Risteys · M13_ILIACCRESTSPUR

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M76.2 Cause of death: ICD-10 — M76.2 2 out of 7 registries used, show all original rules.	27
4. Check minimum number of events None	27
5. Include endpoints None	27
6. Filter based on genotype QC (FinnGen only)	27

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	139	80	58
Only index persons	131	77	54
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	49.41	50.58	48.15
Only index persons	48.80	50.15	46.87

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	27	15	12
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	55.18	52.29	58.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

3.27

1.72

1.6

1.5

—

(3019060) Gas panel - Arterial blood

3.58

1.51

10.4

2.6

—

(3019225) pH of Specimen

3.36

1.42

5.8

6.8

—

(3023368) Bacteria identified in Blood by Culture

2.51

1.36

3.1

3.7

—

(42870588) Differential panel, method unspecified - Blood

2.46

1.31

5.3

3.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.59

1.19

1.7

1.6

—

(40768804) Tissue Pathology biopsy report

0.42

1.04

3.0

2.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.84

0.0

1.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

0.00

0.83

0.0

3.3

—

4.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

0.00

0.82

0.0

3.3

—

1.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

137

1.94

0.81

6.0

4.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

141

1.83

0.79

2.7

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

127

1.91

0.77

7.3

3.6

mmol/l

7.2

6.7

0.23

115

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.96

0.70

1.0

1.3

—

(1761868) Lipid panel - Serum or Plasma

0.54

0.68

3.2

2.8

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.88

0.67

3.2

5.0

ug/l

2.5

7.9

—

(3000492) Spirometry study

0.00

0.63

0.0

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.69

0.54

4.7

4.0

—

(3006504) Eosinophils/100 leukocytes in Blood

1.66

0.53

5.9

4.0

3.3

2.6

0.79

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.58

0.51

1.3

1.9

pmol/l

367.3

410.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.64

0.49

3.8

4.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.75

0.46

1.4

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.75

0.46

1.0

1.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.51

0.45

3.2

3.6

ng/l

644.2

2145.6

—

(3022096) Basophils/100 leukocytes in Blood

1.57

0.44

5.4

4.0

0.8

0.6

0.48

(3014111) Lactate [Moles/volume] in Serum or Plasma

0.00

0.42

0.0

6.4

—

1.5

—

(3000991) Gas panel - Venous blood

0.00

0.42

0.0

8.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.42

0.0

1.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.52

0.42

8.2

7.6

—

(3015736) pH of Urine

1.35

0.30

3.2

3.7

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

162

1.33

0.27

9.9

6.7

u/l

69.4

78.6

1.17

153

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.5

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.22

0.0

1.9

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.22

0.0

2.2

—

260.7

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.22

0.0

1.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

44.9

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.23

0.21

1.7

1.5

mmol/l

1.3

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

212

0.78

0.20

19.0

11.8

35.0

40.0

0.56

161

(3009508) Creatinine [Moles/volume] in Urine

1.27

0.19

3.5

2.9

mmol/l

7.0

7.5

—

(3013512) EKG study

1.20

0.19

3.9

4.1

—

(3044889) 12 lead EKG panel

155

0.80

0.14

4.4

3.3

—

(3000850) Epithelial cells [#/volume] in Urine

1.23

0.11

3.4

2.7

e6/l

0.9

4.4

—

(3026008) Bacteria identified in Urine by Culture

1.17

0.10

2.5

3.0

—

(3003338) MCHC [Mass/volume]

196

0.90

0.08

23.1

14.9

g/l

331.2

332.2

0.15

196

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.10

0.01

5.3

3.3

—

(3003694) ABO and Rh group [Type] in Blood

0.89

0.00

1.4

1.3

—

(36304419) Bacteria [Presence] in Urine

1.05

0.00

3.4

2.6

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.0

1.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

1.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

0.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.2

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

2.8

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.4

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.04

0.00

2.7

4.0

—

(4146454)

0.00

0.0

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.7

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

0.90

0.00

1.7

1.9

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

6.0

—

6.3

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.3

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

0.00

0.0

2.2

—

625.6

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.5

—

402.8

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.2

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.93

0.00

3.1

3.5

—

Mortality – FinRegistry

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Association

Association between endpoint M13_ILIACCRESTSPUR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_ILIACCRESTSPUR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: M13_ILIACCRESTSPUR – Iliac crest spur

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	M13_ILIACCRESTSPUR
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M762
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M762
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Iliac crest spur

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints