No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
214 |
4. Check minimum number of eventsNone |
214 |
5. Include endpointsNone |
214 |
6. Filter based on genotype QC (FinnGen only) |
214 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M31
- Name in latin
- Microangiopathia thrombotica
Similar endpoints
↥List of similar endpoints to
Thrombotic microangiopathy
based on the number of shared cases.
Similar with more cases:
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1214 | 706 | 498 |
| Only index persons | 1034 | 606 | 428 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.61 | 55.13 | 58.60 |
| Only index persons | 55.82 | 54.53 | 57.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 214 | 126 | 88 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 53.33 | 50.64 | 57.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 202
- Matched controls
- 2019
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
206.3
161
*
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
101.9
89
*
L04AX01
ATC
azathioprine; systemic
71.6
97.7
110
33
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
31.7
86.9
125
98
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
57.0
52
*
L04AA06
ATC
mycophenolic acid; systemic
105.7
56.7
60
8
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
51.3
47
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.9
40.2
133
397
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
39.9
37
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
17.4
38.5
63
51
M05BA04
ATC
alendronic acid; oral
15.6
36.7
63
57
L01AA01
ATC
cyclophosphamide; systemic
217.6
36.0
36
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
15.2
33.6
58
52
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
33.2
31
*
WW400
NOMESCO Finland
Plasmaferesis
+∞
32.1
30
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
10.3
29.7
63
85
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
65.3
29.2
33
6
ZX120
NOMESCO Finland
Intravenous
9.3
27.9
63
94
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.0
25.5
137
598
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
12.3
24.7
46
47
H02AB06
ATC
prednisolone; systemic
4.9
24.2
146
701
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
25.1
23.0
32
15
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
24.1
22.1
31
15
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.0
21.9
41
42
TK800
NOMESCO Finland
Hemodialysis
38.6
21.7
27
8
UDH02
NOMESCO Finland
Rhinopharyngoscopy
9.5
21.4
46
61
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
21.2
20
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
34.3
21.2
27
9
H02AB07
ATC
prednisone; oral
5.9
21.0
66
153
TPH04
NOMESCO Finland
Cathetrisation of vein
4.7
19.6
80
246
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.9
19.5
60
134
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
11.9
19.4
36
36
P01BA02
ATC
hydroxychloroquine; oral
8.1
18.7
44
67
H02AB04
ATC
methylprednisolone; systemic
5.3
18.7
64
161
R50.9
ICD-10 Finland
Fever, unspecified
5.8
18.3
57
128
A11CC03
ATC
alfacalcidol; systemic
16.7
18.3
29
20
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
8.8
18.1
40
55
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
18.0
17
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
18.0
17
*
Z94.0
ICD-10 Finland
Kidney transplant status
28.6
17.3
23
9
1XC02
NOMESCO Finland
NA
69.5
17.1
19
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
16.9
16
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.6
16.7
37
51
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.1
16.6
79
273
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
15.8
15
*
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
15.8
15
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
18.0
15.7
24
15
Z49.1
ICD-10 Finland
Extracorporeal dialysis
41.6
15.7
19
5
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
10.3
15.6
31
35
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.1
14.7
37
62
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
7.3
14.7
36
58
M35.1
ICD-10 Finland
Other overlap syndromes
161.2
14.7
15
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
9.8
14.3
29
34
N18.0
ICD-10 Finland
End-stage renal disease
32.7
14.1
18
6
A12AA04
ATC
calcium carbonate; oral
17.8
13.8
21
13
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
80.8
13.8
15
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
80.8
13.8
15
*
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
+∞
13.7
13
*
GD1AD
NOMESCO Finland
Thorax CT examination
9.1
13.4
28
35
L04AD01
ATC
ciclosporin; systemic
18.3
13.3
20
12
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
30.7
13.2
17
6
127
Kela drug reimbursment
Transplant complication
18.9
12.8
19
11
ZX108
NOMESCO Finland
Inhalation
34.5
12.8
16
5
DHA10
NOMESCO Finland
Biopsy of cavity of nose
26.3
12.7
17
7
B03XA02
ATC
darbepoetin alfa; parenteral
26.3
12.7
17
7
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
12.6
12
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
12.6
12
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
+∞
12.6
12
*
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
12.6
12
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
24.7
11.8
16
7
V03AE02
ATC
sevelamer; oral
69.1
11.7
13
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.0
11.7
39
92
Z2446
NOMESCO Finland
Social worker
5.9
11.6
33
65
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
11.6
11
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
11.6
11
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.8
11.4
52
167
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.0
11.2
31
59
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.0
11.2
80
359
TGC00
NOMESCO Finland
Bronchial lavation
11.5
11.1
20
19
C08CA05
ATC
nifedipine; systemic
5.7
10.9
32
65
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
10.9
38
94
L04AA01
ATC
[U] ciclosporin; systemic
14.0
10.9
18
14
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
23.0
10.9
15
7
A41.9
ICD-10 Finland
Sepsis, unspecified
10.1
10.8
21
23
C03CA01
ATC
furosemide; systemic
3.0
10.8
78
350
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.3
10.5
41
114
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.2
10.4
25
39
R4110
NOMESCO Finland
Physiotherapy
3.0
10.2
73
324
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.1
10.2
41
117
B03XA01
ATC
erythropoietin; parenteral
42.3
10.1
12
*
C09AA02
ATC
enalapril; systemic
3.1
10.0
62
250
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.5
9.9
52
184
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
16.1
9.7
15
10
ZXA00
NOMESCO Finland
Right side
2.9
9.7
73
334
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.3
9.5
18
19
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
9.4
9
*
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
9.4
9
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
9.4
9
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
9.4
9
*
A02BC02
ATC
pantoprazole; systemic
2.6
9.4
142
957
TPX10
NOMESCO Finland
Implantation of vascular injection port
7.7
9.3
21
30
M05BA07
ATC
risedronic acid; oral
9.8
9.2
18
20
RS221
NOMESCO Finland
NA
12.3
9.2
16
14
WX892
NOMESCO Finland
Monitored bed care
4.9
9.2
30
69
N18.8
ICD-10 Finland
Other chronic renal failure
6.9
9.1
22
35
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.3
9.0
18
21
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
8.9
88
466
WX002
NOMESCO Finland
Sedation and analgesia
3.0
8.9
56
226
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.1
8.9
55
218
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.2
8.8
34
93
J01MA12
ATC
levofloxacin; systemic
3.0
8.8
56
228
A02BC01
ATC
omeprazole; systemic
2.7
8.8
72
340
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.4
8.8
26
54
Z49.2
ICD-10 Finland
Other dialysis
52.3
8.8
10
*
A02BC03
ATC
lansoprazole; oral
2.7
8.8
76
371
TPH07
NOMESCO Finland
Cathetrisation of artery
4.1
8.7
34
94
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
10.7
8.7
16
16
Z3226
NOMESCO Finland
Physiotherapist
3.0
8.7
57
234
Z3231
NOMESCO Finland
Registered nurse
2.6
8.7
76
375
137
Kela drug reimbursment
Uraemia requiring dialysis
21.1
8.6
12
6
H26.3
ICD-10 Finland
Drug-induced cataract
21.1
8.6
12
6
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
93.8
8.5
9
*
J01MA14
ATC
moxifloxacin; systemic
4.1
8.4
33
92
4466A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Thrombotic microangiopathy
+∞
8.4
8
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
8.4
8
*
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
8.4
8
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
8.4
59
255
B07.9
ICD-10 Finland
Verruca simplex
7.4
8.3
19
28
XG410
NOMESCO Finland
Flow-volume spirometry
6.0
8.3
22
40
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
4.2
8.2
31
83
H04.10
ICD-10 Finland
Dry eye syndrome
3.8
8.2
35
105
J01FF01
ATC
clindamycin; systemic
2.6
8.2
73
359
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
10.7
8.2
15
15
B05DB
ATC
Hypertonic solutions
34.9
8.2
10
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.1
8.1
19
29
M35.3
ICD-10 Finland
Polymyalgia rheumatica
13.8
8.0
13
10
WX203
NOMESCO Finland
Infraclavicular plexus blockade
11.5
7.9
14
13
C08CA01
ATC
amlodipine; oral
2.4
7.7
85
468
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
12.5
7.7
13
11
UDM02
NOMESCO Finland
Sinoscopy
9.4
7.7
15
17
V03AE01
ATC
polystyrene sulfonate; oral
19.3
7.7
11
6
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
19.3
7.7
11
6
B05DA
ATC
Isotonic solutions
26.1
7.6
10
*
ZXA05
NOMESCO Finland
Left side
2.6
7.6
64
303
A07AA02
ATC
nystatin; oral
4.7
7.5
25
59
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.0
7.5
46
181
R04.0
ICD-10 Finland
Epistaxis
5.1
7.5
23
50
M05BB03
ATC
alendronic acid and colecalciferol; oral
8.9
7.5
15
18
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
7.4
71
363
C08CA02
ATC
felodipine; oral
3.8
7.4
31
92
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.8
7.4
31
92
ZXE20
NOMESCO Finland
More than three and less than five hours
3.2
7.3
40
144
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
7.3
7
*
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
7.3
7
*
J01MA02
ATC
ciprofloxacin; systemic
2.3
7.3
96
572
ZXD05
NOMESCO Finland
Urgent procedure
2.4
7.3
81
446
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.1
7.2
28
77
Z49.0
ICD-10 Finland
Preparatory care for dialysis
31.2
7.2
9
*
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
12.7
7.2
12
10
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
9.3
7.2
14
16
H65.3
ICD-10 Finland
Chronic mucoid otitis media
10.6
7.1
13
13
L88
ICPC
Rheumatoid/seropositive arthritis
6.8
7.1
17
27
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
6.8
68
352
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
41.5
6.8
8
*
M13.9
ICD-10 Finland
Arthritis, unspecified
4.4
6.7
23
57
C02CA01
ATC
prazosin; oral
10.5
6.6
12
12
ZXE00
NOMESCO Finland
One hour or less
2.2
6.5
95
585
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
14.9
6.5
10
7
H65.2
ICD-10 Finland
Chronic serous otitis media
14.9
6.5
10
7
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
72.0
6.5
7
*
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
72.0
6.5
7
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
6.4
25
70
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
6.3
6
*
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
+∞
6.3
6
*
N085, M318
ICD-10 Finland
NA
+∞
6.3
6
*
4464A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Wegener's granulomatosis
+∞
6.3
6
*
6BA02
NOMESCO Finland
NA
27.6
6.3
8
*
J05AB01
ATC
aciclovir; systemic
2.5
6.3
52
242
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.7
6.2
20
46
205
Kela drug reimbursment
Chronic hypertension
2.3
6.2
68
366
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
13.1
6.1
10
8
J01DA01
ATC
[U] cefalexin; systemic
2.1
6.0
136
995
J31.0
ICD-10 Finland
Chronic rhinitis
3.7
6.0
25
74
Mortality – FinRegistry
↥Association
Association between endpoint M13_HTROMBMICROANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HTROMBMICROANG | 3.027 [2.31, 3.96] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.064 |
During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 569 females with M13_HTROMBMICROANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HTROMBMICROANG | 2.429 [1.94, 3.05] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.065 |
During the follow-up period (1.1.1998 — 31.12.2019), 137 out of 411 males with M13_HTROMBMICROANG died.
Mortality risk
Mortality risk for people of age
years, who have M13_HTROMBMICROANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.267% | 0.436% |
| 5 | 1.504% | 2.909% |
| 10 | 3.987% | 7.723% |
| 15 | 7.418% | 14.785% |
| 20 | 12.635% | 24.923% |
Relationships between endpoints
↥Index endpoint: M13_HTROMBMICROANG – Thrombotic microangiopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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