

0.45

127

1140

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

3.43

1.76

1.3

1.7

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.43

1.76

1.0

3.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

131

1187

1.95

1.76

4.7

4.2

mmol/l

6.0

5.9

0.21

124

1097

(3022313) Gas panel - Capillary blood

2.40

1.75

3.1

3.8

—

(3012516) Albumin [Mass/volume] in Urine

321

1.58

1.69

3.3

2.9

mg/l

1484.9

63.4

0.50

204

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

133

1215

1.99

1.68

5.0

4.3

mmol/l

4.7

4.8

0.56

125

1133

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

202

1.68

1.66

5.7

3.4

ng/l

1341.9

295.0

0.47

159

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

125

1125

1.74

1.60

6.8

5.3

mmol/mol

39.7

39.4

0.13

120

1051

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

172

1.70

1.57

5.1

2.4

e6/l

3.6

2.6

0.30

(21494755) Public health laboratory ask at order entry panel

153

0.43

1.54

1.1

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

125

1.79

1.54

2.4

—

(3018095) Leukocytes [#/volume] in Urine

400

1.51

1.53

6.9

3.1

e6/l

59.1

57.7

0.02

276

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.67

1.53

3.6

2.9

—

(40768797) Stomach Pathology biopsy report

157

1.71

1.53

1.0

1.2

—

(3045424) Erythrocytes [Presence] in Urine

2.93

1.52

3.2

1.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.93

1.52

1.0

1.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

250

1.58

1.51

1.4

1.2

u/ml

3.0

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

439

1.49

4.6

3.3

ng/l

74.1

31.8

0.57

288

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

440

1.48

1.47

6.2

3.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

2.80

1.45

1.0

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

2.27

1.39

2.0

2.4

ug/l

0.8

1.9

—

(3045414) Leukocytes [Presence] in Urine

2.16

1.33

2.7

1.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.04

1.25

2.4

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

117

1.72

1.25

2.3

2.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

538

1.41

1.23

7.5

3.9

—

(40768443) Skin Pathology biopsy report

2.23

1.23

1.8

1.2

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.17

1.20

1.3

1.2

g/l

8.3

9.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.36

1.20

1.2

—

(40761536) Microorganisms panel - Urine sediment

1.83

1.17

3.5

3.6

—

(3021788) Differential panel - Synovial fluid

2.55

1.16

1.6

1.5

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.55

1.16

1.0

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.55

1.16

1.4

1.5

—

(3027801) Oxygen [Partial pressure] in Arterial blood

128

1.65

1.16

5.8

7.7

kpa

12.9

12.4

0.14

123

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

128

1.65

1.16

5.8

7.7

kpa

5.0

5.2

0.40

122

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.97

1.15

4.4

6.3

mmol/l

23.6

25.5

0.92

(3021960) Folate [Moles/volume] in Serum or Plasma

248

1.48

1.14

1.3

1.4

nmol/l

17.3

21.0

0.93

209

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.43

1.10

1.2

9.5

—

156.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.11

1.04

1.1

1.2

—

(3002256) Pathology report gross observation

149

1.56

1.03

1.3

1.2

—

(3022621) pH of Urine by Test strip

1.87

1.01

4.3

2.5

—

(3002582) Erythrocytes [#/volume] in Urine

336

1.40

1.00

5.2

2.8

e6/l

19.8

66.7

1.46

252

(3025941) Bacteria identified in Stool by Culture

1.91

0.99

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

291

1.41

0.99

7.4

3.3

estimate

0.0

0.50

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.78

0.96

6.1

7.9

mmol/l

24.0

24.6

0.23

(3018405) Lactate [Moles/volume] in Arterial blood

1.94

0.95

5.6

4.9

mmol/l

1.0

1.3

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.27

0.94

4.2

2.0

mmol/l

23.7

25.7

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.67

0.91

2.1

2.8

g/l

8.5

10.3

1.15

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

296

1.38

0.90

3.9

3.2

ng/l

2407.4

1043.7

0.73

249

(3008898) HLA-B27 [Presence]

1.91

0.89

1.1

1.0

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.75

0.85

7.4

9.2

94.7

93.9

0.28

(36304419) Bacteria [Presence] in Urine

299

1.37

0.84

3.2

2.7

—

(1761868) Lipid panel - Serum or Plasma

471

0.74

0.83

3.7

2.8

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

106

1.57

0.83

5.4

8.8

g/l

120.4

122.8

0.14

101

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

137

1308

1.70

0.83

14.0

9.3

u/l

27.9

26.3

0.54

132

1261

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.78

0.82

1.1

1.5

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.72

0.81

7.4

9.0

0.5

0.7

0.73

(3007164) IgA [Mass/volume] in Serum or Plasma

239

1.38

0.78

1.6

1.5

g/l

2.3

2.6

0.25

151

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

125

1175

1.43

0.77

4.4

3.8

mmol/l

1.4

1.3

0.94

116

1084

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.80

0.77

1.7

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

748

1.29

0.76

3.1

—

(3044889) 12 lead EKG panel

820

1.29

0.74

4.6

3.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

820

1.29

0.74

3.6

2.8

u/l

46.5

48.6

0.11

769

(3052851) Hemolysis interference index of Serum or Plasma

1.83

0.73

2.6

3.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.03

0.73

1.6

1.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.59

0.71

1.6

1.9

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.69

0.70

1.5

1.2

u/ml

83.2

494.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.54

0.69

1.4

—

(3019225) pH of Specimen

111

1.50

0.69

4.5

5.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

113

1.47

0.64

1.8

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

248

1.32

0.62

5.5

2.9

—

(3008037) Lactate [Moles/volume] in Venous blood

1.69

0.62

3.4

3.0

mmol/l

1.2

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

114

1.45

0.62

2.0

1.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.57

0.61

1.5

1.6

—

(4281824)

0.00

0.61

0.0

1.0

—

(3033658) Prothrombin time (PT) actual/Normal

286

1.29

0.60

3.4

3.3

93.3

92.5

0.06

279

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.60

0.0

1.1

—

4.3

—

(3000494) Fungus identified in Specimen by Culture

141

1.40

0.60

1.4

1.3

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.54

0.59

1.4

2.3

u/l

28.8

42.2

—

(40761535) Cells panel - Urine sediment

1.52

0.59

5.4

3.4

—

(3030467) Casts [#/volume] in Urine by Automated count

306

1.28

0.58

4.2

2.8

e6/l

0.2

0.6

1.26

224

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

1.74

0.58

1.0

1.4

g/l

1.3

1.2

—

(40761511) CBC panel - Blood by Automated count

133

1278

1.43

0.56

20.2

11.4

—

(3012544) pH of Venous blood

1.46

0.56

4.5

3.2

—

(3000991) Gas panel - Venous blood

1.50

0.56

5.4

8.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.60

0.55

1.0

1.3

—

(3020891) Body temperature

1.56

0.53

6.5

4.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.46

0.53

1.1

1.0

—

(3019060) Gas panel - Arterial blood

1.50

0.52

5.1

4.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

283

1.26

0.51

3.9

2.2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.53

0.51

8.0

8.9

1.4

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

182

1.31

0.50

1.8

1.6

—

(4010399)

1.48

0.49

1.1

1.5

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.48

0.49

8.0

2.8

ng/l

117.1

92.6

0.27

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.48

0.47

1.3

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

166

1.31

0.46

2.0

1.9

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.42

0.45

1.9

6.5

1.6

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.63

0.43

1.2

1.1

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.63

0.43

2.0

1.6

nmol/l

32.6

38.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.63

0.43

1.2

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.63

0.43

1.2

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

215

1.25

0.42

2.1

2.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.41

0.0

2.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

1.49

0.41

1.0

1.2

g/l

40.6

38.4

—

(40768795) Lymph node Pathology biopsy report

0.00

0.40

0.0

1.2

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

109

1.31

0.35

1.8

1.9

g/l

0.3

0.2

0.56

103

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

120

1156

1.21

0.34

18.2

11.3

ml/min/173m2

79.0

83.2

1.11

937

(3009542) Hematocrit [Volume Fraction] of Blood

118

1136

1.20

0.33

19.7

13.1

38.0

40.3

1.10

840

(3000330) Specific gravity of Urine by Test strip

1.29

0.30

5.0

4.0

—

(1002224) Polysomnography panel

1.24

0.29

1.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.29

0.23

6.4

4.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.29

0.23

1.6

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

116

1.23

0.23

1.2

1.4

—

(3003694) ABO and Rh group [Type] in Blood

327

1.13

0.22

1.5

1.4

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

1.9

—

13.1

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.21

0.0

1.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

17.1

—

853.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

21.7

—

1589.6

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3015183) Erythrocyte sedimentation rate

0.00

0.21

0.0

1.2

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

18.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.5

—

2.7

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.26

0.20

1.0

1.3

iu/l

40.8

28.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

184

1.16

0.20

3.5

2.3

e6/l

1.0

1.2

0.06

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.20

0.0

1.0

—

(4035726)

122

0.81

0.20

1.7

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

206

0.86

0.19

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

234

1.13

0.18

1.9

1.7

pmol/l

384.9

445.4

0.72

208

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.76

0.17

1.6

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

254

0.89

0.16

4.0

4.2

22.7

21.4

0.15

110

(3017143) Hepatitis C virus Ab [Presence] in Serum

150

1.15

0.15

1.7

1.5

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

171

1.13

0.13

2.4

1.7

28.2

29.4

0.62

164

(3022145) Colonoscopy Study observation

124

1.14

0.11

1.4

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

116

1.13

0.09

1.8

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.05

0.08

6.2

9.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

144

1.05

0.00

15.7

7.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

146

0.95

0.00

3.6

4.3

32.6

—

(3000492) Spirometry study

116

1.04

0.00

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

109

1.01

0.00

2.2

1.8

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

22.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

2.2

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.98

0.00

4.0

2.1

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.7

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

13.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.98

0.00

2.2

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.5

—

1536.3

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.4

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.3

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(44813793)

0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3009871) Measles virus Ab [Titer] in Serum

0.00

0.0

1.4

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

115.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.93

0.00

3.7

2.1

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_INFTENOSYNOVITIS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
M13_INFTENOSYNOVITIS	1.32 [0.99, 1.76]	0.057
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 406 males with M13_INFTENOSYNOVITIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_INFTENOSYNOVITIS.

N-year risk	Females	Males
1	No data	0.255%
5	No data	1.532%
10	No data	3.809%
15	No data	7.078%
20	No data	11.844%

Relationships between endpoints

↥

Index endpoint: M13_INFTENOSYNOVITIS – Other infective (teno)synovitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other infective (teno)synovitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints