Hypersensitivity angiitis

M13_HYPERANG

hypersensitivity vasculitis: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M31.0
  • Hospital discharge: ICD-9 4462A
  • Hospital discharge: ICD-8 4461
  • Cause of death: ICD-10 M31.0
  • Cause of death: ICD-9 4462A
  • Cause of death: ICD-8 4461

2 out of 7 registries used, show all original rules.

164

4. Check minimum number of events

None

164

5. Include endpoints

None

164

6. Filter based on genotype QC (FinnGen only)

160

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M31
Name in latin
Angi(i)tis hypersensitivitatis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1066 579 476
Only index persons 811 452 359
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 60.49 61.23 59.53
Only index persons 57.92 58.46 57.23

-FinnGen-

Key figures

All Female Male
Number of individuals 160 82 78
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 57.70 56.09 59.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
164
Matched controls
1638
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
111.6
94
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
65.0
58
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
60.2
54
*
L04AX01
ATC
azathioprine; systemic
61.2
54.1
62
16
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
19.8
52.3
87
88
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
48.3
44
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
59.1
43.4
50
12
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
67.1
42.6
48
10
L04AA06
ATC
mycophenolic acid; systemic
96.1
40.2
43
6
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
36.9
34
*
H02AB04
ATC
methylprednisolone; systemic
10.3
31.8
71
113
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
17.5
31.4
51
41
A11CC03
ATC
alfacalcidol; systemic
32.6
30.6
40
16
4462A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Hypersensitivity angiitis
+∞
30.1
28
*
Z94.0
ICD-10 Finland
Kidney transplant status
98.2
30.0
32
*
TK800
NOMESCO Finland
Hemodialysis
30.3
27.1
36
15
A12AA04
ATC
calcium carbonate; oral
43.7
26.4
32
9
127
Kela drug reimbursment
Transplant complication
69.8
26.0
29
5
Z49.1
ICD-10 Finland
Extracorporeal dialysis
47.2
26.0
31
8
WW400
NOMESCO Finland
Plasmaferesis
292.6
25.4
25
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
66.9
24.9
28
5
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
139.5
23.2
24
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.5
23.2
97
339
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
45.7
22.5
27
7
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.4
22.5
44
51
L01AA01
ATC
cyclophosphamide; systemic
+∞
22.4
21
*
B03XA02
ATC
darbepoetin alfa; parenteral
40.0
21.9
27
8
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
15.6
20.5
34
27
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
10.9
19.3
38
44
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
41.9
18.1
22
6
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
17.0
16
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
100.4
16.9
18
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
12.8
16.8
30
28
N18.0
ICD-10 Finland
End-stage renal disease
45.1
16.8
20
5
ZXD05
NOMESCO Finland
Urgent procedure
4.2
16.3
84
327
KA1AE
NOMESCO Finland
Kidney ultrasound examination
19.8
16.2
24
14
N18.8
ICD-10 Finland
Other chronic renal failure
16.0
16.2
26
19
M05BA04
ATC
alendronic acid; oral
7.1
16.1
42
76
TPX10
NOMESCO Finland
Implantation of vascular injection port
17.1
16.0
25
17
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
16.0
101
469
C03CA01
ATC
furosemide; systemic
4.1
15.9
85
340
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
15.9
15
*
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
15.9
15
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
15.9
15
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
94.3
15.9
17
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.4
15.0
50
123
H02AB06
ATC
prednisolone; systemic
3.8
14.7
103
506
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
11.0
14.7
28
30
TPH04
NOMESCO Finland
Cathetrisation of vein
4.5
14.6
61
191
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.1
14.5
29
34
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.9
14.1
51
137
H02AB07
ATC
prednisone; oral
5.5
13.8
44
102
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
13.7
13
*
L04AD01
ATC
ciclosporin; systemic
28.6
13.7
18
7
WW200
NOMESCO Finland
Immunization
17.0
13.5
21
14
B03XA01
ATC
erythropoietin; parenteral
31.3
13.2
17
6
ZX120
NOMESCO Finland
Intravenous
6.0
13.1
38
78
A07AA02
ATC
nystatin; oral
7.2
13.0
32
53
137
Kela drug reimbursment
Uraemia requiring dialysis
75.9
12.8
14
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
75.9
12.8
14
*
Z2446
NOMESCO Finland
Social worker
7.4
12.8
31
50
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
12.7
12
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
12.7
12
*
WX892
NOMESCO Finland
Monitored bed care
6.8
12.5
32
56
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
40.9
12.4
15
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
23.5
12.3
17
8
R4110
NOMESCO Finland
Physiotherapy
3.7
12.1
66
254
ZX108
NOMESCO Finland
Inhalation
50.7
12.1
14
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
12.5
11.9
21
19
V03AE01
ATC
polystyrene sulfonate; oral
32.7
11.9
15
5
R50.9
ICD-10 Finland
Fever, unspecified
5.1
11.9
40
98
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
10.9
11.7
22
23
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.2
11.1
36
84
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
11.1
40
105
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.0
11.1
50
163
Z3231
NOMESCO Finland
Registered nurse
3.4
10.9
66
270
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
11.2
10.9
20
20
J01MA02
ATC
ciprofloxacin; systemic
3.1
10.8
87
437
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
6.8
10.7
27
46
Z3226
NOMESCO Finland
Physiotherapist
3.8
10.6
51
175
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.4
10.6
28
51
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
10.5
10
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
8.9
10.5
22
28
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.1
10.3
19
19
L04AA01
ATC
[U] ciclosporin; systemic
28.0
10.0
13
5
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.2
9.9
64
272
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
105.8
9.5
10
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
9.5
9
*
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
9.5
9
*
J01MA14
ATC
moxifloxacin; systemic
5.3
9.4
29
64
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
25.7
9.0
12
5
TKC20
NOMESCO Finland
Catheterisation of bladder
5.8
8.9
25
49
R31
ICD-10 Finland
Unspecified haematuria
4.8
8.9
30
73
XF400
NOMESCO Finland
ECG with 12 standard connections
3.6
8.9
44
153
B05DA
ATC
Isotonic solutions
94.7
8.5
9
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
8.4
8
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
8.4
8
*
N19
ICD-10 Finland
Unspecified kidney failure
7.5
8.3
19
28
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.5
8.3
21
36
J01FF01
ATC
clindamycin; systemic
2.9
8.2
61
276
TK810
NOMESCO Finland
Hemofiltration
35.2
8.2
10
*
Z2221
NOMESCO Finland
Medical doctor
2.9
8.1
56
245
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.7
8.0
27
66
205
Kela drug reimbursment
Chronic hypertension
2.7
7.9
68
339
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.4
7.8
28
73
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
4.6
7.6
26
64
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.1
7.6
30
85
ZXE20
NOMESCO Finland
More than three and less than five hours
3.4
7.6
38
132
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
7.6
58
267
A02BC02
ATC
pantoprazole; systemic
2.6
7.6
115
775
B01AB10
ATC
tinzaparin; parenteral
5.2
7.6
23
50
GD1AD
NOMESCO Finland
Thorax CT examination
6.8
7.5
18
29
D69.0
ICD-10 Finland
Allergic purpura
83.7
7.5
8
*
Z49.2
ICD-10 Finland
Other dialysis
83.7
7.5
8
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
83.7
7.5
8
*
321
Kela drug reimbursment
Paricalcitol and cinacalcet
83.7
7.5
8
*
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
83.7
7.5
8
*
WX203
NOMESCO Finland
Infraclavicular plexus blockade
11.6
7.4
13
12
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
7.3
7
*
N085, M318
ICD-10 Finland
NA
+∞
7.3
7
*
N25.0
ICD-10 Finland
Renal osteodystrophy
+∞
7.3
7
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
+∞
7.3
7
*
C08CA02
ATC
felodipine; oral
3.8
7.3
31
94
ZXA00
NOMESCO Finland
Right side
2.7
7.2
61
298
Z49.0
ICD-10 Finland
Preparatory care for dialysis
21.1
7.2
10
5
R4190
NOMESCO Finland
Nutritional therapy
9.4
7.2
14
16
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
9.4
7.2
14
16
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
6.0
7.2
19
35
J01MA12
ATC
levofloxacin; systemic
3.0
7.2
44
177
P01BA02
ATC
hydroxychloroquine; oral
5.0
7.1
22
49
TGC00
NOMESCO Finland
Bronchial lavation
8.1
7.1
15
20
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
11.6
6.9
12
11
N17.8
ICD-10 Finland
Other acute renal failure
17.6
6.8
10
6
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
41.8
6.8
8
*
WX002
NOMESCO Finland
Sedation and analgesia
2.9
6.7
46
196
A41.9
ICD-10 Finland
Sepsis, unspecified
7.4
6.7
15
22
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
10.7
6.6
12
12
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.1
6.6
37
139
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.3
6.5
35
126
ZXE40
NOMESCO Finland
More than seven and less than nine hours
15.1
6.5
10
7
XQ845
NOMESCO Finland
Dermatoscopy
15.1
6.5
10
7
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
72.5
6.5
7
*
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
72.5
6.5
7
*
A02BC01
ATC
omeprazole; systemic
2.5
6.4
58
290
N02AX02
ATC
tramadol; systemic, rectal
2.4
6.4
79
462
TPH07
NOMESCO Finland
Cathetrisation of artery
3.4
6.4
31
105
L57.0
ICD-10 Finland
Actinic keratosis
3.7
6.4
27
82
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
6.8
6.3
15
24
C08CA01
ATC
amlodipine; oral
2.4
6.3
71
396
V03AE02
ATC
sevelamer; oral
27.8
6.3
8
*
B05DB
ATC
Hypertonic solutions
+∞
6.3
6
*
N085M
ICD-10 Finland
NA
+∞
6.3
6
*
1CX01
NOMESCO Finland
NA
+∞
6.3
6
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
6.3
6
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
+∞
6.3
6
*
PAW37
NOMESCO Finland
Biopsy of temporal artery
+∞
6.3
6
*
6BA02
NOMESCO Finland
NA
+∞
6.3
6
*
4476A
ICD-9 Finland
Other disorders of arteries and arterioles, Arteritis, unspecified
+∞
6.3
6
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
5.3
6.3
18
37
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
6.3
57
284
UKC02
NOMESCO Finland
Cystoscopy
3.1
6.1
34
126
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
6.1
69
387
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.1
6.1
23
63
TQW99
NOMESCO Finland
Other minor procedure on skin
5.8
6.0
16
30

Mortality – FinRegistry

Association

Association between endpoint M13_HYPERANG and mortality.

Females

Parameter HR [95% CI] p-value
M13_HYPERANG 3.134 [2.31, 4.24] < 0.001
Birth year 0.994 [0.99, 1.0] 0.178

During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 383 females with M13_HYPERANG died.

Males

Parameter HR [95% CI] p-value
M13_HYPERANG 2.479 [1.81, 3.4] < 0.001
Birth year 0.99 [0.98, 1.0] 0.032

During the follow-up period (1.1.1998 — 31.12.2019), 118 out of 304 males with M13_HYPERANG died.

Mortality risk

Mortality risk for people of age

years, who have M13_HYPERANG.

N-year risk Females Males
1 0.298% 0.555%
5 1.629% 3.059%
10 4.34% 7.777%
15 7.969% 14.342%
20 13.634% 23.512%

Relationships between endpoints

Index endpoint: M13_HYPERANG – Hypersensitivity angiitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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