Deformity of finger(s)

M13_FINGERDEFORM

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M20.00, M20.01, M20.08 Hospital discharge: ICD-9 — 7362 Cause of death: ICD-10 — M20.00, M20.01, M20.08 Cause of death: ICD-9 — 7362 2 out of 7 registries used, show all original rules.	226
4. Check minimum number of events None	226
5. Include endpoints None	226
6. Filter based on genotype QC (FinnGen only)	226

Control definitions (FinnGen only)

Control exclude: M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	M13_FINGERDEFORM
CONTROL_EXCLUDE	M13_ARTHROPATHIES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M200
HD_ICD_9	7362
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M200
COD_ICD_9	7362
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Deformity of finger(s) based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1492	854	627
Only index persons	1395	803	592
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.03	0.03	0.02
Median age at first event (years)
Whole population	50.52	50.87	49.88
Only index persons	50.09	50.51	49.51

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	226	133	93
Unadjusted period prevalence (%)	0.04	0.05	0.04
Median age at first event (years)	52.14	50.39	54.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
207: Matched controls
2068

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M20.00

ICD-10 Finland

Buttonhole deformity of fingers

+∞

126.3

108

M20.01

ICD-10 Finland

Swan neck deformity of fingers

+∞

51.2

M20.08

ICD-10 Finland

Deformity of finger(s)

+∞

50.0

M20.1

ICD-10 Finland

Hallux valgus (acquired)

51.7

38.1

M19.0

ICD-10 Finland

Primary arthrosis of other joints

52.2

29.8

M17.1

ICD-10 Finland

Other primary gonarthrosis

21.1

23.1

NDU20

NOMESCO Finland

Removal of internal fixation device from wrist or hand

40.1

22.7

NHK30

NOMESCO Finland

Osteotomy or rotation osteotomy of first metatarsal or tarsal bone

+∞

22.3

NHG80

NOMESCO Finland

Fusion of first tarsometatarsal joint

+∞

21.2

M20.4

ICD-10 Finland

Other hammer toe(s) (acquired)

64.2

20.3

A07EC01

ATC

sulfasalazine; oral, rectal

20.0

18.8

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

+∞

18.0

M16.1

ICD-10 Finland

Other primary coxarthrosis

104.0

17.9

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

11.7

17.7

NHG70

NOMESCO Finland

Arthroplasty of first tarsometatarsal joint

+∞

16.9

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

+∞

15.8

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

+∞

15.8

M25.5

ICD-10 Finland

Pain in joint

4.4

15.4

192

M20.2

ICD-10 Finland

Hallux rigidus

+∞

14.8

NHK40

NOMESCO Finland

Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone

+∞

14.8

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

7.5

14.1

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

11.6

13.1

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

13.5

12.9

NDG76

NOMESCO Finland

Fusion of DIP joint

74.5

12.7

S66.3

ICD-10 Finland

Injury of extensor muscle and tendon of other finger at wrist and hand level

14.4

12.7

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

9.4

12.7

NDL99

NOMESCO Finland

Other operation on muscle or tendon of wrist or hand

+∞

12.6

NHG77

NOMESCO Finland

Arthroplasty of interphalangeal tarsal joint(s)

+∞

12.6

P01BA02

ATC

hydroxychloroquine; oral

11.6

12.6

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

137.9

12.6

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

11.0

11.8

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

24.6

11.8

NFB30

NOMESCO Finland

Primary total prosthetic replacement of hip joint not using cement

+∞

10.5

L04AA13

ATC

leflunomide; oral

+∞

10.5

73799

ICD-8 Finland

Hallux valgus and varus

+∞

10.5

R4120

NOMESCO Finland

Occupational therapy

6.2

10.4

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

27.5

9.9

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

5.9

9.8

L88

ICPC

Rheumatoid/seropositive arthritis

23.0

9.5

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

+∞

9.4

M05.9

ICD-10 Finland

Seropositive rheumatoid arthritis, unspecified

+∞

9.4

M79.6

ICD-10 Finland

Pain in limb

2.7

9.2

384

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

38.5

9.1

N03AX12

ATC

gabapentin; oral

3.7

9.0

130

M19.1

ICD-10 Finland

Post-traumatic arthrosis of other joints

52.2

8.7

NDL32

NOMESCO Finland

Suture or reinsertion of tendon of wrist or hand, extensor tendon

28.8

8.6

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

13.5

8.5

7362A

ICD-9 Finland

Other acquired deformities of limbs, Other acquired deformities of finger[DEFORMATIO BOUTONNIôRE]

+∞

8.4

T92.5

ICD-10 Finland

Sequelae of injury of muscle and tendon of upper limb

+∞

8.4

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.4

8.3

543

X58

ICD-10 Finland

Exposure to other specified factors

3.7

8.3

115

M01AH05

ATC

etoricoxib; oral

2.3

8.0

116

730

N03AX16

ATC

pregabalin; oral

2.9

8.0

226

N02AX02

ATC

tramadol; systemic, rectal

2.4

7.9

494

H02AB06

ATC

prednisolone; systemic

2.3

7.8

573

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

46.7

7.8

NDM99

NOMESCO Finland

Other operation on fascia, ganglion, synovial sheath or bursa of wrist or hand

46.7

7.8

S18

ICPC

Laceration/cut

2.3

7.6

503

NF1AA

NOMESCO Finland

Hip X-ray examination

8.2

7.5

ZXA00

NOMESCO Finland

Right side

2.7

7.5

268

NHG76

NOMESCO Finland

Arthroplasty of other tarsometatarsal joint

82.9

7.5

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

82.9

7.5

WX320

NOMESCO Finland

Spinalanesthesy

3.2

7.4

149

ZXA05

NOMESCO Finland

Left side

2.7

7.4

247

M01AX05

ATC

glucosamine; oral

3.4

7.4

120

L04AX01

ATC

azathioprine; systemic

7.8

7.3

M19.2

ICD-10 Finland

Other secondary arthrosis

+∞

7.3

T92.3

ICD-10 Finland

Sequelae of dislocation, sprain and strain of upper limb

31.2

7.2

NH3EA

NOMESCO Finland

Feet X-ray examination with load

31.2

7.2

SPAT1149

SPAT

Suture or treatment of traumatic wound

3.3

7.2

129

M75.1

ICD-10 Finland

Rotator cuff syndrome

2.7

7.1

226

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.2

6.7

568

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

12.8

6.7

L12

ICPC

Hand/finger symptom/complaint

3.1

6.6

137

M24.4

ICD-10 Finland

Recurrent dislocation and subluxation of joint

71.9

6.5

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

14.9

6.5

N06AA09

ATC

amitriptyline; systemic

3.9

6.4

NDL62

NOMESCO Finland

Shortening of tendon of hand

+∞

6.3

NDL54

NOMESCO Finland

Tenolysis of hand

+∞

6.3

NF1DA

NOMESCO Finland

X-ray of hips

27.6

6.3

TQW40

NOMESCO Finland

Remowal of suture of skin

4.3

6.2

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.3

6.2

350

TNX33

NOMESCO Finland

Custom moulded cast, unspecified region

5.1

6.1

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.3

6.1

307

M01AX17

ATC

nimesulide; oral

2.5

6.0

239

Mortality – FinRegistry

↥

Association

Association between endpoint M13_FINGERDEFORM and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_FINGERDEFORM	1.24 [0.96, 1.6]	0.096
Birth year	0.999 [0.99, 1.01]	0.752

During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 690 females with M13_FINGERDEFORM died.

Males

Parameter	HR [95% CI]	p-value
M13_FINGERDEFORM	1.117 [0.87, 1.43]	0.381
Birth year	0.991 [0.98, 1.0]	0.189

During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 494 males with M13_FINGERDEFORM died.

Mortality risk

Mortality risk for people of age

years, who have M13_FINGERDEFORM.

N-year risk	Females	Males
1	0.155%	0.254%
5	0.81%	1.674%
10	2.038%	3.989%
15	3.924%	7.081%
20	6.915%	11.933%

Relationships between endpoints

↥

Index endpoint: M13_FINGERDEFORM – Deformity of finger(s)

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Deformity of finger(s)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints