Other crystal arthropathies

M13_CRYSTALARTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M11
  • Hospital discharge: ICD-9 712
  • Cause of death: ICD-10 M11
  • Cause of death: ICD-9 712

2 out of 7 registries used, show all original rules.

572

4. Check minimum number of events

None

572

5. Include endpoints

None

572

6. Filter based on genotype QC (FinnGen only)

548

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M05-M14
Name in latin
Aliae arthropathiae crystallinae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4483 2473 1985
Only index persons 3918 2148 1770
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.06
Only index persons 0.07 0.08 0.07
Median age at first event (years)
Whole population 74.22 76.55 71.34
Only index persons 73.90 76.25 71.05

-FinnGen-

Key figures

All Female Male
Number of individuals 548 266 282
Unadjusted period prevalence (%) 0.12 0.10 0.14
Median age at first event (years) 71.44 71.06 71.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
572
Matched controls
5720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M11.2
ICD-10 Finland
Other chondrocalcinosis
7486.9
323.0
348
*
M13.9
ICD-10 Finland
Arthritis, unspecified
105.1
204.5
217
33
M17.1
ICD-10 Finland
Other primary gonarthrosis
45.3
188.6
234
86
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
45.6
131.8
162
49
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
70.8
127.3
144
27
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
33.7
119.3
158
64
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
117.9
109
*
M11.9
ICD-10 Finland
Crystal arthropathy, unspecified
+∞
106.7
99
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
69.7
95.1
108
19
H02AB06
ATC
prednisolone; systemic
6.6
93.8
408
1568
M11.8
ICD-10 Finland
Other specified crystal arthropathies
+∞
93.3
87
*
M10.9
ICD-10 Finland
Gout, unspecified
21.0
77.1
117
69
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
15.9
73.1
124
98
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
793.2
72.8
70
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
780.3
71.7
69
*
M25.5
ICD-10 Finland
Pain in joint
7.1
71.4
203
412
M19.0
ICD-10 Finland
Primary arthrosis of other joints
38.8
70.2
89
27
M16.1
ICD-10 Finland
Other primary coxarthrosis
39.7
69.8
88
26
P01BA02
ATC
hydroxychloroquine; oral
22.9
68.8
101
53
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
729.0
67.4
65
*
N02AX02
ATC
tramadol; systemic, rectal
4.5
61.9
330
1326
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
343.0
61.6
61
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
18.0
61.4
98
65
M01AX05
ATC
glucosamine; oral
5.4
51.4
181
454
L15
ICPC
Knee symptom/complaint
5.7
50.9
167
385
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
17.8
49.6
79
51
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
9.3
49.0
108
140
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
40.0
48.7
61
17
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
47.6
45
*
M01AH05
ATC
etoricoxib; oral
3.7
47.4
341
1639
N02AJ06
ATC
codeine and paracetamol; systemic
4.0
46.9
245
897
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
59.4
46.4
54
10
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
10.4
45.4
93
105
N02BE01
ATC
paracetamol; systemic, rectal
6.1
44.9
529
3812
M79.6
ICD-10 Finland
Pain in limb
3.8
44.8
251
968
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
14.8
42.2
72
55
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
425.9
40.6
40
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.4
40.3
289
1326
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
113.1
39.3
42
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
39.1
337
1754
M11.1
ICD-10 Finland
Familial chondrocalcinosis
+∞
36.9
35
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
12.7
36.8
67
59
NF1AA
NOMESCO Finland
Hip X-ray examination
7.5
36.2
90
139
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.7
36.1
139
367
M09AX01
ATC
hyaluronic acid; parenteral
16.4
35.7
58
39
A07EC01
ATC
sulfasalazine; oral, rectal
11.5
35.7
68
66
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
46.4
35.5
43
10
B01AB05
ATC
enoxaparin; parenteral
3.4
35.4
219
876
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
368.6
35.3
35
*
SPAT1263
SPAT
Sampling
3.1
34.9
302
1530
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
+∞
34.7
33
*
A02BC02
ATC
pantoprazole; systemic
3.1
34.1
412
2591
M10.0
ICD-10 Finland
Idiopathic gout
22.2
33.7
49
24
TNG10
NOMESCO Finland
Puncture of knee
345.9
33.2
33
*
J01DB01
ATC
cefalexin; oral
3.7
33.2
487
3484
S18
ICPC
Laceration/cut
2.9
32.2
290
1483
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
63.8
31.4
36
6
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
7.0
30.9
80
130
M04AA01
ATC
allopurinol; systemic
4.2
29.9
125
353
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.8
29.8
147
481
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.3
29.7
124
349
L90
ICPC
Osteoarthrosis of knee
10.2
29.7
60
65
SPAT1153
SPAT
Removal of sutures
3.0
29.7
232
1065
212
Kela drug reimbursment
Gout
+∞
29.4
28
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
28.4
27
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
28.4
27
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.4
28.1
89
187
NG2AA
NOMESCO Finland
Patella X-ray examination
152.4
27.9
29
*
N03AX16
ATC
pregabalin; oral
3.3
27.9
166
625
N03AX12
ATC
gabapentin; oral
4.3
27.6
112
305
WX320
NOMESCO Finland
Spinalanesthesy
3.7
27.6
140
465
A46
ICD-10 Finland
Erysipelas
3.7
27.5
136
443
NG1DA
NOMESCO Finland
X-ray of knees
79.1
27.0
30
*
M01AH01
ATC
celecoxib; oral (coxibs)
3.6
26.3
134
445
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.8
26.0
230
1119
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
25.5
26.0
36
15
L04AA13
ATC
leflunomide; oral
272.2
25.9
26
*
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
46.6
25.8
31
7
L88
ICPC
Rheumatoid/seropositive arthritis
30.0
25.7
34
12
M48.0
ICD-10 Finland
Spinal stenosis
4.1
25.4
107
301
M11.0
ICD-10 Finland
Hydroxyapatite deposition disease
+∞
25.2
24
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
6.0
24.5
70
129
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.8
24.2
193
873
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
90.7
23.9
26
*
1220
FHL
Arthroscopy
16.2
23.6
38
25
B01AA03
ATC
warfarin; systemic
2.7
23.6
203
957
R06.0
ICD-10 Finland
Dyspnoea
2.8
23.4
184
821
C03CA01
ATC
furosemide; systemic
2.5
23.4
260
1420
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
87.0
22.8
25
*
NH3EA
NOMESCO Finland
Feet X-ray examination with load
125.0
22.7
24
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.0
22.5
150
600
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
22.5
22.4
32
15
M20.1
ICD-10 Finland
Hallux valgus (acquired)
13.0
22.1
39
32
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
83.4
21.8
24
*
R50.9
ICD-10 Finland
Fever, unspecified
3.4
21.8
117
399
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
6.6
21.7
57
94
B01AF01
ATC
rivaroxaban; oral
4.1
21.6
89
243
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
21.6
214
1083
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
45.2
21.6
26
6
1221
FHL
Arthroscopy and meniscus surgery
18.3
21.6
33
19
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.5
20.9
64
128
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
79.8
20.8
23
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.2
20.7
126
470
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
43.4
20.6
25
6
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
23.4
20.6
29
13
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
49.9
20.3
24
5
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.8
20.3
91
268
M15
ICD-10 Finland
Polyarthrosis
8.0
19.8
45
60
ACC51
NOMESCO Finland
Release of median nerve
5.6
19.6
59
116
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.9
19.5
86
249
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
72.4
18.8
21
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
18.8
231
1287
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
21.7
18.8
27
13
M35.3
ICD-10 Finland
Polymyalgia rheumatica
6.9
18.7
47
73
M13.0
ICD-10 Finland
Polyarthritis, unspecified
103.4
18.7
20
*
L17
ICPC
Foot/toe symptom/complaint
2.6
18.2
161
755
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
6.3
18.1
49
84
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
17.9
142
621
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.3
17.8
207
1114
M01AC06
ATC
meloxicam; systemic, rectal
2.4
17.8
202
1076
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
+∞
17.8
17
*
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
17.8
17
*
X59
ICD-10 Finland
Exposure to unspecified factor
3.1
17.6
107
396
L12
ICPC
Hand/finger symptom/complaint
3.4
17.5
92
307
M03BX02
ATC
tizanidine; oral
2.2
17.4
306
1988
N02AA05
ATC
oxycodone; systemic
2.8
17.4
124
510
X58
ICD-10 Finland
Exposure to other specified factors
3.6
17.4
82
251
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.3
17.1
203
1100
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
17.1
192
1013
J01FF01
ATC
clindamycin; systemic
2.5
17.1
169
835
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.9
16.8
110
427
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
16.7
16
*
M19.9
ICD-10 Finland
Arthrosis, unspecified
9.9
16.6
33
35
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
20.8
16.5
24
12
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
16.3
162
799
M02AA07
ATC
piroxicam; topical
2.2
16.0
231
1360
SPAT1216
SPAT
Assessment of functional ability
2.6
16.0
129
566
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
61.8
15.8
18
*
J01CA04
ATC
amoxicillin; systemic
2.2
15.8
425
3249
M54.5
ICD-10 Finland
Low back pain
2.3
15.6
170
876
WX111
NOMESCO Finland
Local infiltration anesthesia
164.2
15.6
16
*
SPAT1310
SPAT
Counselling related to known health issue
2.2
15.5
198
1099
N06AA09
ATC
amitriptyline; systemic
3.4
15.5
78
251
M01AB05
ATC
diclofenac; systemic, rectal
2.1
15.5
342
2394
M13.8
ICD-10 Finland
Other specified arthritis
39.2
15.5
19
5
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
39.2
15.5
19
5
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
10.1
15.4
30
31
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
16.6
15.4
24
15
L01
ICPC
Neck symptom/complaint
3.2
15.2
84
289
NFB50
NOMESCO Finland
Primary total prosthetic replacement of hip joint using cement
46.3
15.1
18
*
M01AE02
ATC
naproxen; oral, rectal
2.0
15.1
282
1840
SAA02
NOMESCO Finland
Basic examination of mouth
2.0
15.0
300
2009
SPAT1249
SPAT
Treatment-related counselling outside office
2.1
15.0
240
1468
SPAT1211
SPAT
Application of soft bandage
3.4
14.9
76
247
B01AX06
ATC
[U] rivaroxaban; oral
58.2
14.9
17
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.5
14.8
130
598
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
14.8
120
528
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
14.6
14
*
ZXA05
NOMESCO Finland
Left side
2.3
14.5
158
810
M19.2
ICD-10 Finland
Other secondary arthrosis
153.7
14.5
15
*
L03
ICPC
Low back symptom/complaint
2.5
14.4
132
618
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.3
14.4
79
268
NF1DA
NOMESCO Finland
X-ray of hips
28.0
14.3
19
7
ZXA00
NOMESCO Finland
Right side
2.3
14.3
160
832
SPAT1260
SPAT
Consultation of another employee
2.5
14.2
126
581
L28
ICPC
Limited function/disability (L)
2.5
14.1
121
547
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
14.1
184
1024
SPAT1202
SPAT
Intra-articular injection
8.1
14.0
31
40
L13
ICPC
Hip symptom/complaint
3.0
14.0
88
331
M10
ICD-10 Finland
Gout
5.8
13.9
39
71
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
13.8
139
681
M25.0
ICD-10 Finland
Haemarthrosis
77.0
13.6
15
*
M20.2
ICD-10 Finland
Hallux rigidus
77.0
13.6
15
*
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
77.0
13.6
15
*
M01AX17
ATC
nimesulide; oral
2.3
13.6
150
769
9271
FHL
Hallux surgery
+∞
13.6
13
*
L08
ICPC
Shoulder symptom/complaint
2.6
13.5
112
496
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.6
13.3
111
492
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.3
13.2
69
229
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
13.2
111
498
WX110
NOMESCO Finland
Local anesthesy
1.9
13.1
340
2465
I50.9
ICD-10 Finland
Heart failure, unspecified
2.4
13.0
126
605
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
13.0
188
1086
R60.0
ICD-10 Finland
Localized oedema
2.9
13.0
85
325
H02AB04
ATC
methylprednisolone; systemic
2.7
12.9
98
412
H02AB07
ATC
prednisone; oral
2.7
12.9
96
401
M17.5
ICD-10 Finland
Other secondary gonarthrosis
51.2
12.9
15
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
51.2
12.9
15
*
M01AH02
ATC
rofecoxib; oral
2.8
12.9
90
362
207
Kela drug reimbursment
Chronic arrhythmias
2.4
12.8
125
605
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
71.5
12.6
14
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
12.6
84
327
M19.8
ICD-10 Finland
Other specified arthrosis
7.6
12.6
29
40
SPAT1254
SPAT
Administration of medicine
2.5
12.6
114
527
NHG22
NOMESCO Finland
Fusion of subtalar joint
+∞
12.5
12
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
12.5
12
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.0
12.5
51
138
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
132.7
12.5
13
*
SPAT1229
SPAT
Assessment of need for aid
3.1
12.4
70
244
Z01.2
ICD-10 Finland
Dental examination
2.0
12.4
190
1118
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
12.4
98
423
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.8
12.3
53
150
L40.5
ICD-10 Finland
Arthropathic psoriasis
38.4
12.3
15
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.9
12.2
253
1671
J01DA01
ATC
[U] cefalexin; systemic
1.9
12.2
339
2486
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.3
12.1
62
202
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
11.4
12.1
22
20
AA1AD
NOMESCO Finland
CT of head and brain
2.1
12.1
169
959
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
21.8
12.1
17
8
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
6.7
12.0
30
47
WZA00
NOMESCO Finland
Short statement of of health and health related matters
5.7
12.0
34
63
C07AB07
ATC
bisoprolol; oral
1.9
12.0
318
2290
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
8.2
12.0
26
33
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.4
11.9
110
513
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
8.7
11.9
25
30
SPAT1301
SPAT
No procedures
2.0
11.8
192
1153
L20
ICPC
Joint symptom/complaint NOS
6.7
11.7
29
45
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
11.7
213
1336
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.9
11.6
48
132
B01AF02
ATC
apixaban; oral
2.7
11.5
82
333
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.3
11.5
59
193
NG1EA
NOMESCO Finland
Knee X-ray examination with wrench
+∞
11.5
11
*
NGC00
NOMESCO Finland
Exchange of a loose part of prosthesis in knee joint
+∞
11.5
11
*
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
+∞
11.5
11
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
11.5
11
*
K78
ICPC
Atrial fibrillation/flutter
2.8
11.5
78
308
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.2
11.4
35
71
S83.2
ICD-10 Finland
Tear of meniscus, current
5.7
11.3
32
59
M23.3
ICD-10 Finland
Other meniscus derangements
35.8
11.3
14
*
M01AB55
ATC
diclofenac, combinations; oral
3.6
11.3
51
151
J01MA12
ATC
levofloxacin; systemic
2.2
11.2
127
655
S80.0
ICD-10 Finland
Contusion of knee
4.3
11.2
41
101
Z00.0
ICD-10 Finland
General medical examination
2.2
11.0
118
593
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
5.9
11.0
30
53
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
4.4
11.0
39
93
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
11.0
89
386
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.3
11.0
40
98
M47.82
ICD-10 Finland
Other spondylosis, cervical region
5.2
10.9
33
66
SPAT1204
SPAT
Arthrocentesis
28.6
10.8
14
5
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
10.7
379
2955
M70.6
ICD-10 Finland
Trochanteric bursitis
2.9
10.6
65
240
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
5.4
10.6
31
60
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
10.5
108
530
M79.1
ICD-10 Finland
Myalgia
2.9
10.5
65
242
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
+∞
10.4
10
*
M25.4
ICD-10 Finland
Effusion of joint
33.2
10.4
13
*
M18.1
ICD-10 Finland
Other primary arthrosis of first carpometacarpal joint
33.2
10.4
13
*
M01AE01
ATC
ibuprofen; systemic, rectal
1.9
10.3
444
3673
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
10.3
100
476
NJ3NA
NOMESCO Finland
Measurement of difference in extremity lengty with X-ray
23.9
10.3
14
6
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.8
10.2
68
265
UKC02
NOMESCO Finland
Cystoscopy
2.2
10.1
116
600
M16
ICD-10 Finland
Coxarthrosis [arthrosis of hip]
6.3
10.1
26
43
R02
ICPC
Shortness of breath/dyspnoea
2.5
10.1
81
349
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.0
10.1
27
47
A98
ICPC
Health maint/preventive medicine
2.3
10.0
512
4499
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
10.0
195
1239
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
10.0
235
1587
M02AA10
ATC
ketoprofen; topical
2.4
10.0
92
429
ND1AA
NOMESCO Finland
Wrist X-ray examination
3.7
10.0
43
123
L16
ICPC
Ankle symptom/complaint
3.0
9.9
57
203
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
20.4
9.8
14
7
J01MA02
ATC
ciprofloxacin; systemic
1.8
9.8
232
1569
P01AB01
ATC
metronidazole; oral, rectal
1.8
9.8
204
1323
H25.8
ICD-10 Finland
Other senile cataract
2.3
9.7
99
484
M10.3
ICD-10 Finland
Gout due to impairment of renal function
55.9
9.7
11
*
Z94.0
ICD-10 Finland
Kidney transplant status
11.6
9.6
17
15
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.8
9.6
233
1585
UJF32
NOMESCO Finland
Coloscopy
1.9
9.5
157
938
N06AX21
ATC
duloxetine; oral
2.9
9.5
56
203
NK4EA
NOMESCO Finland
Joint X-ray examintion with load or wrench not elsewhere classified
+∞
9.4
9
*
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
9.4
9
*
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
+∞
9.4
9
*
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
7.1
9.4
22
32
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.6
9.3
68
278
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
6.2
9.3
24
40
A01
ICPC
Pain general/multiple sites
3.1
9.3
52
179
D07AC01
ATC
betamethasone; topical
1.8
9.3
189
1211
Z3231
NOMESCO Finland
Registered nurse
1.9
9.3
161
975
E0000UV
ATC
NA
1.8
9.3
208
1376
B01AB04
ATC
dalteparin; parenteral
4.2
9.2
34
85
M03BC01
ATC
orphenadrine (citrate); systemic
2.1
9.1
107
556
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.0
9.1
127
708
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
9.2
9.1
18
20
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
4.5
9.1
31
72
M18.9
ICD-10 Finland
Arthrosis of first carpometacarpal joint, unspecified
37.3
9.0
11
*
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.0
9.0
51
178
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
9.0
247
1736
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
7.6
9.0
20
27
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
8.9
113
605
WZA90
NOMESCO Finland
Other doctors statement
2.1
8.8
109
578
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.0
8.8
51
182
S97
ICPC
Chronic ulcer skin
3.3
8.8
44
142
R03AC02
ATC
salbutamol; inhalant
1.7
8.8
256
1831
R53
ICD-10 Finland
Malaise and fatigue
2.0
8.8
125
702
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.9
8.8
35
94
A03
ICPC
Fever
2.4
8.8
76
341
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
8.8
168
1053
L11
ICPC
Wrist symptom/complaint
3.1
8.8
47
160
M47.9
ICD-10 Finland
Spondylosis, unspecified
5.2
8.7
26
52
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.2
8.7
32
80
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.2
8.7
92
457
H04.10
ICD-10 Finland
Dry eye syndrome
2.8
8.7
56
215
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
8.7
102
531
W19
ICD-10 Finland
Unspecified fall
2.7
8.6
61
246
A04
ICPC
Weakness/tiredness general
2.3
8.6
83
395
NG1AD
NOMESCO Finland
Knee CT examination
11.8
8.6
15
13
L89
ICPC
Osteoarthrosis of hip
7.1
8.6
20
29
H02.4
ICD-10 Finland
Ptosis of eyelid
5.1
8.6
26
53
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
8.5
95
482
NBB20
NOMESCO Finland
Primary total prosthetic replacement of humero-scapular joint
28.0
8.5
11
*
A02BC01
ATC
omeprazole; systemic
1.8
8.5
167
1052
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
8.5
314
2397
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.1
8.5
46
158
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
13.0
8.4
14
11
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.0
8.4
22
38
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.6
8.4
37
109
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
+∞
8.3
8
*
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
+∞
8.3
8
*
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
+∞
8.3
8
*
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
+∞
8.3
8
*
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
+∞
8.3
8
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
8.3
65
275
Z3226
NOMESCO Finland
Physiotherapist
2.1
8.3
98
510
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
8.2
129
753
M03BC51
ATC
orphenadrine, combinations; systemic
1.9
8.1
127
737
N06AX11
ATC
mirtazapine; oral
1.8
8.1
164
1040
9255
FHL
Joint auger removal
33.8
8.1
10
*
M22.4
ICD-10 Finland
Chondromalacia patellae
33.8
8.1
10
*
NH1AD
NOMESCO Finland
Ankle and foot CT
9.1
8.1
16
18
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
9.1
8.1
16
18
L04AA01
ATC
[U] ciclosporin; systemic
9.1
8.1
16
18
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.7
8.1
247
1778
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
4.5
8.0
27
62
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.7
8.0
33
92
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.2
8.0
85
422
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
4.1
8.0
30
77
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
6.7
7.9
19
29
SPAT1053
SPAT
Memory test
1.9
7.9
122
703
SPAT1325
SPAT
Vaccination
1.7
7.9
210
1449
S06.0
ICD-10 Finland
Concussion
2.5
7.9
61
260
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.7
7.9
236
1684
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
7.9
80
388
R51.80
ICD-10 Finland
Headache
2.4
7.9
66
293
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.0
7.9
45
159
A02BC05
ATC
esomeprazole; systemic
1.7
7.9
199
1353
R06AE07
ATC
cetirizine; oral
1.7
7.9
195
1318
NB1AD
NOMESCO Finland
Shoulder CT examination
11.0
7.8
14
13
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.7
7.8
53
209
1225
FHL
Arthroscopy and other therapeutic procedure
45.6
7.7
9
*
L04AB01
ATC
etanercept; parenteral
45.6
7.7
9
*
M25.9
ICD-10 Finland
Joint disorder, unspecified
45.6
7.7
9
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
7.7
114
650
205
Kela drug reimbursment
Chronic hypertension
1.7
7.7
203
1397
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
7.7
53
212
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.1
7.7
23
47
SPAT1262
SPAT
Handing over of treatment supplies
1.9
7.6
118
681
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
18.6
7.6
11
6
R52.9
ICD-10 Finland
Pain, unspecified
2.9
7.6
45
164
M23.8
ICD-10 Finland
Other internal derangements of knee
12.1
7.6
13
11
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.8
7.6
164
1060
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.4
7.6
64
285
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
25.4
7.6
10
*
SPAT1312
SPAT
General health counselling
1.8
7.6
167
1088
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
5.9
7.6
20
35
M54.4
ICD-10 Finland
Lumbago with sciatica
2.2
7.6
76
368
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
7.6
175
1156
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
3.5
7.6
34
102
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
10.2
7.6
14
14
A11CC03
ATC
alfacalcidol; systemic
4.9
7.5
23
48
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.6
7.5
55
228
ZXA10
NOMESCO Finland
Bilateral
1.9
7.5
112
640
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.7
7.5
49
191
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
81.1
7.4
8
*
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
5.7
7.4
20
36
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.9
7.4
128
768
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
4.5
7.4
25
58
RF410
NOMESCO Finland
NA
13.6
7.4
12
9
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.0
7.4
28
73
M16.5
ICD-10 Finland
Other post-traumatic coxarthrosis
+∞
7.3
7
*
TND10
NOMESCO Finland
Joint puncture, wrist or finger joint
+∞
7.3
7
*
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
+∞
7.3
7
*
ZXD05
NOMESCO Finland
Urgent procedure
1.7
7.2
166
1092
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
7.2
53
221
Y88.1
ICD-10 Finland
Sequelae of misadventures to patients during surgical and medical procedures
20.3
7.1
10
5
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.7
7.1
23
51
L04AA06
ATC
mycophenolic acid; systemic
8.1
7.1
15
19
C03DA01
ATC
spironolactone; oral
2.2
7.1
77
385
K02.1
ICD-10 Finland
Caries of dentine
1.6
7.1
242
1777
J01AA02
ATC
doxycycline; systemic
1.7
7.1
407
3420
WX002
NOMESCO Finland
Sedation and analgesia
1.9
7.1
107
611
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.6
7.0
240
1763
M01AB01
ATC
indometacin; systemic, rectal
2.5
7.0
52
217
M54.2
ICD-10 Finland
Cervicalgia
3.3
7.0
34
109
J01EA01
ATC
trimethoprim; systemic
1.8
7.0
146
933
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.8
6.9
44
167
Z71.8
ICD-10 Finland
Other specified counselling
1.9
6.9
109
636
R03BA05
ATC
fluticasone; inhalant
2.0
6.8
89
480
R4110
NOMESCO Finland
Physiotherapy
1.8
6.8
131
813
84400
ICD-8 Finland
Sprains and strains of knee and leg
11.1
6.8
12
11
ZXE00
NOMESCO Finland
One hour or less
1.7
6.8
197
1380
NFH30
NOMESCO Finland
Reduction of dislocation prosthesis of hip joint, closed
40.5
6.8
8
*
R32
ICD-10 Finland
Unspecified urinary incontinence
4.2
6.8
24
59
ND1AD
NOMESCO Finland
Wrist CT examination
16.9
6.8
10
6
G04BD12
ATC
mirabegron; oral
2.3
6.7
63
294
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.4
6.7
31
96
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
22.8
6.7
9
*
K03.64
ICD-10 Finland
Dental calculus supragingival
1.9
6.7
109
641
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
7.9
6.6
14
18
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.6
6.6
193
1355
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
12.4
6.6
11
9
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.7
6.6
44
174
G44.2
ICD-10 Finland
Tension-type headache
2.3
6.6
60
278
R03AC03
ATC
terbutaline; inhalant
2.1
6.6
72
364
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.9
6.6
38
137
M01AE11
ATC
tiaprofenic acid; oral, rectal
3.5
6.5
29
87
M79.7
ICD-10 Finland
Fibromyalgia
5.8
6.5
17
30
I50.0
ICD-10 Finland
Congestive heart failure
2.3
6.5
60
282
M77.4
ICD-10 Finland
Metatarsalgia
3.7
6.5
26
72
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.5
6.5
49
208
N18.8
ICD-10 Finland
Other chronic renal failure
4.0
6.4
24
62
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
70.6
6.4
7
*
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.2
6.4
32
105
M01AX01
ATC
nabumetone; oral
3.6
6.4
27
78
D82
ICPC
Teeth/gum disease
1.7
6.4
139
895
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
8.3
6.4
13
16
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.4
6.3
51
223
A12BA01
ATC
potassium chloride; oral
2.7
6.3
41
159
RD211
NOMESCO Finland
NA
3.3
6.3
29
90
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
+∞
6.3
6
*
7174A
ICD-9 Finland
Internal derangement of knee, Derangement of lateral meniscus
+∞
6.3
6
*
M06.4
ICD-10 Finland
Inflammatory polyarthropathy
+∞
6.3
6
*
M16.7
ICD-10 Finland
Other secondary coxarthrosis
+∞
6.3
6
*
M00.0
ICD-10 Finland
Staphylococcal arthritis and polyarthritis
+∞
6.3
6
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
+∞
6.3
6
*
73799
ICD-8 Finland
Hallux valgus and varus
+∞
6.3
6
*
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
6.3
6
*
M15.4
ICD-10 Finland
Erosive (osteo)arthrosis
+∞
6.3
6
*
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
6.3
6
*
M11
ICD-10 Finland
Other crystal arthropathies
+∞
6.3
6
*
M17.4
ICD-10 Finland
Other secondary gonarthrosis, bilateral
+∞
6.3
6
*
D07AC13
ATC
mometasone; topical
1.7
6.2
145
950
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
27.0
6.2
8
*
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
27.0
6.2
8
*
N30.0
ICD-10 Finland
Acute cystitis
2.0
6.2
79
424
SPAT1097
SPAT
Recording of ECG
1.9
6.2
95
544
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
6.4
6.2
15
24
127
Kela drug reimbursment
Transplant complication
6.4
6.2
15
24
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
5.8
6.2
16
28
R60.9
ICD-10 Finland
Oedema, unspecified
3.0
6.2
33
114
Z97.2
ICD-10 Finland
Presence of dental prosthetic device (complete)(partial)
4.3
6.2
21
50
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.7
6.2
40
155
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
6.2
211
1536
WX204
NOMESCO Finland
Axillary plexus blockaced
4.1
6.2
22
55
S40.0
ICD-10 Finland
Contusion of shoulder and upper arm
4.1
6.2
22
55
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
4.1
6.2
22
55
M01AH03
ATC
valdecoxib; oral
3.1
6.1
31
103
ZX120
NOMESCO Finland
Intravenous
2.2
6.1
59
281
SPAT1255
SPAT
Intravenous administration of medicine
2.6
6.1
43
175
S93.4
ICD-10 Finland
Sprain and strain of ankle
2.7
6.1
39
149
SDA02
NOMESCO Finland
Parodonthologic therapy
1.7
6.1
141
926
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
3.3
6.1
28
87
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.6
6.1
41
164
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.8
6.1
112
683
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.4
6.0
49
216

Mortality – FinRegistry

Association

Association between endpoint M13_CRYSTALARTH and mortality.

Females

Parameter HR [95% CI] p-value
M13_CRYSTALARTH 1.431 [1.21, 1.69] < 0.001
Birth year 0.996 [0.99, 1.0] 0.367

During the follow-up period (1.1.1998 — 31.12.2019), 770 out of 1835 females with M13_CRYSTALARTH died.

Males

Parameter HR [95% CI] p-value
M13_CRYSTALARTH 1.52 [1.24, 1.86] < 0.001
Birth year 0.986 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 558 out of 1418 males with M13_CRYSTALARTH died.

Mortality risk

Mortality risk for people of age

years, who have M13_CRYSTALARTH.

N-year risk Females Males
1 0.12% 0.257%
5 0.769% 1.859%
10 2.002% 4.559%
15 4.112% 8.323%
20 7.602% 14.276%

Relationships between endpoints

Index endpoint: M13_CRYSTALARTH – Other crystal arthropathies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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