No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
292 |
4. Check minimum number of eventsNone |
292 |
5. Include endpointsNone |
292 |
6. Filter based on genotype QC (FinnGen only) |
292 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M20
- Name in latin
- Alia deformitas hallucis [acquisita]
Similar endpoints
↥List of similar endpoints to
Other deformity of hallux (acquired)
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1768 | 1316 | 446 |
| Only index persons | 1661 | 1261 | 400 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.00 | 56.11 | 55.53 |
| Only index persons | 55.69 | 55.82 | 55.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 292 | 222 | 70 |
| Unadjusted period prevalence (%) | 0.06 | 0.08 | 0.03 |
| Median age at first event (years) | 55.15 | 53.92 | 59.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 267
- Matched controls
- 2669
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M20.3
ICD-10 Finland
Other deformity of hallux (acquired)
+∞
312.6
235
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
83.7
98.1
107
21
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
90.9
82
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
268.6
78.9
77
*
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
58.5
54
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
56.6
49.7
58
13
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
21.7
46.1
69
42
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
+∞
45.1
42
*
M20.2
ICD-10 Finland
Hallux rigidus
169.9
42.1
43
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
18.3
41.5
66
47
9271
FHL
Hallux surgery
422.9
38.0
37
*
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
37.4
35
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
36.3
34
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
35.2
33
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
383.1
34.8
34
*
7351A
ICD-9 Finland
Acquired deformities of toe, Hallux varus (acquired)
+∞
34.1
32
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
33.0
31
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
351.7
31.5
31
*
WX320
NOMESCO Finland
Spinalanesthesy
6.3
31.2
96
218
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
23.9
28.9
41
20
M25.5
ICD-10 Finland
Pain in joint
5.3
25.9
93
246
M16.1
ICD-10 Finland
Other primary coxarthrosis
43.5
25.5
31
8
73799
ICD-8 Finland
Hallux valgus and varus
+∞
24.3
23
*
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
262.4
24.0
24
*
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
250.4
23.0
23
*
NHG82
NOMESCO Finland
Fusion of other tarsal joint
+∞
22.2
21
*
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
238.6
21.9
22
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
238.6
21.9
22
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
47.8
21.8
26
6
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
9.9
21.4
44
52
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
21.1
20
*
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
21.1
20
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.4
20.2
143
669
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
25.0
16.7
23
10
N02AX02
ATC
tramadol; systemic, rectal
3.1
16.5
128
609
ZXA00
NOMESCO Finland
Right side
3.4
16.0
96
381
L17
ICPC
Foot/toe symptom/complaint
3.4
15.8
91
348
NH3EA
NOMESCO Finland
Feet X-ray examination with load
60.2
15.0
17
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
11.9
14.9
27
25
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
14.7
14
*
M79.6
ICD-10 Finland
Pain in limb
2.9
14.5
115
545
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
5.2
14.3
46
102
M01AX05
ATC
glucosamine; oral
3.9
14.3
65
204
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
9.0
14.2
30
37
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
8.9
13.7
29
36
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
17.4
13.7
21
13
S18
ICPC
Laceration/cut
2.7
13.5
130
687
M01AH05
ATC
etoricoxib; oral
2.7
13.4
158
938
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
21.3
12.6
18
9
B01AB05
ATC
enoxaparin; parenteral
2.9
12.4
90
395
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
14.3
12.1
20
15
M19.9
ICD-10 Finland
Arthrosis, unspecified
11.3
12.0
22
21
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
49.0
12.0
14
*
Z01.2
ICD-10 Finland
Dental examination
2.6
11.8
120
641
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
11.8
107
534
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
125.1
11.5
12
*
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
5.5
11.4
34
69
L15
ICPC
Knee symptom/complaint
3.3
11.3
63
230
1221
FHL
Arthroscopy and meniscus surgery
26.3
11.3
15
6
N03AX12
ATC
gabapentin; oral
3.6
11.0
53
172
M09AX01
ATC
hyaluronic acid; parenteral
10.2
11.0
21
22
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
62.5
10.7
12
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
62.5
10.7
12
*
M13.9
ICD-10 Finland
Arthritis, unspecified
15.0
10.6
17
12
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
7.6
10.5
24
34
M67.0
ICD-10 Finland
Short Achilles tendon (acquired)
114.2
10.5
11
*
M01AE01
ATC
ibuprofen; systemic, rectal
3.3
9.8
241
1970
ZXA05
NOMESCO Finland
Left side
2.7
9.6
77
352
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
31.2
9.5
12
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
103.5
9.5
10
*
SPAT1153
SPAT
Removal of sutures
2.5
9.5
93
475
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
9.4
9
*
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
+∞
9.4
9
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
9.4
9
*
L84
ICD-10 Finland
Corns and callosities
9.6
9.2
18
20
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
9.1
105
580
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
38.1
9.1
11
*
J01DB01
ATC
cefalexin; oral
2.6
9.0
220
1722
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
8.9
86
431
M03BX02
ATC
tizanidine; oral
2.2
8.8
170
1182
A02BC03
ATC
lansoprazole; oral
2.4
8.8
85
428
N03AX16
ATC
pregabalin; oral
2.6
8.7
70
319
M01AX17
ATC
nimesulide; oral
2.5
8.6
74
349
P01BA02
ATC
hydroxychloroquine; oral
7.1
8.5
20
30
M54.4
ICD-10 Finland
Lumbago with sciatica
3.0
8.5
51
193
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
92.8
8.5
9
*
L13
ICPC
Hip symptom/complaint
3.1
8.4
48
177
A02BC05
ATC
esomeprazole; systemic
2.2
8.3
120
727
J02AC01
ATC
fluconazole; systemic
2.1
8.1
127
795
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
10.5
8.1
15
15
M01AH01
ATC
celecoxib; oral (coxibs)
2.8
8.1
56
232
J01FF01
ATC
clindamycin; systemic
2.4
8.0
77
383
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.8
7.8
25
56
M77.4
ICD-10 Finland
Metatarsalgia
4.6
7.8
26
61
N02BE01
ATC
paracetamol; systemic, rectal
2.6
7.7
231
1903
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
25.8
7.6
10
*
M02AA07
ATC
piroxicam; topical
2.1
7.6
108
646
UJF32
NOMESCO Finland
Coloscopy
2.3
7.5
76
389
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
82.2
7.5
8
*
H02AB06
ATC
prednisolone; systemic
2.1
7.4
118
735
L16
ICPC
Ankle symptom/complaint
3.3
7.3
36
119
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.8
7.3
49
199
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
7.3
7
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
7.3
7
*
M22.4
ICD-10 Finland
Chondromalacia patellae
30.9
7.2
9
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.5
7.2
61
284
WX110
NOMESCO Finland
Local anesthesy
2.0
7.1
173
1269
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
7.0
53
231
R51.80
ICD-10 Finland
Headache
3.0
7.0
41
154
SFA10
NOMESCO Finland
Fillning on one surface of tooth
2.0
7.0
137
924
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
3.2
7.0
36
124
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
3.9
6.8
27
75
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
41.1
6.8
8
*
B01AF01
ATC
rivaroxaban; oral
3.5
6.6
30
94
WX002
NOMESCO Finland
Sedation and analgesia
2.4
6.5
60
291
SAA01
NOMESCO Finland
Simple examination of mouth
2.0
6.5
176
1321
M48.0
ICD-10 Finland
Spinal stenosis
3.0
6.5
37
136
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
71.4
6.5
7
*
NG2AA
NOMESCO Finland
Patella X-ray examination
71.4
6.5
7
*
M01AC06
ATC
meloxicam; systemic, rectal
2.0
6.4
100
607
E0000UV
ATC
NA
2.0
6.3
107
673
ZXA10
NOMESCO Finland
Bilateral
2.3
6.3
61
303
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
18.5
6.3
9
5
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.9
6.3
39
149
9351
FHL
Metatarsus osteotomies
+∞
6.3
6
*
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
6.3
6
*
WX214
NOMESCO Finland
Plexus blockade at the ankle
+∞
6.3
6
*
M01AB05
ATC
diclofenac; systemic, rectal
1.9
6.2
168
1250
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
6.1
112
722
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.7
6.1
25
72
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.5
6.1
27
83
N06AA09
ATC
amitriptyline; systemic
3.0
6.1
34
122
N05BA01
ATC
diazepam; systemic, rectal
2.6
6.1
45
194
WX290
NOMESCO Finland
Other blockade of nerve
2.0
6.0
102
639
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.9
6.0
140
984
Mortality – FinRegistry
↥Association
Association between endpoint M13_HALLUDEFORMOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HALLUDEFORMOTH | 0.675 [0.54, 0.85] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.581 |
During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 970 females with M13_HALLUDEFORMOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HALLUDEFORMOTH | 0.93 [0.7, 1.24] | 0.625 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 341 males with M13_HALLUDEFORMOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_HALLUDEFORMOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.058% | 0.114% |
| 5 | 0.403% | 1.004% |
| 10 | 1.009% | 2.475% |
| 15 | 2.078% | 4.616% |
| 20 | 3.681% | 7.893% |
Relationships between endpoints
↥Index endpoint: M13_HALLUDEFORMOTH – Other deformity of hallux (acquired)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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